LOCUS       NM_005931               2416 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MHC class I polypeptide-related sequence B (MICB),
            transcript variant 1, mRNA.
ACCESSION   NM_005931
VERSION     NM_005931.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Siemaszko,J., Dratwa,M., Szeremet,A., Majcherek,M., Czyz,A.,
            Sobczyk-Kruszelnicka,M., Fidyk,W., Solarska,I.,
            Nasilowska-Adamska,B., Skowronska,P., Bieniaszewska,M.,
            Tomaszewska,A., Basak,G.W., Giebel,S., Wrobel,T. and
            Bogunia-Kubik,K.
  TITLE     MICB Genetic Variants and Its Protein Soluble Level Are Associated
            with the Risk of Chronic GvHD and CMV Infection after Allogeneic
            HSCT
  JOURNAL   Arch Immunol Ther Exp (Warsz) 72 (1) (2024)
   PUBMED   38847554
  REMARK    GeneRIF: MICB Genetic Variants and Its Protein Soluble Level Are
            Associated with the Risk of Chronic GvHD and CMV Infection after
            Allogeneic HSCT.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Niu,Q., Li,Z., Jiang,H. and Hu,B.
  TITLE     Linc-ROR inhibits NK cell-killing activity by promoting RXRA
            ubiquitination and reducing MICB expression in gastric cancer
            patients
  JOURNAL   J Cell Biochem 125 (2), e30516 (2024)
   PUBMED   38205878
  REMARK    GeneRIF: Linc-ROR inhibits NK cell-killing activity by promoting
            RXRA ubiquitination and reducing MICB expression in gastric cancer
            patients.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Aguilar,O.A., Qualls,A.E., Gonzalez-Hinojosa,M.D.R., Obeidalla,S.,
            Kerchberger,V.E., Tsao,T., Singer,J.P., Looney,M.R., Raymond,W.,
            Hays,S.R., Golden,J.A., Kukreja,J., Shaver,C.M., Ware,L.B.,
            Christie,J., Diamond,J.M., Lanier,L.L., Greenland,J.R. and
            Calabrese,D.R.
  TITLE     MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung
            Injury and Death
  JOURNAL   Am J Respir Crit Care Med 209 (1), 70-82 (2024)
   PUBMED   37878820
  REMARK    GeneRIF: MICB Genomic Variant Is Associated with NKG2D-mediated
            Acute Lung Injury and Death.
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Wang,S., Onyeaghala,G.C., Pankratz,N., Nelson,H.H., Thyagarajan,B.,
            Tang,W., Norby,F.L., Ugoji,C., Joshu,C.E., Gomez,C.R., Couper,D.J.,
            Coresh,J., Platz,E.A. and Prizment,A.E.
  TITLE     Associations between MICA and MICB Genetic Variants, Protein
            Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities
            (ARIC)
  JOURNAL   Cancer Epidemiol Biomarkers Prev 32 (6), 784-794 (2023)
   PUBMED   36958849
  REMARK    GeneRIF: Associations between MICA and MICB Genetic Variants,
            Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in
            Communities (ARIC).
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Wei,A., Zhang,L., Ma,H., Cui,L., Zhang,Q., Wang,D., Chen,S., Du,J.,
            Zhao,X., Wang,T., Zhang,R., Zheng,H. and Li,Z.
  TITLE     Clinical Significance of Plasma Soluble MICB in Children With
            EBV-associated Hemophagocytic Lymphohistiocytosis
  JOURNAL   J Pediatr Hematol Oncol 45 (4), e446-e454 (2023)
   PUBMED   36898046
  REMARK    GeneRIF: Clinical Significance of Plasma Soluble MICB in Children
            With EBV-associated Hemophagocytic Lymphohistiocytosis.
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Groh,V., Bahram,S., Bauer,S., Herman,A., Beauchamp,M. and Spies,T.
  TITLE     Cell stress-regulated human major histocompatibility complex class
            I gene expressed in gastrointestinal epithelium
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12445-12450 (1996)
   PUBMED   8901601
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Nalabolu,S.R., Shukla,H., Nallur,G., Parimoo,S. and Weissman,S.M.
  TITLE     Genes in a 220-kb region spanning the TNF cluster in human MHC
  JOURNAL   Genomics 31 (2), 215-222 (1996)
   PUBMED   8824804
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Bahram,S. and Spies,T.
  TITLE     Nucleotide sequence of a human MHC class I MICB cDNA
  JOURNAL   Immunogenetics 43 (4), 230-233 (1996)
   PUBMED   8575823
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Bahram,S., Bresnahan,M., Geraghty,D.E. and Spies,T.
  TITLE     A second lineage of mammalian major histocompatibility complex
            class I genes
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6259-6263 (1994)
   PUBMED   8022771
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Leelayuwat,C., Townend,D.C., Degli-Esposti,M.A., Abraham,L.J. and
            Dawkins,R.L.
  TITLE     A new polymorphic and multicopy MHC gene family related to
            nonmammalian class I
  JOURNAL   Immunogenetics 40 (5), 339-351 (1994)
   PUBMED   7927538
  REMARK    Erratum:[Immunogenetics 1995;41(2-3):174]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314228.1, DC364717.1,
            CN389975.1, BC044218.1 and BQ216247.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005931.4.
            
            Summary: This gene encodes a heavily glycosylated protein which is
            a ligand for the NKG2D type II receptor. Binding of the ligand
            activates the cytolytic response of natural killer (NK) cells, CD8
            alphabeta T cells, and gammadelta T cells which express the
            receptor. This protein is stress-induced and is similar to MHC
            class I molecules; however, it does not associate with
            beta-2-microglobulin or bind peptides. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314228.1, X91625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252229.7/ ENSP00000252229.6
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AK314228.1         1-271
            272-455             DC364717.1         231-414
            456-1195            AK314228.1         456-1195
            1196-1701           CN389975.1         141-646
            1702-2402           BC044218.1         1630-2330
            2403-2416           BQ216247.1         41-54               c
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2416
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /note="MHC class I polypeptide-related sequence B"
                     /db_xref="GeneID:4277"
                     /db_xref="HGNC:HGNC:7091"
                     /db_xref="IMGT/GENE-DB:MICB"
                     /db_xref="MIM:602436"
     exon            1..119
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1201
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MHC class I-like molecule PERB11.2-IMX; stress
                     inducible class I homolog; MHC class I mic-B antigen; MHC
                     class I chain-related protein B; MHC class I
                     antigen-related protein B"
                     /codon_start=1
                     /product="MHC class I polypeptide-related sequence B
                     isoform 1 precursor"
                     /protein_id="NP_005922.2"
                     /db_xref="CCDS:CCDS43449.1"
                     /db_xref="GeneID:4277"
                     /db_xref="HGNC:HGNC:7091"
                     /db_xref="IMGT/GENE-DB:MICB"
                     /db_xref="MIM:602436"
                     /translation="MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSG
                     FLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTH
                     IKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQT
                     LAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSE
                     GNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGE
                     EQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKK
                     TSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT"
     exon            120..374
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..662
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..941
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1073
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..2416
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2416
                     /gene="MICB"
                     /gene_synonym="PERB11.2"
                     /note="major polyA site"
ORIGIN      
        1 attcagttgg ccactgctga gcagctgaga aggtggcgac gtaggggcca tggggctggg
       61 ccgggtcctg ctgtttctgg ccgtcgcctt cccttttgca cccccggcag ccgccgctga
      121 gccccacagt cttcgttaca acctcatggt gctgtcccag gatggatctg tgcagtcagg
      181 gtttctcgct gagggacatc tggatggtca gcccttcctg cgctatgaca ggcagaaacg
      241 cagggcaaag ccccagggac agtgggcaga aaatgtcctg ggagctaaga cctgggacac
      301 agagaccgag gacttgacag agaatgggca agacctcagg aggaccctga ctcatatcaa
      361 ggaccagaaa ggaggcttgc attccctcca ggagattagg gtctgtgaga tccatgaaga
      421 cagcagcacc aggggctccc ggcatttcta ctacgatggg gagctcttcc tctcccaaaa
      481 cctggagact caagaatcga cagtgcccca gtcctccaga gctcagacct tggctatgaa
      541 cgtcacaaat ttctggaagg aagatgccat gaagaccaag acacactatc gcgctatgca
      601 ggcagactgc ctgcagaaac tacagcgata tctgaaatcc ggggtggcca tcaggagaac
      661 agtgcccccc atggtgaatg tcacctgcag cgaggtctca gagggcaaca tcaccgtgac
      721 atgcagggct tccagcttct atccccggaa tatcacactg acctggcgtc aggatggggt
      781 atctttgagc cacaacaccc agcagtgggg ggatgtcctg cctgatggga atggaaccta
      841 ccagacctgg gtggccacca ggattcgcca aggagaggag cagaggttca cctgctacat
      901 ggaacacagc gggaatcacg gcactcaccc tgtgccctct gggaaggcgc tggtgcttca
      961 gagtcaacgg acagactttc catatgtttc tgctgctatg ccatgttttg ttattattat
     1021 tattctctgt gtcccttgtt gcaagaagaa aacatcagcg gcagagggtc cagagcttgt
     1081 gagcctgcag gtcctggatc aacacccagt tgggacagga gaccacaggg atgcagcaca
     1141 gctgggattt cagcctctga tgtcagctac tgggtccact ggttccactg agggcaccta
     1201 gactctacag ccaggcggcc aggattcaac tccctgcctg gatctcacca gcactttccc
     1261 tctgtttcct gacctatgaa acagagaaaa taacatcact tatttattgt tgttggatgc
     1321 tgcaaagtgt tagtaggtat gaggtgtttg ctgctctgcc acgtagagag ccagcaaagg
     1381 gatcatgacc aactcaacat tccattggag gctatatgat caaacagcaa attgtttatc
     1441 atgaatgcag gatgtgggca aactcacgac tgctcctgcc aacagaaggt ttgctgaggg
     1501 cattcactcc atggtgctca ttggagttat ctactgggtc atctagagcc tattgtttga
     1561 ggaatgcagt cttacaagcc tactctggac ccagcagctg actccttctt ccacccctct
     1621 tcttgctatc tcctatacca ataaatacga agggctgtgg aagatcagag cccttgttca
     1681 cgagaagcaa gaagccccct gaccccttgt tccaaatata ctcttttgtc tttctcttta
     1741 ttcccacgtt cgccctttgt tcagtccaat acagggttgt ggggccctta acagtgccat
     1801 attaattggt atcattattt ctgttgtttt tgtttttgtt tttgtttttg tttttgagac
     1861 agagtctcac tctgtcaccc aggctgcagt tcactggtgt gatctcagct cactgcaacc
     1921 tctgcctccc aggttcaagc acttctcgta cctcagactc ccgaatagct gggattacag
     1981 acaggcacca ccacacccag ctaatttttg tattttttgt agagacgggg tttcgccaag
     2041 ttgaccagcc cagtttcaaa ctcctgacct caggtgatct gcctgccttg gcatcccaaa
     2101 gtgctgggat tacaagaatg agccaccgtg cctggcctat tttattatat tgtaatatat
     2161 tttattatat tagccaccat gcctgtccta ttttcttatg ttttaatata ttttaatata
     2221 ttacatgtgc agtaattaga ttatcatggg tgaactttat gagtgagtat cttggtgatg
     2281 actcctcctg accagcccag gaccagcttt cttgtcacct tgaggtcccc tcgccccgtc
     2341 acaccgttat gcattactct gtgtctacta ttatgtgtgc ataatttata ccgtaaatgt
     2401 ttactcttta aataga
//
