LOCUS       NM_001388306            3892 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens midnolin (MIDN), transcript variant 1, mRNA.
ACCESSION   NM_001388306 XM_005259671
VERSION     NM_001388306.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3892)
  AUTHORS   Gu,X., Nardone,C., Kamitaki,N., Mao,A., Elledge,S.J. and
            Greenberg,M.E.
  TITLE     The midnolin-proteasome pathway catches proteins for
            ubiquitination-independent degradation
  JOURNAL   Science 381 (6660), eadh5021 (2023)
   PUBMED   37616343
  REMARK    GeneRIF: The midnolin-proteasome pathway catches proteins for
            ubiquitination-independent degradation.
REFERENCE   2  (bases 1 to 3892)
  AUTHORS   Sato,H., Ishii,K. and Obara,Y.
  TITLE     Structural Variants of Midnolin, a Genetic Risk Factor for
            Parkinson's Disease, in a Yamagata Cohort
  JOURNAL   Biol Pharm Bull 46 (3), 379-381 (2023)
   PUBMED   36858566
  REMARK    GeneRIF: Structural Variants of Midnolin, a Genetic Risk Factor for
            Parkinson's Disease, in a Yamagata Cohort.
REFERENCE   3  (bases 1 to 3892)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3892)
  AUTHORS   Obara,Y., Sato,H., Nakayama,T., Kato,T. and Ishii,K.
  TITLE     Midnolin is a confirmed genetic risk factor for Parkinson's disease
  JOURNAL   Ann Clin Transl Neurol 6 (11), 2205-2211 (2019)
   PUBMED   31588691
  REMARK    GeneRIF: Midnolin is a confirmed genetic risk factor for
            Parkinson's disease.
REFERENCE   5  (bases 1 to 3892)
  AUTHORS   Obara,Y., Imai,T., Sato,H., Takeda,Y., Kato,T. and Ishii,K.
  TITLE     Midnolin is a novel regulator of parkin expression and is
            associated with Parkinson's Disease
  JOURNAL   Sci Rep 7 (1), 5885 (2017)
   PUBMED   28724963
  REMARK    GeneRIF: MIDN promotes the expression of parkin E3 ubiquitin
            ligase, and that MIDN loss can trigger Parkinson's disease-related
            pathogenic mechanisms.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3892)
  AUTHORS   Hofmeister-Brix,A., Kollmann,K., Langer,S., Schultz,J., Lenzen,S.
            and Baltrusch,S.
  TITLE     Identification of the ubiquitin-like domain of midnolin as a new
            glucokinase interaction partner
  JOURNAL   J Biol Chem 288 (50), 35824-35839 (2013)
   PUBMED   24187134
  REMARK    GeneRIF: midnolin plays a role in cellular signaling of adult
            tissues and regulates glucokinase enzyme activity in pancreatic
            beta cells
REFERENCE   7  (bases 1 to 3892)
  AUTHORS   Tsukahara,M., Suemori,H., Noguchi,S., Ji,Z.S. and Tsunoo,H.
  TITLE     Novel nucleolar protein, midnolin, is expressed in the
            mesencephalon during mouse development
  JOURNAL   Gene 254 (1-2), 45-55 (2000)
   PUBMED   10974535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004221.2.
            
            On Oct 21, 2020 this sequence version replaced XM_005259671.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.31633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682408.1/ ENSP00000507955.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC004221.2         23354-23431
            79-718              AC004221.2         24661-25300
            719-806             AC004221.2         26333-26420
            807-869             AC004221.2         26610-26672
            870-998             AC004221.2         28725-28853
            999-1310            AC004221.2         28938-29249
            1311-1470           AC004221.2         29673-29832
            1471-1743           AC004221.2         30193-30465
            1744-3892           AC004221.2         31766-33914
FEATURES             Location/Qualifiers
     source          1..3892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3892
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /note="midnolin"
                     /db_xref="GeneID:90007"
                     /db_xref="HGNC:HGNC:16298"
                     /db_xref="MIM:606700"
     exon            1..78
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            79..718
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..2021
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /note="isoform 1 is encoded by transcript variant 1;
                     midbrain nucleolar protein; stuxnet homolog"
                     /codon_start=1
                     /product="midnolin isoform 1"
                     /protein_id="NP_001375235.1"
                     /db_xref="CCDS:CCDS92478.1"
                     /db_xref="GeneID:90007"
                     /db_xref="HGNC:HGNC:16298"
                     /db_xref="MIM:606700"
                     /translation="MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYD
                     LAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTV
                     EAGLMSQASRPEQSVMQALESLTETQPPAAPGPGRAGGGGFRKYRFILFKRPWHRQGP
                     QSPERGGERPQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAA
                     AAARGDPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQ
                     MDCSPTASSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPN
                     CQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRT
                     TSCEKLTAAPSASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRK
                     ARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEF
                     VVA"
     exon            719..806
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            807..869
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            870..998
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1310
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1470
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1743
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..3892
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3871..3876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /note="hexamer: AATAAA"
     polyA_site      3892
                     /gene="MIDN"
                     /gene_synonym="Stx"
                     /note="major polyA site"
ORIGIN      
        1 agaccggccc ggccagcgcg cattcggccc cggacgaagg tactcgcagc acttggagcg
       61 cagaaccggc cgcgcccgat cctccgagcg gcggcgacgg ctgttgctaa gggaggggac
      121 gcgcgaggaa gcgcgacccg ggcggcagac ggcacccagc gccaccagcc gagcggcgcc
      181 ccctccccag gacccttaac cgcgccgcgt cccggtcgcg cccgccgccc tttgaaggag
      241 aagcaagtgc cgtccccacc cccggaaggc gcccccagga gccggagcga cctcggagcg
      301 ccactcggat tttggatttc ggtctcgcat tccgcggccg ggactttctc gaggaggacg
      361 cgcgctgctc cgcgcccccg agtgcccgga ggacccggca tccggggagc ctctcgcccc
      421 tgtcccggag gcgcggcgag gattggcggc gcccgccgcc cccagccccc cagcgcgcgc
      481 cggggatgga gccgcagccc ggcggcgccc ggagctgccg gcgcggggcc cccggcggcg
      541 cctgcgagct gggcccggcg gccgaggcgg cgcccatgag cctcgccatc cacagcacca
      601 cgggcacccg ctacgacctg gccgtgccgc ccgacgagac ggtggagggg ctgcgcaagc
      661 ggttgtccca gcgcctcaaa gtgcccaagg agcgcctggc tcttctccac aaagacaccc
      721 ggctcagttc ggggaagctg caggagttcg gcgtgggtga tggcagcaag ctgaccttgg
      781 tacccaccgt ggaagcgggc ctcatgtctc aggcctcaag gccggaacag tccgtgatgc
      841 aagctctcga gagtctcacg gagacgcagc ccccagcggc gcccgggccg ggccgggctg
      901 gcggaggagg cttccggaaa tacagattca ttttatttaa gcgtccgtgg caccgacagg
      961 gaccccagag cccagagagg ggcggcgaga ggccccaggt cagtgacttc ctgtcgggcc
     1021 gttcgccact gacactggcc ttgcgtgtgg gcgaccacat gatgttcgtg cagctgcagc
     1081 tcgcggccca gcacgctcca ctgcaacacc gccatgtgct ggccgctgcg gccgccgccg
     1141 ctgctgcgcg gggggacccc agcatagcct cccccgtgtc ctcgccctgc cggccggtgt
     1201 ccagtgccgc ccgagtcccc ccggtgccca ccagcccgtc ccctgcatct ccctcgccca
     1261 tcacagccgg ctccttccgg tcccacgcag cctccaccac ctgcccggag cagatggact
     1321 gctcccccac ggccagcagc agtgccagtc ctggtgccag caccacgtct accccagggg
     1381 ccagccctgc cccccgctcc cgaaaacccg gcgccgtcat cgagagcttt gtgaatcacg
     1441 ccccgggggt cttctcaggg accttctctg gcacgctaca ccccaactgc caagacagca
     1501 gcgggcggcc gcggcgtgac atcggcacca tcctgcagat cctgaacgac ctcctgagcg
     1561 ccacccggca ctaccagggc atgccccctt cgctggccca gctccgctgc cacgcccagt
     1621 gctccccggc ctcaccggcc cccgacctgg cccccagaac tacctcctgc gagaagctca
     1681 cggctgcccc ctcagcctcc ctgctgcagg gccagagcca gatccgcatg tgcaagcccc
     1741 cgggggaccg gcttcggcag acagaaaacc gcgccacgcg ctgcaaggtg gaacggctgc
     1801 agctgcttct gcagcagaaa cggctccgta gaaaggcccg gcgggacgcg cggggtccgt
     1861 accactggtc acccagccgc aaggccggcc gcagcgacag cagtagcagc gggggcggcg
     1921 gcagccccag cgaggcctcc ggcttgggcc tcgacttcga ggactccgtg tggaagccag
     1981 aagtcaaccc tgacatcaag tcagagttcg tggtggctta ggatcttcgg atcggccacc
     2041 ctcgcccctc gcaccccagc ccagggcggc ggggactccg agagccccgg agagaacgtg
     2101 gcccagccct ggagggcagg cggccactcc cccagccaga agtctttttt tcttttcttc
     2161 ttttttatta tttttttctt tttttaaaaa gttctgaccg tggtttcctg gactcttcat
     2221 gggctttgct tcctacctcc ttcacccttc actcctgccc tcctcttcct cctcctcctc
     2281 ctcctccgtc tgtctccttt cacctctgcg ccaggtcggt cctccctgcc aaccttcccc
     2341 agctccaata tgtagcagtc tctctggatg gcggagagtg aaggagacgg agaaacgcgc
     2401 cccatccctt ccgccgcctc ctttcccccc cgaccctatt caggttttaa gtcaaaaatg
     2461 tcgatatgtc attatgcact ttacagatga ggggaggggc cgcagtgcgc agaacccacc
     2521 ccacccccca gtgcagactt cggggtctcc accccaggcc agcagcgccc actgggctac
     2581 agcaagccaa caggtcacag aagccaacga ggggactgtt tctcttccac tcctatcctc
     2641 ttttcttgat cttttttttg cattttcctt catttcttta acaaggagag caaagctgtt
     2701 ttagcagagg ctggggctga ggtccccatg gggtttgggt gcaggggcat ggcacccttt
     2761 cctgtcggga agggagaggg gaactacccc cccagcctgc cctccgcccc gccccagccg
     2821 gcggactgtg ctgtttcctc cgcccccact cccgtgtttt ctgacctcct gcctgagttt
     2881 ggggtattta tagactatta attttctgac tgagccaata gtggttgggg aactcttgaa
     2941 aaaggggaga gaatggctgg gtgctgggga gttcccccct ccgagccctc cttcccggcc
     3001 caacctgagg gatgtggatt tgggactgtc tgggggcccc tcctgcagcg aggatgggag
     3061 ggggtgctga gctgtgaatc ccctgggcag ggggcgacaa ctccgtgtag cattaacccc
     3121 cgtggcgggg tccgctgctg gtctaatttg gaccccctgc ctctcagtgc ccctgcccta
     3181 ggggtgtctg tctccagagg ggagggacaa atcccctact ggggccattt caatggggta
     3241 gtttttggat ttttttcccc actcactttt tattttttaa tgataatgga gatgtctgga
     3301 cccttcctca ccccacctgt cggtcttgtc ctggctctgc ctgtccccca ccgttgttct
     3361 cgtaggtgaa ccccaggtcc tcaactcccc ccctttatgt gttgaaagtt aatggtttca
     3421 gatgtgaaca tcacgtgtta taactgtagc gctgtaaatt tttttgtggg agggtgggca
     3481 gggaggggtc ccagagggta gagctcaagg attttgggtt ttgttttgtt ttcatttttc
     3541 caaaaaaaaa agaaaaaaaa atagaaaaaa aaggagtaaa aggggcgggt ttgttttttg
     3601 aagaactgtc ttggatacct atttaaatgt gtgttctgtt ttgtttttta acgattttta
     3661 aataacgtct gtgcctccac tggttgaggg tggaacctcc aggcaggaac cggctcgcca
     3721 ccctctgccc ggtaagggct gcccaagaaa gcattacccg ccctcggggg gtcgggctgt
     3781 gggggtcccg gcacctggcg tgagtttcat gtatgaaaac ataaaattga aaaaaaaaaa
     3841 aaaacctaca cgagcaccgt gatttcaagt aataaacaga aaatgaaaca ca
//
