LOCUS       NM_001416120            6382 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens mitoguardin 1 (MIGA1), transcript variant 17, mRNA.
ACCESSION   NM_001416120
VERSION     NM_001416120.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6382)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6382)
  AUTHORS   Liu,X.M., Zhang,Y.P., Ji,S.Y., Li,B.T., Tian,X., Li,D., Tong,C. and
            Fan,H.Y.
  TITLE     Mitoguardin-1 and -2 promote maturation and the developmental
            potential of mouse oocytes by maintaining mitochondrial dynamics
            and functions
  JOURNAL   Oncotarget 7 (2), 1155-1167 (2016)
   PUBMED   26716412
REFERENCE   3  (bases 1 to 6382)
  AUTHORS   Zhang,Y., Liu,X., Bai,J., Tian,X., Zhao,X., Liu,W., Duan,X.,
            Shang,W., Fan,H.Y. and Tong,C.
  TITLE     Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is
            Required for Neuronal Homeostasis
  JOURNAL   Mol Cell 61 (1), 111-124 (2016)
   PUBMED   26711011
  REMARK    GeneRIF: Propose that MIGA proteins promote mitochondrial fusion by
            regulating mitochondrial phospholipid metabolism via MitoPLD.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114487.2 and AC138392.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1371086.1, BX537792.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000370791.9/
                                                ENSP00000359827.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC114487.2         139273-139360
            89-202              AC114487.2         142862-142975
            203-205             AC114487.2         160955-160957
            206-380             AC138392.2         22686-22860
            381-517             AC138392.2         24622-24758
            518-644             AC138392.2         28327-28453
            645-778             AC138392.2         35086-35219
            779-902             AC138392.2         36460-36583
            903-1003            AC138392.2         64659-64759
            1004-1122           AC138392.2         80290-80408
            1123-1195           AC138392.2         80666-80738
            1196-1282           AC138392.2         81392-81478
            1283-1381           AC138392.2         82576-82674
            1382-1516           AC138392.2         85246-85380
            1517-1570           AC138392.2         87690-87743
            1571-1687           AC138392.2         94356-94472
            1688-6382           AC138392.2         96198-100892
FEATURES             Location/Qualifiers
     source          1..6382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..6382
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /note="mitoguardin 1"
                     /db_xref="GeneID:374986"
                     /db_xref="HGNC:HGNC:24741"
                     /db_xref="MIM:616773"
     exon            1..88
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            89..202
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1906
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /note="isoform 3 is encoded by transcript variant 17;
                     protein FAM73A; family with sequence similarity 73, member
                     A"
                     /codon_start=1
                     /product="mitoguardin 1 isoform 3"
                     /protein_id="NP_001403049.1"
                     /db_xref="GeneID:374986"
                     /db_xref="HGNC:HGNC:24741"
                     /db_xref="MIM:616773"
                     /translation="MSEETVSESQFSLKTAALRVFDLPLTWYYSLSQIKFSPVAKKLF
                     VVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQN
                     LTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKAD
                     EDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDA
                     IAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDKDTDITMKG
                     NVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKI
                     YSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKAR
                     KNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDLEN
                     PPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHISPV
                     LAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTEL
                     LMAYLEADALRHTSSCLSSHGHVMSTGLLEAKVQ"
     exon            203..380
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            381..517
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            518..644
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            645..778
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            779..902
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1003
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1122
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1195
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1282
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1381
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1516
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1570
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1687
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..6382
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6365..6370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /note="hexamer: AATAAA"
     polyA_site      6382
                     /gene="MIGA1"
                     /gene_synonym="FAM73A"
                     /note="major polyA site"
ORIGIN      
        1 cttctccatg tcagactgct gctcagcgcc aggcatcagc tgggaagctg gcgtgggcag
       61 gccagctgta cctggcctgg agctccagat tagaagagga gccatgtcag aagaaacagt
      121 aagtgaatca cagttttcct tgaagacagc agcgctaaga gtgtttgatc ttcctctgac
      181 ttggtactat tctctctccc agatcaaatt ttctccggtg gctaaaaagt tgtttgtggt
      241 aactgcagtg agtgctatat ctgtaatttt tctggctcat cactttaaaa gaaaacgtgg
      301 aaagaagaaa ggaaaaatat taccatggga accagagcac ctcatacttg aatacactaa
      361 aagagcagca tcagacaaag gttcaagttg ttccagtagc agacagaatt tgacattatc
      421 tttaagttct accaaagaca aaggatctca agtttgtaac tatgctaatg gaggactttt
      481 cagtaaatat tcaggttctg cacagagttt ggcctctgtc cagagtgtca attcttgtca
      541 tagctgcgct tgtggcaatt ctaattcctg ggacaaagca gatgaagatg atattaaact
      601 tgttaatatt cctgtgacta ctccagagaa cttatactta atgggtatgg aattgtttga
      661 agaggcattg cgtcgatggg aacaagctct gacctttcgc aatagacagg ctgaagatga
      721 agcctgtggt tccattaaac tgggtgcagg agatgccatt gctgaagaaa atgtagatga
      781 tattattagt actgaattta tccataaact cgaagctctg ctgcaaagag cctatcgtct
      841 ccaagaggag tttgaagcta cccttggggc atctgatcct aattcccttg ctgatgatat
      901 tgataaagat acagatatca ccatgaaggg taatgtggaa gactttggcc tgcgagacac
      961 cttgagcatc gcatccacgg attcctttgc ttccgcagca gagcttgcag aacacagaga
     1021 agtacggcat acctacagcc tggagtccct ttgtcactgc ccattttacg aggaagccat
     1081 gcatttagtt gaagaaggaa aaatttactc cagagtactg agaactgaaa tgttggagtg
     1141 cctaggagac agtgattttc ttgccaaact tcactgtatt cgacaggctt ttcaggtaat
     1201 tctttcagaa tcagctaaca ggatattcct cgctgagagc ggaaggaaaa ttttatcagc
     1261 tttaattgtg aaagcacgaa agaatccaaa gaagtttgaa gatgtttttg atgaaatgat
     1321 ctatttttta gagcagaccg atcactgggg tagtactgaa atggaacttg ctgctagagg
     1381 ggtgaaaaat ctaaattttt atgatgttgt tctggatttt atattaatgg actcctttga
     1441 agatttggaa aacccaccca catccataca gaatgtagta aataatcgat ggctaaactc
     1501 atccttcaaa gaaacagctg tggcttcaag ttgttggtcg gtgctgaaac agaaaagaca
     1561 acagatgaag atcccagatg gattttttgc ccatttttat gccatttgtg aacacatcag
     1621 tcctgtccta gcctggggct ttttgggtcc tagaaattct ctgtatgatt tatgttgctt
     1681 ttttaagaat caagttcttt tatttctcaa agacattttt gactttgaga aggtgcgcta
     1741 ttcaagtaca gagactttag ctgaagacct catgcagtta ctcattcgcc gcactgagct
     1801 tttaatggcc tatcttgaag cagatgccct gaggcataca agtagttgtc taagcagtca
     1861 tggtcatgtt atgtccactg ggctactgga agccaaagta caataagtac cataagaatc
     1921 atacaatttg agtgtgctat gaaatatttt aaggtaacta ttgattttgt aacatatatt
     1981 acaaagttaa cagaattgat gcatgtggat tcagggagga aaaaaaaatc tactaaaaaa
     2041 tgagcaactg tactgtattt atacagaagt tctgtcattg aattcctgtg tagtgtagtc
     2101 atagtggctt tttgcattca ttaggtaata attgaagtca tgaaatgtat attttacaga
     2161 aatatcgctt gaattgaagc caatatttgg gagttaattg gtttgtcttc ttgaagctgt
     2221 cattctcaaa agctctgttt ttatgctttg cacctttaaa atgtacactt tagccaaggt
     2281 ctttgtggcc cacacatgca agaatatatt acttctaatg tcaatatatt taactttgcc
     2341 tagaaacata tttttaatta taaagttatt catttgttta atcaagttta ggcagtaatg
     2401 atgtttaata tgtactgcat acattattgc ttgtgcattt gcttatgtat ttgaatcaaa
     2461 gaaattgtaa tcactgaata ttgttataga acatttaaat gggccacttg cagtggctca
     2521 tgcctgtaat acattgggag gctgaggcag gaggacagtt tgaggccagg aggttgagac
     2581 tagcctggac aacataagga gatgcctgtc tctacaaaaa cataaaaata aattagctgg
     2641 tatcaagcag agttccatgg aaatattaaa atttttttaa aaaataaaaa taggctgggt
     2701 gtggtggttc atgcctgtaa tcctagcact ttgggaggcc aaggtgggcg gatcacctga
     2761 ggtcaggtgt tcgagaccag cctccccaat atggtgaaac cccgtctcta ctaaaaatac
     2821 aaaaattagc caggtgtggt ggcgggcgcc tgtagtccca gctactcggg aggctgacac
     2881 aggagtattg cttgaaccca ggaagtggag gctgcagtga gccgagatcg caccactgca
     2941 ctccagcctg ggcaacaaag tgagactctg tctcaaaaaa taaattaatt aaattaaatt
     3001 aattagttgg gtgtggtggc atgtgtctgt ggtcccagct acttgggagg ctgaggtggg
     3061 aggatcactt gagtccagaa ggtcaaggct gtcatgagct gtgattgcat cactgcactc
     3121 cagcctgggc gacagcaaga ccctatctca gaagtgaata aataaaacaa atacagcatt
     3181 taaatgaatt gacattgaga aatttacaat ttacaaattt atattaactg tagtttccaa
     3241 aatatgttac tgttggtcct gtaagttaca aagagactga agaactttct ttttatacat
     3301 tagagcattt tcccctggaa tgagtattga ttaaaaagat aacatttatt aattaataaa
     3361 ggcaatttaa aatttagtgt tatttgaaga ctgtcaacat ctgaaggtat gaaacttggt
     3421 acagtgaaat aatttctcct ttctccttcc ttttagttat tcccacagaa aactcagccc
     3481 agtgggaatt tgtcatatta tgcccatgtt ttaaaaatat tcatagtttg aatcttattg
     3541 acattttaaa gaagagtttt ttcctccctg gaatgtaaaa caaaaatatt ttttaatgat
     3601 gtggaagtat atatttcatg ttcattatga taaatctaca aacaaatgaa ttgtttttat
     3661 gggtggagtt cttctataag agtatattaa atgctttcag agttgtatta attttgtttc
     3721 taaataatat accacttatt tggagtgact aactcagtat gtaagtagat gagatttgtt
     3781 gattttgccc ctaaaacggg ctttagtcat tttaggagtg agttgcacaa aaggacctaa
     3841 aatgcattgt tttttgcctt cttttaagag atggggtctc gctctattgc ccaggctgga
     3901 gtgcagtgtg ctatcataca tagctcactg cagtctccaa ctcctcatac cagaggcatg
     3961 tgtcaccatg tcttactcct aaaatgcatt tttaaaaagc gaatttttag attaaagtgc
     4021 ctagtttctg attaataaat agaagatgaa aaaagtgggc gggaaaagca taatctttta
     4081 agatttgtaa ttttctgtat gtgccacatt tatgtaaatt aactataaaa tatggaattc
     4141 aggatcatgc tgttttgcat gtactttata ggttatatag catgaaacat acaaattatc
     4201 actgttcttt agtatatagc tccttgcctt ttcttacata gatgcttaat ttaacaatta
     4261 cctatttata gttcttatta ttgacgggaa tatgattaga agtaccaaaa ctaaaaattc
     4321 cattatgtac tgtttacttt ttatttaata ttacatgttt ttaccttgtt gcggtatctt
     4381 tggccttcac acacacatgt gtgcgtgcac gtgcatttca ttaccatgta gacaagacag
     4441 ttattgctta tagtaattta cccatttgag ggctaagtgt tttaagctgt ggttttataa
     4501 gcaaagctgt aagtaaatgt aatttatttt agaaagatat tatttgaaat caattttgaa
     4561 gaattgcact atttgataat gctgctacta catgagataa ctctggggaa ttaattttat
     4621 gagataagat gaatggcttt ctagaaggtg ttgctttttg ttttttcttt ttctttttta
     4681 catttcatct tagaaaaagt tgcttatatt cagcaggttg gtttgtcaaa ttcagtgttt
     4741 gagtttgttt ctggtcagtt cagtagctgc tactttagca agatgtggcc tttcacaaaa
     4801 gaggtaagag tgaccaaata gaattttagg acaataagta taggaaatat ctctttatcg
     4861 taagataaga aacttgaact ttttaaagga aatgtcctct tgaaaagaac atttctgact
     4921 gcatgcagaa gggtacttaa gacatatata acaggccagg agcagtggct cacgcctgta
     4981 atcccagcac tttgggaggc ccaagtgggc agataacctg aggtcaggag tttgagacca
     5041 gcctgaccaa catggtgaaa ccccatctct actaaaaata caaaaattag ccaggcatgg
     5101 tggcgcatgc ctgtaatccc agctactcga gaggctgagg caggagaatc gcttgaaccc
     5161 gggaggcgga ggttgcagtt agccgagatc gtgccattgc actccagcct gggcaacaag
     5221 agtaaaactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaagacatat gtaacggttt
     5281 ccatttgcct taaaattggg ttaaatagca aaagcaatgt ctttaaaaat gattagttta
     5341 gagcctttta gggtaaaccc tgtttaaaca cttaatcatg gaattgccct tgccaccatg
     5401 agctctacca tccacttcca tatgtaaatt ataagaggga cttcaattaa gtcactcctg
     5461 agaaaatatc cttttttcta gaagaaagaa gataaatttt gaggcaattt acatttggta
     5521 tttcttttaa tttcattttt tgtattttaa tttccctaca tttttgttca actaagagtg
     5581 cttatttctt cttgaaggtt aacattatgt ttattaagta tcaaaatgga attatctttt
     5641 aaaaaagaag acaagttttc catactgtca cagtaagctc caaagaactt tgtctttctc
     5701 ataaagtaat attctttatt tgcatccatt tactatgatt ccgttaattt gttgaattaa
     5761 atgcctttat aaaaatattt acaaatgttt tcttgcctta aaatgtaaca ttttctactt
     5821 aaatttaatt tccaagagag tgattatttg cattacaaag gaattcttaa taattcctgt
     5881 aagcctagga aataggaatg ccaaagtaac atttaatgta cttctctata acttttcata
     5941 atcagaaatt ttaaattatg tttatataac ccatttactt ttattttaat gtgaatatat
     6001 attcagaaat tatttgatgt aaatttcaaa atgattatag gaattaagct gaattctaat
     6061 ttttttgctt agatttagaa atatgtatgt gaaatttaag aatttatata atctgtgatt
     6121 agtggaaata agaacatccc tactttgttc ctaatgagta tattatgtta ttgttttgtt
     6181 tagtttgtga acaaccatgt attagcttta cttagctgat gtcagtaaat gtttctgtct
     6241 cctaaatgta aggactgtac tcattaattt gtgtaaaagt aaaacactac agtagcagaa
     6301 aaaattgcac tggctcttta gccaaaataa gcactgtaac atggatgtat tactattact
     6361 gccaaataaa aaagtgatgg ta
//
