LOCUS       NM_182924               3096 bp    mRNA    linear   PRI 09-AUG-2024
DEFINITION  Homo sapiens MICAL like 2 (MICALL2), mRNA.
ACCESSION   NM_182924
VERSION     NM_182924.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Xia,T., Ye,F., Zhao,W., Min,P., Qi,C., Wang,Q., Zhao,M., Zhang,Y.
            and Du,J.
  TITLE     Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in
            EGFR Stabilization and Ovarian Cancer Cell Invasion
  JOURNAL   Int J Mol Sci 25 (1), 518 (2023)
   PUBMED   38203692
  REMARK    GeneRIF: Comprehensive Analysis of MICALL2 Reveals Its Potential
            Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Wen,P., Wang,H., Li,Y., Sui,X., Hou,Z., Guo,X., Xue,W., Liu,D.,
            Wang,Y. and Gao,J.
  TITLE     MICALL2 as a substrate of ubiquitinase TRIM21 regulates
            tumorigenesis of colorectal cancer
  JOURNAL   Cell Commun Signal 20 (1), 170 (2022)
   PUBMED   36307841
  REMARK    GeneRIF: MICALL2 as a substrate of ubiquitinase TRIM21 regulates
            tumorigenesis of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Sakane,A., Yano,T.A., Uchihashi,T., Horikawa,K., Hara,Y., Imoto,I.,
            Kurisu,S., Yamada,H., Takei,K. and Sasaki,T.
  TITLE     JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form
            tubular recycling endosomes
  JOURNAL   Commun Biol 4 (1), 551 (2021)
   PUBMED   33976349
  REMARK    GeneRIF: JRAB/MICAL-L2 undergoes liquid-liquid phase separation to
            form tubular recycling endosomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Sakane,A., Alamir Mahmoud Abdallah,A., Nakano,K., Honda,K.,
            Kitamura,T., Imoto,I., Matsushita,N. and Sasaki,T.
  TITLE     Junctional Rab13-binding protein (JRAB) regulates cell spreading
            via filamins
  JOURNAL   Genes Cells 18 (9), 810-822 (2013)
   PUBMED   23890175
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Kanda,I., Nishimura,N., Nakatsuji,H., Yamamura,R., Nakanishi,H. and
            Sasaki,T.
  TITLE     Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell
            scattering
  JOURNAL   Oncogene 27 (12), 1687-1695 (2008)
   PUBMED   17891173
  REMARK    GeneRIF: Involved in epithelial cell scattering.
REFERENCE   8  (bases 1 to 3096)
  AUTHORS   Terai,T., Nishimura,N., Kanda,I., Yasui,N. and Sasaki,T.
  TITLE     JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the
            endocytic recycling of occludin
  JOURNAL   Mol Biol Cell 17 (5), 2465-2475 (2006)
   PUBMED   16525024
REFERENCE   9  (bases 1 to 3096)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3096)
  AUTHORS   Terman,J.R., Mao,T., Pasterkamp,R.J., Yu,H.H. and Kolodkin,A.L.
  TITLE     MICALs, a family of conserved flavoprotein oxidoreductases,
            function in plexin-mediated axonal repulsion
  JOURNAL   Cell 109 (7), 887-900 (2002)
   PUBMED   12110185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027124.1, BC037988.1, AK074068.1, DA945802.1 and AY358755.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182924.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037988.1, BK000467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297508.8/ ENSP00000297508.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK027124.1         4-112
            110-1277            BC037988.1         100-1267
            1278-1763           AK074068.1         1173-1658
            1764-1769           DA945802.1         447-452
            1770-3089           BC037988.1         1760-3079
            3090-3096           AY358755.1         1398-1404
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..3096
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /note="MICAL like 2"
                     /db_xref="GeneID:79778"
                     /db_xref="HGNC:HGNC:29672"
                     /db_xref="MIM:620912"
     exon            1..287
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2859
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /note="junctional Rab13-binding protein; molecule
                     interacting with CasL-like 2"
                     /codon_start=1
                     /product="MICAL-like protein 2"
                     /protein_id="NP_891554.1"
                     /db_xref="CCDS:CCDS5324.1"
                     /db_xref="GeneID:79778"
                     /db_xref="HGNC:HGNC:29672"
                     /db_xref="MIM:620912"
                     /translation="MAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHR
                     PDLINFSALKKENIYENNKLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQY
                     YNYFHGRSPIGGMAGVKRASEDSEEEPSGKKAPVQAAKLPSPAPARKPPLSPAQTNPV
                     VQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQC
                     SCTLHSGAYKATGEPGTFVCTSHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKA
                     QEANKARPSAWEPAAGNSPARASVPAAPNPAATSATSVHVRSPARPSESRLAPTPTEG
                     KVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLS
                     SSSTSAATVDPPAWTPSASRTQQARNKFFQTSAVPPGTSLSGRGPTPSLVLSKDSSKE
                     QARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPLAKPLQSSSPRVL
                     GLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKST
                     TLTQDMSTSLQEGQEDGPAGWRANLKPVDRRSPAERTLKPKEPRALAEPRAGEAPRKV
                     SGSFAGSVHITLTPVRPDRTPRPASPGPSLPARSPSPPRRRRLAVPASLDVCDNWLRP
                     EPPGQEARVQSWKEEEKKPHLQGKPGRPLSPANVPALPGETVTSPVRLHPDYLSPEEI
                     QRQLQDIERRLDALELRGVELEKRLRAAEGDDAEDSLMVDWFWLIHEKQLLLRQESEL
                     MYKSKAQRLEEQQLDIEGELRRLMAKPEALKSLQERRREQELLEQYVSTVNDRSDIVD
                     SLDEDRLREQEEDQMLRDMIEKLGLQRKKSKFRLSKIWSPKSKSSPSQ"
     exon            288..336
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..478
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..669
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..785
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1562
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1855
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1949
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2110
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2266
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2331
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2455
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2546
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2620
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2735
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2782
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..3096
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3068..3073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="MICALL2"
                     /gene_synonym="JRAB; MICAL-L2"
                     /note="major polyA site"
ORIGIN      
        1 agtccggctc agctggggct gggcgccgtg ggtctggcgg ttccgtagcg gtcccagcgt
       61 ctgtcccgcc ggccgggcgg tcgcggcaca gccgcgggaa ggtgtcggag ggcggttccg
      121 ccgcgcggcg ggcgcgccgc ccacatggcg gccatcaggg cgctgcaaca gtggtgccgg
      181 cagcagtgcg agggctaccg cgacgtgaat atctgcaaca tgaccacgtc gttccgcgac
      241 ggcctggctt tctgcgccat cctgcaccgc caccggcccg acctcataaa cttcagtgct
      301 ctcaagaagg aaaatattta tgaaaacaat aaactggcct tccgcgtggc cgaggagcac
      361 ttgggcatcc cagccttgct ggatgccgag gacatggtgg ccttgaaggt gcctgaccgg
      421 ctgagcatct tgacctacgt gtcccagtat tacaactact tccacggccg ctcccccatt
      481 gggggcatgg caggcgtgaa gagggcctcg gaggactctg aggaggagcc gtcagggaag
      541 aaggctccag tccaggcggc caagctgccc tcgcccgccc cagcccggaa gcctccacta
      601 tctccagccc agacaaaccc tgtggtccag aggaggaatg agggtgcagg gggcccgccc
      661 cccaagactg accaggcatt ggcgggcagc ttggtcagca gcacctgcgg ggtctgcggc
      721 aagcacgtgc acctggtaca gcggcacctg gccgacggga ggctttacca ccggagctgc
      781 ttcaggtgta agcagtgctc ctgcacgctg cactcggggg cctacaaggc cacaggagag
      841 ccgggcacct tcgtctgcac cagccacctc cccgcagccg cctctgcaag ccccaagttg
      901 acgggtctgg tcccccgaca gccaggggcc atgggtgtgg attccaggac ctcctgttcc
      961 ccacagaagg cccaggaggc aaacaaggcc agaccgtcgg cctgggagcc tgctgcgggc
     1021 aactcgcctg ccagggcttc cgttccagct gcacccaacc ctgcagccac cagcgccacg
     1081 tccgtccacg tgaggagccc agccaggccc tctgagagcc gcctggcccc cactcccacg
     1141 gaggggaaag tccgccctcg tgtgaccaat agctccccga tgggctggtc gtcagctgcc
     1201 ccgtgcacag cagcggctgc ctcccatccc gccgtgcccc cgagtgcccc agaccctcgc
     1261 ccggccacac cccagggtgg gggagccccc cgagtggcag ctcctcaaac cacactcagt
     1321 tcaagctcca catctgcagc cacggtggac cccccagcct ggaccccgtc cgcctccagg
     1381 acccagcagg cccggaataa gtttttccaa acatcagcag tgccccccgg caccagcctt
     1441 tctggcagag gtcccacccc gtcacttgtt ctatccaagg acagcagcaa ggagcaggcg
     1501 cggaacttcc tcaagcaggc cctctcagcg ctggaagagg ctggcgctcc ggcgcctggc
     1561 aggccctccc cagccactgc cgctgttccc agttctcagc ccaaaactga agcaccacaa
     1621 gcaagtccct tagccaagcc gttacagtcc tcgtctcccc gggtgcttgg cctcccttcg
     1681 aggatggaac cgccagcccc gctgagcacg agcagtacct ctcaggcatc cgcgttgccc
     1741 ccggcaggca ggaggaactt ggcggaatcc tcaggggtcg gcagggtggg tgctggctcc
     1801 aggccgaagc cagaggcccc gatggcaaag ggtaaaagca ccaccttaac gcaggacatg
     1861 agcaccagcc tccaggaagg ccaggaggac gggccggcag gatggagagc gaatctgaag
     1921 cccgtggaca ggagaagccc agctgagagg actctgaagc ccaaggaacc acgggccctg
     1981 gcagagccga gggcggggga ggcccccagg aaggtctcag gcagctttgc tgggagtgtc
     2041 cacatcaccc tgacccccgt gaggcctgac aggaccccac gcccagccag cccaggaccc
     2101 agcctcccag ccaggtcccc ctccccaccc cgccgcagga gactggccgt ccctgccagc
     2161 ctcgacgttt gtgacaactg gcttcggccg gagccccctg gccaggaagc ccgagtgcag
     2221 agctggaagg aggaggagaa gaaacctcac cttcagggca aaccagggag acccttgtcc
     2281 ccggccaatg tccctgctct gcctggcgag acggtgacct ccccagtcag gctgcacccc
     2341 gactacctct ccccggagga gatacagagg cagctgcagg acatcgagag gcggctggac
     2401 gccctggagc tccgcggcgt ggagctggag aagcgactgc gggcggccga gggagatgac
     2461 gctgaggata gcctcatggt ggactggttc tggctcattc acgagaagca gcttctgctg
     2521 agacaggagt cagagctgat gtacaagtcc aaggcccagc gtctggagga gcagcagctg
     2581 gacatcgagg gcgagctgcg ccggctcatg gccaagcccg aggctctgaa gtcactgcag
     2641 gagcggcggc gggagcagga gctgctggag cagtacgtga gcaccgtgaa cgaccgcagt
     2701 gacatcgtgg actcgctgga cgaggaccgg ctccgggaac aagaggagga tcagatgctg
     2761 cgggacatga ttgagaagct gggcctccag aggaagaagt ccaagttccg cttgtccaag
     2821 atctggtcac caaaaagcaa aagcagcccc tcccagtagt agccagtagg gccgtgggct
     2881 cggcccggac ctggcatccg gacttggact cggggccatg ggcttggccc ggacccggaa
     2941 cccggacttg tactcggggc cgtgggctcg gcccggaccc ggcattcgga cttggactcg
     3001 ggaagggcct cctgtcccta caaggggcat gtggacagca gggacctgcg ctaccgtctg
     3061 tggtctcaat aaagaaaccg accacatggc cccgga
//
