LOCUS       NM_024948               2364 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens MINDY lysine 48 deubiquitinase 3 (MINDY3), transcript
            variant 1, mRNA.
ACCESSION   NM_024948
VERSION     NM_024948.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2364)
  AUTHORS   Yong,M., Zeng,Y., Yao,Y., Yang,M., Tang,F., Zhu,H. and Hu,J.
  TITLE     CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in
            Epithelial Ovarian Carcinoma
  JOURNAL   Cancer Rep (Hoboken) 7 (9), e2128 (2024)
   PUBMED   39229655
  REMARK    GeneRIF: CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in
            Epithelial Ovarian Carcinoma.
REFERENCE   2  (bases 1 to 2364)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2364)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2364)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2364)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2364)
  AUTHORS   Abdul Rehman,S.A., Kristariyanto,Y.A., Choi,S.Y., Nkosi,P.J.,
            Weidlich,S., Labib,K., Hofmann,K. and Kulathu,Y.
  TITLE     MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally
            Distinct New Family of Deubiquitinating Enzymes
  JOURNAL   Mol Cell 63 (1), 146-155 (2016)
   PUBMED   27292798
REFERENCE   7  (bases 1 to 2364)
  AUTHORS   Lu,F., Xue,J.X., Hu,Y.C., Gan,L., Shi,Y., Yang,H.S. and Wei,Y.Q.
  TITLE     CARP is a potential tumor suppressor in gastric carcinoma and a
            single-nucleotide polymorphism in CARP gene might increase the risk
            of gastric carcinoma
  JOURNAL   PLoS One 9 (5), e97743 (2014)
   PUBMED   24870804
  REMARK    GeneRIF: CARP is a potential tumor suppressor of gastric carcinoma
            and the rs2297882 C>T phenotype of CARP may serve as a predictor of
            gastric carcinoma.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2364)
  AUTHORS   Shi,Y., Chen,J., Li,Z., Zhang,Z., Yu,H., Sun,K., Wang,X., Song,X.,
            Wang,Y., Zhen,Y., Yang,T., Lou,K., Zhang,Y., Zhang,G., Hu,Y., Ji,J.
            and Hui,R.
  TITLE     C10ORF97 is a novel tumor-suppressor gene of non-small-cell lung
            cancer and a functional variant of this gene increases the risk of
            non-small-cell lung cancer
  JOURNAL   Oncogene 30 (39), 4107-4117 (2011)
   PUBMED   21499297
  REMARK    GeneRIF: results indicated that C10ORF97 functions as a novel tumor
            suppressor by modulating several key G(1)/S-regulatory proteins by
            interacting with JAB1
REFERENCE   9  (bases 1 to 2364)
  AUTHORS   Daw,E.W., Chen,S.N., Czernuszewicz,G., Lombardi,R., Lu,Y., Ma,J.,
            Roberts,R., Shete,S. and Marian,A.J.
  TITLE     Genome-wide mapping of modifier chromosomal loci for human
            hypertrophic cardiomyopathy
  JOURNAL   Hum Mol Genet 16 (20), 2463-2471 (2007)
   PUBMED   17652099
REFERENCE   10 (bases 1 to 2364)
  AUTHORS   Liu,B., Liu,Y., Chen,J., Wei,Z., Yu,H., Zhen,Y., Lu,L. and Hui,R.
  TITLE     CARP is a novel caspase recruitment domain containing pro-apoptotic
            protein
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1396-1404 (2002)
   PUBMED   12054670
  REMARK    GeneRIF: CARP is a novel caspase recruitment domain containing
            pro-apoptotic protein.  (CARP, CARD containing Protein)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA063140.1, AK023459.1 and
            AI573091.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024948.3.
            
            Summary: The protein encoded by this gene contains a
            caspase-associated recruitment domain and may function in
            apoptosis. It has been identified as a tumor suppressor in lung and
            gastric cancers, and a polymorphism in the gene may be associated
            with gastric cancer risk. Alternative splicing of this gene results
            in multiple transcript variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067799.1, AK023459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277632.8/ ENSP00000277632.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               DA063140.1         27-230
            205-2351            AK023459.1         218-2364
            2352-2364           AI573091.1         30-42               c
FEATURES             Location/Qualifiers
     source          1..2364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..2364
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /note="MINDY lysine 48 deubiquitinase 3"
                     /db_xref="GeneID:80013"
                     /db_xref="HGNC:HGNC:23578"
                     /db_xref="MIM:611649"
     exon            1..302
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1546
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     caspase recruitment domain containing pro-apoptotic
                     protein; CARD-containing protein; dermal papilla-derived
                     protein 5; protein FAM188A; ubiquitin carboxyl-terminal
                     hydrolase FAM188A; family with sequence similarity 188
                     member A; MINDY deubiquitinase 3; deubiquitinating enzyme
                     MINDY-3; ubiquitin carboxyl-terminal hydrolase MINDY-3"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-3
                     isoform a"
                     /protein_id="NP_079224.1"
                     /db_xref="CCDS:CCDS7110.1"
                     /db_xref="GeneID:80013"
                     /db_xref="HGNC:HGNC:23578"
                     /db_xref="MIM:611649"
                     /translation="MSELTKELMELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALE
                     QFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDILESACCDHS
                     GSYCLVSWLRGKTTEETASISGSPAESSCQVEHSSALAVEELGFERFHALIQKRSFRS
                     LPELKDAVLDQYSMWGNKFGVLLFLYSVLLTKGIENIKNEIEDASEPLIDPVYGHGSQ
                     SLINLLLTGHAVSNVWDGDRECSGMKLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPK
                     FPIWIVGSETHLTVFFAKDMALVAPEAPSEQARRVFQTYDPEDNGFIPDSLLEDVMKA
                     LDLVSDPEYINLMKNKLDPEGLGIILLGPFLQEFFPDQGSSGPESFTVYHYNGLKQSN
                     YNEKVMYVEGTAVVMGFEDPMLQTDDTPIKRCLQTKWPYIELLWTTDRSPSLN"
     exon            303..382
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            383..443
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            444..617
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            618..669
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            670..784
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            785..858
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            859..938
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1009
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1090
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1163
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1236
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1324
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1396
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2364
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1663..1668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /note="hexamer: ATTAAA"
     polyA_site      1685
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /note="hexamer: AATAAA"
     polyA_site      2364
                     /gene="MINDY3"
                     /gene_synonym="C10orf97; CARP; DERP5; FAM188A; MST126;
                     MSTP126; my042"
                     /note="major polyA site"
ORIGIN      
        1 acttccggta cggaaaactc gctgctgccc caacctggct tgacaggctt ggtctctgca
       61 agtggctctc agccccttct tctttcctgc ctcaccttcc aattcgtttg ccgccgccgt
      121 cccgcagctg ctgtttccgg agttgcccct tccccatgtt ccggggcagg agtccgcaaa
      181 gcgaagatcc gcccgccggt tcctcatcat gtccgaactg actaaagagc tgatggagct
      241 ggtgtggggc accaagagca gccccggtct ctcggacacc attttctgcc gctggacgca
      301 agggtttgtg tttagtgaat cagagggatc tgcattagaa cagtttgaag gtggcccctg
      361 tgctgttatt gcacctgttc aggcatttct tttgaagaag ctcctgtttt cttcggagaa
      421 gtcttcttgg cgggattgtt cagaggaaga gcagaaggaa ctcctttgtc ataccttgtg
      481 tgatatttta gaaagtgctt gttgtgacca ctctggatca tactgcttgg tttcatggtt
      541 aagaggaaag acaactgagg aaactgctag tatttctggg agtcctgcag agtctagttg
      601 ccaagtggaa cattcttctg ccttggctgt cgaagagctt ggctttgagc gatttcatgc
      661 attaattcaa aaaagatcgt tcagaagttt accagaatta aaagatgctg tcttggacca
      721 gtattcaatg tggggaaata aatttggagt attgcttttt ctgtattctg tattactgac
      781 aaagggcatt gaaaacataa aaaacgaaat tgaagatgca agtgaaccct tgatagatcc
      841 tgtatatgga catggcagcc aaagtttaat taatctcctg ctgacgggac atgctgtttc
      901 taatgtatgg gatggtgata gagagtgctc aggaatgaaa cttcttggta tacatgaaca
      961 agcagcagta ggatttttaa cactaatgga agctttaaga tactgtaagg ttggttctta
     1021 cttgaaatct ccaaaattcc ctatttggat tgttggcagt gagactcacc tcaccgtatt
     1081 ttttgccaag gatatggctt tagttgcccc tgaagctcct tcagaacaag ccagaagagt
     1141 ttttcaaacc tacgacccag aagataatgg attcataccc gattcacttc tggaagatgt
     1201 gatgaaagca ttggaccttg tttcagatcc tgaatatata aatctcatga agaataaatt
     1261 agatccagaa ggattaggaa tcatattatt gggcccattt cttcaagaat tttttcctga
     1321 tcagggctcc agtggtccag aatcttttac tgtctaccac tacaatggat tgaagcagtc
     1381 aaattataat gaaaaggtca tgtacgtaga agggactgca gttgtgatgg gttttgaaga
     1441 tcccatgcta cagacagatg acactcctat taaacgctgt ctgcaaacca aatggccata
     1501 cattgagtta ctctggacca cagatcgctc tccttcacta aattaatttg tctaagtatt
     1561 tataaggaag atcttaataa cagatgttga aagaaggagt caagactggc aattggctgg
     1621 attaagctaa acactggtat cactgattaa ctgtaaataa caattaaaaa cacattttca
     1681 gtgtttatga tatgtttaaa ttatttgtcc taaagcttta tgttaaagat tatcctattt
     1741 taccccttcg tgtgaaattt actagcaaaa ttaagctttc atcaaagttc atcacttttg
     1801 cattcagata cttggtcatt tacttaccaa attacaaacg caatactaca gcatttgtat
     1861 attaagtatc acagttacta ttgataaact acttttgggt tttatttcat tgaggcactt
     1921 tttttattgt ttgaatgatt ccggcttgta atatatcagc ctctacaatg aaatgcagaa
     1981 gagttcattt ttctaagatc tgtttttcat tagaaatatt gacaaataac acattgtcaa
     2041 cctggatcct ttgacaattt acttaactct ggcatgttca caaaaagtag aaactctaag
     2101 agaccattac catttattca cagatgtata ggggatgtat tctaaaaact gacagaaaag
     2161 agaatctgat agtcaacact gttaactttt actgtgtaat tgccaaatac acttttccaa
     2221 atttgtccca acagccctgt aagccagctt tcttctatat ttataaacac gataaatgca
     2281 tgagaagatc tgttattaca ttagtatatt acgttattta ttatgatcct agttgatggc
     2341 ctaaataaac acctttttct ttaa
//
