LOCUS       NM_015206               6926 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens membrane integral NOTCH2 associated receptor 1
            (MINAR1), mRNA.
ACCESSION   NM_015206 XM_044580
VERSION     NM_015206.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6926)
  AUTHORS   Qu,X., Zhao,L., Wang,M., Zhang,R., Cheng,L., Qiu,L., Tong,X.,
            Cai,S., Wei,Q. and Li,Q.
  TITLE     Novel functional variants in the Notch pathway and survival of
            Chinese colorectal cancer
  JOURNAL   Int J Cancer 149 (1), 84-96 (2021)
   PUBMED   33728681
  REMARK    GeneRIF: Novel functional variants in the Notch pathway and
            survival of Chinese colorectal cancer.
REFERENCE   2  (bases 1 to 6926)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6926)
  AUTHORS   Zhang,H., Zhang,Q., Gao,G., Wang,X., Wang,T., Kong,Z., Wang,G.,
            Zhang,C., Wang,Y. and Peng,G.
  TITLE     UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through
            mTOR signaling
  JOURNAL   PLoS Genet 14 (8), e1007583 (2018)
   PUBMED   30080879
  REMARK    GeneRIF: Ubtor inhibits mTOR signaling by stabilizing the mTOR
            complex component DEPTOR. Inhibiting Ubtor function promotes cell
            growth in neurons and cancer cells. Increasing Ubtor function
            reduces cancer cell growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6926)
  AUTHORS   Ho,R.X., Meyer,R.D., Chandler,K.B., Ersoy,E., Park,M.,
            Bondzie,P.A., Rahimi,N., Xu,H., Costello,C.E. and Rahimi,N.
  TITLE     MINAR1 is a Notch2-binding protein that inhibits angiogenesis and
            breast cancer growth
  JOURNAL   J Mol Cell Biol 10 (3), 195-204 (2018)
   PUBMED   29329397
  REMARK    GeneRIF: MINAR1 physically interacts with Notch2 and its binding to
            Notch2 increases its stability and function. While MINAR1 is highly
            expressed in the normal human breast, its expression is
            significantly downregulated in advanced human breast cancer and its
            re-expression in breast cancer cells inhibited tumor growth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105231.7.
            
            On Jul 26, 2019 this sequence version replaced NM_015206.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028947.2, SRR14038194.2330610.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305428.8/ ENSP00000307461.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC105231.7         124743-124947       c
            206-2553            AC105231.7         98838-101185        c
            2554-2808           AC105231.7         93962-94216         c
            2809-6926           AC105231.7         84979-89096         c
FEATURES             Location/Qualifiers
     source          1..6926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..6926
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /note="membrane integral NOTCH2 associated receptor 1"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
     exon            1..205
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            206..2553
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3006
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /note="major intrinsically disordered Notch2-associated
                     receptor 1; ubiquitination and mTOR signaling protein"
                     /codon_start=1
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1"
                     /protein_id="NP_056021.1"
                     /db_xref="CCDS:CCDS32306.1"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
                     /translation="METSQETSLFLVKILEELDSKQNTVSYQDLCKSLCARFDLSQLA
                     KLRSVLFYTACLDPNFPATLFKDKMKCTVNNQQSKKIMVAADIVTIFNLIQMNGGAAK
                     EKLPTGRQKVRKKEASFESCRSDTEICNAAECEPLNCELSERSFSRGYPIRQSSKCRK
                     MDCKDCPQFVPASEPNFLLGVSKEVKNRAASLDRLQALAPYSVTSPQPCEMQRTYFPM
                     NIENESISDQDSLPINQSIKETFISNEEPFVVQSCVQKRNIFKEDFHNLMAVSPSLVG
                     PISKAENEHREPQSRKEPHKPPFFNHSFEMPYNSQYLNPVYSPVPDKRRAKHESLDDL
                     QASTYFGPTPVMGTQEARRCLGKPNKQTPWPAKSWSLNTEEVPDFERSFFNRNPSEEK
                     LHYPNASSQTPNFPAPERRPTYLVPKDQQPILPIAYAAKQNGLKSKEISSPVDLEKHE
                     PVKKFKDKSINCTSGQLSSDTSSVGTQTEHVLEPKKCRDLCTSGQGKYSDRHTMKHSD
                     DDSEIVSDDISDIFRFLDDMSISGSTGVIQSSCYNSTGSLSQLHKSDCDSSPEHNLTK
                     IANGVPNSKGDKGNRPENTHHSEEELKTSVCKLVLRIGEIERKLESLSGVRDEISQVL
                     GKLNKLDQKMQQPEKVSVQIDLNSLTSEGPSDDSASPRMFHAHSGSHGPKLENNPDWC
                     CSDASGSNSESLRVKALKKSLFTRPSSRSLTEENSATESKIASISNSPRDWRTITYTN
                     RVGLNEEEIKDTGPGDNKDWHRKSKEADRQYDIPPQHRLPKQPKDGFLVEQVFSPHPY
                     PASLKAHMKSNPLYTDMRLTELAEVKRGQPSWTIEEYARNAGDKGKLTALDLQTQESL
                     NPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKVCKIAALIAAAACTVILVIVVPICTM
                     KS"
     exon            2554..2808
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..6926
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6904..6909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /note="hexamer: AATAAA"
     polyA_site      6926
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /note="major polyA site"
ORIGIN      
        1 agacctggac tcgggcggcg gaggcgaaag tcgctccatc cgcggggtgc aaccctgggc
       61 gcggaatccg ggctgccggg tgacagtgac cagctgactc tggagcctac cggaggcgcg
      121 gcatcggagg ccgtgcggac cactgccgaa cagccgctgg agacccgcag agaagggcgg
      181 gccctgcgcc cggggcgcct cggagaactg acctgaagtt tcagtgtagt cagagagctc
      241 ttcaagtaat aaatcatgga gaccagtcag gaaacttccc tcttcttggt gaagatcttg
      301 gaggaactgg acagcaagca aaataccgtt tcttatcagg acctgtgcaa atctctctgt
      361 gcccggttcg acctgtcgca gcttgccaaa ctgagaagtg tgctcttcta cacagcttgt
      421 ctcgatccca attttccagc cacgctattc aaagacaaga tgaaatgcac tgtgaataac
      481 cagcaatcaa agaaaatcat ggtggcagca gatattgtga cgatattcaa cctgatccaa
      541 atgaatggcg gggctgccaa ggagaagctg cccacgggcc gccagaaggt acgcaagaag
      601 gaggcatcct ttgaatcatg taggtcggac acagagatct gcaatgcagc tgagtgtgag
      661 cccctgaact gtgagctgag tgagaggtct ttcagccggg gctaccccat caggcagtcg
      721 tccaagtgcc ggaagatgga ctgcaaggac tgcccacagt ttgtccctgc ctctgagcct
      781 aacttcctgt tgggagttag caaagaggtg aaaaaccgcg ccgcttccct ggacaggttg
      841 caggccctgg ctccgtactc tgtgaccagc cctcagccct gtgagatgca gaggacctac
      901 ttccccatga acatcgaaaa cgagtccatt tcagaccagg actccctgcc catcaatcag
      961 agcatcaagg agaccttcat ttccaatgag gagccatttg tggtccagtc ctgtgtccag
     1021 aaaaggaata tcttcaaaga ggattttcac aatttgatgg cagtgtcccc cagtttggtt
     1081 ggccccatca gcaaagcaga gaatgagcac agggaacccc agagtcgaaa ggaaccccac
     1141 aagccaccct tcttcaacca cagctttgaa atgccctata acagccagta cctgaatcca
     1201 gtgtattccc cggttcctga caaaaggcga gcaaagcacg aaagcttaga tgaccttcaa
     1261 gcctctacat attttgggcc cactcccgtg atgggaaccc aagaagccag gcgctgtcta
     1321 gggaagccca acaagcagac tccctggcca gccaaaagct ggagcctaaa cacagaggaa
     1381 gttcctgact ttgaacggtc ctttttcaat agaaatccct ccgaggagaa gctacactat
     1441 ccaaatgcca gtagccagac ccccaatttc ccagccccag aaaggcgccc aacttacctt
     1501 gtgccaaagg atcaacagcc aattctcccc attgcttatg cggcaaaaca aaatgggctc
     1561 aaatctaaag agatctcatc ccctgttgac ctggagaagc atgaaccagt caaaaagttt
     1621 aaagacaaga gcattaactg caccagtggg cagctcagct cagacaccag tagcgtgggc
     1681 acccagactg agcacgtgct ggagcccaag aaatgcagag acctgtgcac ctctggtcag
     1741 ggcaagtaca gtgacaggca caccatgaag cactcagacg atgactcaga aattgtcagc
     1801 gacgacatca gtgacatttt ccgatttctt gatgacatga gcatcagtgg ctccacggga
     1861 gtgatacagt cgtcctgcta caacagcaca ggatccttgt ctcagctcca taagtcagac
     1921 tgcgacagtt cccctgagca caacttaacc aaaattgcca atggggtccc caacagcaag
     1981 ggagacaagg gcaaccggcc tgaaaacacc caccactcgg aagaagagct gaagaccagt
     2041 gtgtgcaaac tggtgctcag gattggcgaa attgaacgga agctggaatc cctgtcgggt
     2101 gtccgtgatg aaatctccca ggtcttgggc aaactaaata aattggacca gaaaatgcaa
     2161 cagcctgaga aggtgagtgt gcagatagat ctgaactcct tgacaagcga gggtccgtct
     2221 gatgacagtg cctctccccg gatgttccac gcacacagtg gctcccacgg acccaaacta
     2281 gagaacaacc ctgactggtg ctgctctgat gctagcggga gcaacagtga aagcctgcgg
     2341 gtcaaggcct taaaaaaaag cctcttcacc aggccatcct ctaggtccct aacagaggag
     2401 aacagtgcca cagagtccaa aattgccagc atctccaact cgcccagaga ctggcgcacc
     2461 atcacttata ccaaccgtgt gggcctcaat gaggaggaga taaaagacac aggcccagga
     2521 gataataaag actggcatcg gaaatctaaa gaggcagaca ggcagtacga cattccccca
     2581 cagcaccgac tgcccaagca gcccaaagat ggcttcctgg tggagcaggt gttcagccct
     2641 cacccctacc ctgcctccct caaggcccac atgaagagca accccctgta cacagacatg
     2701 cggctgaccg agttggccga ggtgaagcgg ggccaacctt cttggaccat tgaggagtat
     2761 gcacggaatg cgggcgacaa gggcaagctg acagccctgg acctgcagac gcaagaatct
     2821 ttaaacccaa ataatttaga gtactggatg gaagacattt atactccagg atacgattca
     2881 ttactaaaac gtaaagaagc cgaattcaga cgagccaagg tctgcaagat agctgctctg
     2941 atcgctgctg cggcatgcac cgtcatcctc gttattgtcg tgcccatctg cacaatgaaa
     3001 tcatgagcta agaatgcaac cttacgtaca gcttatgact accaatgtcg tcgtctgtat
     3061 cttagaatct tgcagcagtg aggcaacaat ttgttgaaat ggagatgaaa tcatggaggc
     3121 atttctacaa atgttgaatg aaggtggttt tcagaaagta tacattctag tgagaaatct
     3181 acctacctat tagctttgac tcaattacac tctgacgcat ttttagaagt gcaatatctt
     3241 ttcctaccaa aagaacatca tggactatca ataaatacaa attgaatatt ccaagccaaa
     3301 aaaggaagat taattgggtt ctttccattt tgatgatgtt tcatggtggg gaataagtta
     3361 tacagaagat atttaataca cgcctcttta gaagaaacta agggaaatag caacataaga
     3421 agaaaagagg tggcttctct tttccataat gttcttagac cattgctggt gaagtaacag
     3481 ggtgtgtgtc cctaaagggt attacttctc tgtcgacttt tatcaagggc tactgacgtt
     3541 tcattcttgc ccttttgtca tcaacacgac agagtgtctg catcactgca gatcttcatg
     3601 gaaacattct ggaccttctt ccttgcactt ggagtgagaa ggagctggac taccaagtca
     3661 ggcgtggaat gaagtatgct cagactgcat gatgggccaa ggtattcagg ccaggagacc
     3721 tcgtcctcaa tccaaagtgt aggggagctg cctgctaacg atgtaaggtc agtatttgaa
     3781 aatcatggcc actccaaagg atctcctgtt cttgctttgg tgtgtggctc cattccttga
     3841 ttttctatct cctggtggta ccagatgctc tgcctctcat acatgagttg aagagtttgg
     3901 aacttgtcct tgtgccttga agagtagaga caatggctaa acgttgacat tctatctgta
     3961 aaccatggtt ttcacgcacc actaatatct gccattttca atggctttaa aaagattttg
     4021 aaagcttgct caataatgtt caataatata ataataataa aggcactgag gtcttctcag
     4081 ttaccccaac acctactcca gagttttgaa tacttgtcag cagtgcaaaa aatattatct
     4141 gtttaaccac ttatctatat gtctatctat ctatctatat gtctatctat ctatctaaat
     4201 acttgatttt tatttattgt cttctctgtt aaataacttg agagcaaggt ttctttcgtg
     4261 taaaagaagc tgttgtaatt tcatccaaat ttgatctgtt tccacctgct gaatggtgct
     4321 ctgacaataa tggaacagaa agaatcctta tcagcatctg attccaatgt cttgttacag
     4381 gtcaaagaaa aaaggattga cagaaactag ctaccttata tatatttttt gataataagg
     4441 tgggatataa atagattttg gtagcaagtg taatcactcc gtatgatata ataaatttct
     4501 aaaagatttg agagcatctc aatttttaaa gcaataggag tctagcatcc attctgaaaa
     4561 atcgcaaata atgcttagct tgctgtgtct gattctgttg ttcaccatta aggggtagac
     4621 agttaatttt attatgttaa caagtgaggg atgaatgttt tcatctgtgg tgaaccttta
     4681 tttttagaag tcttcatgtt atctatttgt attatcatgt ttatgtatgg attttcaatt
     4741 tcagtaaccg aaaacttaag ccttagtatg aaaaactgag gatttataat tgaaaatgaa
     4801 aaaaatatgt tactctctat catcagaatt atagtctttg gtgctctgtt ttcaatgggg
     4861 catattacat aaggttgttt ctttcacccc aaagagacta ctaggttacc actctgggca
     4921 ttgcctttcc acctaacccc tcaaccagta agactctaca ccatattgta gccccactat
     4981 tctcctcttt atcacagatg aagtgccaga gcatcagaga taggtagctc ccaacctctt
     5041 gctctggatt tgcagaagag ggggagatgt acttacccag gataagaaaa atctagtcaa
     5101 atccacccca aatcttccat ttaacaggta ggaccatcga ggctggacca aaccactttt
     5161 tccactgccc ttggtgaatc tattcctagt ggaccccatt tgggcatgtg cctagctacc
     5221 ttgggaaggc atgactataa gtcacacctc aggcttggaa atgaaaggat tctatagaat
     5281 attctatact ttccatagct ggagaggtag tcagaaattc agtcttgctc tgagtccaca
     5341 gtagctttaa aattcaactc aacattgttg tcacgtaacg gaaacatcta gacctggtaa
     5401 taatccagga aattgcaaaa tggaggccaa aagtaaggtg ggtttctctg gaaaggggtc
     5461 atcctcagtc tgataatacc aagtctgacg ctgaggttat gaatcattac catggcttgg
     5521 agctattgga tgcttggggt cttgggatag atagaaggtg aggttcacag ttggagcttt
     5581 tcttgccatt gaccccaagc tcaccccagc cttccttccc tgaccctgag actcacccta
     5641 tctatctccc ctattccctc agtttgcaga atgagcaaga tagagtctgg ctaggaggga
     5701 aacatctatc catctctcta atctttgccc atcacctcct gttgcaatga gttcccgcag
     5761 gtgacatacg gactggcctc tctactgtac tgggtgccat ctcccaccat actctggcat
     5821 ttttatgtaa aggataattt cttgtacctg agtctaaaat tacaacgtta tcaaaattca
     5881 cttcgttttt cctgcatttt aaaagtaata aaatattatt tgagattatt ttgaaattaa
     5941 atatccttaa ccaatgatta aattcataat catttcatct tctttcataa tcatttcatc
     6001 ttctaatctg aatttgtttt gaacacagcc ttgcagaaaa gcaaaaaata tttccccgct
     6061 caaattttgc cgacatttta taccagtatc cccttcatta cagtaaacta aatcataact
     6121 tacatcatcc attactagct gatcataaat tgttagtatt ttaaggtatg caactatgtg
     6181 attgacatct gtaaggctag tttaatagac gtgctaaata tcactgttct gaatatctgt
     6241 gccatagttc tgataccctt attggaatca aggcagtgct gtttctgttt acaagttatc
     6301 aagataagag cagtggcatc acatttgttg ttgttgtttt tttttttgaa atagaaaaaa
     6361 acagaagaag ctctgccaac aataaaagat tttgttaagt ggtataaaaa tttgtgaatg
     6421 ttgaaattca acatgcttca tattataacc aacctgcaag aatattgtgg tcaattgtgt
     6481 gaataccaaa tcagtatata ctgtatactg tactatgaaa atttgtattt aaaggcaaag
     6541 atacaagtaa ttgttggtat aattggggaa aagggtattc aatatttatt aagtaacaat
     6601 gagaaatgca acaaacttcc ttatttatgc cttatgaata aaagagtgtg gaatgtaagg
     6661 tgaaatttta tgtgcaagat cctgaaggaa tgggtattct tgaaggcagg gactgtcttt
     6721 tctatgtttg ttctgtacag ctctcagcac actcttggtg cttgataaat gttatgttat
     6781 ataataccaa taactaagca catttttaga tcttttttca aatggcttgt gtaaaatttg
     6841 gttaatgtac aatggttggt ttgaagctat catgtaaaat tggcctctcc aaatataatc
     6901 agaaataaac cgaaaaaaat ataaaa
//
