LOCUS       NM_017550               2769 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens MIER family member 2 (MIER2), transcript variant 1,
            mRNA.
ACCESSION   NM_017550 XM_041843
VERSION     NM_017550.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Derwish,R., Paterno,G.D. and Gillespie,L.L.
  TITLE     Differential HDAC1 and 2 Recruitment by Members of the MIER Family
  JOURNAL   PLoS One 12 (1), e0169338 (2017)
   PUBMED   28046085
  REMARK    GeneRIF: Histone deacetylase assays confirmed that MIER2, but not
            MIER3 complexes, have associated deacetylase activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Lee,Y., Yoon,K.A., Joo,J., Lee,D., Bae,K., Han,J.Y. and Lee,J.S.
  TITLE     Prognostic implications of genetic variants in advanced non-small
            cell lung cancer: a genome-wide association study
  JOURNAL   Carcinogenesis 34 (2), 307-313 (2013)
   PUBMED   23144319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016588.9.
            
            On Sep 23, 2020 this sequence version replaced NM_017550.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028203.1, SRR11853563.16011.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264819.7/ ENSP00000264819.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC016588.9         112706-112728       c
            24-114              AC016588.9         104015-104105       c
            115-257             AC016588.9         102332-102474       c
            258-383             AC016588.9         95796-95921         c
            384-507             AC016588.9         95065-95188         c
            508-599             AC016588.9         94439-94530         c
            600-669             AC016588.9         93567-93636         c
            670-821             AC016588.9         81424-81575         c
            822-903             AC016588.9         80123-80204         c
            904-998             AC016588.9         79777-79871         c
            999-1123            AC016588.9         76733-76857         c
            1124-1212           AC016588.9         76509-76597         c
            1213-1630           AC016588.9         75051-75468         c
            1631-2769           AC016588.9         73505-74643         c
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2769
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /note="MIER family member 2"
                     /db_xref="GeneID:54531"
                     /db_xref="HGNC:HGNC:29210"
                     /db_xref="MIM:620092"
     exon            1..23
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1652
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mesoderm induction early response protein 2; mesoderm
                     induction early response 1, family member 2"
                     /codon_start=1
                     /product="mesoderm induction early response protein 2
                     isoform 1"
                     /protein_id="NP_060020.1"
                     /db_xref="CCDS:CCDS32855.1"
                     /db_xref="GeneID:54531"
                     /db_xref="HGNC:HGNC:29210"
                     /db_xref="MIM:620092"
                     /translation="MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQF
                     NLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPI
                     SDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFP
                     NRSGSRFLADEDREPGSSASSDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEK
                     IYENEDQLLWDPSVLPEREVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVK
                     CNFNVEEALRRLRFNVKVIRDGLCAWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSV
                     GECVEYYYLWKKSERYDYFAQQTRLGRRKYVPSGTTDADQDLDGSDPDGPGRPRPEQD
                     TLTGMRTDPLSVDGTAGGLDEPGVASDGLPSSEPGPCSFQQLDESPAVPLSHRPPALA
                     DPASYQPAVTAPEPDASPRLAVDFALPKELPLISSHVDLSGDPEETVAPAQVALSVTE
                     FGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHCNVMTC"
     exon            24..114
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..257
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..383
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..507
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..599
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..669
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..821
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..903
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            904..998
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1123
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1212
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1630
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2769
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2747..2752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /note="hexamer: ATTAAA"
     polyA_site      2769
                     /gene="MIER2"
                     /gene_synonym="KIAA1193; Mi-er2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacacac ggccatggcg gaggcctcct cgctggggag gcagagtcct cgcgtggtct
       61 cctgcctcga gcacagcctg tgcccagggg agccgggctt gcagacaaca gcagtggtgt
      121 ccatgggctc tggagaccat cagttcaacc tcgcagagat cctgtcacag aactacagtg
      181 ttagggggga gtgcgaggag gcctcgaggt gcccagacaa gcccaaggag gagctggaga
      241 aggacttcat ctcccagagc aacgacatgc cctttgatga gctgcttgcg ctctatggct
      301 acgaggcgtc agaccccatt tcagaccggg agagtgaggg tggtgacgtg gccccgaacc
      361 tcccagacat gaccctggac aaagaacaaa tagcgaagga tttgctttca ggggaagaag
      421 aggaagagac gcaatcatct gctgacgacc tcaccccgtc cgtgacctcc cacgaggcct
      481 ccgacctctt ccctaaccgg agtggatctc gtttcctggc tgatgaagac agagagcctg
      541 gctcttctgc ctcctccgac accgaggagg actctcttcc tgccaacaaa tgtaagaagg
      601 agatcatggt gggacctcag ttccaagctg acctcagcaa cctgcacttg aaccggcact
      661 gtgagaagat ctacgagaac gaagaccagc tgctctggga ccccagcgtc ctccctgaga
      721 gggaggtgga ggagttcctg tacagggcgg tgaagcggcg ttggcacgag atggccgggc
      781 ctcagctccc agagggagaa gccgtgaaag acagtgagca ggcgctgtac gagttggtga
      841 aatgcaactt caatgtggag gaggccctgc gaaggctgcg gttcaacgtg aaggtgatcc
      901 gagatgggct ctgtgcttgg agtgaagagg agtgcaggaa ctttgagcac ggcttccgtg
      961 tgcatggaaa gaactttcac ctgatccagg ccaacaaggt gcgcacacgg tcagtgggcg
     1021 agtgtgtcga gtactactac ctgtggaaga agtcggagcg ctacgactac ttcgcccagc
     1081 agacgcggct gggccggagg aagtacgtcc cgtccggaac cacggacgca gaccaggacc
     1141 tggatggcag cgaccccgat ggccccggcc gtccgcgccc ggagcaagac accctgactg
     1201 ggatgcgcac agatccactg agcgtggatg gcacggccgg tggtctcgat gagcccggag
     1261 tggcctctga tggactcccg tcctcggagc cagggccgtg ttccttccag cagctggatg
     1321 agtcccccgc tgtacccctg tcccatcggc ccccagccct ggccgaccca gcctcatacc
     1381 agccagctgt cactgctccg gagccagacg ccagcccaag gctggccgtg gacttcgccc
     1441 tgcccaagga gctgcccctc atctccagcc atgtggacct cagcggggat ccggaggaga
     1501 ctgtggcccc agcacaggtg gctttgtcgg tcaccgagtt tggactcatc ggcattgggg
     1561 acgtgaaccc cttcctggcc gcccacccca cgtgcccggc ccccgggcta cactcggagc
     1621 ccctgtcaca ctgtaacgtg atgacctgct gactcctggc cgcgggcggc gtatgcggcc
     1681 cagactggac ttagcgctgc cgctgggccc gcctctgtca gtcttcctga ccccttcccc
     1741 accccccggg ccttggggta gcacctcctt ctgcttcaga acacgtcagg actggggtga
     1801 ggtggctggg ccgtgagccc ttgcccctgt ccacacagaa tggacccacg gccccaccca
     1861 gcgccgtcag cgcccggcac tgccacccgg gtccgggccg ctgcctgcac gtgggatccg
     1921 tcgggcagcc ggggacagaa gagaccccgc cgttgggacg cagggcagag ccggccacct
     1981 agtcccttcc agccagcaga ggcgagggaa ggcgtcactg ccccggcggg gagacgggca
     2041 ggacgccctg ccccgcacca gcagcctccg ccggggcgcc ctcagctccc tgcttggctc
     2101 tgtctctcca cacccggcag ggccgcgggc tgccccagcc ctgggggtcg tgggcagctg
     2161 ctactcagtg ccaaccccgt ggggcacaga gccatatacc tcgctgtccg gcccccaccc
     2221 cagcctcgcc ttcccacccc atcgtctcca cttcaggaaa agccgcactt tacaccccca
     2281 cctgcctctt ccccctccat ccctgctccc cgatcctgag cggttggggt ggggtccctc
     2341 agcaacccca ggcgtgggtt tgaggagaca ggtgatttac atcccctttg ctgtcctccc
     2401 ccggtaccaa ggcagggagc ctccggagga gccggccctg ctggccacgc aggggccaga
     2461 ctccagcctg tttccccagc cctgcaggtc ttccttctgt gggaagcttc ctagcaagat
     2521 ggcttggagt cctggtcccc ctcctccctg gccctctcgt tcgtttctgt ttctgtttac
     2581 acgttggagt ggggtcctcc gtgggcggcg gcgcgccctg ccccgggtgt cgtccggcct
     2641 cttgtgctcg agcccctttc cgagttggac tcgaccatcc ctcaccccac caaggaccac
     2701 actgtgaagt gataactgcc ttgaaccccc ctttgctgtt ttatttatta aacttgattt
     2761 gaagcccgg
//
