LOCUS       NM_001282663            3903 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens microtubule associated monooxygenase, calponin and LIM
            domain containing 2 (MICAL2), transcript variant 2, mRNA.
ACCESSION   NM_001282663
VERSION     NM_001282663.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Liu,Z., Sun,B., Xu,A., Tang,J., Zhang,H., Gao,J. and Wang,L.
  TITLE     MICAL2 implies immunosuppressive features and acts as an
            independent and adverse prognostic biomarker in pancreatic cancer
  JOURNAL   Sci Rep 14 (1), 3177 (2024)
   PUBMED   38326344
  REMARK    GeneRIF: MICAL2 implies immunosuppressive features and acts as an
            independent and adverse prognostic biomarker in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Wang,Q., Qi,C., Min,P., Wang,Y., Ye,F., Xia,T., Zhang,Y. and Du,J.
  TITLE     MICAL2 contributes to gastric cancer cell migration via
            Cdc42-dependent activation of E-cadherin/beta-catenin signaling
            pathway
  JOURNAL   Cell Commun Signal 20 (1), 136 (2022)
   PUBMED   36064550
  REMARK    GeneRIF: MICAL2 contributes to gastric cancer cell migration via
            Cdc42-dependent activation of E-cadherin/beta-catenin signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Qi,C., Min,P., Wang,Q., Wang,Y., Song,Y., Zhang,Y., Bibi,M. and
            Du,J.
  TITLE     MICAL2 Contributes to Gastric Cancer Cell Proliferation by
            Promoting YAP Dephosphorylation and Nuclear Translocation
  JOURNAL   Oxid Med Cell Longev 2021, 9955717 (2021)
   PUBMED   34650666
  REMARK    GeneRIF: MICAL2 Contributes to Gastric Cancer Cell Proliferation by
            Promoting YAP Dephosphorylation and Nuclear Translocation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Galloni,C., Carra,D., Abella,J.V.G., Kjaer,S., Singaravelu,P.,
            Barry,D.J., Kogata,N., Guerin,C., Blanchoin,L. and Way,M.
  TITLE     MICAL2 enhances branched actin network disassembly by oxidizing
            Arp3B-containing Arp2/3 complexes
  JOURNAL   J Cell Biol 220 (8) (2021)
   PUBMED   34106209
  REMARK    GeneRIF: MICAL2 enhances branched actin network disassembly by
            oxidizing Arp3B-containing Arp2/3 complexes.
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Wang,F., Chen,X., Cheng,H., Song,L., Liu,J., Caplan,S., Zhu,L. and
            Wu,J.Y.
  TITLE     MICAL2PV suppresses the formation of tunneling nanotubes and
            modulates mitochondrial trafficking
  JOURNAL   EMBO Rep 22 (7), e52006 (2021)
   PUBMED   34096155
  REMARK    GeneRIF: MICAL2PV suppresses the formation of tunneling nanotubes
            and modulates mitochondrial trafficking.
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Lundquist,M.R., Storaska,A.J., Liu,T.C., Larsen,S.D., Evans,T.,
            Neubig,R.R. and Jaffrey,S.R.
  TITLE     Redox modification of nuclear actin by MICAL-2 regulates SRF
            signaling
  JOURNAL   Cell 156 (3), 563-576 (2014)
   PUBMED   24440334
  REMARK    GeneRIF: These data show that SRF/MRTF-A signaling is regulated by
            MICAL-2-dependent redox regulation of nuclear actin.
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Giridharan,S.S., Rohn,J.L., Naslavsky,N. and Caplan,S.
  TITLE     Differential regulation of actin microfilaments by human MICAL
            proteins
  JOURNAL   J Cell Sci 125 (Pt 3), 614-624 (2012)
   PUBMED   22331357
  REMARK    GeneRIF: although MICAL1 is auto-inhibited by its C-terminal
            coiled-coil region, MICAL2 remains constitutively active and
            affects stress fibers, suggesting differential but complementary
            roles for MICAL1 and MICAL2 in actin microfilament regulation
REFERENCE   8  (bases 1 to 3903)
  AUTHORS   Ashida,S., Furihata,M., Katagiri,T., Tamura,K., Anazawa,Y.,
            Yoshioka,H., Miki,T., Fujioka,T., Shuin,T., Nakamura,Y. and
            Nakagawa,H.
  TITLE     Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer
            variants), increases with high Gleason score and prostate cancer
            progression
  JOURNAL   Clin Cancer Res 12 (9), 2767-2773 (2006)
   PUBMED   16675569
  REMARK    GeneRIF: MICAL2-PV is likely to be involved in cancer progression
            of prostate cancer and could be a candidate as a novel molecular
            marker and/or target for treatment of prostate cancers.
REFERENCE   9  (bases 1 to 3903)
  AUTHORS   Fischer,J., Weide,T. and Barnekow,A.
  TITLE     The MICAL proteins and rab1: a possible link to the cytoskeleton?
  JOURNAL   Biochem Biophys Res Commun 328 (2), 415-423 (2005)
   PUBMED   15694364
REFERENCE   10 (bases 1 to 3903)
  AUTHORS   Terman,J.R., Mao,T., Pasterkamp,R.J., Yu,H.H. and Kolodkin,A.L.
  TITLE     MICALs, a family of conserved flavoprotein oxidoreductases,
            function in plexin-mediated axonal repulsion
  JOURNAL   Cell 109 (7), 887-900 (2002)
   PUBMED   12110185
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA246062.1, AB018293.1 and
            AK294845.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2019 this sequence version replaced NM_001282663.1.
            
            Summary: The protein encoded by this gene is a monooxygenase that
            enhances depolymerization of F-actin and is therefore involved in
            cytoskeletal dynamics. The encoded protein is a regulator of the
            SRF signaling pathway. Increased expression of this gene has been
            associated with cancer progression and metastasis. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 8 all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018293.1, SRR1803617.248573.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683283.1/ ENSP00000507067.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA246062.1         15-35
            22-698              AB018293.1         1-677
            699-699             AK294845.1         533-533
            700-2951            AB018293.1         679-2930
            2952-2952           AK294845.1         2786-2786
            2953-3903           AB018293.1         2932-3882
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..3903
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 2"
                     /db_xref="GeneID:9645"
                     /db_xref="HGNC:HGNC:24693"
                     /db_xref="MIM:608881"
     exon            1..137
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            138..208
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            209..549
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3660
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /EC_number="1.14.13.225"
                     /note="isoform a is encoded by transcript variant 2;
                     flavoprotein oxidoreductase MICAL2; molecule interacting
                     with CasL protein 2; protein-methionine sulfoxide oxidase
                     MICAL2; microtubule associated monoxygenase, calponin and
                     LIM domain containing 2; [F-actin]-methionine sulfoxide
                     oxidase MICAL2; [F-actin]-monooxygenase MICAL2; MICAL
                     C-terminal like; ebitein-1; ERK2-binding testicular
                     protein 1; MICAL C-terminal-like protein"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL2 isoform a"
                     /protein_id="NP_001269592.1"
                     /db_xref="CCDS:CCDS7809.1"
                     /db_xref="GeneID:9645"
                     /db_xref="HGNC:HGNC:24693"
                     /db_xref="MIM:608881"
                     /translation="MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPL
                     DHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTA
                     IELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIR
                     QLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDV
                     IIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQ
                     DLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDN
                     LLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLL
                     VALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
                     TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSV
                     NLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFD
                     SLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGT
                     PLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKG
                     FTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQER
                     RVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSA
                     GSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQ
                     NLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAAS
                     SSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMN
                     DHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCS
                     ICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAP
                     RRDTPTESSCAVAAIGTLEGSPPVHFSLPVLHPLLG"
     exon            550..757
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            758..874
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            875..976
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1132
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1233
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1491
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1607
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1734
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1825
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1973
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2173
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2280
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2349
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2499
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2622
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2841
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2943
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3069
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3132
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3240
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3427
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3516
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3619
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3677
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3903
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /note="hexamer: AATAAA"
     polyA_site      3903
                     /gene="MICAL2"
                     /gene_synonym="Ebitein1; MICAL-2; mical-cL; MICAL2PV1;
                     MICAL2PV2; MICALCL"
                     /note="major polyA site"
ORIGIN      
        1 gctcggctgg ctaagcctgc gccgggccgc ctcgctcgct cccagctctg tcagtggccc
       61 gcggggcccg atcgctgcgc ccgcggccag ggccgaggca ggcctgaccc ggggccgggc
      121 agcccgcgcg actttcggaa catggcaacc cgtgtgtgtc tcatcccaga aagagaagac
      181 tttaaccact gtgatgcctg agaatccagt gtgacgtttc tccagatact tcatgctgtt
      241 cacctgtgtc ctcgccgcac cactgccgca cacgactcct gaaccatggg ggaaaacgag
      301 gatgagaagc aggcccaggc ggggcaggtt tttgagaact ttgtccaggc atccacgtgc
      361 aaaggtaccc tccaggcctt caacattctc acacgacacc tggacctaga ccctctggac
      421 cacagaaact tttattccaa gctcaagtcc aaggtgacca cctggaaagc caaagccctg
      481 tggtacaaat tggataagcg tggttcccac aaagagtata agcgagggaa gtcgtgcacg
      541 aacaccaagt gtctcatagt tgggggagga ccctgtggct tgcgcactgc cattgaactt
      601 gcctacctgg gagccaaagt ggtcgtggtg gagaagaggg actccttctc ccggaacaac
      661 gtgctacacc tctggccttt caccatccat gaccttcgtg gcctgggagc caagaagttc
      721 tatgggaagt tctgtgctgg ctccatcgac catatcagta ttcgccaact acagctcatc
      781 ctattcaagg tggccctgat gctgggagtt gaaatccatg tgaatgtgga gttcgtgaag
      841 gttctagagc ctcctgaaga tcaagaaaat caaaaaattg gctggcgggc agaatttctc
      901 cctacagacc attctctgtc ggagtttgag tttgacgtca tcattggtgc cgatggccgc
      961 aggaacaccc tggaagggtt cagaagaaaa gaattccgtg ggaagctggc gattgccatc
     1021 accgccaact tcataaacag aaacagcaca gcggaagcca aggtggaaga gattagtggt
     1081 gtggctttca tcttcaatca gaaatttttt caggacctta aagaagaaac aggcatagat
     1141 cttgagaaca ttgtttacta caaggactgc acccactatt ttgtaatgac agccaagaag
     1201 cagagcctgc tcgacaaagg tgtcatcatt aacgactaca tcgacacaga gatgctgctg
     1261 tgtgcggaga acgtgaacca agacaacctg ctatcctatg cccgggaagc tgcagacttt
     1321 gccaccaact accagctgcc atccttagac tttgccatga accactatgg gcagcctgat
     1381 gtggccatgt ttgactttac ctgcatgtat gcctcagaga acgcggccct ggtgcgggag
     1441 cggcaggcgc accagctgct cgtggccctt gtgggtgaca gcttgcttga gccattttgg
     1501 cccatgggta caggctgtgc ccgtggcttc ctggcagcct ttgacacggc atggatggtg
     1561 aagagctgga accagggcac ccctcccctg gagctgctgg ctgaaaggga aagtctctac
     1621 cggctgttac ctcagacaac cccggagaac atcaacaaga actttgagca gtacacgttg
     1681 gacccaggga cacggtaccc aaacctcaac tcacactgtg tcaggcccca tcaggtgaag
     1741 catttgtata tcactaagga gctggagcac taccctctcg agagactggg ctcggtgagg
     1801 agatctgtca acctctccag gaaggagtca gatatccggc ccagcaagct cctgacctgg
     1861 tgccagcagc agacagaggg ctaccagcat gtcaacgtca ccgacctgac cacatcctgg
     1921 cgcagtgggt tggccctgtg tgccatcatc caccgcttcc ggcctgagct catcaacttt
     1981 gactctttga atgaagatga tgctgtggag aacaaccagc tcgcatttga tgtggccgag
     2041 cgagagtttg ggatccctcc agtgaccacg ggcaaagaga tggcatctgc ccaggagcct
     2101 gacaagctca gcatggtcat gtacctctcc aagttctacg agctcttccg gggcacccca
     2161 ctgaggcccg tggattcttg gcgcaaaaac tatggagaaa atgctgacct cagcttggcc
     2221 aaatcatcca tttctaataa ctatctcaac ctcacatttc caaggaagag gactccacgg
     2281 gtggatggtc aaaccggaga gaatgacatg aacaaacgga gacggaaggg cttcaccaac
     2341 ctggacgagc cttcaaactt ttccagccgt agcttgggct ccaatcaaga gtgtgggagc
     2401 agtaaggaag gtggaaatca gaacaaagtc aagtccatgg cgaatcagct gctggccaag
     2461 tttgaggaga gcactcggaa cccctcactc atgaagcagg aacgccgtgt ctcagggata
     2521 ggtaagccgg tcctgtgctc ttcctccggc cctcctgttc actcttgctg ccccaagccg
     2581 gaggaggcca cacccagccc atcacctcct ctgaaaaggc agttcccctc tgtggtcgtg
     2641 acggggcacg tgctcagaga gctcaagcaa gtgtctgctg gcagtgagtg cctgagcaga
     2701 ccttggagag ccagagccaa gtctgaccta cagctgggtg ggacagaaaa tttcgctacc
     2761 ctgccttcta cccgcccgag ggcgcaggct ctttccgggg tgctgtggcg gctgcagcaa
     2821 gtggaggaaa agattctcca gaagagggct cagaacttgg ccaacaggga atttcacaca
     2881 aagaacatta aggagaaggc ggctcacctt gcctccatgt ttggacacgg ggatttcccg
     2941 cagaataaac tactctctaa aggcctgtct catactcatc ctccatctcc tccctctcgc
     3001 cttccgtctc ctgatccagc tgcttcttcc tctccatcaa ctgttgactc tgcttctcct
     3061 gccagaaagg aaaagaagtc accttcaggg ttccattttc atcccagcca tttgagaaca
     3121 gtgcatcctc agctgacggt agggaaagtg tccagcggaa taggggctgc agctgaagtc
     3181 ctggtcaatc tgtacatgaa tgatcacaga cctaaggccc aggccacctc tccagacctg
     3241 gaatctatgc gaaagtcatt tccccttaac ctgggaggca gcgacacgtg ttacttctgt
     3301 aagaaacgtg tgtacgtgat ggaacggctg agcgccgagg gccacttctt ccaccgggag
     3361 tgtttccgct gcagcatctg tgccaccacc ttgcgcctgg ccgcctacac ctttgactgc
     3421 gatgaaggca aattttactg caagcctcac ttcattcact gtaaaaccaa tagcaaacaa
     3481 cggaagagac gggcagagtt gaagcaacaa agagaggagg aggcaacatg gcaagagcag
     3541 gaagcccctc ggagagacac tcccaccgaa agttcttgcg cagtggccgc cattggcacc
     3601 ctggaaggca gccccccagt tcatttcagc cttccagtgc tacacccact tcttggctga
     3661 cacacttctg ctctaagagt ctccctccct ttatagaatg tcaaccaaag agtgccctcc
     3721 tcccctctca gcctcctctt tagctagcct ccccatctca tcacaacgca tgtctgtgac
     3781 ctttggtaat catttacagt gccacacgga accctgtatt ttgcacacag caaaacaaac
     3841 aatgtttagc tttatttatg gtatttgatg ctgtaaatgg aaataaatat tgttctttat
     3901 aaa
//
