LOCUS       XM_047437676            9287 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens MIB E3 ubiquitin protein ligase 1 (MIB1),
            transcript variant X1, mRNA.
ACCESSION   XM_047437676
VERSION     XM_047437676.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000018.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
     gene            1..9287
                     /gene="MIB1"
                     /gene_synonym="DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6"
                     /note="MIB E3 ubiquitin protein ligase 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 6 mRNAs, 23 ESTs, 2507 long SRA reads, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 15 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:57534"
                     /db_xref="HGNC:HGNC:21086"
                     /db_xref="MIM:608677"
     CDS             229..3000
                     /gene="MIB1"
                     /gene_synonym="DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MIB1 isoform X1"
                     /protein_id="XP_047293632.1"
                     /db_xref="GeneID:57534"
                     /db_xref="HGNC:HGNC:21086"
                     /db_xref="MIM:608677"
                     /translation="MCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRI
                     TTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWS
                     ASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNP
                     GGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSG
                     NRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWA
                     EAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQ
                     LLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNG
                     HVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTP
                     LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTI
                     TNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE
                     LLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEAL
                     RHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGAD
                     LSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCS
                     DMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPC
                     GHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKD
                     NTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRK
                     AIERRILLY"
ORIGIN      
        1 agaagcgcgg ttccaagacc ggccaccggg agggcgggcg gactgggttc tcccagctag
       61 gtcgcagtgg gcgatgggga tccccaaggg tgggccgaga gctgacggat cggcagcgct
      121 ggttaaggcc ccgcacctgc agccccagtg accttgaacg attccgctct gcggcgggtg
      181 tccctaaact agcagtttag ggtgtcaggc atcaagcatg atggaaccat gtgtgatacc
      241 tgccgccagc aaccaatcat tggcattcga tggaagtgtg cagagtgtac aaattatgat
      301 ttgtgcacag tgtgttatca tggagataaa catcatttaa gacatcgctt ttaccgaatt
      361 actacaccgg gaagtgagag ggttctgtta gagtctcgta ggaaatctaa gaagattaca
      421 gccagaggaa tctttgcagg tgccagagtg gtgcgaggag tggactggca gtgggaagat
      481 caagatggag gaaatggacg taggggaaag gtaacagaaa tccaggactg gagtgcatca
      541 agcccacata gcgcagcata tgtcctctgg gataatggtg ctaagaacct ttacagagtt
      601 ggctttgagg gcatgtctga tctgaaatgt gtccaggatg ccaagggagg ttctttctac
      661 agagatcact gccctgtgct aggtgagcag aatggcaaca ggaatcctgg tggattgcag
      721 attggtgacc tggtaaatat agatctcgac ctcgaaattg tacagtcttt gcagcatggt
      781 catggaggat ggactgatgg aatgtttgag actttaacta caactggaac tgtttgtggc
      841 attgatgaag atcatgacat tgtagtacag tatccaagtg gcaataggtg gaccttcaat
      901 cctgctgttc tcactaaagc gaacattgtc cgaagtggag atgctgctca gggtgcagaa
      961 ggaggcacct cgcagtttca agtgggtgat cttgtacaag tttgttatga cctggaacga
     1021 attaaacttc tacaaagagg acatggagaa tgggctgaag cgatgcttcc aactttaggt
     1081 aaagttggcc gagtacaaca gatttattca gacagtgatt taaaggtgga agtttgtgga
     1141 acatcttgga catacaatcc agcagcagtt tccaaggtgg catctgcagg atcagccatt
     1201 agcaatgcat ctggtgaaag actctcacaa ctcctgaaga aattatttga aacccaagaa
     1261 tctggtgacc tcaatgaaga attagttaag gctgctgcca atggagatgt tgctaaagtg
     1321 gaagatttgc ttaaaagacc agatgtggat gtaaatgggc aatgtgctgg ccacacagct
     1381 atgcaagctg ctagtcagaa tggacatgtt gacattttga agttactttt gaagcaaaac
     1441 gtggatgtcg aagcagagga taaagatggt gatagagcag ttcaccatgc agcttttgga
     1501 gatgaaggcg ctgttataga agtactacat cgaggtagtg ctgatttgaa tgctcgaaac
     1561 aagcgccgac agacaccact tcatattgct gtcaataaag gtcatcttca agttgtgaag
     1621 actttattgg actttggctg tcatcccagt ctccaggatt ctgaaggtga tacccctctt
     1681 catgatgcaa taagtaagaa acgtgatgat atcctagcag ttcttttgga agctggagca
     1741 gatgttacca tcacaaacaa taatggattt aatgctctgc atcatgctgc actaagggga
     1801 aatcccagtg caatgcgtgt tttactatct aaattaccaa gaccatggat tgtggatgag
     1861 aagaaagatg atggttatac tgccttacat ctggctgccc ttaataatca cgtagaagtg
     1921 gctgaactgt tggtacatca gggtaatgca aacctggata tccagaatgt gaaccaacaa
     1981 actgccctac accttgctgt tgaacgacag catacccaga ttgttaggct tttggtccgt
     2041 gcaggtgcca agcttgatat tcaggataag gatggggata ctcctttgca tgaagctcta
     2101 aggcatcaca ctttgtctca gctacgtcag ctccaagata tgcaagatgt ggggaaggtg
     2161 gatgctgcct gggagccatc caaaaacacg ttaataatgg gacttggtac ccagggggca
     2221 gagaagaaga gtgcagcatc tattgcctgt ttcttggcag ccaatggtgc tgacctgagc
     2281 attcgaaata agaagggtca atcgccactt gatctctgtc ctgatccgaa tctctgcaaa
     2341 gcactggcaa agtgtcataa ggaaaaagtc agtggtcaag tgggttctcg gagtccttct
     2401 atgattagta atgattctga aaccttagaa gagtgtatgg tgtgctcaga tatgaagaga
     2461 gatactcttt ttggtccatg tggacatatt gctacctgtt ctttatgttc tccacgtgtc
     2521 aagaaatgcc tcatctgtaa agaacaggtt caatccagga caaagattga agaatgtgtg
     2581 gtatgctctg acaagaaagc agctgttctt tttcaaccct gtggccacat gtgtgcttgt
     2641 gagaactgtg ctaacctgat gaaaaagtgt gtgcagtgtc gagcagtagt tgaacgaaga
     2701 gtgcctttca ttatgtgctg tggagggaaa agttcagaag atgccactga tgatatctca
     2761 agtgggaata ttccagtatt acaaaaggac aaggataata ccaatgtcaa tgcagatgtg
     2821 caaaagttgc agcaacagtt acaagacatt aaagagcaga caatgtgccc tgtgtgtcta
     2881 gatcgtctga agaatatgat tttcctttgt ggtcacggaa cctgtcaact ctgtggagac
     2941 cgcatgagtg aatgtcctat ctgtcgcaag gctattgaac gaaggattct tttgtattaa
     3001 ctaagacaca tggtgtattt tgttagctaa tgtatctagt catgagatct taataggctt
     3061 ttgatctagt tggaagttct gatgagttaa tttctaatat catagtttct ttactagagt
     3121 ataattgggc tgtaaatgta ccagaacaaa aaaccctaca aaatggtgtt ggaaattgtg
     3181 ttttttgttt ttgttttaaa tttgaaacat caaattcatg taactcatag gataatttac
     3241 ctttggcttc taagaggaaa gtcctttaag gatatccttt tttaaaaaat tgcatttttc
     3301 tcttataatt tgtaaatttg ttggatctca aaagacataa ttctttgtga tcagttatcc
     3361 ttcatttcat cgtggtttta cacagtgagt tgataacagg ttctctgaga agtcatgcat
     3421 caaataaaag aggcaggtca aacaattatg tcacatggta aattataaaa tgacagtaca
     3481 agttccagat agttaaggga ataccgaagg gatgattctt tttttaagat aacaggaagt
     3541 tacccacatg tttgtttctg aattcttaga gtaaatggaa gcatagaatg agggaataat
     3601 gactttgcat ttctcttgtt ttctagattc aaaaggaaca ttgtttaact tgaatcagat
     3661 taccagtttc aaggtgactg atagacaaga aaaggaaaaa taagcaataa tagtgggcaa
     3721 ctgaagagaa aaaaaaaacg agtatctatt aactggccac taacagttgc ctttcttaca
     3781 ttaatttata cactattttg ttcagccagt gtttttaaaa aaaatctatg aaaagtgtac
     3841 ttccggtttt ctgtgattac ttatctgggc ttgatctgac cagtgaaatg acattgccct
     3901 atttggacct ctgaggttct atttagcttt gcagatgtac atagtatccc agtgatctgc
     3961 aaaattaatg ccttttccaa gaaaaaatct tttcttctct gtatcagtta attctgacag
     4021 tgttagtgat tctgtcttca ttataggcct tatttccatt atctctttct ttatagtatt
     4081 ttttgttata aagaaaacag tctttctgtg tatacctacg gatgagggta ttatttaaac
     4141 tgccaacaat atccaagaca tggtcaataa cctaattata aatactttag aaagagtgac
     4201 caggacatgt atagaaatgt ctgcttacct gtagacttta aaaacaaaca aaatttttgg
     4261 agcatttaat catttttttt ctccttttat ctcctttgta atcttattgt ctcctgagta
     4321 aatatacaca taaatgtttg gggattcatt gctgctagat tatatcaggt gtttacatag
     4381 tgtctactat atgctgttga taagcttttt cctaaaaata gttatcctct tttgtagttt
     4441 ttttccctcc tttaaatctg gctagctttt cttacttcag tttttataga acaccaacta
     4501 aatttgaaag tatgaagtct ctagccctct tacactgttt ctggctgttt aatccttgct
     4561 gcctttgcaa gtcctggtga aagcaatggg gagctttgct ggctggtttt gtagtctcaa
     4621 caattccatg tctgtgttta gctgagtaac tgctatcatt tagaacagta aaatttttat
     4681 agatttcaaa tttgaaaatt catgtacact cagttatcta ataaggggcc accgacgctg
     4741 tttttaaaac tattttgaag ttataaaaag gtagaacatc tgactgatga tgttcacata
     4801 aagagacaga cagactatca tgttgcagac atgaaaacag catgtcaggt ttttcctttc
     4861 cttccatgcc atgggctacc catctcttcc cactagatca cctggtgagg agggagcacc
     4921 tggctgactc atgcagagtt tggccaatca gagaattgtg tggtctccag ctctactttc
     4981 cttaaacaaa tcctttctgt tttctgagct gcagtgctaa aacagatccc taaaaggtaa
     5041 tagcatcttc cagactagtt taattatttc ctttataaga atatgacata aatttttatt
     5101 atagaaataa tgtcattata attttagtgc tagtacttgt gggttttctg tatttgtatc
     5161 accttgaaat ttgttccatg aatagaaaat acttctttat tcatgttttc aatcacttag
     5221 aattatttta aatttatttt gggtttgtga gagataataa gattaagaac ttcatcattt
     5281 cagtgacttt cctccaactc tctgaatctg ctacctctta ttatatgtcc cttagcagta
     5341 cttttccagt taggttcgtt accctgctca ttagctaaac ctctttatct tgtgcctcaa
     5401 aagagctttt acttttctta gaaacattta taaaaaagaa aaaaactgac acgcattcat
     5461 tcaaaaaagt atttattggg ctttagggat tagatacaca acagtggaaa aatggcatct
     5521 tagcacactc agaatttatt gtgcagcagt tgtgtatttt aaggaatctg tagttaaaag
     5581 gaagagatcc aaaggtcctg ataacatttc ctaacgtttc agaagagttg tcattgagta
     5641 gtgtttggat ttcctctctg tatccctcac cctaccattt tctcctttat tcttctaaga
     5701 ttgttagcgt tgttactcaa aacatacaca tacaacatac cagatggtgc tgttctaatg
     5761 gtatttgttc acgtaattta acgttcttac tgcttatact atatacatat ttaattttgt
     5821 tgggagcaag aaggttttca agaaaagata attttgtatt agtgtaggaa tatattagac
     5881 aaatgtttag ttggtcaaat tatgcataag atatttgtaa ctttaaacat tgcaaattga
     5941 ccagctagct atggaagcat aaaattaatt gataattaat gttggaaata catttctaaa
     6001 atttatattt ttatggtgtt agcctgtaag agcattttag catattgaaa tgcatgctgc
     6061 ttaagatgtg tctggttcaa atatcaaaac ttgctgggtc atttttacat agtagaaaca
     6121 tactgtctat gtgttgccca attgctgttt gtccactctg aattctggac cctttttgga
     6181 ctaagaatta gttaaattca tgaactaaga gaattagaga tggggtagag taggatcagg
     6241 acagtggggt tacaacagat aggaaaggaa agtcagcatt tgagtgtaga gaaaaaaaga
     6301 ggatcataca gatgtcatca aattataggc tttaatacag gttgcttttt ttaatccaaa
     6361 aggaaaagca cttatcctat cagaatgtct accatgtttt atagtaataa tttgtgtaaa
     6421 aaattgaatt tttgaatagt tttttgtatt ttttgtgatg aaaaactcat aacataaaat
     6481 ttaccatatt aactgtttct aaagaataca gttcagccat gtgaagtaca tttacactgt
     6541 tgtgaagcag atctccagaa ctttttcatc ttgcaaaact gaaactccat acccattaaa
     6601 caactcccct ttttgttttc tcctcagtgg aatagaattt tgactccata taaatcaaga
     6661 aacacctaaa ttctttagtt gtttgtgttt gcaagatcta aggtcatggt aaacattaag
     6721 ttcttaaaat ttttgggagg gacagtgcac ctctcctctg aattgttagc aattaaattg
     6781 agtaggtttt aaatgtctat tcattggaag ggtttgttat ttcattttga gccagagggg
     6841 agaggcacat tttaaatatc agaattagat tagctttgag tttgtacaat tgggaacata
     6901 atagattttc ataaattatg tgtgccttgt tggaagtgtc aactgtcttt atgtctgctt
     6961 gtaaaagttt caaaatatgt tttccctcaa aaaggcaacg ttacttcatt tgcttgaata
     7021 ttatgatagg aatgcttact gatattactt gatagtcata tatagcctag gaaatttaac
     7081 atatatataa ctatagcagt attaataatg atagttgtac ttctttaaaa cattaaattt
     7141 gaggaaactt taatgctgtc tcgtgtacat tgctttacta cagtgagggg gaatatcctt
     7201 tagattgagc ctcaatttac tggttagtag tatgtgaaac tctggtataa aaacgtaaac
     7261 tagacagtag agccgatgaa ttaaaattgt aaattgctac attggcattt tctacctcct
     7321 tttctgtcag agtattactt tttccagcat ttattcttat ttgtgagtaa agaggaaatg
     7381 ggaacctgag gttaaaattg acatttttgt ttcattgaga atttaagcag taggtacagg
     7441 agaagtgact tgtcacatta atttggtgcc taaatctgta actacaagtt gtgatcgaca
     7501 tgtacaaaat gtctaagaaa ggtcatatgc tgaatatttt acttttcctg tatagtctgc
     7561 atgatttgtt tcataaaccc agcttatttc ctccaaaaag caaaatggtc ctgtaatttt
     7621 taaagtaaaa taaacgtgcc attttgtctg caatctataa tttcaggaag ttattgaaag
     7681 ttctgactca gggcttttta acagttcaag caattgtcag ttatattttg gaaactccat
     7741 ctgtgtaatt ctccagtgcc ttgaaagaat tattaacttg gcaacactat taaaacttta
     7801 taaaagatgg tctttagtgc acgtgtatca ttatatacac gttttaaagt catattgctt
     7861 agcttgttaa taatgattct gcatgtgtgc tgggtttggg taattcttta aaggaagttt
     7921 tctagatttg cacttgatgt ttgtttttta aaaactgatt atttatggcc gtgacactgt
     7981 taccagaaaa gtaattctaa ttaagttatt atgcaaagtc atctataagt agcatctggg
     8041 aagaggagat cgaggccaca gtttgctatt ttagtatgaa aggaggatct gtttgggaaa
     8101 catagattgt cttcccctca aatgagggga aaaaaaaaag accctttgtt caaatggatt
     8161 ctgttgtaaa aaattatttt taaaggaaat cacaaattgt atgtcattct taatgctagt
     8221 cttatagaat aaatccataa aattgttttt atgttcagta tgtttatgtc attctaaatg
     8281 cagcaaattc aatgatagca gttcaattga ctcatagcag tgttttgtat tttttctaat
     8341 tctttagctt tcaatattgg attaaagtct tgtttgtgaa tatagtttcc gtatggcaaa
     8401 tgatttcttg cttattagct tttgttaaag aatgcttagt aagagctaag cttttaaaag
     8461 taatgcaaac atttatcgtt aataaaacct atggtgtaat atcatataat gcttttcttt
     8521 gatctttgga gaattattct tttatagtag tatacatgaa ttttgatttt taaagcattt
     8581 aaaaacaaat ctcaatacat taaaaaacct gttattgtta aaaaggaaat taccatgcct
     8641 ttaagaaaca aggatgtaca tcttcaattc agcataagtg tccacatcta gaaggctctc
     8701 attgcagttg tttacagtta aggtacctct atctaaaggg ccaaagaagc atttcatatt
     8761 ttaacacctc acattctttc aggattaaga catatgaaaa tagtctgaat aggataaatt
     8821 tgataggaag taacttaacc agtctggaag attcagcttt ttctataaaa agcttattcc
     8881 tcttcacaac tcagatgtag atttcatttt caagaggtag atattttaaa gcaatgatct
     8941 atttgggttt tagttttatg agtaaatcat taattgtatg gtttgggggt tattttattt
     9001 tccatgttaa tataagcact tatttctgaa gttattgaga ggtcatctag ctccagttca
     9061 aaagattatg tatatctgat gtttaagagg aaaaacatct gaaaaaatat cttttgttta
     9121 tttgaaaaaa gcatatatat tccaacttta aaattgtgaa tttattttga gtaacctcta
     9181 attaactgta tttttttgtt tctgttgctg tatagttaga aatttcatgg caatattttt
     9241 tactaaattg aaactatagg ttttaaaaat aaagacattt tagaaaa
//
