LOCUS       NM_001177519            1370 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MHC class I polypeptide-related sequence A (MICA),
            transcript variant 1*00801, mRNA.
ACCESSION   NM_001177519
VERSION     NM_001177519.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Phanabamrung,S., Jumnainsong,A., Anuwongcharoen,N.,
            Phanus-Umporn,C., Rareongjai,S. and Leelayuwat,C.
  TITLE     Expression and function of the major histocompatibility complex
            (MHC) class I chain-related A (MICA)*010 in NK cell killing
            activity
  JOURNAL   Hum Immunol 85 (5), 111085 (2024)
   PUBMED   39116667
  REMARK    GeneRIF: Expression and function of the major histocompatibility
            complex (MHC) class I chain-related A (MICA)*010 in NK cell killing
            activity.
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Ivanova,M. and Shivarov,V.
  TITLE     Characterisation of the novel MICA*112:02 allele by next generation
            sequencing
  JOURNAL   HLA 103 (6), e15583 (2024)
   PUBMED   38923360
  REMARK    GeneRIF: Characterisation of the novel MICA*112:02 allele by next
            generation sequencing.
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Wang,C.M., Tan,K.P., Wu,Y.J., Zheng,J.W., Wu,J. and Chen,J.Y.
  TITLE     Functional MICA Variants Are Differentially Associated with
            Immune-Mediated Inflammatory Diseases
  JOURNAL   Int J Mol Sci 25 (5), 3036 (2024)
   PUBMED   38474281
  REMARK    GeneRIF: Functional MICA Variants Are Differentially Associated
            with Immune-Mediated Inflammatory Diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1370)
  AUTHORS   Jinushi,M., Vanneman,M., Munshi,N.C., Tai,Y.T., Prabhala,R.H.,
            Ritz,J., Neuberg,D., Anderson,K.C., Carrasco,D.R. and Dranoff,G.
  TITLE     MHC class I chain-related protein A antibodies and shedding are
            associated with the progression of multiple myeloma
  JOURNAL   Proc Natl Acad Sci U S A 105 (4), 1285-1290 (2008)
   PUBMED   18202175
  REMARK    GeneRIF: Multiple myeloma patients harbor circulating MHC class I
            chain-related protein A (MICA), which triggers the down-regulation
            of NK cell receptor D (NKG2D) and impaired lymphocyte cytotoxicity.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2410959121.
            doi: 10.1073/pnas.2410959121.. PMID: 38968129]
REFERENCE   5  (bases 1 to 1370)
  AUTHORS   Gonzalez,S., Martinez-Borra,J., Lopez-Vazquez,A.,
            Garcia-Fernandez,S., Torre-Alonso,J.C. and Lopez-Larrea,C.
  TITLE     MICA rather than MICB, TNFA, or HLA-DRB1 is associated with
            susceptibility to psoriatic arthritis
  JOURNAL   J Rheumatol 29 (5), 973-978 (2002)
   PUBMED   12022360
  REMARK    GeneRIF: MICA is associated with susceptibility to psoriatic
            arthritis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1370)
  AUTHORS   Stephens,H.A.
  TITLE     MICA and MICB genes: can the enigma of their polymorphism be
            resolved?
  JOURNAL   Trends Immunol 22 (7), 378-385 (2001)
   PUBMED   11429322
  REMARK    Review article
REFERENCE   7  (bases 1 to 1370)
  AUTHORS   Fodil,N., Laloux,L., Wanner,V., Pellet,P., Hauptmann,G., Mizuki,N.,
            Inoko,H., Spies,T., Theodorou,I. and Bahram,S.
  TITLE     Allelic repertoire of the human MHC class I MICA gene
  JOURNAL   Immunogenetics 44 (5), 351-357 (1996)
   PUBMED   8781120
REFERENCE   8  (bases 1 to 1370)
  AUTHORS   Bahram,S., Mizuki,N., Inoko,H. and Spies,T.
  TITLE     Nucleotide sequence of the human MHC class I MICA gene
  JOURNAL   Immunogenetics 44 (1), 80-81 (1996)
   PUBMED   8613147
REFERENCE   9  (bases 1 to 1370)
  AUTHORS   Leelayuwat,C., Townend,D.C., Degli-Esposti,M.A., Abraham,L.J. and
            Dawkins,R.L.
  TITLE     A new polymorphic and multicopy MHC gene family related to
            nonmammalian class I
  JOURNAL   Immunogenetics 40 (5), 339-351 (1994)
   PUBMED   7927538
  REMARK    Erratum:[Immunogenetics 1995;41(2-3):174]
REFERENCE   10 (bases 1 to 1370)
  AUTHORS   Parham,P., Lawlor,D.A., Lomen,C.E. and Ennis,P.D.
  TITLE     Diversity and diversification of HLA-A,B,C alleles
  JOURNAL   J Immunol 142 (11), 3937-3950 (1989)
   PUBMED   2715640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN483948.1, BX342160.2,
            AK299135.1 and BM991681.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 3, 2018 this sequence version replaced NM_001177519.2.
            
            Summary: This gene encodes the highly polymorphic major
            histocompatability complex class I chain-related protein A. The
            protein product is expressed on the cell surface, although unlike
            canonical class I molecules it does not seem to associate with
            beta-2-microglobulin. It is a ligand for the NKG2-D type II
            integral membrane protein receptor. The protein functions as a
            stress-induced antigen that is broadly recognized by intestinal
            epithelial gamma delta T cells. Variations in this gene have been
            associated with susceptibility to psoriasis 1 and psoriatic
            arthritis, and the shedding of MICA-related antibodies and ligands
            is involved in the progression from monoclonal gammopathy of
            undetermined significance to multiple myeloma. Alternative splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1*00801, also known as 1) is
            derived from the MICA*00801 allele. It contains a 4 nt insertion
            (rs9279200) that results in a frameshift and truncation of the CDS,
            compared to variant 1 (allele MICA*001). The resulting isoform (2)
            has a shorter and distinct C-terminus, compared to isoform 1. The
            MICA*00801 allele is found in the primary, ALT_REF_LOCI_2 and
            ALT_REF_LOCI_7 assembly units of the GRCh38 reference genome
            sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299135.1, AK225393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449934.7/ ENSP00000413079.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CN483948.1         45-58
            15-59               BX342160.2         1-45
            60-1365             AK299135.1         60-1365
            1366-1370           BM991681.1         17-21               c
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1370
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /note="MHC class I polypeptide-related sequence A"
                     /db_xref="GeneID:100507436"
                     /db_xref="HGNC:HGNC:7090"
                     /db_xref="IMGT/GENE-DB:MICA"
                     /db_xref="MIM:600169"
     exon            1..108
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1037
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /note="isoform 2 (MICA*00801) precursor is encoded by
                     transcript variant 1*00801; stress inducible class I
                     homolog; HLA class I antigen; MHC class I chain-related
                     protein A; MHC class I related sequence A; MHC class I
                     related chain A; major histocompatibility complex class I
                     chain-related protein A"
                     /codon_start=1
                     /product="MHC class I polypeptide-related sequence A
                     isoform 2 (MICA*00801) precursor"
                     /protein_id="NP_001170990.1"
                     /db_xref="CCDS:CCDS56412.1"
                     /db_xref="GeneID:100507436"
                     /db_xref="HGNC:HGNC:7090"
                     /db_xref="IMGT/GENE-DB:MICA"
                     /db_xref="MIM:600169"
                     /translation="MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSG
                     FLAEVHLDGQPFLRYDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAH
                     IKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETEEWTVPQSSRAQT
                     LAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLESGVVLRRTVPPMVNVTRSEASE
                     GNITVTCRASSFYPRNIILTWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICRGE
                     EQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAGCCYFCYYYFLCPLL"
     exon            109..363
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..651
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..930
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1066
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1370
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /note="hexamer: AATAAA"
     polyA_site      1314
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
     polyA_site      1370
                     /gene="MICA"
                     /gene_synonym="MIC-A; PERB11.1"
                     /note="major polyA site"
ORIGIN      
        1 actgcttgag ccgctgagag ggtggcgacg tcggggccat ggggctgggc ccggtctttc
       61 tgcttctggc tggcatcttc ccttttgcac ctccgggagc tgctgctgag ccccacagtc
      121 ttcgttataa cctcacggtg ctgtcctggg atggatctgt gcagtcaggg tttcttgctg
      181 aggtacatct ggatggtcag cccttcctgc gctatgacag gcagaaatgc agggcaaagc
      241 cccagggaca gtgggcagaa gatgtcctgg gaaataagac atgggacaga gagaccaggg
      301 acttgacagg gaacggaaag gacctcagga tgaccctggc tcatatcaag gaccagaaag
      361 aaggcttgca ttccctccag gagattaggg tctgtgagat ccatgaagac aacagcacca
      421 ggagctccca gcatttctac tacgatgggg agctcttcct ctcccaaaac ctggagactg
      481 aggaatggac agtgccccag tcctccagag ctcagacctt ggccatgaac gtcaggaatt
      541 tcttgaagga agatgccatg aagaccaaga cacactatca cgctatgcat gcagactgcc
      601 tgcaggaact acggcgatat ctagaatccg gcgtagtcct gaggagaaca gtgcccccca
      661 tggtgaatgt cacccgcagc gaggcctcag agggcaacat caccgtgaca tgcagggctt
      721 ccagcttcta tccccggaat atcatactga cctggcgtca ggatggggta tctttgagcc
      781 acgacaccca gcagtggggg gatgtcctgc ctgatgggaa tggaacctac cagacctggg
      841 tggccaccag gatttgccga ggagaggagc agaggttcac ctgctacatg gaacacagcg
      901 ggaatcacag cactcaccct gtgccctctg ggaaagtgct ggtgcttcag agtcattggc
      961 agacattcca tgtttctgct gttgctgctg gctgctgcta tttttgttat tattattttc
     1021 tatgtccgtt gttgtaagaa gaaaacatca gctgcagagg gtccagagct cgtgagcctg
     1081 caggtcctgg atcaacaccc agttgggacg agtgaccaca gggatgccac acagctcgga
     1141 tttcagcctc tgatgtcagc tcttgggtcc actggctcca ctgagggcac ctagactcta
     1201 cagccaggcg gctggaattg aattccctgc ctggatctca caagcacttt ccctcttggt
     1261 gcctcagttt cctgacctat gaaacagaga aaataaaagc acttatttat tgttgttgga
     1321 ggctgcaaaa tgttagtaga tatgaggcat ttgcagctgt gccatattaa
//
