LOCUS       NM_001032363            3723 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial contact site and cristae organizing
            system subunit 10 (MICOS10), transcript variant 1, mRNA.
ACCESSION   NM_001032363 XM_496352
VERSION     NM_001032363.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Urbach,J., Kondadi,A.K., David,C., Naha,R., Deinert,K.,
            Reichert,A.S. and Anand,R.
  TITLE     Conserved GxxxG and WN motifs of MIC13 are essential for bridging
            two MICOS subcomplexes
  JOURNAL   Biochim Biophys Acta Biomembr 1863 (12), 183683 (2021)
   PUBMED   34271005
  REMARK    GeneRIF: Conserved GxxxG and WN motifs of MIC13 are essential for
            bridging two MICOS subcomplexes.
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Hu,C., Shu,L., Huang,X., Yu,J., Li,L., Gong,L., Yang,M., Wu,Z.,
            Gao,Z., Zhao,Y., Chen,L. and Song,Z.
  TITLE     OPA1 and MICOS Regulate mitochondrial crista dynamics and formation
  JOURNAL   Cell Death Dis 11 (10), 940 (2020)
   PUBMED   33130824
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Pape,J.K., Stephan,T., Balzarotti,F., Buchner,R., Lange,F.,
            Riedel,D., Jakobs,S. and Hell,S.W.
  TITLE     Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins
  JOURNAL   Proc Natl Acad Sci U S A 117 (34), 20607-20614 (2020)
   PUBMED   32788360
  REMARK    GeneRIF: Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS
            proteins.
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Stephan,T., Bruser,C., Deckers,M., Steyer,A.M., Balzarotti,F.,
            Barbot,M., Behr,T.S., Heim,G., Hubner,W., Ilgen,P., Lange,F.,
            Pacheu-Grau,D., Pape,J.K., Stoldt,S., Huser,T., Hell,S.W.,
            Mobius,W., Rehling,P., Riedel,D. and Jakobs,S.
  TITLE     MICOS assembly controls mitochondrial inner membrane remodeling and
            crista junction redistribution to mediate cristae formation
  JOURNAL   EMBO J 39 (14), e104105 (2020)
   PUBMED   32567732
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   von der Malsburg,K., Muller,J.M., Bohnert,M., Oeljeklaus,S.,
            Kwiatkowska,P., Becker,T., Loniewska-Lwowska,A., Wiese,S., Rao,S.,
            Milenkovic,D., Hutu,D.P., Zerbes,R.M., Schulze-Specking,A.,
            Meyer,H.E., Martinou,J.C., Rospert,S., Rehling,P., Meisinger,C.,
            Veenhuis,M., Warscheid,B., van der Klei,I.J., Pfanner,N.,
            Chacinska,A. and van der Laan,M.
  TITLE     Dual role of mitofilin in mitochondrial membrane organization and
            protein biogenesis
  JOURNAL   Dev Cell 21 (4), 694-707 (2011)
   PUBMED   21944719
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA523181.1, BC070388.1, AL031727.43 and DB323148.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001032363.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA245944.1, SRR1803617.6377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000322753.7/
                                                  ENSP00000325562.6
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA523181.1         3-13
            12-526              BC070388.1         1-515
            527-3187            AL031727.43        55028-57688
            3188-3723           DB323148.1         2-537               c
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3723
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="mitochondrial contact site and cristae organizing
                     system subunit 10"
                     /db_xref="GeneID:440574"
                     /db_xref="HGNC:HGNC:32068"
                     /db_xref="MIM:616574"
     exon            1..131
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..304
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="isoform a is encoded by transcript variant 1;
                     UPF0327 protein C1orf151; mitochondrial inner membrane
                     organizing system protein 1; RP5-1056L3.2; MICOS complex
                     subunit MIC10; mitochondrial inner membrane organizing
                     system 1"
                     /codon_start=1
                     /product="MICOS complex subunit MIC10 isoform a"
                     /protein_id="NP_001027535.1"
                     /db_xref="CCDS:CCDS30620.1"
                     /db_xref="GeneID:440574"
                     /db_xref="HGNC:HGNC:32068"
                     /db_xref="MIM:616574"
                     /translation="MSESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLA
                     FGSGMGLGMAYSNCQHDFQAPYLLHGKYVKEQEQ"
     exon            132..179
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /inference="alignment:Splign:2.1.0"
     exon            180..289
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /inference="alignment:Splign:2.1.0"
     exon            290..3723
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      510..515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="hexamer: AATAAA"
     regulatory      515..520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="hexamer: ATTAAA"
     polyA_site      526
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="major polyA site"
     polyA_site      537
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
     regulatory      3697..3702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
                     /note="hexamer: AATAAA"
     polyA_site      3723
                     /gene="MICOS10"
                     /gene_synonym="C1orf151; Mic10; MINOS1; MIO10"
ORIGIN      
        1 gcgagacttt caggggtcgg agcgcggggg ccggccgaga ggaaagctgg aggcgcgggt
       61 ggggaacatg tctgagtcgg agctcggcag gaagtgggac cggtgtctgg cggatgcggt
      121 cgtgaagata ggtactggtt ttggattagg aattgttttc tcacttacct tctttaaaag
      181 aagaatgtgg ccattagcct tcggttctgg catgggatta ggaatggctt attccaactg
      241 tcagcatgat ttccaggctc catatcttct acatggaaaa tatgtcaaag agcaggagca
      301 gtgacttcac ctgagaacat cccagcggga ggacaagaga aatcatgttt attcctcagg
      361 aatactgaag tgccctggag taagctgcca ttcttctgta acaatgttat cagtaatgct
      421 ttaaactcca gcacctggtt atgcatttga aaccaagtct gtttcttgtt ttgtattttc
      481 tctctggaag ttgtaaggag gtggtcttaa ataaattaaa caaaaagagg aagtccattg
      541 catggccttt gtttcttcac ctttggtctc tgagcatgag gaggactgtg tgtgaactgc
      601 cagcagctgt agccacctgc tcacagcctc tctgagaacc ccctgaaacc agttgttggg
      661 tatccttccc atttgccccc tcaggcgtag ttttcagaac tgcttccacc tcgtaatcag
      721 aagttgaaga ttgctgctgc gtggcctgat ggagatgact gatgtcttaa ggcgcctttc
      781 cttctgtggc acctcttcgt gtgttctcac ctggggacct ggcagggcac atctccgctg
      841 tgcctactgc aaggcggtcc cactgctgct gtattagcag gggaagaatc ctggctgtgt
      901 ggatggccca ctccattgaa gtcaagtcct gcagcttcat agagcttgag acagtccaag
      961 cttcagctct ggagggcgga ggaaagctca tggcataccc acctggccgg aggagcccga
     1021 ttggggttaa ttttatcttc acgtagcagc tgaagtttga ggacaaaagg gccacttctg
     1081 atgcccctct gagtttgttc ctgtggtttc acttgaacca gggatgctag atgcaaaagt
     1141 catattttag caatttcttc agacgatata cagaacccca gcgctcagcc gttcttattt
     1201 ctttttcctt atcgtagaat taagataggg agagcccgat cccacttgcc cctgtatcct
     1261 gtaaatgttg atttatcatc tactgtaagc gaggcactgt tgtaagcagc agagataaat
     1321 ggataaatag acacaggctt ctgccttcaa ggagcttaga gtctgatgga aagacagacg
     1381 tgcaaacaca actctgaaag aagtgtttta atggagaaga gaggtgtagg caaagtacac
     1441 tgagaacaaa ggagaaggag caactatgtc tccctaggat ggccccacag gcgacggaat
     1501 gcctgcgctg ggacccgaag ttgactggga atcccagaca gaaggagggt agcctctgtg
     1561 tttgctcagg atcatgtaat gcatattata gctgggaaat cgcaagtagt tcagcatagc
     1621 cagggtgtgt aggggcaggg gaaaggcatg gagggggagg ctgggcaata gggtacaact
     1681 catgtctgac tccagttctg gaacattgat tagaccttag ttcttgcaag tgctatagtg
     1741 agtacattca gggtagcaaa taccctccct cagcctcccc actccctttt ccagaaaggt
     1801 ctgctaggct ctgccctgca aactgtccag gctcctctgc cctctgggct tgttttcctc
     1861 tttattgcta cttggctgtt tttcacttgg tcctcttcat tctatgatta aggcaaccca
     1921 tataattgaa agaaaaataa tgtgcagcct gtttcatccc ttccacttgt tttcttacta
     1981 tttatttatt tatttctgag atggaatttt gctcttgttg cccaggctgg agtgcaatgg
     2041 tggcgatctc ggcctgctgc aacctccgct tcctgggttc aagcgcttct cctgcctcag
     2101 cctcccgagt agctgggatt acaggcatgc gccatcacac ctggctaatt ttgtattttt
     2161 agtagagacg gtgtttctcc ttggtcatgc tggtctccaa ctcccgacct caggtgatcc
     2221 tcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgca cccagcctcc
     2281 tatttgcttt aaaagtaatt tcctggccgg atgcggtggc tcacacctgt aatcccagca
     2341 ctttgggagg ccaaggcagg tggatcatga ggtcaagaga tcaagaccat cctggccaac
     2401 attgtaaaac cctgtctcta ctaaaaatat aaaaatcagc tgggcatggt ggcgcacacc
     2461 tgtagtccca gctactcagg aggttgaggc aggagaatca tttgaacccg ggaggcagag
     2521 gttgcggtga gctgagatcg cgccactgca ctccagcccg gcgacagagc gagaatctgt
     2581 ctcaaaaaaa aaaaaaaaaa aaaagcattt tccttcccca atttttctgt cattttccca
     2641 tcctcattca ggcagagaga agaataacat gcccccttcc aaaaaagaca aaacacaagg
     2701 tagccacaaa ttccctagac acattagaaa aatagggagt ggagaggggc attggaatga
     2761 aagttctcta tctcattagc tgttaggctt taggcattta tttggatgga tccctttggc
     2821 accttggaag caccactgaa gtgctctgag aaaggggtca gctgtctgag ggaatagttc
     2881 tggatagagg ccacaggaag cactggccag ttgctttagt tctagatagc tttgtattcc
     2941 cgccttgttg cccttagcgg aggctggccc aaagcacact tgatcttgtc cccactccct
     3001 gcccccatct cagatcaacc ttcagaaagt cccggcttgt tggcaaaggc acacattctg
     3061 tgttactctt aagtttcatt agaaattcaa gtcctctggg gccctgttcc cttgtgggct
     3121 tgtgcaactg actttgtttc ttgtctgcct ttctggaacc aaatccaagg aaattcatgg
     3181 gtttggggag acagcgatgg gaacccagca gggcacagga tgctaggata aagctgtggc
     3241 gccccaaaag tggcctgctc tgccaacata cataaataca tacagtctga gcttgacact
     3301 gtataatttg gcccagaaca atatgtattt tgagctcatt taggtgaatg actttggcat
     3361 tccatgtacc cactagggga agctttatca ggctgcattt gccttatgca gaagtatgcc
     3421 tttgttctga gaaatggcct cagaacacac tgttgagctg tctcctttag tgagtgtcat
     3481 cctctcatcc atttcaaaag attgcagatg ccgtcttgaa gtcctgcttg taagaaatgc
     3541 aggggttggg aatggaggag atgacgatgt agttttgctt ttagttttcc caaacctgtt
     3601 tacatttttt aaaaatgtaa ccaacccata attgcatttt acttgtcgtg gttcgatctg
     3661 attgtattgt cgaaggacta tttttgaacc tgtccaaata aactctgcaa agtatttcca
     3721 caa
//
