LOCUS       NM_001040450            9250 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens MINDY lysine 48 deubiquitinase 2 (MINDY2), transcript
            variant 1, mRNA.
ACCESSION   NM_001040450
VERSION     NM_001040450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9250)
  AUTHORS   Li,F., Zhao,X., Zhang,Y., Zhuang,Q., Wang,S., Fang,X., Xu,T., Li,X.
            and Chen,G.
  TITLE     Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal
            osteoporosis via regulating miR-578/HMGA2 axis
  JOURNAL   J Orthop Res 42 (6), 1244-1253 (2024)
   PUBMED   38151824
  REMARK    GeneRIF: Exosomal circFAM63Bsuppresses bone regeneration of
            postmenopausal osteoporosis via regulating miR-578/HMGA2 axis.
REFERENCE   2  (bases 1 to 9250)
  AUTHORS   Abdul Rehman,S.A., Armstrong,L.A., Lange,S.M., Kristariyanto,Y.A.,
            Grawert,T.W., Knebel,A., Svergun,D.I. and Kulathu,Y.
  TITLE     Mechanism of activation and regulation of deubiquitinase activity
            in MINDY1 and MINDY2
  JOURNAL   Mol Cell 81 (20), 4176-4190 (2021)
   PUBMED   34529927
  REMARK    GeneRIF: Mechanism of activation and regulation of deubiquitinase
            activity in MINDY1 and MINDY2.
REFERENCE   3  (bases 1 to 9250)
  AUTHORS   Kristariyanto,Y.A., Abdul Rehman,S.A., Weidlich,S., Knebel,A. and
            Kulathu,Y.
  TITLE     A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin
            chains
  JOURNAL   EMBO Rep 18 (3), 392-402 (2017)
   PUBMED   28082312
REFERENCE   4  (bases 1 to 9250)
  AUTHORS   Abdul Rehman,S.A., Kristariyanto,Y.A., Choi,S.Y., Nkosi,P.J.,
            Weidlich,S., Labib,K., Hofmann,K. and Kulathu,Y.
  TITLE     MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally
            Distinct New Family of Deubiquitinating Enzymes
  JOURNAL   Mol Cell 63 (1), 146-155 (2016)
   PUBMED   27292798
REFERENCE   5  (bases 1 to 9250)
  AUTHORS   Starnawska,A., Demontis,D., McQuillin,A., O'Brien,N.L.,
            Staunstrup,N.H., Mors,O., Nielsen,A.L., Borglum,A.D. and
            Nyegaard,M.
  TITLE     Hypomethylation of FAM63B in bipolar disorder patients
  JOURNAL   Clin Epigenetics 8, 52 (2016)
   PUBMED   27175219
  REMARK    GeneRIF: Results identified FAM63B hypomethylation in bipolar
            disorder patients and data support that FAM63B is a shared
            epigenetic risk gene for bipolar disorder and schizophrenia.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090515.2, AK075319.1 and CB321913.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001040450.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.159199.1,
                                           SRR1660809.78983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559228.6/ ENSP00000452885.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC090515.2         63434-63446
            14-1910             AK075319.1         2-1898
            1911-8995           AC090515.2         146693-153777
            8996-9250           CB321913.1         16-270              c
FEATURES             Location/Qualifiers
     source          1..9250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3-q22.1"
     gene            1..9250
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /note="MINDY lysine 48 deubiquitinase 2"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
     exon            1..934
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1960
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /EC_number="3.4.19.12"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM63B; deubiquitinating enzyme MINDY-2; ubiquitin
                     carboxyl-terminal hydrolase MINDY-2; family with sequence
                     similarity 63 member B; MINDY deubiquitinase 2"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform a"
                     /protein_id="NP_001035540.1"
                     /db_xref="CCDS:CCDS42046.1"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
                     /translation="MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVW
                     AAETSGGNGLGAAAARRSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPL
                     RGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSS
                     CSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLC
                     KEEEGEETAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLL
                     LAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQ
                     TGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVE
                     KIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFS
                     TMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQ
                     QDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQ
                     AAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL"
     exon            935..992
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1057
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1216
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1319
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1462
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1636
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1831
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..9250
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9226..9231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /note="hexamer: AATAAA"
     polyA_site      9250
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /note="major polyA site"
ORIGIN      
        1 gctgttgctg ccaatacagc tgtcatggcg tccaaggcgc tggctgcgga gaagtggccg
       61 cggtctccat agagctgggg gcgggcggcc cggtatggag agcagccccg agagcctgca
      121 gccgctagaa cacggggtgg cggccgggcc agcgtcaggg acaggttctt cgcaggaagg
      181 gctacaggag accaggctcg ccgctggtga tggtcctggg gtatgggcgg cggagaccag
      241 cggcgggaat gggctggggg cggcggccgc caggaggagc ctcccggact cggcttctcc
      301 cgcgggctct cctgaggttc ccggaccctg cagctcctcc gcgggtttgg acttgaagga
      361 cagtggtttg gagagtcctg ctgccgccga ggcgcctctg agagggcagt acaaggtgac
      421 cgcctccccg gagacagccg tggccggagt gggtcatgag ttgggtaccg ccggagacgc
      481 gggagcccgc ccggatctcg ccggcacctg ccaagcagaa ctgaccgccg ccggctccga
      541 agagcccagc agcgccggcg gcctcagcag cagttgcagc gacccgagcc ctcctgggga
      601 atctccgagc ctggactctc tggagtcgtt ctctaacctg cattcttttc ccagtagctg
      661 cgagttcaat agtgaggagg gagcggagaa cagggtccct gaggaggagg agggcgcggc
      721 ggtgttgccc ggggctgttc ctctgtgcaa ggaggaggag ggggaggaga ccgctcaggt
      781 gctggcggcc tccaaggaac gcttcccggg acaatctgtg tatcacatca agtggatcca
      841 gtggaaggaa gagaacacac ccatcatcac ccagaatgag aacggaccct gccccttgct
      901 ggccatcctc aatgttttgc tcctggcctg gaaggtgaaa cttccaccga tgatggaaat
      961 cataactgct gagcagctga tggaatattt aggagattac atgcttgatg caaagccaaa
     1021 agaaatttca gaaattcaac gtttaaatta tgaacagaat atgagtgatg ccatggcaat
     1081 tttgcacaaa ctacagacag gcctggatgt aaatgtaaga ttcactggtg ttcgagtgtt
     1141 tgaatataca ccagaatgca tagtatttga tcttcttgat attcctttgt accatgggtg
     1201 gttagtagac cctcagattg atgacattgt aaaagctgtt ggtaactgca gctacaacca
     1261 actagtggag aagatcatct cttgtaaaca gtcagacaat agtgagctgg ttagtgaagg
     1321 ctttgtagct gagcagtttc taaataacac agccactcaa ctgacatacc atggattatg
     1381 tgaactaact tcaacggttc aggaaggaga actttgtgtg ttctttcgga ataatcattt
     1441 tagcaccatg accaaataca agggtcaact gtatttgttg gtaacggacc aggggtttct
     1501 tactgaagag aaagttgttt gggaaagcct acacaacgta gatggtgatg gaaatttctg
     1561 tgactcagaa tttcatcttc gacctccttc agatcctgaa actgtataca aaggacaaca
     1621 agatcagata gatcaggatt atcttatggc attatctcta caacaagaac agcagagcca
     1681 agagatcaat tgggaacaaa tcccggaagg aatcagtgat ttggaactag caaagaaact
     1741 ccaagaggaa gaggacagac gggcttctca atactatcag gaacaggaac aagcagcagc
     1801 tgctgctgct gctgcttcta cacaggctca gcagggccag ccagcacaag cctctccatc
     1861 aagtggaaga caatctggga atagtgaacg taaacggaag gaaccacgag aaaaagataa
     1921 agaaaaagaa aaggaaaaaa atagctgtgt tattttgtaa caagtgttgg cttctgttgg
     1981 aaccacctat atgtcttgag aaacaaaacc acaggaggaa aggaagaaaa accgatcaat
     2041 accgtctgtg cctgatttcc taatggattt tgttcgtttt ttcaggggaa cggttgttac
     2101 ttagttacaa tcagactttt tcaagtcaca caatacactc tttatgagct ggagtttcat
     2161 gttacaagtt ggaaatgctg tgtgttgaca ttcatgaaaa atactgcact tgtagccaga
     2221 ttagcaaatc acagcaaatt ttgtgtcata gtgacattca taactcatat cagttagtaa
     2281 gctattatat cttctgttct aacaatgaat ggaggtaatt gatttagtct gattccttcc
     2341 tgaaatctaa atattagcac aatagtttct gaaattttac aatgttaaat tatgatctaa
     2401 ttcatgagaa accacgggtt taacataggg attcaaaaaa acaaaaacaa aagaatagga
     2461 ataaataacc cttaattgta tattggacta gttcagccct taaacagctt tacctttatt
     2521 taggaatgta cattttaggt attatcttga tcatggagct tagttttaat ttagatagca
     2581 aaaataaaga tttgtatttc ttttccaata gcaaaaagtt acataacact aatacttata
     2641 acctatcaat atcagatatt aatgactttg tagtgttgta aaattttgag gaattttgga
     2701 gtctttatca taggtaacct ggaccacagt tactatttat tgacaatgtg attgagtgta
     2761 tggaggaaag cacagtggat gctaggcttt gtaaatatgg ggatgtagaa aagcagatag
     2821 ttcagtgtct acctttttct agaactacct tgaaccttaa attttaagtc atgttcattg
     2881 ctagaaaatt aaatgtactt attaaaacca atgaaaaagc acatttctga aatgaagtta
     2941 gagataatct ctgtgtctta taaaaagaca ttaataaaaa tctgaaaggg ccgggcgcag
     3001 tggctcacgc ctgtaatccc aacattttgg gaggccaagg tgggcggatc atctgaggcc
     3061 aggagttcga gaccagcctg gccagcatgg tgaaaccctg tctctactaa aaatacaaaa
     3121 aatcagcctg gcatggtggt gcgtgcctgt agtcccagct actcagggct gaggcaggag
     3181 aattgcttga acccggcagg cagaggttgc agtgagccga gatcgccctg ctgcactcca
     3241 gcctgggtga cagagggaga ctccgtctca aaaaaaaaaa agtctgagag tagctaagaa
     3301 tttatgtaaa agcaatcaga gtttttaatt tatgggaacc aaataaaact ataacctcat
     3361 agtgtttata agaactcaga aataatattt atttaacttt attatgaggc cacacatatt
     3421 ttcctgtgtt tctatatata gtttggaaaa ctatccttaa tagtctgttt tatatgcctt
     3481 atatttaaaa gtttgtttta gttattttga aagactattg ctgctgcaaa tagttgtgtg
     3541 ctttacattc taagcttcag tacatttatt taagagcatc ataatctgac ctgagcatcc
     3601 acttggagag tgtttttttt gtgtgtggtc tggggtgaca aaagaccaca aaaatgtgtg
     3661 gtctggattt tttcaactat gtcattaact ttatgatcca agaccagtta taggatgaat
     3721 ctgtatgtaa aaatagagtc ttatttatgg aaggaattat tctaagggaa aaatccaggg
     3781 tcaagctgta tcttttatgt cctttatatt gcatgtctat ttctgttaca caatttgtta
     3841 tttcttcaaa tttcctatgg tagcatgata aatcatcaaa gaacctgttt gggatataaa
     3901 actctgatag aaaatattta atgagtatct tgattataac ctagaatatg tatacgttag
     3961 taaaataacc agatatacta cagaactctc tattggctca aacaggttga cctcaatcca
     4021 agtttactct tgatatcact ctgttggctg aaggaggtaa ctcaaacctc agggtttgtt
     4081 tttcccggga cagatagtag tgatagtgca ttatatttga ataagaaaaa caaaccagta
     4141 taccttgaga aattttaaaa agcatagttg aggcatattt tttcataatt atatacttat
     4201 ctgtttattg cccatggaaa atatatgtgt agaagtattt cttctgttat ttgttactat
     4261 cttcttaatt tgttccaaag aaaatgctgc catactgcat tccctctgga aggaaacaaa
     4321 acaaaacaaa actcactcaa aaccagcagt gctgctatca gataagtaga tgtcaatgta
     4381 tacttacaag gaaaaactaa aaaatgtaat gtgttaattc agcctttttc tatgtaatat
     4441 ttccaagtca gactttctta cattcctgga atttactttg atataccaag aataataatg
     4501 ataaaatgtt tgctttgatt actgtggggg gaaagatgaa atgttcaatt gtattaaaac
     4561 aaacaagctt ttcagagata ctggtttcct gcccttgaag ggtataaaga atttagatca
     4621 tgcctgtaat cccagtactt tgggaggccg aggcaggtgg atcacctgag atcaggagtt
     4681 cgagaccagc ctggccaaca tggcaaaacc ctgtctctac taaaaataca ataattagcc
     4741 aggcatggtg gcgggcacct gtcatcccag ctacttggga ggctgaggca ggagaatcgc
     4801 ttgaacccag gaggcagtga ttgcagtgag ctgagatagc accactgcat gcaagcctgg
     4861 gcaatagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaattaga gctattgtgt
     4921 ctttattttc ttaaattttg cccaaggtaa cgttatatat cccaccactt cattgctggt
     4981 ttgggtacat aggattttga aagtggtata ttaaagtctt tccttccaag tattttgtaa
     5041 tacttgaaaa ttcttagatg tatactgcta acaaaagtta gaacttaaac atttttgttt
     5101 ttatcattta tagcctagat tagggacata tttgcatcaa ccaaatcatc attagatttg
     5161 aaaataggca gatgaatgaa caaatatggt cattgcactt tccttttact ttcagagtct
     5221 aagtatattc cttaaggtta gtaaccagtc tttattaaaa atataaaatt tttcttcatg
     5281 tctaatccca ttgcatccac aatgctgtga tttatagtac atgatcaaca cttaaaagta
     5341 ctttacatat gtgtgtttct gaagcaagtt ttcatgacct ctgttagatt ctcaaaagaa
     5401 ttcagaactt caatttaaga atcaccattt taagaataca tgtgtacata tacacattaa
     5461 gcagtataaa gcagctaaaa ttggcattgg ttttacactg gtgcagtgtg cttaggtaaa
     5521 gtaacttctt ccatgtttca aggtcaggtt cagagttgaa tgaagtgtag atttaaattt
     5581 aggattaggc tttggaatat atcttgtttt tattgtctca catttctgat attgactact
     5641 tatcccatat tctgtttcaa attctttatc atatttcaag ttctttctca tacttcttga
     5701 tcttggctta actaagcaag ttagtatcag agactagttg actgaaccca agattaaaca
     5761 ttttgcactt gcacaaaacc ttcttagcat tttgctttca atgaatcaga aagtcaattc
     5821 actaagagac agatcatgag aggaaagaga actagaggcc aataaataaa ataattgttc
     5881 atatattaat gttcacatgt gaactacata tctaaaatct tggagaaaaa tcaaggcaag
     5941 aatttccaga actgtcctca aatagctcat ttatttaagt tttgttaaaa agcaaaagcg
     6001 aattgattac atttgattaa cttttcctat tccatgcaca agttacctta aaacatgata
     6061 aaaaccttat gggcattacc tatcacacag tacttatgca taaacttata atagtaaaat
     6121 tactaatgtt tgataaaata agatggaggc attacaaata gtctacagtt tgtattttaa
     6181 ggaattggac atgaagaatt ctagatcatt ttgtgtctat aaacccgact ttctatcttg
     6241 ccttgggcaa actttctgtg cctcaatgta ctctttaaat atgtgaagga tgctcttttt
     6301 gattaagtgt tttgcactcc tgaataaagg gcatagtata agcacaaagt atgacttaat
     6361 ttatcacaaa tattacacat cctatgttct tgaatgtgca cacttttttc tcaataacaa
     6421 aatatatctt aagtcagttt ttttaatgct gtcaaaattt gtagaatttt ctttgagtat
     6481 ggcgtgatct cttcccaaat gcattttaca gttttttgtg tgttctatag actatagagt
     6541 caaaatcaag agtattttga gaggatcaga agcatttaaa aatctatttt tttctagtat
     6601 ctttcacaga tctaaatatt tagattctct ttgccttttt ctccatggaa tacggtggta
     6661 tcaaattact aatacagtat ataaacttcg tttgcattgg tggaattcat ttagatctct
     6721 caagtaatat tattttaggg ctatataaat tgtgttttta gtgtaaaatg ttatttgata
     6781 atgtgaagtt aaatcccttt tagaaagtga ctgaaaatgg taaaggaact catcagaatc
     6841 ttagcgttct taagttctct gataatttag tatattttat taatgatgtc caacacctct
     6901 aagattgttg agaaaacatg aagaattgag gttactcttc tcaggtgaca ctttaaatat
     6961 taaaatcaga ggcttcctga acaaaacaaa ttgcaaaata gcgataatgg catgggagag
     7021 gccagatgca ggactctggt aaatttaact tactttgaat atctatctaa attttagttc
     7081 atgcatgttc ttacttaatc ctggtgtttt tgctcttaga tgttagagtt taataaattg
     7141 tgatacgcat atattttttt acatgaagga ttctactttc taattttact tttctgatct
     7201 caagaaaatt aaacttgaaa aacggggtaa aattcttcaa ctattgcctc aagttcagtt
     7261 ttgtcctatt gtcctgagaa aggagattta gacttgtctg cctaacacag gtatttttta
     7321 gggcatcgta ctatcccaga gaaagtgttg agataccatg gcagaaatat aaaacctaag
     7381 ctttgaaccc cagtagactt cttcttctgc cattaagtct ctctttatct gatattctaa
     7441 ggatttcttc aaactactta ataatttgtc accattaact ttaatatcca gttttaatct
     7501 gcactgtaat atcctgcttt gagaagaaag aatgcctcat aaattagaga aggacaaaac
     7561 aaaatgtttt ggaaggtgat cctggctcct ttggctctca taattgtttt atagctgaaa
     7621 ataaaaagtc aggaaactgg cccggtgcgg tggctcatgc ctgtaatccc agcactttgg
     7681 gaggctgagg tgggtggatc acctgaagtc aggagttcga gaccagcctg gccaacatgg
     7741 tgaaaccctg tctctactaa aaatacaaaa aaaattagct gggtgtggtg gcacatgcct
     7801 gtaatcccag ccactgggga ggttgaggcg caagaatcgc ttgaacccgg aaggcagagg
     7861 ttgcagtgag ccaagattgc cccactgcac tccagcctgg gcgactgagc gagactctta
     7921 tatctcaaaa aaaaaaaaaa aaaaaagtca agaaactgaa attcccattt aagttctcaa
     7981 atcagtgatc tgtcaaaata ggccttgtaa ctgaaatacc ttacaaagca gttctaacta
     8041 atgcaatgtg ttttttaaaa atttttaatg aaccttacat tgtgaacata attgcaacat
     8101 gttttaagac aaacagtatt taatccttga agacctgtct tgtatgtctc tcaattttgt
     8161 cagaattttt attattgttt ttcacatatg tgaaataagc agttttttca gggtacatag
     8221 ggtatctttg ttttacagat ttttaaagat gaggttttga aaagccctca gaggtttttg
     8281 ttaaaagact atcttgctta ataaatgaca gcttgttaca gattcacaca ttacaagtag
     8341 gacagtataa caggagattg gtgtgtgaat gctacaaaac agtcagcaaa aggaatcatg
     8401 tttgcttgtg aaacttcaga ggtaccctga aagtcatttc ctaaagctag tgcgtgtgaa
     8461 tcttttcctt gaattgtgca gaataattgg attgaggcac atattttgag gagtagcaag
     8521 tggaatggta taatgactac agagaaaatt atcttgaaat atagcaagga agagaaacaa
     8581 gttttctttc tccactttat tgttggacta attgggtcaa tttgctgtga catatcaaag
     8641 atctctttgt gccaggccaa gactggctac tgagttctca aagcgtttta atatatagat
     8701 tacgtatgag tgcctatttt ttcctcctcc tttcattttt tatcttaata cccattttac
     8761 ttctgaaata attcatctgt tttgctttat gaccagcttt aatttcaatt gaggaataat
     8821 aacaacccta gagattcata ggaaagagca ttgaaataca ttttttgcat aaagatacct
     8881 aaaaccatct acccagctta gggttgaact gaatttctgt gaaataaatt tgttttaaat
     8941 actaattatt ttaaaactac ttaattctta aaaacaatgt catcagtttc aaaactttca
     9001 ctttgggagg atattcctta aaaggcatac atagatggta aagtataaaa tatttctgac
     9061 agaattattc agtattattc aacatttact ttcatgtttg ttattgtacc acaaagatag
     9121 tgtcattgtt gggttaaaat gttggctgtt tttgttaata tacttaaaac tgtaaccagt
     9181 gaataacacc tgtagtattt tttattatag attatatttt atttcaataa actttgatat
     9241 ttagaccaaa
//
