LOCUS       NM_001204088            2204 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MICOS10-NBL1 readthrough (MICOS10-NBL1), transcript
            variant 1, mRNA.
ACCESSION   NM_001204088
VERSION     NM_001204088.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   Nolan,K., Kattamuri,C., Luedeke,D.M., Angerman,E.B., Rankin,S.A.,
            Stevens,M.L., Zorn,A.M. and Thompson,T.B.
  TITLE     Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1):
            insights for the functional variability across bone morphogenetic
            protein (BMP) antagonists
  JOURNAL   J Biol Chem 290 (8), 4759-4771 (2015)
   PUBMED   25561725
REFERENCE   4  (bases 1 to 2204)
  AUTHORS   Kattamuri,C., Luedeke,D.M., Nolan,K., Rankin,S.A., Greis,K.D.,
            Zorn,A.M. and Thompson,T.B.
  TITLE     Members of the DAN family are BMP antagonists that form highly
            stable noncovalent dimers
  JOURNAL   J Mol Biol 424 (5), 313-327 (2012)
   PUBMED   23063586
REFERENCE   5  (bases 1 to 2204)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2204)
  AUTHORS   Ahmed,A., Kandola,P., Ziada,G. and Parenteau,N.
  TITLE     Purification and partial amino acid sequence of proteins from human
            epidermal keratinocyte conditioned medium
  JOURNAL   J Protein Chem 20 (4), 273-278 (2001)
   PUBMED   11594460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031727.43, FY212253.1 and AK289456.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001204088.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring chromosome 1 open reading
            frame 151 (GeneID 440574) and neuroblastoma suppressor of
            tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The
            read-through transcripts produce at least two proteins, each of
            which share identity with proteins translated from the downstream
            neuroblastoma suppressor of tumorigenicity 1 locus. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FY212253.1, FY213683.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 4681, 440574
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL031727.43        25383-25471
            90-181              FY212253.1         1-92
            182-182             AL031727.43        29241-29241
            183-611             FY212253.1         94-522
            612-1048            AK289456.1         427-863
            1049-2204           AL031727.43        85700-86855
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2204
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /note="MICOS10-NBL1 readthrough"
                     /db_xref="GeneID:100532736"
                     /db_xref="HGNC:HGNC:48338"
     exon            1..131
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..316
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..881
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; Neuroblastoma suppressor of tumorigenicity 1;
                     Protein N03; Zinc finger protein DAN; C1orf151-NBL1
                     read-through protein; DAN domain family member 1;
                     MICOS10-NBL1 read-through protein; MINOS1-NBL1
                     readthrough"
                     /codon_start=1
                     /product="neuroblastoma suppressor of tumorigenicity 1
                     isoform a precursor"
                     /protein_id="NP_001191017.1"
                     /db_xref="GeneID:100532736"
                     /db_xref="HGNC:HGNC:48338"
                     /translation="MVNAQQLLALEATGMMLRVLVGAVLPAMLLAAPPPINKLALFPD
                     KSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPA
                     QSMWEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQP
                     GTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAED"
     exon            317..505
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..617
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2204
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /note="hexamer: AATAAA"
     polyA_site      2204
                     /gene="MICOS10-NBL1"
                     /gene_synonym="C1orf151-NBL1; DAN; DAND1; MINOS1-NBL1;
                     NBL1"
                     /note="major polyA site"
ORIGIN      
        1 gcgagacttt caggggtcgg agcgcggggg ccggccgaga ggaaagctgg aggcgcgggt
       61 ggggaacatg tctgagtcgg agctcggcag gaagtgggac cggtgtctgg cggatgcggt
      121 cgtgaagata gagatggggt ttcaccatgt tgcccaggct ggtcttgaac tcagggtcca
      181 aacgatccac ctaccttggc ctcccaacgt gccaggatta caggcatgag ccaccacacc
      241 tggtccatct tgataatttc atactctggc ttggcaaaga ctgaagggaa gccatggtga
      301 atgcacagca acttctggct ctggaggcca cgggcatgat gcttcgggtc ctggtggggg
      361 ctgtcctccc tgccatgcta ctggctgccc caccacccat caacaagctg gcactgttcc
      421 cagataagag tgcctggtgc gaagccaaga acatcaccca gatcgtgggc cacagcggct
      481 gtgaggccaa gtccatccag aacagggcgt gcctaggaca gtgcttcagc tacagcgtcc
      541 ccaacacctt cccacagtcc acagagtccc tggttcactg tgactcctgc atgccagccc
      601 agtccatgtg ggagattgtg acgctggagt gcccgggcca cgaggaggtg cccagggtgg
      661 acaagctggt ggagaagatc ctgcactgta gctgccaggc ctgcggcaag gagcctagtc
      721 acgaggggct gagcgtctat gtgcagggcg aggacgggcc gggatcccag cccggcaccc
      781 accctcaccc ccatccccac ccccatcctg gcgggcagac ccctgagccc gaggaccccc
      841 ctggggcccc ccacacagag gaagaggggg ctgaggactg aggccccccc aactcttcct
      901 cccctctcat ccccctgtgg aatgttgggt ctcactctct ggggaagtca ggggagaagc
      961 tgaagccccc ctttggcact ggatggactt ggcttcagac tcggacttga atgctgcccg
     1021 gttgccatgg agatctgaag gggcggggtt agagccaagc tgcacaattt aatatattca
     1081 agagtggggg gaggaagcag aggtcttcag ggctcttttt ttgggggggg tggtctcttc
     1141 ctgtctggct tctagagatg tgcctgtggg agggggagga agttggctga gccattgagt
     1201 gctgggggag gccatccaag atggcatgaa tcgggctaag gtccctgggg gtgcagatgg
     1261 tactgctgag gtcccgggct tagtgtgagc atcttgccag cctcaggctt gagggagggc
     1321 tgggctagaa agaccactgg cagaaacagg aggctccggc ccacaggttt ccccaaggcc
     1381 tctcacccca cttcccatct ccagggaagc gtcgccccag tggcactgaa gtggccctcc
     1441 ctcagcggag gggtttggga gtcaggcctg ggcaggaccc tgctgactcg tggcgcggga
     1501 gctgggagcc aggctctccg ggcctttctc tggcttcctt ggcttgcctg gtgggggaag
     1561 gggaggaggg gaagaaggaa agggaagagt cttccaaggc cagaaggagg gggacaaccc
     1621 cccaagacca tccctgaaga cgagcatccc cctcctctcc ctgttagaaa tgttagtgcc
     1681 ccgcactgtg ccccaagttc taggcccccc agaaagctgc cagagccggc cgccttctcc
     1741 cctctcccag ggatgctctt tgtaaatatc ggatgggtgt gggagtgagg ggttacctcc
     1801 ctcgccccaa ggttccagag gccctaggcg ggatgggctc gctgaacctc gaggaactcc
     1861 aggacgagga ggacatggga cttgcgtgga cagtcagggt tcacttgggc tctctctagc
     1921 tccccaattc tgcctgcctc ctccctccca gctgcacttt aaccctagaa ggtggggacc
     1981 tggggggagg gacagggcag gcgggcccat gaagaaagcc cctcgttgcc cagcactgtc
     2041 tgcgtctgct cttctgtgcc cagggtggct gccagcccac tgcctcctgc ctggggtggc
     2101 ctggccctcc tggctgttgc gacgcgggct tctggagctt gtcaccattg gacagtctcc
     2161 ctgatggacc ctcagtcttc tcatgaataa attccttcaa cgcc
//
