LOCUS       NM_032339               1397 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens migration and invasion enhancer 1 (MIEN1), transcript
            variant 1, mRNA.
ACCESSION   NM_032339
VERSION     NM_032339.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1397)
  AUTHORS   Tripathi,A.K., Desai,P.P., Tyagi,A., Lampe,J.B., Srivastava,Y.,
            Donkor,M., Jones,H.P., Dzyuba,S.V., Crossley,E., Williams,N.S. and
            Vishwanatha,J.K.
  TITLE     Short peptides based on the conserved regions of MIEN1 protein
            exhibit anticancer activity by targeting the MIEN1 signaling
            pathway
  JOURNAL   J Biol Chem 300 (3), 105680 (2024)
   PUBMED   38272230
  REMARK    GeneRIF: Short peptides based on the conserved regions of MIEN1
            protein exhibit anticancer activity by targeting the MIEN1
            signaling pathway.
REFERENCE   2  (bases 1 to 1397)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1397)
  AUTHORS   Camara-Quilez,M., Barreiro-Alonso,A., Vizoso-Vazquez,A.,
            Rodriguez-Belmonte,E., Quindos-Varela,M., Lamas-Maceiras,M. and
            Cerdan,M.E.
  TITLE     The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins
            and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and
            Drug-Response
  JOURNAL   Cancers (Basel) 12 (9), 2435 (2020)
   PUBMED   32867128
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1397)
  AUTHORS   Yu,X., Xiao,W., Song,H., Jin,Y., Xu,J. and Liu,X.
  TITLE     CircRNA_100876 sponges miR-136 to promote proliferation and
            metastasis of gastric cancer by upregulating MIEN1 expression
  JOURNAL   Gene 748, 144678 (2020)
   PUBMED   32305633
  REMARK    GeneRIF: data identified that the promotion of gastric cancer (GC)
            growth and metastasis induced by circRNA_100876 interacted with
            miR-136 and MIEN1, indicating an emerging announcement for
            uncovering the potential mechanism of GC progression
REFERENCE   5  (bases 1 to 1397)
  AUTHORS   Liang,F., Zhang,H., Qiu,Y., Xu,Q., Jian,K., Jiang,L., Wang,F. and
            Lu,X.
  TITLE     MiR-124-5p Inhibits the Progression of Gastric Cancer by Targeting
            MIEN1
  JOURNAL   Technol Cancer Res Treat 19, 1533033820979199 (2020)
   PUBMED   33349155
  REMARK    GeneRIF: MiR-124-5p Inhibits the Progression of Gastric Cancer by
            Targeting MIEN1.
REFERENCE   6  (bases 1 to 1397)
  AUTHORS   Dikiy,A., Novoselov,S.V., Fomenko,D.E., Sengupta,A., Carlson,B.A.,
            Cerny,R.L., Ginalski,K., Grishin,N.V., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     SelT, SelW, SelH, and Rdx12: genomics and molecular insights into
            the functions of selenoproteins of a novel thioredoxin-like family
  JOURNAL   Biochemistry 46 (23), 6871-6882 (2007)
   PUBMED   17503775
REFERENCE   7  (bases 1 to 1397)
  AUTHORS   Benusiglio,P.R., Pharoah,P.D., Smith,P.L., Lesueur,F., Conroy,D.,
            Luben,R.N., Dew,G., Jordan,C., Dunning,A., Easton,D.F. and
            Ponder,B.A.
  TITLE     HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to
            breast cancer
  JOURNAL   Br J Cancer 95 (12), 1689-1695 (2006)
   PUBMED   17117180
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1397)
  AUTHORS   Evans,E.E., Henn,A.D., Jonason,A., Paris,M.J., Schiffhauer,L.M.,
            Borrello,M.A., Smith,E.S., Sahasrabudhe,D.M. and Zauderer,M.
  TITLE     C35 (C17orf37) is a novel tumor biomarker abundantly expressed in
            breast cancer
  JOURNAL   Mol Cancer Ther 5 (11), 2919-2930 (2006)
   PUBMED   17121940
REFERENCE   9  (bases 1 to 1397)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Evolutionary recombination hotspot around GSDML-GSDM locus is
            closely linked to the oncogenomic recombination hotspot around the
            PPP1R1B-ERBB2-GRB7 amplicon
  JOURNAL   Int J Oncol 24 (4), 757-763 (2004)
   PUBMED   15010812
  REMARK    GeneRIF: Oncogenomic recombination hotspot around the
            PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at
            human chromosome 17q12 is closely linked to evolutionary
            recombination hotspot around the GSDML-GSDM locus.
REFERENCE   10 (bases 1 to 1397)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on
            human chromosome 17q12, encodes the seven-transmembrane receptor
            with extracellular six-cystein domain
  JOURNAL   Int J Oncol 22 (6), 1369-1374 (2003)
   PUBMED   12739007
  REMARK    GeneRIF: MGC14832 gene is located within human chromosome 17q12
            amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832
            and GRB7 genes.  PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human
            gastric cancer and breast cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY508814.1, BC006006.1, BC063395.1 and AC079199.9.
            
            On Nov 23, 2018 this sequence version replaced NM_032339.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP314231.1, SRR3476690.455268.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394231.8/ ENSP00000377778.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AY508814.1         32-61
            31-751              BC006006.1         1-721
            752-827             BC063395.1         1340-1415
            828-828             AC079199.9         73538-73538         c
            829-1397            BC063395.1         1417-1985
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1397
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="migration and invasion enhancer 1"
                     /db_xref="GeneID:84299"
                     /db_xref="HGNC:HGNC:28230"
                     /db_xref="MIM:611802"
     exon            1..126
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..385
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein C17orf37; HBV XAg-transactivated protein 4; HBV
                     X-transactivated gene 4 protein"
                     /codon_start=1
                     /product="migration and invasion enhancer 1 isoform 1"
                     /protein_id="NP_115715.3"
                     /db_xref="CCDS:CCDS11344.1"
                     /db_xref="GeneID:84299"
                     /db_xref="HGNC:HGNC:28230"
                     /db_xref="MIM:611802"
                     /translation="MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELAS
                     AVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETL
                     EKITNSRPPCVIL"
     exon            127..224
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            225..301
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            302..1397
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      727..732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="hexamer: AGTAAA"
     polyA_site      751
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="major polyA site"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="hexamer: AATATA"
     polyA_site      1280
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
     regulatory      1378..1383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
                     /note="hexamer: AGTAAA"
     polyA_site      1397
                     /gene="MIEN1"
                     /gene_synonym="C17orf37; C35; ORB3; RDX12; XTP4"
ORIGIN      
        1 acacccggaa gcaggggccc gagcggagcc ggccgcgatg agcggggagc cggggcagac
       61 gtccgtagcg ccccctcccg aggaggtcga gccgggcagt ggggtccgca tcgtggtgga
      121 gtactgtgaa ccctgcggct tcgaggcgac ctacctggag ctggccagtg ctgtgaagga
      181 gcagtatccg ggcatcgaga tcgagtcgcg cctcgggggc acaggtgcct ttgagataga
      241 gataaatgga cagctggtgt tctccaagct ggagaatggg ggctttccct atgagaaaga
      301 tctcattgag gccatccgaa gagccagtaa tggagaaacc ctagaaaaga tcaccaacag
      361 ccgtcctccc tgcgtcatcc tgtgactgca caggactctg ggttcctgct ctgttctggg
      421 gtccaaacct tggtctccct ttggtcctgc tgggagctcc ccctgcctct ttcccctact
      481 tagctcctta gcaaagagac cctggcctcc actttgccct ttgggtacaa agaaggaata
      541 gaagattccg tggccttggg ggcaggagag agacactctc catgaacact tctccagcca
      601 cctcataccc ccttcccagg gtaagtgccc acgaaagccc agtccactct tcgcctcggt
      661 aatacctgtc tgatgccaca gattttattt attctcccct aacccagggc aatgtcagct
      721 attggcagta aagtggcgct acaaacacta atgctaacta gtgtgtgttt ttatacgtcc
      781 agtctgggaa tgtggggggc acagaagtcc ggtcagccca gcctttgcac cgccagggtg
      841 gctgtgctgg ctgggtgggc tttctggaca gctactcctt aggtcagtga gctcctctgg
      901 catagccaag gcaaggaaaa tgagtcccac agtagaccct gcctcgtctt tcccccaccc
      961 tacccaccac tctcctcact cacaaggagg aaataacccc attctggtga gtggccttag
     1021 gaattagttc gttctaaata agaatgatct ggtcgtcaaa gggctctcag atctgaatcc
     1081 agcttcccga tctcccccaa ccctgaagct ggagaactgg atgtctggct cctcatccaa
     1141 gctttctgaa gattcccagc cactccctcc aggaaaagag gaattgagtg taaggtgagc
     1201 aggaagggat ggcacagagc cacccccaga cataggccgg tgcctagctg ttttccaaaa
     1261 tatatttgca aatggacaaa gtgggtgtgg agaaggaccc cccacacttg cctccccata
     1321 caacacccat tctccccctg ggtctttatt tcatctttaa aaaaacaaaa caaaaaaagt
     1381 aaaaactaaa cagaaaa
//
