LOCUS       NM_022765               3430 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens microtubule associated monooxygenase, calponin and LIM
            domain containing 1 (MICAL1), transcript variant 1, mRNA.
ACCESSION   NM_022765
VERSION     NM_022765.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Ye,F., Xia,T., Zhao,M., Zhao,W., Min,P., Wang,Y., Wang,Q., Zhang,Y.
            and Du,J.
  TITLE     PlexinA1 promotes gastric cancer migration through preventing
            MICAL1 protein ubiquitin/proteasome-mediated degradation in a
            Rac1-dependent manner
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167124 (2024)
   PUBMED   38508474
  REMARK    GeneRIF: PlexinA1 promotes gastric cancer migration through
            preventing MICAL1 protein ubiquitin/proteasome-mediated degradation
            in a Rac1-dependent manner.
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Yang,Y., Ye,F., Xia,T., Wang,Q. and Du,J.
  TITLE     High MICAL1 expression correlates with cancer progression and
            immune infiltration in renal clear cell carcinoma
  JOURNAL   BMC Cancer 22 (1), 1355 (2022)
   PUBMED   36575439
  REMARK    GeneRIF: High MICAL1 expression correlates with cancer progression
            and immune infiltration in renal clear cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Haikazian,S. and Olson,M.F.
  TITLE     MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal
            Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer
  JOURNAL   Genes (Basel) 13 (5), 715 (2022)
   PUBMED   35627100
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Prifti,E., Tsakiri,E.N., Vourkou,E., Stamatakis,G., Samiotaki,M.,
            Skoulakis,E.M.C. and Papanikolopoulou,K.
  TITLE     Mical modulates Tau toxicity via cysteine oxidation in vivo
  JOURNAL   Acta Neuropathol Commun 10 (1), 44 (2022)
   PUBMED   35379354
  REMARK    GeneRIF: Mical modulates Tau toxicity via cysteine oxidation in
            vivo.
            Erratum:[Acta Neuropathol Commun. 2022 Apr 25;10(1):63. doi:
            10.1186/s40478-022-01369-w.. PMID: 35468811]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Pasterkamp,R.J., Dai,H.N., Terman,J.R., Wahlin,K.J., Kim,B.,
            Bregman,B.S., Popovich,P.G. and Kolodkin,A.L.
  TITLE     MICAL flavoprotein monooxygenases: expression during neural
            development and following spinal cord injuries in the rat
  JOURNAL   Mol Cell Neurosci 31 (1), 52-69 (2006)
   PUBMED   16230022
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Fischer,J., Weide,T. and Barnekow,A.
  TITLE     The MICAL proteins and rab1: a possible link to the cytoskeleton?
  JOURNAL   Biochem Biophys Res Commun 328 (2), 415-423 (2005)
   PUBMED   15694364
REFERENCE   7  (bases 1 to 3430)
  AUTHORS   Weide,T., Teuber,J., Bayer,M. and Barnekow,A.
  TITLE     MICAL-1 isoforms, novel rab1 interacting proteins
  JOURNAL   Biochem Biophys Res Commun 306 (1), 79-86 (2003)
   PUBMED   12788069
  REMARK    GeneRIF: MICAL-1 isoforms with their multidomain structure are
            novel rab1 interacting proteins that function as scaffold proteins
            connecting different components in the cell.
REFERENCE   8  (bases 1 to 3430)
  AUTHORS   Terman,J.R., Mao,T., Pasterkamp,R.J., Yu,H.H. and Kolodkin,A.L.
  TITLE     MICALs, a family of conserved flavoprotein oxidoreductases,
            function in plexin-mediated axonal repulsion
  JOURNAL   Cell 109 (7), 887-900 (2002)
   PUBMED   12110185
REFERENCE   9  (bases 1 to 3430)
  AUTHORS   Suzuki,T., Nakamoto,T., Ogawa,S., Seo,S., Matsumura,T.,
            Tachibana,K., Morimoto,C. and Hirai,H.
  TITLE     MICAL, a novel CasL interacting molecule, associates with vimentin
  JOURNAL   J Biol Chem 277 (17), 14933-14941 (2002)
   PUBMED   11827972
  REMARK    GeneRIF: a CasL interacting molecule that associates with vimentin
REFERENCE   10 (bases 1 to 3430)
  AUTHORS   Michelucci,R., Pasini,E. and Dazzo,E.
  TITLE     Autosomal Dominant Epilepsy with Auditory Features
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC042144.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022765.3.
            
            Summary: This gene encodes an enzyme that oxidizes methionine
            residues on actin, thereby promoting depolymerization of actin
            filaments. This protein interacts with and regulates signalling by
            NEDD9/CAS-L (neural precursor cell expressed, developmentally
            down-regulated 9). Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) contains an alternate 5' exon
            and thus differs in its 5' UTR and initiates translation at a
            downstream in-frame start codon, compared to variant 3. The encoded
            isoform (1, also known as MICAL-1a) is shorter at the N-terminus,
            compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042144.1, AB048948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358807.8/ ENSP00000351664.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3430              BC042144.1         112-3541
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3430
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /note="microtubule associated monooxygenase, calponin and
                     LIM domain containing 1"
                     /db_xref="GeneID:64780"
                     /db_xref="HGNC:HGNC:20619"
                     /db_xref="MIM:607129"
     exon            1..54
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            55..355
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3301
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /EC_number="1.6.3.1"
                     /EC_number="1.14.13.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NEDD9-interacting protein with calponin homology and LIM
                     domains; molecule interacting with CasL protein 1;
                     protein-methionine sulfoxide oxidase MICAL1;
                     [F-actin]-methionine sulfoxide oxidase MICAL1;
                     [F-actin]-monooxygenase MICAL1"
                     /codon_start=1
                     /product="[F-actin]-monooxygenase MICAL1 isoform 1"
                     /protein_id="NP_073602.3"
                     /db_xref="CCDS:CCDS5076.1"
                     /db_xref="GeneID:64780"
                     /db_xref="HGNC:HGNC:20619"
                     /db_xref="MIM:607129"
                     /translation="MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGG
                     LPQYHKIKDQLNYWSAKSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVE
                     LALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQL
                     QLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAA
                     GGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKA
                     TGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFT
                     RAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGARLLLGLVG
                     DCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPEN
                     MHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSA
                     GTQEELLRWCQEQTAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGAL
                     EATAWALKVAENELGITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKSMAHSPGPVSQA
                     SPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPDPEPGVPL
                     TPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHP
                     GDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDP
                     SQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPV
                     QSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTSGTMNNYPTWRRTLL
                     RRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVG
                     QLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAE
                     DQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG"
     exon            356..563
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            564..668
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            669..773
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            774..929
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1030
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1288
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1404
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1531
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1613
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1761
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1952
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2041
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2083
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2167
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2324
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2401
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2678
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2770
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2884
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2978
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3078
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3152
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3430
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3409..3414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /note="hexamer: ATTAAA"
     polyA_site      3430
                     /gene="MICAL1"
                     /gene_synonym="MICAL; MICAL-1; NICAL"
                     /note="major polyA site"
ORIGIN      
        1 agacctggtt gccagcccaa caggaagcgg cccctcccgg cttcggagcc gccgccactc
       61 atctctgccc agctgctgcc ctccccagga ggcctccatg gcttcaccta cctccaccaa
      121 cccagcgcat gcccactttg agagcttcct gcaggcccag ctgtgccagg acgtgctgag
      181 cagcttccag gagctgtgtg gggccctggg gctggaaccc ggtggggggc tgccccagta
      241 ccacaagatc aaggaccagc tcaactactg gagcgccaag tcactgtgga ccaagctgga
      301 caagcgagca ggccagcctg tctaccagca gggccgggcc tgcaccagca ccaagtgcct
      361 ggtggtgggt gctggacctt gcgggctgcg ggtcgctgtg gagctggcgc tgctgggggc
      421 ccgagtggtg ctggtggaaa agcgcaccaa gttctctcgc cacaacgtgc tccacctctg
      481 gcccttcacc atccacgacc tgcgggcact cggtgctaag aagttctacg ggcgcttctg
      541 caccggcacc ctggaccaca tcagcatcag gcagctccag ctgcttctgc tgaaggtagc
      601 attgctgctg ggggtggaaa ttcactgggg tgtcactttc actggcctcc agccccctcc
      661 taggaagggg agtggctggc gtgcccagct ccaacccaac ccccctgccc agctggccaa
      721 ctatgaattt gacgtcctta tctcggctgc aggaggtaaa ttcgtccctg aaggcttcaa
      781 agttcgagaa atgcgaggca aactggccat tggcatcaca gccaactttg tgaatggacg
      841 caccgtggag gagacacagg tgccggagat cagtggtgta gccaggatct acaaccagag
      901 cttcttccag agccttctca aagccacagg cattgatctg gagaacattg tgtactacaa
      961 ggacgacacc cactactttg tgatgacagc caagaagcag tgcctgctgc ggctgggggt
     1021 gctgcgccag gactggccag acaccaatcg gctgctgggc agtgccaatg tggtgcccga
     1081 ggctctgcag cgctttaccc gggcagctgc tgactttgcc acccatggca agctcgggaa
     1141 actagagttt gcccaggatg cccatgggca gcctgatgtc tctgcctttg acttcacgag
     1201 catgatgcgg gcagagagtt ctgctcgtgt gcaagagaag catggcgccc gcctgctgct
     1261 gggactggtg ggggactgcc tggtggagcc cttctggccc ctgggcactg gagtggcacg
     1321 gggcttcctg gcagcctttg atgcagcctg gatggtgaag cggtgggcag agggcgctga
     1381 gtccctagag gtgttggctg agcgtgagag cctgtaccag cttctgtcac agacatcccc
     1441 agaaaacatg catcgcaatg tggcccagta tgggctggac ccagccaccc gctaccccaa
     1501 cctgaacctc cgggcagtga cccccaatca ggtacgagac ctgtatgatg tgctagccaa
     1561 ggagcctgtg cagaggaaca acgacaagac agatacaggg atgccagcca ccgggtcggc
     1621 aggcacccag gaggagctgc tacgctggtg ccaggagcag acagctgggt acccgggagt
     1681 ccacgtctcc gatttgtctt cctcctgggc tgatgggcta gctctgtgtg ccctggtgta
     1741 ccggctgcag cctggcctgc tggaaccctc agagctgcag gggctgggag ctctggaagc
     1801 aactgcttgg gcactaaagg tggcagagaa tgagctgggc atcacaccgg tggtgtctgc
     1861 acaggccgtg gtagcaggga gtgacccact gggcctcatt gcctacctca gccacttcca
     1921 cagtgccttc aagagcatgg cccacagccc aggccctgtc agccaggcct ccccagggac
     1981 ctccagtgct gtattattcc ttagtaaact tcagaggacc ctgcagcgat cccgggccaa
     2041 ggaaaatgca gaggatgctg gtggcaagaa gctgcgcttg gagatggagg ccgagacccc
     2101 aagtactgag gtgccacctg acccagagcc tggtgtaccc ctgacacccc catcccaaca
     2161 ccaggaggcc ggtgctgggg acctgtgtgc actttgtggg gaacacctct atgtcctgga
     2221 acgcctctgt gtcaacggcc atttcttcca ccggagctgc ttccgctgcc atacctgtga
     2281 ggccacactg tggccaggtg gctacgagca gcacccagga gatggacatt tctactgcct
     2341 ccagcacctg ccccagacag accacaaagc ggaaggcagc gatagaggcc ctgagagtcc
     2401 ggagctcccc acaccaagtg agaatagcat gccaccaggc ctctcaactc ccacagcctc
     2461 gcaggagggg gccggtcctg ttccagatcc cagccagccc acccgtcggc agatccgcct
     2521 ctccagcccg gagcgccagc ggttgtcctc ccttaacctt acccctgacc cggaaatgga
     2581 gcctccaccc aagcctcccc gcagctgctc cgccttggcc cgccacgccc tggagagcag
     2641 ctttgtgggc tggggcctgc cagtccagag ccctcaagct cttgtggcca tggagaagga
     2701 ggaaaaagag agtcccttct ccagtgaaga ggaagaagaa gatgtgcctt tggactcaga
     2761 tgtggaacag gccctgcaga cctttgccaa gacctcaggc accatgaata actacccaac
     2821 atggcgtcgg actctgctgc gccgtgcgaa ggaggaggag atgaagaggt tctgcaaggc
     2881 ccagaccatc caacggcgac taaatgagat tgaggctgcc ttgagggagc tagaggccga
     2941 gggcgtgaag ctggagctgg ccttgaggcg ccagagcagt tccccagaac agcaaaagaa
     3001 actatgggta ggacagctgc tacagctcgt tgacaagaaa aacagcctgg tggctgagga
     3061 ggccgagctc atgatcacgg tgcaggaatt gaatctggag gagaaacagt ggcagctgga
     3121 ccaggagcta cgaggctaca tgaaccggga agaaaaccta aagacagctg ctgatcggca
     3181 ggctgaggac caggtcctga ggaagctggt ggatttggtc aaccagagag atgccctcat
     3241 ccgcttccag gaggagcgca ggctcagcga gctggccttg gggacagggg cccagggcta
     3301 gacgagggtg ggccgtctgc tttcgttccc acaaagaaag cacctcaccc cagcacagtg
     3361 ccacccctgt tcatctgggc tgcctggcag agagccttgc tgtttacaat taaaatgttt
     3421 ctgccacaaa
//
