LOCUS       NM_021933               1541 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens migration and invasion inhibitory protein (MIIP),
            mRNA.
ACCESSION   NM_021933
VERSION     NM_021933.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Yan,F., Wang,Q., Xia,M., Ru,Y., Hu,W., Yan,G., Xiong,X., Zhang,M.,
            Wang,J., Li,Q., Zhang,B., Wang,H., Lin,W., Wu,G. and Li,X.
  TITLE     MIIP inhibits clear cell renal cell carcinoma proliferation and
            angiogenesis via negative modulation of the HIF-2alpha-CYR61 axis
  JOURNAL   Cancer Biol Med 19 (6), 818-835 (2021)
   PUBMED   34931765
  REMARK    GeneRIF: MIIP inhibits clear cell renal cell carcinoma
            proliferation and angiogenesis via negative modulation of the
            HIF-2alpha-CYR61 axis.
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Fang,J., Chen,Y.L., Yao,H.B., Peng,S.S., Yang,P. and Ding,Z.Y.
  TITLE     MIIP inhibits malignant progression of hepatocellular carcinoma
            through regulating AKT
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2335-2346 (2020)
   PUBMED   32196585
  REMARK    GeneRIF: MIIP inhibits malignant progression of hepatocellular
            carcinoma through regulating AKT.
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Wu,Y., Song,S.W., Sun,J., Bruner,J.M., Fuller,G.N. and Zhang,W.
  TITLE     IIp45 inhibits cell migration through inhibition of HDAC6
  JOURNAL   J Biol Chem 285 (6), 3554-3560 (2010)
   PUBMED   20008322
  REMARK    GeneRIF: Data show a novel mechanism by which IIp45 inhibits cell
            motility through inhibition of HDAC6.
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Song,F., Ji,P., Zheng,H., Song,F., Wang,Y., Hao,X., Wei,Q.,
            Zhang,W. and Chen,K.
  TITLE     Definition of a functional single nucleotide polymorphism in the
            cell migration inhibitory gene MIIP that affects the risk of breast
            cancer
  JOURNAL   Cancer Res 70 (3), 1024-1032 (2010)
   PUBMED   20103646
  REMARK    GeneRIF: Results suggest MIIP K167E as a functional genetic marker
            of breast cancer development and prognosis.
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Song,S.W., Fuller,G.N., Zheng,H. and Zhang,W.
  TITLE     Inactivation of the invasion inhibitory gene IIp45 by alternative
            splicing in gliomas
  JOURNAL   Cancer Res 65 (9), 3562-3567 (2005)
   PUBMED   15867349
  REMARK    GeneRIF: IIp45 gene is inactivated by a tumor-specific alternative
            splicing that generates an aberrant and unstable IIp45 isoform in
            infiltrative gliomas.
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Song,S.W., Fuller,G.N., Khan,A., Kong,S., Shen,W., Taylor,E.,
            Ramdas,L., Lang,F.F. and Zhang,W.
  TITLE     IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2)
            binding protein, antagonizes IGFBP-2 stimulation of glioma cell
            invasion
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 13970-13975 (2003)
   PUBMED   14617774
  REMARK    GeneRIF: identified a gene, invasion inhibitory protein 45 (IIp45),
            whose protein product bound to IGFBP-2 through the
            thyroglobulin-RGD region of the C terminus of IGFBP-2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FJ618905.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021933.3.
            
            Summary: This gene encodes a protein that interacts with the
            oncogene protein insulin-like growth factor binding protein 2 and
            may function as an inhibitor of cell migration and invasion. This
            protein also interacts with the cell division protein 20 and may be
            involved in regulating mitotic progression. This protein may
            function as a tumor suppressor by inhibiting the growth or certain
            cancers. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.769016.1, FJ618905.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235332.6/ ENSP00000235332.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1541              FJ618905.1         257-1797
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1541
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /note="migration and invasion inhibitory protein"
                     /db_xref="GeneID:60672"
                     /db_xref="HGNC:HGNC:25715"
                     /db_xref="MIM:608772"
     exon            1..55
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            56..251
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1304
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /note="IGFBP2-binding protein; invasion-inhibitory protein
                     45"
                     /codon_start=1
                     /product="migration and invasion-inhibitory protein"
                     /protein_id="NP_068752.2"
                     /db_xref="CCDS:CCDS143.1"
                     /db_xref="GeneID:60672"
                     /db_xref="HGNC:HGNC:25715"
                     /db_xref="MIM:608772"
                     /translation="MVEAEELAQLRLLNLELLRQLWVGQDAVRRSVARAASESSLESS
                     SSYNSETPSTPETSSTSLSTSCPRGRSSVWGPPDACRGDLRDVARSGVASLPPAKCQH
                     QESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRSILAQQSKLSKPRVTFS
                     EESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHP
                     EPQLPGLRESSGSGVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLA
                     QPAHVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSEKSSAPR
                     NLDLWSSVSAEAQHQKLSGTSSPFHPASPMQMLPPTPTWSVPQVPRPHVPRQKP"
     exon            252..599
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            600..684
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            685..793
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            794..852
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            853..982
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1079
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1217
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1541
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1515..1520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /note="hexamer: AATAAA"
     polyA_site      1541
                     /gene="MIIP"
                     /gene_synonym="IIP45"
                     /note="major polyA site"
ORIGIN      
        1 aacggctcag gcggctgcgg ctgctacggc ggcgcatgct aggggattct gccgggtaga
       61 agagctgggc ctggaaccca gccctgagga catcctgcgg cccaggggca agtgacacct
      121 gctgagagag gcccaggatg gtggaggctg aggaactggc acagctgcgg ctgctcaatc
      181 tggagctcct gaggcagctg tgggtggggc aggatgctgt gcggcggtca gtggccaggg
      241 cagcctcgga gtcaagcctg gaatccagca gcagctacaa ctcagagact ccatcgaccc
      301 cagagacgtc ctcaacttcc ttgagcacct cctgcccacg gggccggtcc tccgtgtggg
      361 gcccaccaga tgcctgtcga ggggacctcc gtgatgtggc cagatcgggg gtggcctctc
      421 tcccacctgc caaatgccag caccaggagt ccctgggccg accgagaccc cactcagcac
      481 cctcgctggg cacctcaagc ctgagggacc cagagccctc agggaggctg ggtgatccag
      541 gaccccagga ggcacagacc ccgaggtcca tcctggctca acagagcaag ctgtccaagc
      601 ccagggtgac cttctctgag gagtctgcag ttcctaagag gagctggcgc ctcaggccat
      661 acctgggcta tgactggatt gcagggtctc tggacaccag ctcttccatc accagccagc
      721 ctgaggcctt cttctccaag ctgcaggagt ttcgggaaac caacaaggag gagtgtatct
      781 gcagccatcc tgaaccccag ttgccaggcc tgcgtgagag cagtggcagc ggcgtggagg
      841 aagaccatga atgcgtgtac tgttaccgtg tcaaccggcg cctgttcccg gtgcctgtgg
      901 atcccggtac cccctgccgc ctgtgcagga caccgcgaga ccagcagggc cctgggaccc
      961 tggcgcagcc agcgcacgtc agggtgagca tcccgctgtc gatcctggag cccccgcacc
     1021 ggtaccacat ccaccggcga aagagctttg acgcctctga cacactggcc ctgccccggc
     1081 actgcctgct gggctgggac atttttcctc cgaagtctga gaaaagctca gcccccagga
     1141 acctggacct ctggtcctct gtctccgctg aggcccagca ccagaagctg tccggcacca
     1201 gcagcccttt tcacccggcc tcaccaatgc agatgctgcc cccgaccccg acctggtcag
     1261 tgccccaggt ccctcggccc cacgtcccac ggcagaagcc ctgaggactg actcctgggg
     1321 gagaacagca ttcccgccgc ctccagcctc tcccctctgg caggcgcacc caggagatgg
     1381 aatcccctgc ccgcccagct caggcccagc tgtcctaggt tgggcaggtg ggtggaccca
     1441 agcttgtctg ctgcctgagt tccagagagg gaggaccctg gggtggaggg tgagggattc
     1501 tgtggaagtt tgtaaataaa gctcagtgct ctgcagctca a
//
