LOCUS       NM_152726               1885 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial calcium uptake 2 (MICU2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_152726
VERSION     NM_152726.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Vishnu,N., Hamilton,A., Bagge,A., Wernersson,A., Cowan,E.,
            Barnard,H., Sancak,Y., Kamer,K.J., Spegel,P., Fex,M., Tengholm,A.,
            Mootha,V.K., Nicholls,D.G. and Mulder,H.
  TITLE     Mitochondrial clearance of calcium facilitated by MICU2 controls
            insulin secretion
  JOURNAL   Mol Metab 51, 101239 (2021)
   PUBMED   33932586
  REMARK    GeneRIF: Mitochondrial clearance of calcium facilitated by MICU2
            controls insulin secretion.
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Zhuo,W., Zhou,H., Guo,R., Yi,J., Zhang,L., Yu,L., Sui,Y., Zeng,W.,
            Wang,P. and Yang,M.
  TITLE     Structure of intact human MCU supercomplex with the auxiliary MICU
            subunits
  JOURNAL   Protein Cell 12 (3), 220-229 (2021)
   PUBMED   32862359
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Van Keuren,A.M., Tsai,C.W., Balderas,E., Rodriguez,M.X.,
            Chaudhuri,D. and Tsai,M.F.
  TITLE     Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial
            Calcium Uniporter Complex
  JOURNAL   Cell Rep 33 (10), 108486 (2020)
   PUBMED   33296646
  REMARK    GeneRIF: Mechanisms of EMRE-Dependent MCU Opening in the
            Mitochondrial Calcium Uniporter Complex.
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Tsai,L.C., Chan,G.C., Nangle,S.N., Shimizu-Albergine,M.,
            Jones,G.L., Storm,D.R., Beavo,J.A. and Zweifel,L.S.
  TITLE     Inactivation of Pde8b enhances memory, motor performance, and
            protects against age-induced motor coordination decay
  JOURNAL   Genes Brain Behav 11 (7), 837-847 (2012)
   PUBMED   22925203
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Smith,M., Woodroffe,A., Smith,R., Holguin,S., Martinez,J.,
            Filipek,P.A., Modahl,C., Moore,B., Bocian,M.E., Mays,L.,
            Laulhere,T., Flodman,P. and Spence,M.A.
  TITLE     Molecular genetic delineation of a deletion of chromosome
            13q12-->q13 in a patient with autism and auditory processing
            deficits
  JOURNAL   Cytogenet Genome Res 98 (4), 233-239 (2002)
   PUBMED   12826745
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Lin,P.T., Gleeson,J.G., Corbo,J.C., Flanagan,L. and Walsh,C.A.
  TITLE     DCAMKL1 encodes a protein kinase with homology to doublecortin that
            regulates microtubule polymerization
  JOURNAL   J Neurosci 20 (24), 9152-9161 (2000)
   PUBMED   11124993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138680.15, BC031089.1 and BQ438851.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152726.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034965.1, KU178890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000382374.9/
                                                  ENSP00000371811.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL138680.15        81702-81703         c
            3-1478              BC031089.1         3-1478
            1479-1885           BQ438851.1         20-426
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..1885
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /note="mitochondrial calcium uptake 2"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
     exon            1..232
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1327
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /note="EF hand domain family A1; EF hand domain family,
                     member A1; EF-hand domain-containing family member A1;
                     Smhs2 homolog"
                     /codon_start=1
                     /product="calcium uptake protein 2, mitochondrial"
                     /protein_id="NP_689939.1"
                     /db_xref="CCDS:CCDS9297.1"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
                     /translation="MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAAL
                     AGAGAAWHHSRVSVAARDGSFTVSAQKNVEHGIIYIGKPSLRKQRFMQFSSLEHEGEY
                     YMTPRDFLFSVMFEQMERKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISY
                     TEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKLQKIISKQDDLMTVKTNET
                     GYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLS
                     FMRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIA
                     MQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLK
                     NRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVWKQAGKGLF"
     exon            233..380
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..412
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            413..488
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..536
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..619
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..685
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..783
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..955
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1064
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1222
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1885
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /note="hexamer: AATAAA"
     polyA_site      1885
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /note="major polyA site"
ORIGIN      
        1 gcctagctgc gcttccgcaa agatggcggc ggctgcgggt agctgcgcgc gggtggcggc
       61 ctggggcgga aaactgcgac gggggctcgc tgtcagccga caggctgtgc ggagtcccgg
      121 ccccttggca gcggcagtgg ccggcgcggc cctggcagga gcaggagcgg cctggcacca
      181 cagccgcgtc agtgttgcgg cgcgggatgg cagttttaca gtctccgcac agaaaaatgt
      241 tgaacatgga ataatatata ttgggaaacc gtctcttcgt aagcagcgct tcatgcagtt
      301 ttcttcactc gaacatgaag gagaatatta tatgacacca cgagacttcc tcttctcagt
      361 gatgtttgag caaatggaac gtaaaacttc agtcaagaag ctgacaaaaa aggacatcga
      421 ggatacactg tcagggatcc aaacagctgg ctgtggatca acttttttca gagaccttgg
      481 cgataaaggg ctaatttcat ataccgagta tcttttcttg cttacaatcc tcactaaacc
      541 ccattctgga tttcatgttg cttttaaaat gctggataca gatggtaatg agatgattga
      601 aaaaagggaa ttttttaagc tgcagaagat cataagtaaa caagatgact tgatgacagt
      661 gaaaactaat gaaactggat atcaggaagc aatagtgaaa gaacctgaaa ttaacacaac
      721 tcttcagatg cgtttctttg gaaaaagagg acaaagaaaa cttcattata aagaatttcg
      781 aagatttatg gaaaatttac aaacagagat tcaagaaatg gaattccttc agttttctaa
      841 aggtttgagt ttcatgagaa aagaagactt tgcagagtgg ctactttttt tcactaacac
      901 tgaaaataaa gatatttatt ggaaaaatgt gagagagaag ttgtcagcag gagagagcat
      961 tagtttggat gaattcaagt cattttgcca ttttacaacc cacttggaag actttgctat
     1021 tgccatgcag atgttcagtt tagctcatcg tcctgtcaga ctagcggagt ttaagagagc
     1081 tgtgaaagta gcaacaggac aagaactctc aaacaatatt ttggacactg tctttaagat
     1141 ctttgatttg gatggtgatg aatgtcttag tcatgaagag tttcttgggg tgttaaaaaa
     1201 cagaatgcat cgaggtttat gggtaccaca acatcagagt atacaagaat actggaagtg
     1261 tgtgaagaaa gaaagcatta aaggagtaaa agaagtctgg aaacaagctg gaaaaggtct
     1321 tttttaataa aagatataat agtatggcaa ttatattgtt ccaaatgtca aaatttgtga
     1381 ttttttagaa gtacttgcta tttatcttct taagtcttca ttgatattct gtgtgaaata
     1441 agcatgtctt gtacttgctt tctgattcat aattttatta aagaacttag tagaaagaaa
     1501 agtaagtata aaaatagata ttggattctg tcagaaggcc tagatttgaa ataatgtttt
     1561 gtacttcggt aagatggaaa acttagtgat tcactgattt cttagacact ctaatatgat
     1621 atgctttctg gaaggataaa acaaatacat atgggaaaaa gtacttgaga ccaaggccag
     1681 catcaattcc agacatcttc atgttcctaa taggctaaat gaagttaaaa acttatttca
     1741 gatttttctc atctgtacct tatatctcat aaatttattg catattttat gtcagtagct
     1801 tagctgttta ttgtctttaa aataacatgt aaacttcaat gttctatctg gaagcagaat
     1861 aaaatattta catagataca aaaaa
//
