LOCUS       NM_001297599            5199 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens MIER family member 3 (MIER3), transcript variant 2,
            mRNA.
ACCESSION   NM_001297599 XM_005248448
VERSION     NM_001297599.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5199)
  AUTHORS   Huang,W., Chen,J., Liu,X., Liu,X., Duan,S., Chen,L., Liu,X.,
            Lan,J., Zou,Y., Guo,D. and Zhou,J.
  TITLE     MIER3 induces epithelial-mesenchymal transition and promotes breast
            cancer cell aggressiveness via forming a co-repressor complex with
            HDAC1/HDAC2/Snail
  JOURNAL   Exp Cell Res 406 (1), 112722 (2021)
   PUBMED   34242623
  REMARK    GeneRIF: MIER3 induces epithelial-mesenchymal transition and
            promotes breast cancer cell aggressiveness via forming a
            co-repressor complex with HDAC1/HDAC2/Snail.
REFERENCE   2  (bases 1 to 5199)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5199)
  AUTHORS   Peng,M., Hu,Y., Song,W., Duan,S., Xu,Q., Ding,Y., Geng,J. and
            Zhou,J.
  TITLE     MIER3 suppresses colorectal cancer progression by down-regulating
            Sp1, inhibiting epithelial-mesenchymal transition
  JOURNAL   Sci Rep 7 (1), 11000 (2017)
   PUBMED   28887525
  REMARK    GeneRIF: our data suggested that MIER3 plays a potential tumor
            suppressor role in CRC progression and may be a potentially
            valuable clinical prognostic marker of this disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5199)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    GeneRIF: Histone deacetylase assays confirmed that MIER2, but not
            MIER3 complexes, have associated deacetylase activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5199)
  AUTHORS   denDekker,A.D., Xu,X., Vaughn,M.D., Puckett,A.H., Gardner,L.L.,
            Lambring,C.J., Deschenes,L. and Samuelson,D.J.
  TITLE     Rat Mcs1b is concordant to the genome-wide association-identified
            breast cancer risk locus at human 5q11.2 and MIER3 is a candidate
            cancer susceptibility gene
  JOURNAL   Cancer Res 72 (22), 6002-6012 (2012)
   PUBMED   22993404
  REMARK    GeneRIF: Data suggest that the human 5q11.2 breast cancer risk
            allele marked by rs889312 is mammary gland autonomous, and MIER3 is
            a candidate breast cancer susceptibility gene.
REFERENCE   6  (bases 1 to 5199)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016644.9 and AC008937.7.
            
            On Feb 27, 2020 this sequence version replaced NM_001297599.1.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the coding region but maintains the reading frame, compared to
            variant 1. The resulting isoform (2) lacks an internal segment,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537798.1, SRR14372080.930620.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381199.8/ ENSP00000370596.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC016644.9         23013-23042
            31-55               AC016644.9         24484-24508
            56-201              AC016644.9         28065-28210
            202-336             AC016644.9         36119-36253
            337-457             AC016644.9         37438-37558
            458-543             AC016644.9         39385-39470
            544-616             AC016644.9         39636-39708
            617-768             AC008937.7         679-830
            769-850             AC008937.7         3332-3413
            851-945             AC008937.7         5216-5310
            946-1073            AC008937.7         10035-10162
            1074-1216           AC008937.7         10244-10386
            1217-5199           AC008937.7         10492-14474
FEATURES             Location/Qualifiers
     source          1..5199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..5199
                     /gene="MIER3"
                     /note="MIER family member 3"
                     /db_xref="GeneID:166968"
                     /db_xref="HGNC:HGNC:26678"
                     /db_xref="MIM:620100"
     exon            1..30
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1674
                     /gene="MIER3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mesoderm induction early response protein 3; mi-er3;
                     mesoderm induction early response 1, family member 3"
                     /codon_start=1
                     /product="mesoderm induction early response protein 3
                     isoform 2"
                     /protein_id="NP_001284528.1"
                     /db_xref="CCDS:CCDS75248.1"
                     /db_xref="GeneID:166968"
                     /db_xref="HGNC:HGNC:26678"
                     /db_xref="MIM:620100"
                     /translation="MAEASFGSSSPVGSLSSEDHDFDPTAEMLVHDYDDERTLEEEEM
                     MDEGKNFSSEIEDLEKEGTMPLEDLLAFYGYEPTIPAVANSSANSSPSELADELPDMT
                     LDKEEIAKDLLSGDDEETQSSADDLTPSVTSHETSDFFPRPLRSNTACDGDKESEVED
                     VETDSGNSPEDLRKEIMIGLQYQAEIPPYLGEYDGNEKVYENEDQLLWCPDVVLESKV
                     KEYLVETSLRTGSEKIMDRISAGTHTRDNEQALYELLKCNHNIKEAIERYCCNGKASQ
                     EGMTAWTEEECRSFEHALMLFGKDFHLIQKNKVRTRTVAECVAFYYMWKKSERYDYFA
                     QQTRFGKKRYNHHPGVTDYMDRLVDETEALGGTVNASALTSNRPEPIPDQQLNILNSF
                     TASDLTALTNSVATVCDPTDVNCLDDSFPPLGNTPRGQVNHVPVVTEELLTLPSNGES
                     DCFNLFETGFYHSELNPMNMCSEESERPAKRLKMGIAVPESFMNEVSVNNLGVDFENH
                     THHITSAKMAVSVADFGSLSANETNGFISAHALHQHAALHSE"
     exon            31..55
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            56..201
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..336
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..457
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..543
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            544..616
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..768
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..945
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1073
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1216
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..5199
                     /gene="MIER3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5179..5184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIER3"
                     /note="hexamer: AATAAA"
     polyA_site      5199
                     /gene="MIER3"
                     /note="major polyA site"
ORIGIN      
        1 gttcgcccta aaggtaccaa tatggcggag gcttcttttg gaagttcgag cccagttggg
       61 tctttgtctt ctgaggatca tgattttgac cccactgctg agatgttggt ccatgactat
      121 gatgatgaaa gaactcttga agaagaggaa atgatggatg agggtaaaaa cttcagttca
      181 gaaattgaag acttagaaaa ggaaggaacc atgcctctag aagatttact ggcattctat
      241 ggctatgaac ctacaattcc agcagttgca aattccagtg caaatagttc cccaagtgaa
      301 ctggcagatg aactaccaga catgacacta gacaaagagg aaatagcaaa agacctgttg
      361 tcaggtgatg acgaggaaac tcagtcttct gcggatgatc tgacgccatc tgtgacttcc
      421 catgaaactt ctgatttctt ccctaggcct ttacgatcaa atactgcatg tgatggtgat
      481 aaggaatcag aggttgaaga tgttgaaaca gacagtggta attcacctga agatttgagg
      541 aaggaaataa tgattggttt acaatatcag gcagagattc ccccttatct tggagagtac
      601 gatggtaatg agaaagtata tgaaaacgaa gaccagttac tttggtgtcc tgatgtggtt
      661 ttggagagca aagttaagga ataccttgtt gagacttcat taaggactgg cagtgaaaaa
      721 ataatggata ggatttctgc aggaacacac acaagggaca atgaacaggc attatatgaa
      781 cttctcaagt gtaaccacaa tataaaggaa gcaatcgaaa gatactgctg caatggaaag
      841 gcctctcaag aaggaatgac tgcatggacg gaagaagaat gccgaagctt tgaacatgca
      901 ctcatgcttt ttggaaaaga ttttcatctt atacagaaga ataaggtgag aactaggaca
      961 gttgctgagt gtgtagcatt ctactatatg tggaagaaat ctgaacgtta tgattacttt
     1021 gctcaacaga caagatttgg gaaaaaaaga tataaccatc accctggagt tacggactat
     1081 atggatcgtt tagtagatga aacagaagct ttgggtggga cggtaaatgc ttcagcctta
     1141 acttctaacc ggcctgagcc tattcctgat caacagctaa acattctcaa ctccttcact
     1201 gccagtgact tgacagcttt gaccaacagt gtagcaaccg tctgcgaccc cacagatgtg
     1261 aattgtttgg atgatagctt tcctccactg ggcaacacac cccgtggaca agttaatcat
     1321 gtgcctgttg taacagaaga gttactcacc ctgcccagca atggggaaag tgattgtttt
     1381 aatttatttg agactggatt ttatcactcg gagctaaacc ctatgaacat gtgcagtgaa
     1441 gagtcagaga gaccagcaaa aagattgaaa atgggcattg ccgtccctga atcctttatg
     1501 aatgaagttt ctgtaaataa cctgggtgtg gactttgaaa atcacacaca tcacatcacc
     1561 agtgccaaaa tggctgtttc tgtggctgac tttggcagtc tctctgccaa cgagaccaat
     1621 ggtttcatca gtgcccatgc tctgcatcag cacgcggccc tacactctga gtgacctgag
     1681 tgaggatccc ggaactgcgt gtgcagcacc agtaaacttg aggggagcta tcaggtttgc
     1741 atagtctttc actggaagtt tgaacctttc tcactatgac atcagtgatg tcagtatgta
     1801 tagaactata tcttgattta tcaagagtat tttcattttt caatccataa atgtggaaat
     1861 gaactatgat cagcagagtt gggaactaag attgaactct gtggtgcagc tttaagctct
     1921 gcttctctct tcctcatctc ccaatacctc ttccccactc ccttcttttt ctattctttt
     1981 gtgttcccca ctgccctcac tcccaatttt aaaacctgta gacagaggcc accagctcaa
     2041 aaccagcaca gatgttctga actgaatggt gtggcctgtt tttgtgtaaa ttccttttgc
     2101 cgtaatggat gcagtggaat aacaatgttt acaggtaccg atcccgatcc ctgctcaatg
     2161 tagcattttt ttggttttat tttcttaata aaagcagggg taggtttctt taaactgcac
     2221 aaacatgcaa ggatttttta aaaatggaaa cttctctcat gttattcaac tagagcactt
     2281 cagtttacaa aacagcaagt ccatctttat ggaagccagc acaaggaact gtgtgcaaat
     2341 aatgaagacg cttgcttgga tcctgtttca aaattctaga ccagggctac cttacacaga
     2401 attggtcatg ttactgccag gagatttctg tgtaacttca tttattggct acagttttgg
     2461 catttgaaga tgtggtactc agatggggtt ttgtccacca ttgtcaagat tgtaatctta
     2521 aaaatcatac cagtcattga taatttagtt tatcctgagg cagtcgactt gcagaggcac
     2581 agtctacaaa gcctaggatg ttgccactca atggtttaca ttttgggaca tcttttaagt
     2641 tgtttgtagc actgcagttc aaagtgttaa tatttagagg gacttctaga ttttatacct
     2701 aatgcagtag aaccttgaag tatatttaag cttttttgtt aagcttgaac agttggcaag
     2761 aataatgtga gttcctatct gaaatagaat ggtacattac cacttttaag ttttaaaaat
     2821 tgatagatgt tcagatgtat ctcaaactca gttttatttt tattccaaat attgtgaatg
     2881 agaagccatt gtcctaaact ttggccattt ttgtgctata aacatgcatt tttaagttat
     2941 aaggtgaatc aaacaatatg taatacagta ttaggatgta atctttgctt ttgtagtact
     3001 gttaaaatag agaattatgt tgtttgcacc gtcttaatta aaattcttga tttttactag
     3061 ttgctttgca aaaaacaaat gtttggctgc attgctaata tttgtaagta taagttgctt
     3121 caaggttgtg ctgatgagta gataggatgt agtgatctta gtagtgattg aaagggaggg
     3181 tatttattat acaaactgtg aactgcaatg acatccttag ttttggatga tgtgtattct
     3241 tgtttttctt tgcagcattt taatgaagat tgctttgaag tgtttacgca gtagcacatt
     3301 agtataaaat ttagtttagc acagtggaca aaaagtagtt aaattaataa cttaaaatca
     3361 gtctctaatt tatacatctg aagtatagca ttcctgtatg cacacagtaa ataatgggta
     3421 gcctgggctc tgtgttactt tcttgtattt ttatccaagt tgtcagcttc ttattgctgt
     3481 gttgttgtgc taaactttga accttatttc ttttattaaa aatcagtaca ctttctataa
     3541 tttagtaaga tactggccat aatcttccat tgttataacc ttaattttca ctctgggttt
     3601 acagtggctg gtctgtataa ataatttaca caaagatgac tgaatgctaa taccagttgc
     3661 acttaaatga acatgcccat tctcagtagc tgatgcagta atatattcag tttatctatg
     3721 cattgctggg gtcttgatat aagatggaaa cagtgtttct tatctaaagt tttgattatc
     3781 agcaagttga atggacactt tagttattta aataaagatt tttgaccaaa atccagaaaa
     3841 tggtatgaga gaaaaataaa ttccagctag tttaatagat ttttaaatgt caatctgatt
     3901 ttagcctctt agagagtgct aactagctgg taatgtttac ttttaattcc ttgttaaaat
     3961 gaggcaataa tttgcaagat ttttgtatat aagtgtaaat tcttcatatc tttttagatc
     4021 taattcaata ttttctgact acttctgcca tgtataatac catttttgtg catgcttgat
     4081 gtgacattca taaattgtac cactatgact ttatccatgt aaaatagcta tttattgaat
     4141 tttcttttaa aagctggatt tactgggttt tttttttctc tcagtttaaa catcttaaca
     4201 gagaatttgt tactgtttat taaaagaatt gcatttggaa gcaagaaaac aaccggattt
     4261 gcaatcatgt gaagaaacaa taatgccttt attatcaagt gttaagcaca attcttataa
     4321 caaactgtga taaattcttt ttgttttttt ttcctttgcc ccattatttt cttatgaaca
     4381 aaccaaaaat tcatggtgag cagttgcagt gttggctgat atatctttta tgtacaggga
     4441 atttgaaaag gacagtggat tcatttagaa gtgtaactgg tgctgtgatt atagcaatac
     4501 atttgttagt tgtacttcat ctttttcatg ctagcttttt aaatgtttag ttttcctctt
     4561 gtcatggtca gctgctgaat ttacttgaag gatgtagaat actgtttaaa aaatactaaa
     4621 atttgtacaa ttagatcaaa gaattgtgca atcatttcct ttttaatttt taaaatgttg
     4681 aggctcataa atatttgaga acatcagatc taatagagca tagtgatact atttaattta
     4741 accaaagtct ctagtgaata tttcaacttt gaatgtaaac taacaaataa acctgaccac
     4801 caaggagatt gtttgcccag agtttcaaag cacattgtct acaaatggaa attgaaataa
     4861 tttataaaat attgacgtta ctatgttttt taaaaagttc ctaatttttt cactaaatgg
     4921 aggaaactat tagttttatt gttaaatatg gtagatatta atattcctct tagatgacca
     4981 gtgattccaa ttgtcccagt ttgaaataag taccctgtga gtatgagata aattagtgac
     5041 aatcagaaca agtttcagta tcagatgttc aagaggaagt tgctattgca ttgattttaa
     5101 tatttgtaca taaacactga tttttttgag cattattttg tatttgttgt actttaatac
     5161 ctggtgtaca gttccagaaa taaaaatctg ggaatcttt
//
