LOCUS       NM_153827               5017 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens misshapen like kinase 1 (MINK1), transcript variant 3,
            mRNA.
ACCESSION   NM_153827
VERSION     NM_153827.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Zhan,K., Zhu,K., Gu,B., Yao,S., Fu,F., Zeng,H., Tian,K., Ji,W.,
            Jin,H., Tong,P., Wu,C., Yue,M. and Ruan,H.
  TITLE     MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and
            exacerbates intervertebral disc degeneration
  JOURNAL   Int Immunopharmacol 134, 112202 (2024)
   PUBMED   38723371
  REMARK    GeneRIF: MINK1 deficiency stimulates nucleus pulposus cell
            pyroptosis and exacerbates intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Daulat,A.M., Wagner,M.S., Audebert,S., Kowalczewska,M.,
            Ariey-Bonnet,J., Finetti,P., Bertucci,F., Camoin,L. and Borg,J.P.
  TITLE     The serine/threonine kinase MINK1 directly regulates the function
            of promigratory proteins
  JOURNAL   J Cell Sci 135 (17) (2022)
   PUBMED   35971817
  REMARK    GeneRIF: The serine/threonine kinase MINK1 directly regulates the
            function of promigratory proteins.
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   Eisfeldt,J., Schuy,J., Stattin,E.L., Kvarnung,M., Falk,A., Feuk,L.
            and Lindstrand,A.
  TITLE     Multi-Omic Investigations of a 17-19 Translocation Links MINK1
            Disruption to Autism, Epilepsy and Osteoporosis
  JOURNAL   Int J Mol Sci 23 (16), 9392 (2022)
   PUBMED   36012658
  REMARK    GeneRIF: Multi-Omic Investigations of a 17-19 Translocation Links
            MINK1 Disruption to Autism, Epilepsy and Osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Zhang,J., Lei,H. and Li,X.
  TITLE     LncRNA SNHG14 contributes to proinflammatory cytokine production in
            rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK
            pathway
  JOURNAL   Environ Toxicol 36 (12), 2484-2492 (2021)
   PUBMED   34529319
  REMARK    GeneRIF: LncRNA SNHG14 contributes to proinflammatory cytokine
            production in rheumatoid arthritis via the regulation of the
            miR-17-5p/MINK1-JNK pathway.
REFERENCE   6  (bases 1 to 5017)
  AUTHORS   Fatini,C., Sticchi,E., Genuardi,M., Sofi,F., Gensini,F., Gori,A.M.,
            Lenti,M., Michelucci,A., Abbate,R. and Gensini,G.F.
  TITLE     Analysis of minK and eNOS genes as candidate loci for
            predisposition to non-valvular atrial fibrillation
  JOURNAL   Eur Heart J 27 (14), 1712-1718 (2006)
   PUBMED   16760206
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5017)
  AUTHORS   Hu,Y., Leo,C., Yu,S., Huang,B.C., Wang,H., Shen,M., Luo,Y.,
            Daniel-Issakani,S., Payan,D.G. and Xu,X.
  TITLE     Identification and functional characterization of a novel human
            misshapen/Nck interacting kinase-related kinase, hMINK beta
  JOURNAL   J Biol Chem 279 (52), 54387-54397 (2004)
   PUBMED   15469942
  REMARK    GeneRIF: results suggest that human Misshapen/NIKs-related kinase
            beta (hMINK beta) plays an important role in cytoskeleton
            reorganization, cell adhesion, and cell motility(hMINKbeta)
            Erratum:[J Biol Chem. 2005 Feb 11;280(6):5128]
REFERENCE   8  (bases 1 to 5017)
  AUTHORS   Campdelacreu,J., Ezquerra,M., Munoz,E., Oliva,R. and Tolosa,E.
  TITLE     Mutational study of the nuclear factor kappa B inducing kinase gene
            in patients with progressive supranuclear palsy
  JOURNAL   Neurosci Lett 340 (2), 158-160 (2003)
   PUBMED   12668260
  REMARK    GeneRIF: Analysis of the coding region of the NIK gene in
            progressive supranuclear palsy (PSP) patients through single strand
            conformation polymorphism and direct sequencing does not support a
            pathogenic role of the NIK gene in PSP.
REFERENCE   9  (bases 1 to 5017)
  AUTHORS   Dan,I., Watanabe,N.M., Kajikawa,E., Ishida,T., Pandey,A. and
            Kusumi,A.
  TITLE     Overlapping of MINK and CHRNE gene loci in the course of mammalian
            evolution
  JOURNAL   Nucleic Acids Res 30 (13), 2906-2910 (2002)
   PUBMED   12087176
REFERENCE   10 (bases 1 to 5017)
  AUTHORS   Dan,I., Watanabe,N.M., Kobayashi,T., Yamashita-Suzuki,K.,
            Fukagaya,Y., Kajikawa,E., Kimura,W.K., Nakashima,T.M.,
            Matsumoto,K., Ninomiya-Tsuji,J. and Kusumi,A.
  TITLE     Molecular cloning of MINK, a novel member of mammalian GCK family
            kinases, which is up-regulated during postnatal mouse cerebral
            development
  JOURNAL   FEBS Lett 469 (1), 19-23 (2000)
   PUBMED   10708748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA653105.1, BC034673.1,
            AB035698.1, AB041926.1 and AL157418.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_153827.4.
            
            Summary: This gene encodes a serine/threonine kinase belonging to
            the germinal center kinase (GCK) family. The protein is
            structurally similar to the kinases that are related to NIK and may
            belong to a distinct subfamily of NIK-related kinases within the
            GCK family. Studies of the mouse homolog indicate an up-regulation
            of expression in the course of postnatal mouse cerebral development
            and activation of the cJun N-terminal kinase (JNK) and the p38
            pathways. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (3) includes an additional
            in-frame exon, compared to variant 1, resulting in the longest
            isoform (3) which has a unique internal segment, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355280.11/ ENSP00000347427.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DA653105.1         1-48
            49-2555             BC034673.1         1-2507
            2556-2568           AB035698.1         2201-2213
            2569-4823           BC034673.1         2521-4775
            4824-5010           AB041926.1         4677-4863
            5011-5017           AL157418.1         4566-4572
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..5017
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /note="misshapen like kinase 1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:HGNC:17565"
                     /db_xref="MIM:609426"
     exon            1..301
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..4243
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     misshapen/NIK-related kinase; GCK family kinase MINK; MEK
                     kinase kinase 6; MAPK/ERK kinase kinase kinase 6;
                     mitogen-activated protein kinase kinase kinase kinase 6"
                     /codon_start=1
                     /product="misshapen-like kinase 1 isoform 3"
                     /protein_id="NP_722549.2"
                     /db_xref="CCDS:CCDS45588.1"
                     /db_xref="GeneID:50488"
                     /db_xref="HGNC:HGNC:17565"
                     /db_xref="MIM:609426"
                     /translation="MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLW
                     LVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWS
                     LGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS
                     RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHG
                     EEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLH
                     QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQE
                     YKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYG
                     RGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTP
                     PMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIP
                     APTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTS
                     GAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRS
                     DPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGR
                     PADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRS
                     DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQ
                     PSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT
                     ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGV
                     NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLS
                     WLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPK
                     PYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV
                     HIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYIC
                     SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
                     FMTLNRNCIMNW"
     exon            302..367
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..424
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..550
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..661
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..752
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..883
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            884..938
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1017
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1193
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1263
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1474
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1591
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1810
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1984
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2245
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2331
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2442
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2555
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2644
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2808
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2914
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3052
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3161
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3329
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3473
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3608
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3709
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3859
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..4019
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4159
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..5017
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4989..4994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /note="hexamer: AATAAA"
     polyA_site      5017
                     /gene="MINK1"
                     /gene_synonym="B55; MAP4K6; MEKKK 6; MINK; YSK2; ZC3"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcggt cgctccgcgc ctgcgcagga gaggtggtag gctcgggtgg ctggctccgg
       61 ggagatagcg cctgtcagtc ggtgggtcgg tcctcgcgcc ggccctcccc ctccccggtc
      121 tccgggggag gcgcggtgga gtccgccccc ggggttctcc gatgggggag aagcggcgac
      181 ggcggcagtg gagtaaccga gccggagcgt gagcggcccc ggtgccccgt tccccacgga
      241 ggccatgggc gacccagccc ccgcccgcag cctggacgac atcgacctgt ccgccctgcg
      301 ggaccctgct gggatctttg agcttgtgga ggtggtcggc aatggaacct acggacaggt
      361 gtacaagggt cggcatgtca agacggggca gctggctgcc atcaaggtca tggatgtcac
      421 ggaggacgag gaggaagaga tcaaacagga gatcaacatg ctgaaaaagt actctcacca
      481 ccgcaacatc gccacctact acggagcctt catcaagaag agccccccgg gaaacgatga
      541 ccagctctgg ctggtgatgg agttctgtgg tgctggttca gtgactgacc tggtaaagaa
      601 cacaaaaggc aacgccctga aggaggactg tatcgcctat atctgcaggg agatcctcag
      661 gggtctggcc catctccatg cccacaaggt gatccatcga gacatcaagg ggcagaatgt
      721 gctgctgaca gagaatgctg aggtcaagct agtggatttt ggggtgagtg ctcagctgga
      781 ccgcaccgtg ggcagacgga acactttcat tgggactccc tactggatgg ctccagaggt
      841 catcgcctgt gatgagaacc ctgatgccac ctatgattac aggagtgata tttggtctct
      901 aggaatcaca gccatcgaga tggcagaggg agccccccct ctgtgtgaca tgcaccccat
      961 gcgagccctc ttcctcattc ctcggaaccc tccgcccagg ctcaagtcca agaagtggtc
     1021 taagaagttc attgacttca ttgacacatg tctcatcaag acttacctga gccgcccacc
     1081 cacggagcag ctactgaagt ttcccttcat ccgggaccag cccacggagc ggcaggtccg
     1141 catccagctt aaggaccaca ttgaccgatc ccggaagaag cggggtgaga aagaggagac
     1201 agaatatgag tacagcggca gcgaggagga agatgacagc catggagagg aaggagagcc
     1261 aagctccatc atgaacgtgc ctggagagtc gactctacgc cgggagtttc tccggctcca
     1321 gcaggaaaat aagagcaact cagaggcttt aaaacagcag cagcagctgc agcagcagca
     1381 gcagcgagac cccgaggcac acatcaaaca cctgctgcac cagcggcagc ggcgcataga
     1441 ggagcagaag gaggagcggc gccgcgtgga ggagcaacag cggcgggagc gggagcagcg
     1501 gaagctgcag gagaaggagc agcagcggcg gctggaggac atgcaggctc tgcggcggga
     1561 ggaggagcgg cggcaggcgg agcgcgagca ggaatacaag cggaagcagc tggaggagca
     1621 gcggcagtca gaacgtctcc agaggcagct gcagcaggag catgcctacc tcaagtccct
     1681 gcagcagcag caacagcagc agcagcttca gaaacagcag cagcagcagc tcctgcctgg
     1741 ggacaggaag cccctgtacc attatggtcg gggcatgaat cccgctgaca aaccagcctg
     1801 ggcccgagag gtagaagaga gaacaaggat gaacaagcag cagaactctc ccttggccaa
     1861 gagcaagcca ggcagcacgg ggcctgagcc ccccatcccc caggcctccc cagggccccc
     1921 aggacccctt tcccagactc ctcctatgca gaggccggtg gagccccagg agggaccgca
     1981 caagagcctg gtggcacacc gggtcccact gaagccatat gcagcacctg taccccgatc
     2041 ccagtccctg caggaccagc ccacccgaaa cctggctgcc ttcccagcct cccatgaccc
     2101 cgaccctgcc atccccgcac ccactgccac gcccagtgcc cgaggagctg tcatccgcca
     2161 gaattcagac cccacctctg aaggacctgg ccccagcccg aatcccccag cctgggtccg
     2221 cccagataac gaggccccac ccaaggtgcc tcagaggacc tcatctatcg ccactgccct
     2281 taacaccagt ggggccggag ggtcccggcc agcccaggca gtccgtgcca gacctcgcag
     2341 caactccgcc tggcaaatct atctgcaaag gcgggcagag cggggcaccc caaagcctcc
     2401 agggccccct gctcagcccc ctggcccgcc caacgcctct agtaaccccg acctcaggag
     2461 gagcgaccct ggctgggaac gctcggacag cgtccttcca gcctctcacg ggcacctccc
     2521 ccaggctggc tcactggagc ggaaccgcgt gggagtctcc tccaaaccgg acagctcccc
     2581 tgtgctctcc cctgggaata aagccaagcc cgacgaccac cgctcacggc caggccggcc
     2641 cgcagacttt gtgttgctga aagagcggac tctggacgag gcccctcggc ctcccaagaa
     2701 ggccatggac tactcgtcgt ccagcgagga ggtggaaagc agtgaggacg acgaggagga
     2761 aggcgaaggc gggccagcag aggggagcag agatacccct gggggccgca gcgatgggga
     2821 tacagacagc gtcagcacca tggtggtcca cgacgtcgag gagatcaccg ggacccagcc
     2881 cccatacggg ggcggcacca tggtggtcca gcgcacccct gaagaggagc ggaacctgct
     2941 gcatgctgac agcaatgggt acacaaacct gcctgacgtg gtccagccca gccactcacc
     3001 caccgagaac agcaaaggcc aaagcccacc ctcgaaggat gggagtggtg actaccagtc
     3061 tcgtgggctg gtaaaggccc ctggcaagag ctcgttcacg atgtttgtgg atctagggat
     3121 ctaccagcct ggaggcagtg gggacagcat ccccatcaca gccctagtgg gtggagaggg
     3181 cactcggctc gaccagctgc agtacgacgt gaggaagggt tctgtggtca acgtgaatcc
     3241 caccaacacc cgggcccaca gtgagacccc tgagatccgg aagtacaaga agcgattcaa
     3301 ctccgagatc ctctgtgcag ccctttgggg ggtcaacctg ctggtgggca cggagaacgg
     3361 gctgatgttg ctggaccgaa gtgggcaggg caaggtgtat ggactcattg ggcggcgacg
     3421 cttccagcag atggatgtgc tggaggggct caacctgctc atcaccatct cagggaaaag
     3481 gaacaaactg cgggtgtatt acctgtcctg gctccggaac aagattctgc acaatgaccc
     3541 agaagtggag aagaagcagg gctggaccac cgtgggggac atggagggct gcgggcacta
     3601 ccgtgttgtg aaatacgagc ggattaagtt cctggtcatc gccctcaaga gctccgtgga
     3661 ggtgtatgcc tgggccccca aaccctacca caaattcatg gccttcaagt cctttgccga
     3721 cctcccccac cgccctctgc tggtcgacct gacagtagag gaggggcagc ggctcaaggt
     3781 catctatggc tccagtgctg gcttccatgc tgtggatgtc gactcgggga acagctatga
     3841 catctacatc cctgtgcaca tccagagcca gatcacgccc catgccatca tcttcctccc
     3901 caacaccgac ggcatggaga tgctgctgtg ctacgaggac gagggtgtct acgtcaacac
     3961 gtacgggcgc atcattaagg atgtggtgct gcagtggggg gagatgccta cttctgtggc
     4021 ctacatctgc tccaaccaga taatgggctg gggtgagaaa gccattgaga tccgctctgt
     4081 ggagacgggc cacctcgacg gggtcttcat gcacaaacga gctcagaggc tcaagttcct
     4141 gtgtgagcgg aatgacaagg tgttttttgc ctcagtccgc tctgggggca gcagccaagt
     4201 ttacttcatg actctgaacc gtaactgcat catgaactgg tgacggggcc ctgggctggg
     4261 gctgtcccac actggaccca gctctccccc tgcagccagg cttcccgggc cgcccctctt
     4321 tcccctccct gggcttttgc ttttactggt ttgatttcac tggagcctgc tgggaacgtg
     4381 acctctgacc cctgatgctt tcgtgatcac gtgaccatcc tcttccccaa catgtcctct
     4441 tcccaaaact gtgcctgtcc ccagcttctg gggagggaca cagcttcccc ttcccaggaa
     4501 ttgagtgggc ctagcccctc cccccttttc tccatttgag aggagagtgc ttggggcttg
     4561 aaccccttac cccactgctg ctgactgggc agggccctgg acccctttat ttgcacgtca
     4621 ggggagccgg ctcccccctt gaatgtacca gaccctgggg ggggtcactg ggccctagat
     4681 ttttgggggg tcaccagcca ctccaggggc agggaccatt tcttcatttt ctgaaagcac
     4741 tttaatgatt ccccttcccc caaactccag ggaatggagg ggggaccccg ccagccaaaa
     4801 cattcccccc attcccgacc cccctctcct cttctagccc atgcccttcc ccggtggagg
     4861 gagggagcag ggagccctca ctctccacgc cccttgcttg catctgtata tagtgtgagc
     4921 agcaagtaac ccttctccct ccccccccac ccctcctcaa tgtagtggcc ttggatatcc
     4981 tgtttgttaa taaagacaat tcaaccagct cccacca
//
