LOCUS       NM_021242               3758 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MID1 interacting protein 1 (MID1IP1), transcript
            variant 1, mRNA.
ACCESSION   NM_021242 XM_005272629
VERSION     NM_021242.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Chiu,Y.T., Husain,A., Sze,K.M., Ho,D.W., Suarez,E.M.S., Wang,X.,
            Lee,E., Ma,H.T., Lee,J.M., Chan,L.K. and Ng,I.O.
  TITLE     Midline 1 interacting protein 1 promotes cancer metastasis through
            FOS-like 1-mediated matrix metalloproteinase 9 signaling in HCC
  JOURNAL   Hepatology 78 (5), 1368-1383 (2023)
   PUBMED   36632999
  REMARK    GeneRIF: Midline 1 interacting protein 1 promotes cancer metastasis
            through FOS-like 1-mediated matrix metalloproteinase 9 signaling in
            HCC.
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Jung,J.H., Lee,D., Ko,H.M. and Jang,H.J.
  TITLE     Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal
            Cancer Cells by Activating p53
  JOURNAL   Biomolecules 11 (10), 1492 (2021)
   PUBMED   34680125
  REMARK    GeneRIF: Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in
            Colorectal Cancer Cells by Activating p53.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Izumi,A., Hiraguchi,H., Kodaka,M., Ikeuchi,E., Narita,J.,
            Kobayashi,R., Matsumoto,Y., Suzuki,T., Yamamoto,Y., Sato,R. and
            Inoue,J.
  TITLE     MIG12 is involved in the LXR activation-mediated induction of the
            polymerization of mammalian acetyl-CoA carboxylase
  JOURNAL   Biochem Biophys Res Commun 567, 138-142 (2021)
   PUBMED   34153683
  REMARK    GeneRIF: MIG12 is involved in the LXR activation-mediated induction
            of the polymerization of mammalian acetyl-CoA carboxylase.
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Jung,J.H., Lee,H.J., Kim,J.H., Sim,D.Y., Im,E., Kim,S., Chang,S.
            and Kim,S.H.
  TITLE     Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver
            Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and
            CNOT2
  JOURNAL   Cells 9 (4), 985 (2020)
   PUBMED   32316188
  REMARK    GeneRIF: Colocalization of MID1IP1 and c-Myc is Critically Involved
            in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and
            L11 and CNOT2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Wang,Q., Yang,J., Lin,X., Huang,Z., Xie,C. and Fan,H.
  TITLE     Spot14/Spot14R expression may be involved in MSC adipogenic
            differentiation in patients with adolescent idiopathic scoliosis
  JOURNAL   Mol Med Rep 13 (6), 4636-4642 (2016)
   PUBMED   27082501
  REMARK    GeneRIF: The results of the present study indicated that
            Spot14/S14R were differently expressed in MSC adipogenesis in AIS
            patients, and they may be important in the abnormal adipogenic
            differentiation in AIS.
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Kim,C.W., Moon,Y.A., Park,S.W., Cheng,D., Kwon,H.J. and Horton,J.D.
  TITLE     Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12
            provides a tertiary level of regulation of fatty acid synthesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9626-9631 (2010)
   PUBMED   20457939
  REMARK    GeneRIF: show that MIG12, a 22 kDa cytosolic protein of previously
            unknown function, binds to acetyl-CoA carboxylase and lowers the
            threshold for citrate activation into the physiological range.
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Berti,C., Fontanella,B., Ferrentino,R. and Meroni,G.
  TITLE     Mig12, a novel Opitz syndrome gene product partner, is expressed in
            the embryonic ventral midline and co-operates with Mid1 to bundle
            and stabilize microtubules
  JOURNAL   BMC Cell Biol 5, 9 (2004)
   PUBMED   15070402
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA138791.1, DA449860.1, DA995619.1, CN417714.1, AF241728.2,
            BC008908.2, AJ272057.1 and AW086438.1.
            
            On Aug 13, 2020 this sequence version replaced NM_021242.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.33363.1,
                                           SRR11853564.28709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614558.3/ ENSP00000483547.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA138791.1         28-33
            7-544               DA449860.1         1-538
            545-571             DA995619.1         542-568
            572-1219            CN417714.1         1-648
            1220-1346           AF241728.2         115950-116076
            1347-2802           BC008908.2         33-1488
            2803-3669           AJ272057.1         1090-1956
            3670-3758           AW086438.1         11-99               c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..3758
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="MID1 interacting protein 1"
                     /db_xref="GeneID:58526"
                     /db_xref="HGNC:HGNC:20715"
                     /db_xref="MIM:300961"
     exon            1..29
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /inference="alignment:Splign:2.1.0"
     exon            30..1908
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..3758
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             2173..2724
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="MID1 interacting protein 1 (gastrulation specific
                     G12-like); MID1 interacting G12-like protein; spot 14-R;
                     spot 14-related protein; gastrulation specific G12
                     homolog"
                     /codon_start=1
                     /product="mid1-interacting protein 1"
                     /protein_id="NP_067065.1"
                     /db_xref="CCDS:CCDS14249.1"
                     /db_xref="GeneID:58526"
                     /db_xref="HGNC:HGNC:20715"
                     /db_xref="MIM:300961"
                     /translation="MMQICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLA
                     DPGLDNDVGVEVGGSGGCLEERTPPVPDSGSANGSFFAPSRDMYSHYVLLKSIRNDIE
                     WGVLHQPPPPAGSEEGSAWKSKDILVDLGHLEGADAGEEDLEQQFHYHLRGLHTVLSK
                     LTRKANILTNRYKQEIGFGNWGH"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="hexamer: AATAAA"
     polyA_site      3672
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="major polyA site"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="hexamer: ATTAAA"
     regulatory      3725..3730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
                     /note="hexamer: AATAAA"
     polyA_site      3732
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
     polyA_site      3758
                     /gene="MID1IP1"
                     /gene_synonym="G12-like; MIG12; S14R; STRAIT11499; THRSPL"
ORIGIN      
        1 cttttccttc tggagtttcc ccggcgggta ttagtccttg tggcaccaag tcagaatttc
       61 attcaaaaga caattaggaa gatggttttc tatggaaaat atttaagtgt aggtcttaat
      121 gtgaaagaaa gagggagaga aagaaacccc tttattatgt tctcccttcc ttaggcattt
      181 tttgtcccgt gggaaaaaac tgtactaggg acagagacct ctgttaagtt ttagagaaaa
      241 gggatctttt ttttttttat ttgagacaga gtcttgctct gtcgcccagg ctggagtgca
      301 gtggcacgat ctcggctcac tgcaactccg cctcctgggt tcaagcaatt ctcctgcttc
      361 atcctcccga gtagctggga ttacaggcgc tggccaccac gcccggctaa tttttgtatt
      421 tttagtagag accgggtttc accatgttgg ccaggctagt ctggaacccc tgactttgtg
      481 atccgcccgc ctcggcctcc caaagtgctg ggattacagg cgtgagccac cgtttcaggc
      541 cgagaaaagg gatttaaaat gagaagcttg aatcttattg aacataattg taggactgcc
      601 agagaggact ggtggatgag gaatatggca agggacatga gatgggaaaa attaaatagg
      661 ctgtggtttg gaagtctcaa agtgaaattc aaggtgcaag gctcttaaaa gttaaatcca
      721 gcgattcggt acatagctta ggccctatta aatgacccag tgctttaaga actatctttt
      781 gaaaggaaca cttcacacaa gcaccctcaa aaataattag acacctcccc atttctctgt
      841 taaatggtga aagacaccca agactagacc taactactgt caccctctcc tggcctcttg
      901 gcagccaaaa ggccacatgg cccaggctct ccagcatcac tgtgtagccg acttggacaa
      961 aaatggactt ctccccattg ccacttgcag atctcttcaa agaatcagca gatctgatag
     1021 tgtgcccctc ttcatccccg gcaaccactg ttaaaggaaa gattgggaaa gatcccaccc
     1081 cgccaggagg gaggcaaaag cctctgacgc tcccctcccc ccatagctga ccaaggccag
     1141 ggccactgcg ggagcaccgc gcgtccacgt gcacccagca tgcccggtca ccctttatta
     1201 cgtaagagtc ccaggatgga gttgtacctg ctgccggccc ctcttccccg acggctaata
     1261 ataaacccgg gttcctgttt cccggccgcg gccactccag attcggggct gaggggctca
     1321 ctctgcaacc aaggcacgtg cattctggtc atcccacgcg gggagcgcgc gcaaggcccg
     1381 cccagccccc acatgccagc cccaccctcc agtcggtccg gacgccgacg cctttttgac
     1441 cctcgctgtg cccggccctc ctcatctggc ctgcccaggg cttggtgctg gcggggtcca
     1501 gctgctccaa tccctcctcc tctgctctgc cctgccctgc cctggcctgc cccggcgccc
     1561 tccctcagcc cgggtatcag gcgagaggcg gagctggccc ggcgcgcccc gcccccgctg
     1621 tagaaagggc cgggcgagtg ttactcgcgg tcatcccggc ctgggccttt tatctcggtg
     1681 ctgccggggg aggcgggagg aggagacacc aggggtggcc ctgagcgccg gcgacacctt
     1741 tcctggacta taaattgagc acctgggatg ggtagggggc caacgcagtc accgccgtcc
     1801 gcagtcacag tccagccact gaccgcagca gcgcccttgc gtagcagccg cttgcagcga
     1861 gaacactgaa ttgccaacga gcaggagagt ctcaaggcgc aagaggaggc cagggctcga
     1921 cccacagagc accctcagcc atcgcgagtt tccgggcgcc aaagccagga gaagccgccc
     1981 atcccgcagg gccggtctgc cagcgagacg agagttggcg agggcggagg agtgccggga
     2041 atcccgccac accggctata gccaggcccc cagcgcgggc cttggagagc gcgtgaaggc
     2101 gggcatcccc ttgacccggc cgaccatccc cgtgcccctg cgtccctgcg ctccaacgtc
     2161 cgcgcggcca ccatgatgca aatctgcgac acctacaacc agaagcactc gctctttaac
     2221 gccatgaatc gcttcattgg cgccgtgaac aacatggacc agacggtgat ggtgcccagc
     2281 ttgctgcgcg acgtgcccct ggctgacccc gggttagaca acgatgttgg cgtggaggta
     2341 ggcggcagtg gcggctgcct ggaggagcgc acgcccccag tccccgactc gggaagcgcc
     2401 aatggcagct ttttcgcgcc ctctcgggac atgtacagcc actacgtgct tctcaagtcc
     2461 atccgcaacg acatcgagtg gggggtcctg caccagccgc ctccaccggc tgggagcgag
     2521 gagggcagtg cctggaagtc caaggacatc ctggtggacc tgggccactt ggagggtgcg
     2581 gacgccggcg aagaagacct ggaacagcag ttccactacc acctgcgcgg gctgcacact
     2641 gtgctctcga aactcacgcg caaagccaac atcctcacta acagatacaa gcaggagatc
     2701 ggcttcggca attggggcca ctgaggcgtg gcgcccgtgg ctgcccagca ccttcttcga
     2761 cccatctcac cctctctcat tcctcaaagc tttttttttt tttcctggct ggggggcggg
     2821 aagggcagac tgcaaactgg ggggctgcgt acgtgcagga ggcgcggtgg ggctgcgtgg
     2881 aggagggggc cacgtgtgag agagaagaaa atggtggccg gagatgggag ggcccaagga
     2941 acctcctggg agggggcctg cattctatgt tggtgggaat gggactgggc tgacgccctg
     3001 cattcagcct gtgcctttcc tggggtttct tttctgttct tttcggagga gagggcccga
     3061 gaaggggcca taccagggcg cggcgctggg ttgccacact tgggaaagca gcccggagct
     3121 gggtgctggg gaaggcgggg cgcgtagcct cccgccgccc tgcggttggg ccggtggagg
     3181 cccaggcgtt gctaggattg catcagtttt cctgtttgca ctatttcttt ttgtaacatt
     3241 ggccctgtgt gaagtatttc gaatctcctc cttgctctga aacttcagcg attccattgt
     3301 gataagcgca caaacagcac tgtctgtcgg taatcggtac tactttatta atgattttct
     3361 gttacactgt atagtagtcc tatggcaccc ccaccccatc cctttcgtgc cactcccgtc
     3421 cccaccccca ccccagtgtg tataagctgg catttcgcca gcttgtacgt agcttgccac
     3481 tcagtgaaaa taataacatt attatgagaa agtggactta accgaaatgg aaccaactga
     3541 cattctatcg tgttgtacat agaatgatga agggttccac tgttgttgta tgtcttaaat
     3601 ttatttaaaa ctttttttaa tccagatgta gactatattc taaaaaataa aaaagcaaat
     3661 gtgtcaacta aattggacaa gcgtctggtc ctcattaatc tgccaatgaa tggtttcgtc
     3721 attaaataaa aatcaattta attgatttac tagcaaaa
//
