LOCUS       NM_001370592            1319 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MIF4G domain containing (MIF4GD), transcript variant
            11, mRNA.
ACCESSION   NM_001370592 XM_005257532
VERSION     NM_001370592.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Cakmakci,N.G., Lerner,R.S., Wagner,E.J., Zheng,L. and Marzluff,W.F.
  TITLE     SLIP1, a factor required for activation of histone mRNA translation
            by the stem-loop binding protein
  JOURNAL   Mol Cell Biol 28 (3), 1182-1194 (2008)
   PUBMED   18025107
  REMARK    GeneRIF: downregulation of endogenous SLIP1 reduces the rate of
            translation of endogenous histone mRNA and also reduces cell
            viability.
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022211.5, AF225422.1 and
            BP308696.1.
            
            On May 14, 2019 this sequence version replaced XM_005257532.5.
            
            Summary: This gene encodes a protein which interacts with the
            N-terminus of the stem-loop binding protein (SLBP) and the 3' end
            of histone mRNA. This interaction facilitates the activation of
            histone mRNA translation. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.30332.1,
                                           SRR5189658.26544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161836 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325102.13/ ENSP00000321625.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC022211.5         160870-160878       c
            10-48               AF225422.1         10-48
            49-655              BP308696.1         1-607
            656-1319            AC022211.5         155875-156538       c
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1319
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /note="MIF4G domain containing"
                     /db_xref="GeneID:57409"
                     /db_xref="HGNC:HGNC:24030"
                     /db_xref="MIM:612072"
     exon            1..88
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..220
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..807
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /note="isoform 4 is encoded by transcript variant 11; SLBP
                     (stem loop binding protein)-interacting protein 1; MIF4G
                     domain-containing protein; SLBP-interacting protein 1"
                     /codon_start=1
                     /product="MIF4G domain-containing protein isoform 4"
                     /protein_id="NP_001357521.1"
                     /db_xref="CCDS:CCDS56044.1"
                     /db_xref="GeneID:57409"
                     /db_xref="HGNC:HGNC:24030"
                     /db_xref="MIM:612072"
                     /translation="MGEPSREEYKIQSFDAETQQLLKTALKDPGAVDLEKVANVIVDH
                     SLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWV
                     CYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGE
                     QLEKMNGQRMDELFVLIRDGFLLPTGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYS
                     EVSD"
     exon            221..330
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..486
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..579
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1319
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1319
                     /gene="MIF4GD"
                     /gene_synonym="AD023; MIFD; SLIP1"
                     /note="major polyA site"
ORIGIN      
        1 acggcgggcc ccgcagcgcc ggacgctggt tgcgcgctcc caggcgccga gcggccccgg
       61 gcacgcgcgc gcgccaccgg cccggcaggt gctgtcctta ttcccagccc agtcaagagc
      121 taccggggct ggctagtcat gggggagccc agtagagagg agtataaaat ccagtccttt
      181 gatgcagaga cccagcagct gctgaagaca gcactcaaag atccgggtgc tgtggacttg
      241 gagaaagtgg ccaatgtgat tgtggaccat tctctgcagg actgtgtgtt cagcaaggaa
      301 gcaggacgca tgtgctacgc catcattcag gcagagagta aacaagcagg ccagagtgtc
      361 ttccgacgtg gactcctcaa ccggctgcag caggagtacc aggctcggga gcagctgcga
      421 gcacgctccc tgcagggctg ggtctgctat gtcaccttta tctgcaacat ctttgactac
      481 ctgagggtga acaacatgcc catgatggcc ctggtgaacc ctgtctatga ctgcctcttc
      541 cggctggccc agccagacag tttgagcaag gaggaggagg tggactgttt ggtgctgcag
      601 ctgcaccggg ttggggagca gctggagaaa atgaatgggc agcgcatgga tgagctcttt
      661 gtgctgatcc gggatggctt cctgctccca actggcctca gctccctggc ccagctgctg
      721 ctgctggaga tcattgagtt ccgggcggcc ggctggaaga caacgccagc tgcccacaag
      781 tattactaca gcgaagtctc cgactaggcc tccagatcag ggcttcctca ccagcactgg
      841 cctttcttct acccacctct aaagctggca gtggagtctc tgcctcaccc aaagactttt
      901 cccttccaga ctttgagtgt cttcccttct agactttccc atctcctggt gagatgtttc
      961 ccacttatgc cgtggtcctg ccctgagccc ctttccccac cacaacccac cacggccagg
     1021 cagagaaggg caactcccaa gagccactgc actgtgtaac cattagtgca actactacct
     1081 tggtgcctca gtttacccat ctgtaaaatg ggtaagcata gccactggtg ggatattttg
     1141 ggatgtcaag gggtggaggc agagcacaag tcacaccaga aactgctttt tatacatttt
     1201 gtataaggac aactctggaa acaagcctat ttcctccagc cagtttcact gaatgctgca
     1261 ccacatgcta caccagttca gcgtgagaat tttctaataa atcttttctg atactaaaa
//
