LOCUS       NM_017584               1689 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myo-inositol oxygenase (MIOX), mRNA.
ACCESSION   NM_017584
VERSION     NM_017584.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Meng,L., Gao,J., Mo,W., Wang,B., Shen,H., Cao,W., Ding,M., Diao,W.,
            Chen,W., Zhang,Q., Shu,J., Dai,H. and Guo,H.
  TITLE     MIOX inhibits autophagy to regulate the ROS -driven inhibition of
            STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear
            cell renal cell carcinoma
  JOURNAL   Redox Biol 68, 102956 (2023)
   PUBMED   37977044
  REMARK    GeneRIF: MIOX inhibits autophagy to regulate the ROS -driven
            inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal
            transition in clear cell renal cell carcinoma.
            Erratum:[Redox Biol. 2024 Feb;69:102997. doi:
            10.1016/j.redox.2023.102997.. PMID: 38129197]
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Zhou,W., Yu,C. and Long,Y.
  TITLE     Myo-inositol oxygenase (MIOX) accelerated inflammation in the model
            of infection-induced cardiac dysfunction by NLRP3 inflammasome
  JOURNAL   Immun Inflamm Dis 11 (5), e829 (2023)
   PUBMED   37249295
  REMARK    GeneRIF: Myo-inositol oxygenase (MIOX) accelerated inflammation in
            the model of infection-induced cardiac dysfunction by NLRP3
            inflammasome.
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Zhang,Y., Luo,M., Cui,X., O'Connell,D. and Yang,Y.
  TITLE     Long noncoding RNA NEAT1 promotes ferroptosis by modulating the
            miR-362-3p/MIOX axis as a ceRNA
  JOURNAL   Cell Death Differ 29 (9), 1850-1863 (2022)
   PUBMED   35338333
  REMARK    GeneRIF: Long noncoding RNA NEAT1 promotes ferroptosis by
            modulating the miR-362-3p/MIOX axis as a ceRNA.
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Sharma,I., Deng,F., Liao,Y. and Kanwar,Y.S.
  TITLE     Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression
            of Renal Tubulointerstitial Injury in Diabetes
  JOURNAL   Diabetes 69 (6), 1248-1263 (2020)
   PUBMED   32169892
  REMARK    GeneRIF: Myo-inositol Oxygenase (MIOX) Overexpression Drives the
            Progression of Renal Tubulointerstitial Injury in Diabetes.
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Tominaga,T., Sharma,I., Fujita,Y., Doi,T., Wallner,A.K. and
            Kanwar,Y.S.
  TITLE     Myo-inositol oxygenase accentuates renal tubular injury initiated
            by endoplasmic reticulum stress
  JOURNAL   Am J Physiol Renal Physiol 316 (2), F301-F315 (2019)
   PUBMED   30539651
  REMARK    GeneRIF: MIOX-induced oxidant stress and tunicamycin-induced
            endoplasmic reticulum stress are interlinked, and both of the
            events may feed into each other to amplify the tubulointerstitial
            injury.
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Arner,R.J., Prabhu,K.S., Thompson,J.T., Hildenbrandt,G.R.,
            Liken,A.D. and Reddy,C.C.
  TITLE     myo-Inositol oxygenase: molecular cloning and expression of a
            unique enzyme that oxidizes myo-inositol and D-chiro-inositol
  JOURNAL   Biochem J 360 (Pt 2), 313-320 (2001)
   PUBMED   11716759
  REMARK    GeneRIF: myo-inositol oxygenase (MIOX)
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Yang,Q., Dixit,B., Wada,J., Tian,Y., Wallner,E.I., Srivastva,S.K.
            and Kanwar,Y.S.
  TITLE     Identification of a renal-specific oxido-reductase in newborn
            diabetic mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 9896-9901 (2000)
   PUBMED   10944187
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Koller,F. and Koller,E.
  TITLE     myo-inositol oxygenase from rat kidneys. Substrate-dependent
            oligomerization
  JOURNAL   Eur J Biochem 193 (2), 421-427 (1990)
   PUBMED   2226462
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Parthasarathy,R. and Eisenberg,F. Jr.
  TITLE     The inositol phospholipids: a stereochemical view of biological
            activity
  JOURNAL   Biochem J 235 (2), 313-322 (1986)
   PUBMED   3017301
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012025.1, BC064395.1, AF197129.1 and AL096767.14.
            
            On Nov 23, 2018 this sequence version replaced NM_017584.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073848.1, AY064416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216075.11/ ENSP00000216075.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               BC012025.1         76-454
            380-625             BC012025.1         487-732
            626-774             BC064395.1         609-757
            775-878             AF197129.1         736-839
            879-885             BC064395.1         848-854
            886-951             BC012025.1         830-895
            952-1362            BC064395.1         921-1331
            1363-1689           AL096767.14        65751-66077
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..1689
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /note="myo-inositol oxygenase"
                     /db_xref="GeneID:55586"
                     /db_xref="HGNC:HGNC:14522"
                     /db_xref="MIM:606774"
     exon            1..54
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..897
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /EC_number="1.13.99.1"
                     /note="aldehyde reductase (aldose reductase) like 6;
                     kidney-specific protein 32; MI oxygenase; aldehyde
                     reductase-like 6; renal-specific oxidoreductase"
                     /codon_start=1
                     /product="inositol oxygenase"
                     /protein_id="NP_060054.4"
                     /db_xref="CCDS:CCDS14092.1"
                     /db_xref="GeneID:55586"
                     /db_xref="HGNC:HGNC:14522"
                     /db_xref="MIM:606774"
                     /translation="MKVTVGPDPSLVYRPDVDPEVAKDKASFRNYTSGPLLDRVFTTY
                     KLMHTHQTVDFVRSKHAQFGGFSYKKMTVMEAVDLLDGLVDESDPDVDFPNSFHAFQT
                     AEGIRKAHPDKDWFHLVGLLHDLGKVLALFGEPQWAVVGDTFPVGCRPQASVVFCDST
                     FQDNPDLQDPRYSTELGMYQPHCGLDRVLMSWGHDEYMYQVMKFNKFSLPPEAFYMIR
                     FHSFYPWHTGRDYQQLCSQQDLAMLPWVREFNKFDLYTKCPDLPDVDKLRPYYQGLID
                     KYCPGILSW"
     exon            55..135
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            136..216
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            217..379
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            380..447
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            448..557
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            558..625
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            626..675
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            676..788
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1689
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /note="hexamer: AATAAA"
     polyA_site      1092
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /note="major polyA site"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
                     /note="hexamer: AATAAA"
     polyA_site      1689
                     /gene="MIOX"
                     /gene_synonym="ALDRL6"
ORIGIN      
        1 agcctgtgct ttgccacctg agcgccgctc cctctcagga tgaaggtgac ggtgggccca
       61 gacccttccc tggtctaccg acctgatgtg gacccagagg tggccaaaga caaggccagc
      121 ttccggaact acacgtcagg tcccctcctg gaccgtgtct tcaccaccta caagctcatg
      181 cacacgcacc agacagtgga cttcgtcagg agcaagcatg cccagtttgg gggcttctcc
      241 tacaagaaaa tgacagtcat ggaggccgtg gacctgctgg atgggctggt ggatgagtcg
      301 gacccggacg tagatttccc caactccttc catgccttcc agacagcgga gggcatccgg
      361 aaggcccacc cagacaagga ctggttccac ctcgtcgggc tcctgcacga cctggggaag
      421 gtcctggccc tgttcgggga gccccagtgg gctgtcgtcg gcgacacctt ccccgtcgga
      481 tgccgtccgc aggcctccgt ggttttctgc gactccacct tccaggacaa ccctgacctc
      541 caggatcctc gatacagcac agagctcggg atgtatcagc cccactgtgg gctcgacagg
      601 gtcctcatgt cctggggcca tgatgagtac atgtaccagg tgatgaagtt taacaagttc
      661 tcactgcccc ctgaggcttt ctacatgatc cggttccact ccttctaccc ctggcacacg
      721 ggccgcgact accagcagct gtgcagccag caggacctgg ccatgctgcc ctgggtgcgg
      781 gagttcaaca agttcgacct ctacaccaag tgcccggacc tgccggacgt ggacaagctg
      841 cggccctact accaggggct cattgacaag tactgccctg gcatcctgag ctggtgaccc
      901 tcctgccacc caagctgctg ctggacctag gcctggccct ccgcctgcct ggagaggcct
      961 ggccctgggc aaacagccgc catcagggtt cacctcggtg ggggacccca ctcaccccct
     1021 tagggtcgcc acccctcacg gcaacttgtg cctggcgtca ataaagacct ggaaggatgt
     1081 tgtgcttctg aagccccact gggtgttact gcagcagggc gtggcccagg ccgagggatg
     1141 gtgccagcag ggtggaggcc aagtcccagg ctttcaggtg tgtgtgtccc accacactgg
     1201 ccgtggtaaa catctgccca tcctcccagc tcctgtgtca gagcctgggg gacgagtcac
     1261 ccagctcacc cccacatgct caaaacagtc accaagtcct ctgggctccg tccccttaaa
     1321 aaatacccca atagctaaaa taatacattc atagaaaaca acaaaaaaca aatgcaggct
     1381 gggcacagcg gctcacacct ataatcccag cactttggga gggcgaggtg ggcggatcac
     1441 ctgaggtcag gggttcaaga ccagcctggc caacatggtg aaaccccgtc tctactaaaa
     1501 atacaaaaat tagccgggcg tggtggtggg cgcctgtaat cccagctatt caggaggcta
     1561 aggcaggaga atcgcttgaa cccgggagac aggggttgcc gtgagtcaag attgtgccac
     1621 tgcactccaa cctgggtatc aagagtgaaa ttccatctca aaaaaaataa ataaaataaa
     1681 ataaaacaa
//
