LOCUS       NM_002415                557 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens macrophage migration inhibitory factor (MIF), mRNA.
ACCESSION   NM_002415
VERSION     NM_002415.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 557)
  AUTHORS   Wu,S., Ouyang,Y., Hu,Y., Jiang,L., Fu,C., Lei,L., Zhang,Y., Guo,H.,
            Huang,J., Chen,J. and Zeng,Q.
  TITLE     Macrophage migration inhibitory factor mediates skin aging via
            CD74: Insights from single-cell and bulk RNA sequencing data
  JOURNAL   Clin Immunol 263, 110199 (2024)
   PUBMED   38565329
  REMARK    GeneRIF: Macrophage migration inhibitory factor mediates skin aging
            via CD74: Insights from single-cell and bulk RNA sequencing data.
REFERENCE   2  (bases 1 to 557)
  AUTHORS   Chen,M., Liu,H., Hong,B., Xiao,Y. and Qian,Y.
  TITLE     MIF as a potential diagnostic and prognostic biomarker for
            triple-negative breast cancer that correlates with the polarization
            of M2 macrophages
  JOURNAL   FASEB J 38 (10), e23696 (2024)
   PUBMED   38787620
  REMARK    GeneRIF: MIF as a potential diagnostic and prognostic biomarker for
            triple-negative breast cancer that correlates with the polarization
            of M2 macrophages.
REFERENCE   3  (bases 1 to 557)
  AUTHORS   Alfahel,L., Gschwendtberger,T., Kozareva,V., Dumas,L., Gibbs,R.,
            Kertser,A., Baruch,K., Zaccai,S., Kahn,J., Thau-Habermann,N.,
            Eggenschwiler,R., Sterneckert,J., Hermann,A., Sundararaman,N.,
            Vaibhav,V., Van Eyk,J.E., Rafuse,V.F., Fraenkel,E., Cantz,T.,
            Petri,S. and Israelson,A.
  TITLE     Targeting low levels of MIF expression as a potential therapeutic
            strategy for ALS
  JOURNAL   Cell Rep Med 5 (5), 101546 (2024)
   PUBMED   38703766
  REMARK    GeneRIF: Targeting low levels of MIF expression as a potential
            therapeutic strategy for ALS.
REFERENCE   4  (bases 1 to 557)
  AUTHORS   Dunbar,H., Hawthorne,I.J., McNamee,E.N., Armstrong,M.E.,
            Donnelly,S.C. and English,K.
  TITLE     The human MIF polymorphism CATT7 enhances pro-inflammatory
            macrophage polarization in a clinically relevant model of allergic
            airway inflammation
  JOURNAL   FASEB J 38 (6), e23576 (2024)
   PUBMED   38530238
  REMARK    GeneRIF: The human MIF polymorphism CATT7 enhances pro-inflammatory
            macrophage polarization in a clinically relevant model of allergic
            airway inflammation.
REFERENCE   5  (bases 1 to 557)
  AUTHORS   Parol-Kulczyk,M., Durslewicz,J., Blonkowska,L., Wujec,R., Gzil,A.,
            Piatkowska,D., Ligmanowska,J. and Grzanka,D.
  TITLE     Macrophage migration inhibitory factor (MIF) predicts survival in
            patients with clear cell renal cell carcinoma
  JOURNAL   J Pathol Clin Res 10 (2), e12365 (2024)
   PUBMED   38436543
  REMARK    GeneRIF: Macrophage migration inhibitory factor (MIF) predicts
            survival in patients with clear cell renal cell carcinoma.
REFERENCE   6  (bases 1 to 557)
  AUTHORS   Kozak,C.A., Adamson,M.C., Buckler,C.E., Segovia,L., Paralkar,V. and
            Wistow,G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   7  (bases 1 to 557)
  AUTHORS   Zeng,F.Y., Weiser,W.Y., Kratzin,H., Stahl,B., Karas,M. and
            Gabius,H.J.
  TITLE     The major binding protein of the interferon antagonist sarcolectin
            in human placenta is a macrophage migration inhibitory factor
  JOURNAL   Arch Biochem Biophys 303 (1), 74-80 (1993)
   PUBMED   7683862
REFERENCE   8  (bases 1 to 557)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
REFERENCE   9  (bases 1 to 557)
  AUTHORS   Weiser,W.Y., Temple,P.A., Witek-Giannotti,J.S., Remold,H.G.,
            Clark,S.C. and David,J.R.
  TITLE     Molecular cloning of a cDNA encoding a human macrophage migration
            inhibitory factor
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7522-7526 (1989)
   PUBMED   2552447
REFERENCE   10 (bases 1 to 557)
  AUTHORS   Liu,D.Y., Yu,S.F., Remold,H.G. and David,J.R.
  TITLE     Glycolipid receptor for human migration inhibitory factor: fucose
            and sialic acid are important for the human monocyte response to
            migration inhibitory factor
  JOURNAL   Cell Immunol 90 (2), 539-546 (1985)
   PUBMED   3917866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000350.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 28, 2018 this sequence version replaced NM_002415.1.
            
            Summary: This gene encodes a lymphokine involved in cell-mediated
            immunity, immunoregulation, and inflammation. It plays a role in
            the regulation of macrophage function in host defense through the
            suppression of anti-inflammatory effects of glucocorticoids. This
            lymphokine and the JAB1 protein form a complex in the cytosol near
            the peripheral plasma membrane, which may indicate an additional
            role in integrin signaling pathways. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP204676.1, BP317237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215754.8/ ENSP00000215754.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AP000350.1         88427-88626
            201-373             AP000350.1         88816-88988
            374-557             AP000350.1         89084-89267
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..557
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /note="macrophage migration inhibitory factor"
                     /db_xref="GeneID:4282"
                     /db_xref="HGNC:HGNC:7097"
                     /db_xref="MIM:153620"
     exon            1..200
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..440
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /EC_number="5.3.3.12"
                     /EC_number="5.3.2.1"
                     /note="phenylpyruvate tautomerase; L-dopachrome isomerase;
                     L-dopachrome tautomerase; macrophage migration inhibitory
                     factor (glycosylation-inhibiting factor); epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="macrophage migration inhibitory factor"
                     /protein_id="NP_002406.1"
                     /db_xref="CCDS:CCDS13819.1"
                     /db_xref="GeneID:4282"
                     /db_xref="HGNC:HGNC:7097"
                     /db_xref="MIM:153620"
                     /translation="MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVP
                     DQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDM
                     NAANVGWNNSTFA"
     exon            201..373
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /inference="alignment:Splign:2.1.0"
     exon            374..557
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      538..543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /note="hexamer: AATAAA"
     polyA_site      557
                     /gene="MIF"
                     /gene_synonym="GIF; GLIF; MMIF"
                     /note="major polyA site"
ORIGIN      
        1 agtggtgtcc gagaagtcag gcacgtagct cagcggcggc cgcggcgcgt gcgtctgtgc
       61 ctctgcgcgg gtctcctggt ccttctgcca tcatgccgat gttcatcgta aacaccaacg
      121 tgccccgcgc ctccgtgccg gacgggttcc tctccgagct cacccagcag ctggcgcagg
      181 ccaccggcaa gcccccccag tacatcgcgg tgcacgtggt cccggaccag ctcatggcct
      241 tcggcggctc cagcgagccg tgcgcgctct gcagcctgca cagcatcggc aagatcggcg
      301 gcgcgcagaa ccgctcctac agcaagctgc tgtgcggcct gctggccgag cgcctgcgca
      361 tcagcccgga cagggtctac atcaactatt acgacatgaa cgcggccaat gtgggctgga
      421 acaactccac cttcgcctaa gagccgcagg gacccacgct gtctgcgctg gctccacccg
      481 ggaacccgcc gcacgctgtg ttctaggccc gcccacccca accttctggt ggggagaaat
      541 aaacggttta gagacta
//
