LOCUS       NM_001085423            1448 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mast cell immunoglobulin like receptor 1 (MILR1),
            transcript variant L, mRNA.
ACCESSION   NM_001085423 XM_211305 XM_942446
VERSION     NM_001085423.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Geerdink,R.J., Pascoal Ramos,M.I., van den Hoogen,L.L.,
            Radstake,T.R.D.J., Shibayama,S., Shibuya,A., Bont,L. and Meyaard,L.
  TITLE     Differential isoform expression of Allergin-1 during acute and
            chronic inflammation
  JOURNAL   Immun Inflamm Dis 10 (12), e739 (2022)
   PUBMED   36444625
  REMARK    GeneRIF: Differential isoform expression of Allergin-1 during acute
            and chronic inflammation.
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Nanatsue,K., Ninomiya,T., Tsuchiya,M., Tahara-Hanaoka,S.,
            Shibuya,A., Masuko,H., Sakamoto,T., Hizawa,N., Arinami,T. and
            Noguchi,E.
  TITLE     Influence of MILR1 promoter polymorphism on expression levels and
            the phenotype of atopy
  JOURNAL   J Hum Genet 59 (9), 480-483 (2014)
   PUBMED   25007884
  REMARK    GeneRIF: Data indicate that the rs6504230 polymorphism affects
            MILR1 (mast cell immunoglobulin-like receptor 1; synonyms,
            Allergin-1) expression levels, leading to a susceptibility to
            producing specific IgE antibodies against common allergens.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Tahara-Hanaoka,S. and Shibuya,A.
  TITLE     [Immunoglobulin-like receptor, allergin-1 regulates the activation
            of mast cells]
  JOURNAL   Arerugi 62 (11), 1451-1457 (2013)
   PUBMED   24552759
  REMARK    GeneRIF: It is a immunoglobulin-like receptor which regulates the
            activation of mast cell.(review)
            Review article
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Nagai,K., Tahara-Hanaoka,S., Morishima,Y., Tokunaga,T., Imoto,Y.,
            Noguchi,E., Kanemaru,K., Imai,M., Shibayama,S., Hizawa,N.,
            Fujieda,S., Yamagata,K. and Shibuya,A.
  TITLE     Expression and function of Allergin-1 on human primary mast cells
  JOURNAL   PLoS One 8 (10), e76160 (2013)
   PUBMED   24116093
  REMARK    GeneRIF: Allergin-1S1, a splicing isoform of Allergin-1, is
            predominantly expressed on human primary MC in both bronchoalveolar
            lavage fluid and nasal scratching specimens. Moreover, Allergin-1S1
            inhibits IgE-mediated activation from human primary MC in BAL
            fluid.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Hitomi,K., Tahara-Hanaoka,S., Someya,S., Fujiki,A., Tada,H.,
            Sugiyama,T., Shibayama,S., Shibuya,K. and Shibuya,A.
  TITLE     An immunoglobulin-like receptor, Allergin-1, inhibits
            immunoglobulin E-mediated immediate hypersensitivity reactions
  JOURNAL   Nat Immunol 11 (7), 601-607 (2010)
   PUBMED   20526344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD687595.1, BC053534.1 and BE296352.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001085423.1.
            
            Transcript Variant: This variant (L) represents the longest
            transcript and encodes the longest isoform (Allergin-1L, also known
            as long form).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.826181.1, BC130406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619286.5/ ENSP00000482801.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               CD687595.1         16-629
            615-1151            BC053534.1         509-1045
            1152-1192           BE296352.1         653-693
            1193-1448           BC053534.1         1087-1342
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..1448
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /note="mast cell immunoglobulin like receptor 1"
                     /db_xref="GeneID:284021"
                     /db_xref="HGNC:HGNC:27570"
     exon            1..109
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1086
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /note="isoform Allergin-1L precursor is encoded by
                     transcript variant L; probable mast cell antigen 32
                     homolog; allergy inhibitory receptor 1"
                     /codon_start=1
                     /product="allergin-1 isoform Allergin-1L precursor"
                     /protein_id="NP_001078892.1"
                     /db_xref="CCDS:CCDS74133.1"
                     /db_xref="GeneID:284021"
                     /db_xref="HGNC:HGNC:27570"
                     /translation="MWSHLNRLLFWSIFSSVTCRKAVLDCEAMKTNEFPSPCLDSKTK
                     VVMKGQNVSMFCSHKNKSLQITYSLFRRKTHLGTQDGKGEPAIFNLSITEAHESGPYK
                     CKAQVTSCSKYSRDFSFTIVDPVTSPVLNIMVIQTETDRHITLHCLSVNGSLPINYTF
                     FENHVAISPAISKYDREPAEFNLTKKNPGEEEEYRCEAKNRLPNYATYSHPVTMPSTG
                     GDSCPFCLKLLLPGLLLLLVVIILILAFWVLPKYKTRKAMRNNVPRDRGDTAMEVGIY
                     ANILEKQAKEESVPEVGSRPCVSTAQDEAKHSQELQYATPVFQEVAPREQEACDSYKS
                     GYVYSELNF"
     exon            110..151
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            152..421
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            422..706
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            707..817
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            818..907
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            908..964
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1033
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1114
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1448
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /note="hexamer: AATAAA"
     polyA_site      1448
                     /gene="MILR1"
                     /gene_synonym="Allergin-1; C17orf60; MCA-32; MCA32"
                     /note="major polyA site"
ORIGIN      
        1 accactgtgg ttctactatg ccttctgacc ccgtcttgga cttcaactgg gagaatgtgg
       61 agccatttga acaggctcct cttctggagc atattttctt ctgtcacttg tagaaaagct
      121 gtattggatt gtgaggcaat gaaaacaaat gaattccctt ctccatgttt ggactcaaag
      181 actaaggtgg ttatgaaggg tcaaaatgta tctatgtttt gttcccataa gaacaaatca
      241 ctgcagatca cctattcatt gtttcgacgt aagacacacc tgggaaccca ggatggaaaa
      301 ggtgaacctg cgatttttaa cctaagcatc acagaagccc atgaatcagg cccctacaaa
      361 tgcaaagccc aagttaccag ctgttcaaaa tacagtcgtg acttcagctt cacgattgtc
      421 gacccggtga cttccccagt gctgaacatt atggtcattc aaacagaaac agaccgacat
      481 ataacattac attgcctctc agtcaatggc tcgctgccca tcaattacac tttctttgaa
      541 aaccatgttg ccatatcacc agctatttcc aagtatgaca gggagcctgc tgaatttaac
      601 ttaaccaaga agaatcctgg agaagaggaa gagtataggt gtgaagctaa aaacagattg
      661 cctaactatg caacatacag tcaccctgtc accatgccct caacaggcgg agacagctgt
      721 cctttctgtc tgaagctact acttccaggg ttattactgt tgctggtggt gataatccta
      781 attctggctt tttgggtact gcccaaatac aaaacaagaa aagctatgag aaataatgtg
      841 cccagggacc gtggagacac agccatggaa gttggaatct atgcaaatat ccttgaaaaa
      901 caagcaaagg aggaatctgt gccagaagtg ggatccaggc cgtgtgtttc cacagcccaa
      961 gatgaggcca aacactccca ggagctacag tatgccaccc ccgtgttcca ggaggtggca
     1021 ccaagagagc aagaagcctg tgattcttat aaatctggat atgtctattc tgaactcaac
     1081 ttctgaaatt tacagaaaca aactacatct caggatggag tctcactctg ttgcccaggc
     1141 tggagttcag tagcgcgatc ttggctcact tcaatctcca tcttcccagt tcaagcgatt
     1201 ctcatgcctc gacctcccga gtagctggga ttacaggtgc ccgctaccac gcccagctaa
     1261 tttttgtatt tttagtagag atggggtttc actatggtgg ccaggctggt cttgaactcc
     1321 tgacctcaga tgatctgcct gcctcggcct cccaaagtgc tggaactaca agcctgagcc
     1381 accgtgcccg gccctgaatc gctttagtaa ataaagggtc tccaagaata aattcatccg
     1441 aacatgca
//
