LOCUS       NM_032222               2733 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MINDY lysine 48 deubiquitinase 4 (MINDY4), mRNA.
ACCESSION   NM_032222 XM_351692 XM_353570
VERSION     NM_032222.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Choi,E.S., Lee,H., Sung,J.Y., Lee,C.H., Jang,H., Kim,K.T.,
            Kim,Y.N., Kim,H.P. and Goh,S.H.
  TITLE     FAM188B enhances cell survival via interaction with USP7
  JOURNAL   Cell Death Dis 9 (6), 633 (2018)
   PUBMED   29795372
  REMARK    GeneRIF: FAM188B is a putative oncogene that functions via
            interaction with USP7.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Urabe,Y., Tanikawa,C., Takahashi,A., Okada,Y., Morizono,T.,
            Tsunoda,T., Kamatani,N., Kohri,K., Chayama,K., Kubo,M., Nakamura,Y.
            and Matsuda,K.
  TITLE     A genome-wide association study of nephrolithiasis in the Japanese
            population identifies novel susceptible Loci at 5q35.3, 7p14.3, and
            13q14.1
  JOURNAL   PLoS Genet 8 (3), e1002541 (2012)
   PUBMED   22396660
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA868176.1, AK026027.1, AC004691.1 and BC098569.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032222.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF538962.1, SRR1803617.210050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265299.6/ ENSP00000265299.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               DA868176.1         1-540
            541-1041            AK026027.1         541-1041
            1042-1150           AC004691.1         19861-19969
            1151-2733           BC098569.1         1098-2680
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..2733
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /note="MINDY lysine 48 deubiquitinase 4"
                     /db_xref="GeneID:84182"
                     /db_xref="HGNC:HGNC:21916"
     exon            1..140
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2351
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /EC_number="3.4.19.12"
                     /note="protein FAM188B; probable ubiquitin
                     carboxyl-terminal hydrolase FAM188B; Aquaporin-1;
                     Aquaporin-CHIP; Urine water channel; Water channel protein
                     for red blood cells and kidney proximal tubule; family
                     with sequence similarity 188 member B; MINDY
                     deubiquitinase 4; probable deubiquitinating enzyme
                     MINDY-4"
                     /codon_start=1
                     /product="probable ubiquitin carboxyl-terminal hydrolase
                     MINDY-4"
                     /protein_id="NP_115598.2"
                     /db_xref="CCDS:CCDS43565.1"
                     /db_xref="GeneID:84182"
                     /db_xref="HGNC:HGNC:21916"
                     /translation="MDSLFVEEVAASLVREFLSRKGLKKTCVTMDQERPRSDLSINNR
                     NDLRKVLHLEFLYKENKAKENPLKTSLELITRYFLDHFGNTANNFTQDTPIPALSVPK
                     KNNKVPSRCSETTLVNIYDLSDEDAGWRTSLSETSKARHDNLDGDVLGNFVSSKRPPH
                     KSKPMQTVPGETPVLTSAWEKIDKLHSEPSLDVKRMGENSRPKSGLIVRGMMSGPIAS
                     SPQDSFHRHYLRRSSPSSSSTQPQEESRKVPELFVCTQQDILASSNSSPSRTSLGQLS
                     ELTVERQKTTASSPPHLPSKRLPPWDRARPRDPSEDTPAVDGSTDTDRMPLKLYLPGG
                     NSRMTQERLERAFKRQGSQPAPVRKNQLLPSDKVDGELGALRLEDVEDELIREEVILS
                     PVPSVLKLQTASKPIDLSVAKEIKTLLFGSSFCCFNEEWKLQSFSFSNTASLKYGIVQ
                     NKGGPCGVLAAVQGCVLQKLLFEGDSKADCAQGLQPSDAHRTRCLVLALADIVWRAGG
                     RERAVVALASRTQQFSPTGKYKADGVLETLTLHSLTCYEDLVTFLQQSIHQFEVGPYG
                     CILLTLSAILSRSTELIRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVE
                     LDSGDGNITLLRGIAARSDIGFLSLFEHYNMCQVGCFLKTPRFPIWVVCSESHFSILF
                     SLQPGLLRDWRTERLFDLYYYDGLANQQEQIRLTIDTTQTISEDTDNDLVPPLELCIR
                     TKWKGASVNWNGSDPIL"
     exon            141..260
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            261..496
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            497..740
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1150
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1209
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1316
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1433
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1522
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1624
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1688
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1754
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1822
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1886
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2048
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2229
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2302
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2733
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /note="hexamer: TATAAA"
     polyA_site      2733
                     /gene="MINDY4"
                     /gene_synonym="AQP-1; AQP1; C7orf67; CHIP28; FAM188B"
                     /note="major polyA site"
ORIGIN      
        1 atactgcgcc ggacagaccc agttgcctgg tgctgcggcc cggcgtgggc ctcgtgggca
       61 gagccagagc cagagccatg gacagcctct tcgtggagga ggtggccgcc tccttggtca
      121 gggagttcct cagcagaaag ggcttaaaga agacatgtgt gaccatggac caggaacgcc
      181 cacgctctga cctcagcata aacaacagaa atgatcttcg aaaggttttg catcttgaat
      241 ttctctataa ggagaacaag gcaaaggaaa atcctctaaa aacaagcctt gaactcatca
      301 ccagatactt tctggatcac tttggaaata cggctaacaa tttcactcaa gataccccaa
      361 tccctgcact ctcagttcca aagaaaaata acaaagtgcc atcaagatgc tcagagacta
      421 cactggtaaa tatatatgac ctttcagatg aagatgcagg atggagaaca tcattgtcag
      481 aaacaagcaa agccagacat gacaatcttg atggagatgt acttggtaat tttgtatcat
      541 ctaaaaggcc cccgcacaaa agtaagccca tgcagacggt cccgggtgaa actcctgtgt
      601 tgacttctgc atgggagaag atagacaagc ttcactcgga gccttccttg gatgtgaaga
      661 ggatgggaga gaattccagg ccaaagtctg gtctgattgt gcgaggcatg atgtctgggc
      721 ccatcgccag ctccccacag gattcttttc acagacacta tctgagacgg tcctcaccgt
      781 caagcagctc cacccaaccc caagaagaga gccggaaggt ccctgagctc tttgtctgca
      841 cccaacagga cattctggct tcgagcaaca gctccccctc caggacctcc ctgggtcagc
      901 ttagtgaact gaccgtagaa aggcagaaaa ccactgccag cagccctccc catctgccca
      961 gcaaacggct gcccccatgg gacagggcca ggccgaggga tccctccgag gacaccccag
     1021 cagtggacgg cagcacagac acggacagga tgcccttgaa gctctacttg cctggtggta
     1081 attccaggat gacccaggag aggctggaaa gagcgttcaa acggcagggc agccagcccg
     1141 cacctgtcag gaaaaatcag ttgctgccgt ctgacaaggt ggatggtgag ctgggtgccc
     1201 tgcggctcga ggatgtggag gatgagttga taagggaaga ggtcatcctg tcgccagtcc
     1261 catcagtgct caagttgcag acagcatcaa aaccaattga cctctcagta gcaaaggaaa
     1321 taaagaccct tctgtttggt tccagctttt gctgtttcaa tgaagaatgg aaacttcaga
     1381 gtttttcctt tagtaacaca gcctcattaa aatacggcat agtgcagaac aagggtggtc
     1441 cttgcggagt cctggcagct gtccaaggct gtgtcctaca gaaactcctg tttgaaggag
     1501 atagcaaagc cgactgtgct cagggactgc agccttcaga tgcccaccgg acccgctgcc
     1561 tcgtcctggc cctcgcagac attgtgtggc gggcaggggg ccgagagaga gccgttgttg
     1621 cactggcttc gagaacacag cagttcagtc caacagggaa atacaaagca gatggagtct
     1681 tagaaacact tacgcttcac agtttgacct gctatgagga cctggtgact tttcttcaac
     1741 aaagcattca tcagtttgaa gtgggcccct atggctgcat cctgctcacc ctttctgcca
     1801 tcctgtccag gtctacagag ctcatccgcc aggactttga tgtccccacc agccacctga
     1861 ttggagcaca tggctactgt acacaggaac ttgtcaatct gctcctgact gggaaagctg
     1921 tgtccaacgt tttcaacgat gtggttgagc tggattctgg ggatgggaac atcacacttc
     1981 tcagaggcat tgctgcacgc agtgatattg gcttcttatc tctctttgag cattacaaca
     2041 tgtgccaggt tggctgcttc ctgaagaccc cgaggttccc catctgggtg gtttgcagtg
     2101 agagccactt cagcatcctc tttagcctgc agccggggct cctgcgtgac tggaggactg
     2161 agaggctctt tgacttgtac tactacgatg gcctggccaa ccagcaggag cagatccggc
     2221 tgaccattga caccacccaa accatctctg aggacacaga caacgacctt gtcccacccc
     2281 tcgagctctg catcagaacc aagtggaagg gggcatcagt gaactggaac ggctcagacc
     2341 ccatcctgtg accgttggat gtgggtaaac cctgtggtcc accactcatc acctcatcac
     2401 cgaggatgac agctgaaccc caagcctctg gggcaggtct catgtacccc aacctgggtc
     2461 agcatgactg cagaagcatc cagagcctcc ctgccccttc catgaagggc ccacccaaga
     2521 ctgtgctggg gacccagtgt gttgctgggt cccctcccag ctgagctgtg actgctgagt
     2581 actggaagga ggttgccagg gtctctgcta cctttgtctg catccctccc ttgctccctg
     2641 ctgggtggtc cctcacccag gcctccaatg tggttggccc tggggactca ttacttctgg
     2701 tagctggctt tctataaaaa tgggtcaaac cca
//
