LOCUS       NM_033386               4710 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MICAL like 1 (MICALL1), transcript variant 3, mRNA.
ACCESSION   NM_033386
VERSION     NM_033386.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4710)
  AUTHORS   Frisby,D., Murakonda,A.B., Ashraf,B., Dhawan,K., Almeida-Souza,L.,
            Naslavsky,N. and Caplan,S.
  TITLE     Endosomal actin branching, fission, and receptor recycling require
            FCHSD2 recruitment by MICAL-L1
  JOURNAL   Mol Biol Cell 35 (11), ar144 (2024)
   PUBMED   39382837
  REMARK    GeneRIF: Endosomal actin branching, fission, and receptor recycling
            require FCHSD2 recruitment by MICAL-L1.
REFERENCE   2  (bases 1 to 4710)
  AUTHORS   Sikora,R., Bun,P., Danglot,L., Alqabandi,M., Bassereau,P.,
            Niedergang,F., Galli,T. and Zahraoui,A.
  TITLE     MICAL-L1 is required for cargo protein delivery to the cell surface
  JOURNAL   Biol Open 10 (6) (2021)
   PUBMED   34100897
  REMARK    GeneRIF: MICAL-L1 is required for cargo protein delivery to the
            cell surface.
REFERENCE   3  (bases 1 to 4710)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4710)
  AUTHORS   Malinova,T.S., Angulo-Urarte,A., Nuchel,J., Tauber,M., van der
            Stoel,M.M., Janssen,V., de Haan,A., Groenen,A.G., Tebbens,M.,
            Graupera,M., Plomann,M. and Huveneers,S.
  TITLE     A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin
            trafficking for endothelial migration and angiogenesis
  JOURNAL   Nat Commun 12 (1), 2610 (2021)
   PUBMED   33972531
  REMARK    GeneRIF: A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates
            VE-cadherin trafficking for endothelial migration and angiogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4710)
  AUTHORS   Farmer,T., Xie,S., Naslavsky,N., Stockli,J., James,D.E. and
            Caplan,S.
  TITLE     Defining the protein and lipid constituents of tubular recycling
            endosomes
  JOURNAL   J Biol Chem 296, 100190 (2021)
   PUBMED   33334886
  REMARK    GeneRIF: Defining the protein and lipid constituents of tubular
            recycling endosomes.
REFERENCE   6  (bases 1 to 4710)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 4710)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 4710)
  AUTHORS   Weide,T., Teuber,J., Bayer,M. and Barnekow,A.
  TITLE     MICAL-1 isoforms, novel rab1 interacting proteins
  JOURNAL   Biochem Biophys Res Commun 306 (1), 79-86 (2003)
   PUBMED   12788069
REFERENCE   9  (bases 1 to 4710)
  AUTHORS   Terman,J.R., Mao,T., Pasterkamp,R.J., Yu,H.H. and Kolodkin,A.L.
  TITLE     MICALs, a family of conserved flavoprotein oxidoreductases,
            function in plexin-mediated axonal repulsion
  JOURNAL   Cell 109 (7), 887-900 (2002)
   PUBMED   12110185
REFERENCE   10 (bases 1 to 4710)
  AUTHORS   Marzesco,A.M., Dunia,I., Pandjaitan,R., Recouvreur,M., Dauzonne,D.,
            Benedetti,E.L., Louvard,D. and Zahraoui,A.
  TITLE     The small GTPase Rab13 regulates assembly of functional tight
            junctions in epithelial cells
  JOURNAL   Mol Biol Cell 13 (6), 1819-1831 (2002)
   PUBMED   12058051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR004306.1, AJ496196.1, AL834373.1, CA307559.1 and AL022311.5.
            
            On May 17, 2019 this sequence version replaced NM_033386.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000466.1, AL834373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215957.10/ ENSP00000215957.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DR004306.1         132-205
            75-2776             AJ496196.1         16-2717
            2777-3897           AL834373.1         2583-3703
            3898-4346           CA307559.1         16-464              c
            4347-4710           AL022311.5         70900-71263
FEATURES             Location/Qualifiers
     source          1..4710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4710
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /note="MICAL like 1"
                     /db_xref="GeneID:85377"
                     /db_xref="HGNC:HGNC:29804"
                     /db_xref="MIM:619563"
     exon            1..272
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2718
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /note="isoform 3 is encoded by transcript variant 3;
                     molecule interacting with Rab13; MICAL-like protein 1"
                     /codon_start=1
                     /product="MICAL-like protein 1 isoform 3"
                     /protein_id="NP_203744.1"
                     /db_xref="CCDS:CCDS13961.1"
                     /db_xref="GeneID:85377"
                     /db_xref="HGNC:HGNC:29804"
                     /db_xref="MIM:619563"
                     /translation="MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRH
                     RPDLLDFDSLSKDNVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQ
                     YYNHFCSPGQAGVSPPRKGLAPCSPPSVAPTPVEPEDVAQGEELSSGSLSEQGTGQTP
                     SSTCAACQQHVHLVQRYLADGRLYHRHCFRCRRCSSTLLPGAYENGPEEGTFVCAEHC
                     ARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPAGAEADGPKASPEA
                     RPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRSSLQQENLVEQA
                     GSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDPPWITLVQAEPKKKPAPLPPSSSP
                     GPPSQDSRQVENGGTEEVAQPSPTASLESKPYNPFEEEEEDKEEEAPAAPSLATSPAL
                     GHPESTPKSLHPWYGITPTSSPKTKKRPAPRAPSASPLALHASRLSHSEPPSATPSPA
                     LSVESLSSESASQTAGAELLEPPAVPKSSSEPAVHAPGTPGNPVSLSTNSSLASSGEL
                     VEPRVEQMPQASPGLAPRTRGSSGPQPAKPCSGATPTPLLLVGDRSPVPSPGSSSPQL
                     QVKSSCKENPFNRKPSPAASPATKKATKGSKPVRPPAPGHGFPLIKRKVQADQYIPEE
                     DIHGEMDTIERRLDALEHRGVLLEEKLRGGLNEGREDDMLVDWFKLIHEKHLLVRRES
                     ELIYVFKQQNLEQRQADVEYELRCLLNKPEKDWTEEDRAREKVLMQELVTLIEQRNAI
                     INCLDEDRQREEEEDKMLEAMIKKKEFQREAEPEGKKKGKFKTMKMLKLLGNKRDAKS
                     KSPRDKS"
     exon            273..321
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            322..463
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            464..552
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            553..695
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1150
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1208
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1591
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2007
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2142
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2269
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2360
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2434
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2549
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2596
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..4710
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3873..3878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /note="hexamer: AATAAA"
     polyA_site      3897
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
                     /note="major polyA site"
     polyA_site      4340
                     /gene="MICALL1"
                     /gene_synonym="MICAL-L1; MIRAB13"
ORIGIN      
        1 gcctgccggt cggcgcccga gctcggagcc gcagccgcag ccggaaaccg ggcccgcgcg
       61 gcggccgccg tcccggccaa gccggggccc cgaagccaga gccggagccg ggcgggccgc
      121 ggggtcatgg ctgggccgcg gggcgcgctg ctggcctggt gccgccgcca gtgcgagggc
      181 taccgcggcg tggagatccg cgacctgagc agctccttcc gggacggcct ggccttctgc
      241 gccatcctgc accggcaccg gcccgacctg ctagattttg attcgctttc caaggacaat
      301 gtcttcgaga ataaccgttt ggcctttgaa gtggctgaga aggagctggg gatccccgct
      361 ctcctggacc ccaatgacat ggtctccatg agcgtccctg actgcctcag catcatgacc
      421 tatgtgtccc agtattacaa ccacttctgc agtcctggcc aagctggtgt ctcgccaccc
      481 agaaagggcc ttgcaccctg ttccccgccg tctgtagcac ccactccagt ggaaccagaa
      541 gatgtggctc agggcgagga gctctcctca ggcagcctgt cagagcaggg caccggccag
      601 acccccagca gcacgtgcgc agcctgccag cagcatgtgc acttggtgca gcgctacctg
      661 gctgacggca ggctgtacca tcgccactgc ttccggtgtc ggcggtgctc cagcaccctg
      721 ctccctgggg cttatgagaa tgggcctgag gagggcacct ttgtgtgtgc agaacactgt
      781 gccaggctgg gcccggggac acggtcgggg accaggcctg ggcccttctc acagccaaag
      841 cagcagcacc agcagcaact cgcagaagat gccaaggatg ttccaggagg cggccccagc
      901 tccagtgctc ctgcaggggc tgaggccgat ggacccaagg ccagccctga ggcccggccg
      961 cagatcccta ccaagccccg ggttcctggc aaactacagg agctggccag cccccctgcg
     1021 ggccgcccca cccctgcccc caggaaggcc tctgagagca ccaccccagc accccccacg
     1081 ccccggcccc gctccagtct gcagcaggag aacctggtgg agcaggctgg cagcagcagc
     1141 ctggtgaacg ggagactgca cgaactgcct gtccccaagc cgagggggac accgaagccg
     1201 tccgagggga caccagcccc caggaaggac cccccatgga tcacgctggt gcaggcagaa
     1261 ccaaagaaga agccagcccc acttccccca agcagcagcc cggggccacc aagccaggac
     1321 agcaggcagg tggagaatgg aggcaccgag gaggtggccc agccgagccc aacggccagc
     1381 ctggagtcca aaccctataa cccctttgag gaggaggagg aggacaagga ggaagaggct
     1441 ccagctgcac ccagcctggc caccagccct gccctgggcc acccggagtc cacacccaag
     1501 tccctgcacc cctggtacgg catcacccct accagcagcc ccaagacaaa gaagcgccct
     1561 gccccgcgcg cacccagcgc gtccccactg gctctccacg cctcccgcct ctcgcactcg
     1621 gagccgccct cggccacacc atcgccagcg ctcagcgtgg agagcctgtc gtctgagagc
     1681 gccagccaga ctgcaggtgc agagcttctg gagccgccag ctgtgcccaa gagctcctca
     1741 gagcctgctg tccatgcccc tggtacccct ggaaaccctg tcagcctctc taccaactcc
     1801 tccctggcct cctctgggga actagtggag cctagagtgg aacaaatgcc tcaagccagc
     1861 cctggccttg cccccaggac caggggcagc tcaggtcccc agccagccaa gccctgcagt
     1921 ggcgccaccc caacgcctct cttgttggtt ggagacagga gcccggtgcc ttcccctgga
     1981 agctcgtccc cacagctgca ggtaaagtcc tcctgcaagg agaatccttt taaccggaag
     2041 ccatcacctg cagcgtcccc agccacaaag aaggccacca agggatccaa gccagtgagg
     2101 ccacctgccc ctggacacgg ctttccactc atcaaacgca aggtccaggc tgaccagtac
     2161 atccctgagg aggacatcca tggagagatg gataccattg agcgccggct ggatgccctg
     2221 gagcaccgtg gggtgctgct ggaggagaag ctgcgtggcg gcctgaatga gggccgtgag
     2281 gatgacatgc tggtggactg gttcaagctc atccacgaga agcacctact ggtgcggcga
     2341 gagtccgagc tcatctatgt cttcaagcag cagaacctgg agcagcgcca ggctgatgtc
     2401 gagtatgagc tccggtgcct cctcaataag ccagaaaagg actggacgga ggaggaccgg
     2461 gcccgggaga aggtgctgat gcaggagctt gtgaccctca ttgagcagcg caacgctatc
     2521 atcaactgcc tggatgagga ccggcagagg gaggaagagg aagacaagat gttggaagcc
     2581 atgatcaaga agaaagagtt ccagagggag gctgaacctg agggcaagaa gaaggggaag
     2641 ttcaagacca tgaagatgtt gaaactgcta ggaaacaaac gtgatgccaa gagcaagtcc
     2701 cccagagaca agagctaaca gcacgagaag ccagttgggg actgccccct cctggagcag
     2761 ctcctgggct gtgctctgtt tgaagggggc gccctgctcc cctcagatca gtcaggagga
     2821 agatgactaa ggggagggat cctctgggtg atggcctctt cctcctcagg gacctctgac
     2881 tgctctgggc caaagaatct cttgtttctt ctccgagccc caggcagcgg tgattcagcc
     2941 ctgcccaacc tgattctgat gactgcggat gctgtgacgg acccaagggg caaatagggt
     3001 cccagggtcc agggaggggc gcctgctgag cacttccgcc cctcaccctg cccagcccct
     3061 gccatgagct ctgggctggg tctccgcctc cagggttctg ctcttccagg caggccagca
     3121 agtggcgctg ggccacactg gcttcttcct gccccatccc tggctctgag tctctgtctt
     3181 cctgtcctgt gcaggcgccc ttggatctca gtttccctca ctcaggaact ctgtttctga
     3241 agtcttcagt taagtttgag tttatgactg agtggcctgt actgtcagac gtgaatgggc
     3301 ctgacgggca aatccatccc tctctccctc acagttccag gagcggcttc cctcgtctcc
     3361 ccttactcca cagggagcct cccttgccag gaccagggct gcgacggcca tgctggggca
     3421 ggtgagtgct ctgttagctg ctcccagtgc tgtccccagg ctgcagttct ggtccctggt
     3481 tgtcaggtag gaagggtgca cttgaagcag gtgctcatct cggttcctta acgtttatag
     3541 tctgacccct cacttaggct ttcctctgcc accccggtcc agggaagagg ctcgctcccg
     3601 cccatggtca tcactggtct gtctgctctg ttgtctgttc tttccctgac tccctcccac
     3661 cgaaggcctg atggctactc acccctctgg gatggctatg ggagaggagg agtgatgggg
     3721 accgccacct tttctgcagg aaatgtgccc agcagctctt ggtcaaagca ctgttgctat
     3781 aagctatctc tgggatgcct ctaggccccc ttccctctac acacctctgg gaaaagatta
     3841 cactgtatta actctcgagg agtttcctca ccaataaaca gacaacctca actgccagtg
     3901 ccctgcagcc tcgggccaca gcggcagcct tgtttgcctt cccacctgcc tctgccacac
     3961 ctggtggctg aacatctctg gtcgcccaga ggccatgttg gggccatcct ccaagaggga
     4021 tctctgccct caccgcctgc cactgggcag gatccctttc ctctgcaggg agaggtggct
     4081 cctcggccat gcagcccctg gcaggctcct tctaaacatg cctgttgacc tggagctggc
     4141 gccaccaact ccagggcctt tccagggcca gacaggtaac acgcatgaac ccgagtgaca
     4201 gctctgacgg gctgtttcgg tgtcaggaga caaagctggc aggggcaggg gtgaactgga
     4261 ggcaagtcaa gtcacctgtg gcctgtgggg ctgaatgtgg gcccggtgtt gccagatcct
     4321 ttgtcataag aagctagaaa tccagatttt atgtgtgtgt aatttgtaaa tgctgaaagc
     4381 tagcctgaat tttttttttt tttttttgag acagagtctc gctctgtcgc ccaggctgga
     4441 gtgcagtggc gcgatctcag ctcactgcaa gctccgcctc ctgggttcac gccatcctcc
     4501 tgcctcggcc tcctgagcag ctgggactac aggcgcatgc tacgacgcct ggctaatttt
     4561 ttgtattttt agtagagacg gggtttcacc gtgttaacca ggatggtctc gatctcctga
     4621 ccttgtgatc cacccacctt ggcctcccaa agtgctggga ttacaggcgt gagccaccac
     4681 gcccggccac tagcctgaat ttcaatcaag
//
