LOCUS       NM_198551               8126 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens MIA SH3 domain ER export factor 3 (MIA3), transcript
            variant 1, mRNA.
ACCESSION   NM_198551 XM_046126
VERSION     NM_198551.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8126)
  AUTHORS   Wanbiao,Z., Jing,M., Shi,Z., Tengxiang,C., Xueke,Z. and Haiyang,L.
  TITLE     MIA3 promotes the degradation of GSH (glutathione) by binding to
            CHAC1, thereby promoting the progression of hepatocellular
            carcinoma
  JOURNAL   Mol Cell Biochem 479 (10), 2769-2784 (2024)
   PUBMED   37948019
  REMARK    GeneRIF: MIA3 promotes the degradation of GSH (glutathione) by
            binding to CHAC1, thereby promoting the progression of
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 8126)
  AUTHORS   Connolly,L.M., McFalls,C.M., McMahon,I.G., Bhat,A.M. and
            Artlett,C.M.
  TITLE     Caspase 1 Enhances Transport and Golgi Organization Protein 1
            Expression to Promote Procollagen Export From the Endoplasmic
            Reticulum in Systemic Sclerosis Contributing to Fibrosis
  JOURNAL   Arthritis Rheumatol 75 (10), 1831-1841 (2023)
   PUBMED   37067501
  REMARK    GeneRIF: Caspase 1 Enhances Transport and Golgi Organization
            Protein 1 Expression to Promote Procollagen Export From the
            Endoplasmic Reticulum in Systemic Sclerosis Contributing to
            Fibrosis.
REFERENCE   3  (bases 1 to 8126)
  AUTHORS   Man,J., Zhou,W., Zuo,S., Zhao,X., Wang,Q., Ma,H. and Li,H.Y.
  TITLE     TANGO1 interacts with NRTN to promote hepatocellular carcinoma
            progression by regulating the PI3K/AKT/mTOR signaling pathway
  JOURNAL   Biochem Pharmacol 213, 115615 (2023)
   PUBMED   37211171
  REMARK    GeneRIF: TANGO1 interacts with NRTN to promote hepatocellular
            carcinoma progression by regulating the PI3K/AKT/mTOR signaling
            pathway.
REFERENCE   4  (bases 1 to 8126)
  AUTHORS   Junkiert-Czarnecka,A., Pilarska-Deltow,M., Bak,A., Heise,M. and
            Haus,O.
  TITLE     A novel mutation in collagen transport protein, MIA3 gene, detected
            in a patient with clinical symptoms of Ehlers-Danlos hypermobile
            syndrome
  JOURNAL   Adv Clin Exp Med 32 (7), 777-781 (2023)
   PUBMED   36603143
  REMARK    GeneRIF: A novel mutation in collagen transport protein, MIA3 gene,
            detected in a patient with clinical symptoms of Ehlers-Danlos
            hypermobile syndrome.
REFERENCE   5  (bases 1 to 8126)
  AUTHORS   McCaughey,J., Stevenson,N.L., Mantell,J.M., Neal,C.R., Paterson,A.,
            Heesom,K. and Stephens,D.J.
  TITLE     A general role for TANGO1, encoded by MIA3, in secretory pathway
            organization and function
  JOURNAL   J Cell Sci 134 (17) (2021)
   PUBMED   34350936
  REMARK    GeneRIF: A general role for TANGO1, encoded by MIA3, in secretory
            pathway organization and function.
REFERENCE   6  (bases 1 to 8126)
  AUTHORS   Saito,K., Chen,M., Bard,F., Chen,S., Zhou,H., Woodley,D.,
            Polischuk,R., Schekman,R. and Malhotra,V.
  TITLE     TANGO1 facilitates cargo loading at endoplasmic reticulum exit
            sites
  JOURNAL   Cell 136 (5), 891-902 (2009)
   PUBMED   19269366
REFERENCE   7  (bases 1 to 8126)
  AUTHORS   Arndt,S., Melle,C., Mondal,K., Klein,G., von Eggeling,F. and
            Bosserhoff,A.K.
  TITLE     Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate
            the migration of human monocytes
  JOURNAL   J Leukoc Biol 82 (6), 1466-1472 (2007)
   PUBMED   17726152
  REMARK    GeneRIF: The results from this study present TANGO as a novel
            ligand for CD11c, regulating migratory processes of hematopoietic
            cells.
REFERENCE   8  (bases 1 to 8126)
  AUTHORS   Arndt,S. and Bosserhoff,A.K.
  TITLE     Reduced expression of TANGO in colon and hepatocellular carcinomas
  JOURNAL   Oncol Rep 18 (4), 885-891 (2007)
   PUBMED   17786351
  REMARK    GeneRIF: Reduced expression of TANGO is associated with colon and
            hepatocellular carcinomas
REFERENCE   9  (bases 1 to 8126)
  AUTHORS   Arndt,S. and Bosserhoff,A.K.
  TITLE     TANGO is a tumor suppressor of malignant melanoma
  JOURNAL   Int J Cancer 119 (12), 2812-2820 (2006)
   PUBMED   17044017
  REMARK    GeneRIF: TANGO transfected cell lines revealed that TANGO
            expression reduces motility, whereas reduction of TANGO enhances
            migration.
REFERENCE   10 (bases 1 to 8126)
  AUTHORS   Bosserhoff,A.K., Moser,M. and Buettner,R.
  TITLE     Characterization and expression pattern of the novel MIA homolog
            TANGO
  JOURNAL   Gene Expr Patterns 4 (4), 473-479 (2004)
   PUBMED   15183315
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592148.7, DA040423.1, AK096526.1, D87742.1, BP423646.1 and
            CK724924.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198551.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.49234.1,
                                           SRR1803617.42223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344922.10/ ENSP00000340900.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL592148.7         122448-122452
            6-368               DA040423.1         1-363
            369-3183            AL592148.7         131926-134740
            3184-3812           AK096526.1         1917-2545
            3813-4989           D87742.1           1657-2833
            4990-5498           BP423646.1         50-558
            5499-5938           CK724924.1         21-460              c
            5939-8126           AL592148.7         170171-172358
FEATURES             Location/Qualifiers
     source          1..8126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..8126
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="MIA SH3 domain ER export factor 3"
                     /db_xref="GeneID:375056"
                     /db_xref="HGNC:HGNC:24008"
                     /db_xref="MIM:613455"
     exon            1..147
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..5738
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; C219-reactive peptide; melanoma inhibitory
                     activity protein 3; MIA family member 3, ER export factor;
                     melanoma inhibitory activity family, member 3; transport
                     and Golgi organization protein 1 homolog"
                     /codon_start=1
                     /product="transport and Golgi organization protein 1
                     homolog isoform 1 precursor"
                     /protein_id="NP_940953.2"
                     /db_xref="CCDS:CCDS41470.1"
                     /db_xref="GeneID:375056"
                     /db_xref="HGNC:HGNC:24008"
                     /db_xref="MIM:613455"
                     /translation="MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECS
                     MLMYRGEALEDFTGPDCRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLI
                     QVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEK
                     TLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQAN
                     HAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLK
                     TKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFT
                     DGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVT
                     GGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIP
                     KTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMP
                     AAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQKAAGNQ
                     MNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVL
                     KTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQMSEKIRLSEGEA
                     KEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKVEEDDYPSEELLEDENAINAK
                     RSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQETSMILDSEKTSETAAKG
                     VNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELGEVFQNKDSDYLKND
                     NPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHTSVEP
                     GHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNME
                     KVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRY
                     KHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQR
                     VIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVTPLENAI
                     LLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVV
                     KDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEA
                     IKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM
                     NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELS
                     EQIKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELAN
                     GEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKK
                     LEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRL
                     SAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAER
                     AIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFG
                     PSPVSGGECSPPLTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSP
                     SDPGSGTATMMNSSSRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIR
                     YGPPPQLCGPFGPRPLPPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPF
                     RPLGSLGPREYFIPGTRLPPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCS
                     QALKQSP"
     exon            148..281
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            282..368
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            369..3183
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3345
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3491
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3623
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3645
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3734
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3812
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3923
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..3995
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4100
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4223
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4335
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4391
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4392..4482
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4621
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4723
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4784
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..4820
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4888
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..4989
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5127
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            5128..5196
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5276
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5427
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     exon            5428..8126
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6242..6247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="hexamer: CATAAA"
     polyA_site      6263
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="major polyA site"
     regulatory      8106..8111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="hexamer: ATTAAA"
     polyA_site      8126
                     /gene="MIA3"
                     /gene_synonym="ARNT; D320; ODCD2; TANGO; TANGO1; UNQ6077"
                     /note="major polyA site"
ORIGIN      
        1 gaggtgacca caacatggct gcggcgcctg ggctgctcgt ctggctgctc gtgctccggc
       61 tgccctggcg ggtgccgggc cagctggacc ccagcactgg ccggcggttc tcggagcaca
      121 aactctgcgc ggacgacgaa tgcagcatgt taatgtaccg cggtgaggct cttgaagatt
      181 tcacaggccc ggattgtcgt tttgtgaatt ttaaaaaagg tgatcctgta tatgtttact
      241 ataaactggc aagaggatgg cctgaagttt gggctggaag tgttggacgc acttttggat
      301 attttccaaa agatttaatc caggtagttc atgaatatac caaagaagag ctacaagttc
      361 caacagatga gacggatttt gtttgttttg atggaggaag agatgatttt cataattata
      421 atgtagaaga acttttaggg tttttggaac tgtacaattc tgcagctaca gattctgaga
      481 aagctgtaga aaaaacttta caggatatgg aaaaaaaccc tgaattatct aaggaaaggg
      541 aacctgaacc tgaaccagta gaagccaact cagaggaaag tgatagtgta ttctcagaaa
      601 acactgagga tcttcaggaa cagtttacaa ctcagaagca ccactcccat gcaaacagcc
      661 aagcaaatca tgctcaggga gagcaggctt catttgaatc ttttgaagaa atgctgcaag
      721 ataaactaaa agtgccagaa agtgaaaaca acaaaaccag caatagttct caggtctcaa
      781 atgaacagga taagattgat gcctataaac ttttgaaaaa agaaatgact ctagacttga
      841 aaaccaaatt tggctcaaca gctgatgcac ttgtatctga tgatgagaca accagactcg
      901 ttacttcatt agaagatgat tttgatgagg aattggatac tgagtattat gcagttggaa
      961 aggaagatga ggagaaccaa gaagactttg atgagttgcc attacttacc tttacagatg
     1021 gggaagatat gaaaactcca gcaaagtctg gcgttgagaa atatccaaca gataaagagc
     1081 agaattcaaa tgaagaggac aaggttcagc taactgtgcc ccctggcatc aaaaatgatg
     1141 ataaaaatat actaacaacc tggggggaca ctatcttctc tattgtcaca ggaggtgaag
     1201 aaacaagaga tacgatggat ttagagagct ctagttcaga ggaagaaaaa gaagatgatg
     1261 atgatgcatt agtcccagat agcaaacagg ggaaaccaca gtcagcaaca gattatagtg
     1321 accctgacaa tgtagatgat ggtcttttta ttgtagacat tcctaaaaca aataatgaca
     1381 aagaagtaaa cgcagaacat cacattaaag gaaaagggag gggagttcag gaatccaaga
     1441 ggggcctggt acaagataag acagaattag aggatgaaaa tcaagaaggc atgactgtgc
     1501 acagttctgt tcacagcaat aacctcaact ctatgccagc tgctgaaaag ggtaaagaca
     1561 cattaaaatc agcttatgat gatacagaaa atgacctaaa aggagcagct attcatatct
     1621 caaaaggaat gctccacgaa gaaaagcctg gagagcagat tttggaaggt ggctcagaga
     1681 gtgaatctgc acagaaagct gcagggaatc aaatgaatga cagaaagatt caacaggaat
     1741 ccctgggtag tgcaccactc atgggagatg accaccctaa cgcatccaga gacagtgtgg
     1801 agggagacgc tttggtaaat ggggccaaac tgcacacgct ttcagtggag catcaacgtg
     1861 aggaattgaa agaggaatta gttcttaaaa ctcaaaacca acctagattc tcctctccag
     1921 atgagattga tttgcccaga gaactggaag acgaggttcc cattctggga agaaatcttc
     1981 cctggcaaca agaaagagat gtggctgcca cagccagtaa gcaaatgagt gagaagataa
     2041 ggctctctga gggagaagcc aaagaggact ccttggatga agagtttttt catcacaagg
     2101 caatgcaggg cacagaggta ggacagacag accaaactga cagcacagga ggaccagctt
     2161 tcctttctaa agtagaagag gatgattatc cctctgaaga actactagag gatgaaaacg
     2221 ctataaatgc aaaacggtct aaagaaaaaa accctgggaa tcagggcagg cagtttgatg
     2281 ttaatctgca agtccctgac agagcagttt tagggaccat tcatccagat ccagaaattg
     2341 aagaaagcaa gcaagaaact agtatgattt tggatagcga aaaaacaagt gagactgctg
     2401 ccaaaggggt caacacagga ggcagggaac caaatacaat ggtggaaaaa gaacgccctc
     2461 tggcagataa gaaagcacag agaccatttg aacgaagtga cttttctgac agcataaaaa
     2521 ttcagactcc agaattaggt gaagtgtttc agaataaaga ttctgattat ctgaagaacg
     2581 acaaccctga ggaacatctg aagacctcag ggcttgcagg ggagcctgag ggagaactct
     2641 caaaagagga ccatgagaac acagagaagt acatgggcac agaaagccag gggtctgctg
     2701 ctgcagaacc tgaagatgac tcgttccact ggactccaca tacaagtgta gagccagggc
     2761 atagtgacaa gagggaggac ttacttatca taagcagctt ctttaaagaa caacagtctt
     2821 tgcagcggtt ccagaagtac tttaatgtcc atgagctgga agccttgcta caagaaatgt
     2881 catcaaaact gaagtcagcg cagcaggaga gcctgcccta taatatggaa aaagtcctag
     2941 ataaggtctt ccgtgcttct gagtcacaaa ttctgagcat agcagaaaaa atgcttgata
     3001 ctcgtgtggc tgaaaataga gatctgggaa tgaacgaaaa taacatattt gaagaggctg
     3061 cagtgcttga tgacattcaa gacctcatct attttgtcag gtacaagcac tccacagcag
     3121 aggagacagc cacactggtg atggcaccac ctctagagga aggcttgggt ggagcaatgg
     3181 aagagatgca accactgcat gaagataatt tctcacgaga gaagacagca gaacttaatg
     3241 tgcaggttcc tgaagaaccc acccacttgg accaacgtgt gattggggac actcatgcct
     3301 cagaagtgtc acagaagcca aatactgaga aagacctgga cccagggcca gttacaacag
     3361 aagacactcc tatggatgct attgatgcaa acaagcaacc agagacagcc gccgaagagc
     3421 cggcaagtgt cacacctttg gaaaacgcaa tccttctaat atattcattc atgttttatt
     3481 taactaagtc gctagttgct acattgcctg atgatgttca gcctgggcct gatttttatg
     3541 gactgccatg gaaacctgta tttatcactg ccttcttggg aattgcttcg tttgccattt
     3601 tcttatggag aactgtcctt gttgtgaagg atagagtata tcaagtcacg gaacagcaaa
     3661 tttctgagaa gttgaagact atcatgaaag aaaatacaga acttgtacaa aaattgtcaa
     3721 attatgaaca gaagatcaag gaatcaaaga aacatgttca ggaaaccagg aaacaaaata
     3781 tgattctctc tgatgaagca attaaatata aggataaaat caagacactt gaaaaaaatc
     3841 aggaaattct ggatgacaca gctaaaaatc ttcgtgttat gctagaatct gagagagaac
     3901 agaatgtcaa gaatcaggac ttgatatcag aaaacaagaa atctatagag aagttaaagg
     3961 atgttatttc aatgaatgcc tcagaatttt cagaggttca gattgcactt aatgaagcta
     4021 agcttagtga agagaaggtg aagtctgaat gccatcgggt tcaagaagaa aatgctaggc
     4081 ttaagaagaa aaaagagcag ttgcagcagg aaatcgaaga ctggagtaaa ttacatgctg
     4141 agctcagtga gcaaatcaaa tcatttgaga agtctcagaa agatttggaa gtagctctta
     4201 ctcacaagga tgataatatt aatgctttga ctaactgcat tacacagttg aatctgttag
     4261 agtgtgaatc tgaatctgag ggtcaaaata aaggtggaaa tgattcagat gaattagcaa
     4321 atggagaagt gggaggtgac cggaatgaga agatgaaaaa tcaaattaag cagatgatgg
     4381 atgtctctcg gacacagact gcaatatcgg tagttgaaga ggatctaaag cttttacagc
     4441 ttaagctaag agcctccgtg tccactaaat gtaacctgga agaccaggta aagaaattgg
     4501 aagatgaccg caactcacta caagctgcca aagctggact ggaagatgaa tgcaaaacct
     4561 tgaggcagaa agtggagatt ctgaatgagc tctatcagca gaaggagatg gctttgcaaa
     4621 agaaactgag tcaagaagag tatgaacggc aagaaagaga gcacaggctg tcagctgcag
     4681 atgaaaaggc agtttcggct gcagaggaag taaaaactta caagcggaga attgaagaaa
     4741 tggaggatga attacagaag acagagcggt catttaaaaa ccagatcgct acccatgaga
     4801 agaaagctca tgaaaactgg ctcaaagctc gtgctgcaga aagagctata gctgaagaga
     4861 aaagggaagc tgccaatttg agacacaaat tattagaatt aacacaaaag atggcaatgc
     4921 tgcaagaaga acctgtgatt gtaaaaccaa tgccaggaaa accaaataca caaaaccctc
     4981 cacggagagg tcctctgagc cagaatggct cttttggccc atcccctgtg agtggtggag
     5041 aatgctcccc tccattgaca gtggagccac ccgtgagacc tctctctgct actctcaatc
     5101 gaagagatat gcctagaagt gaatttggat cagtggacgg gcctctacct catcctcgat
     5161 ggtcagctga ggcatctggg aaaccctctc cttctgatcc aggatctggt acagctacca
     5221 tgatgaacag cagctcaaga ggctcttccc ctaccagggt actcgatgaa ggcaaggtta
     5281 atatggctcc aaaagggccc cctcctttcc caggagtccc tctcatgagc acccccatgg
     5341 gaggccctgt accaccaccc attcgatatg gaccaccacc tcagctctgc ggaccttttg
     5401 ggcctcggcc acttcctcca ccctttggcc ctggtatgcg tccaccacta ggcttaagag
     5461 aatttgcacc aggcgttcca ccaggaagac gggacctgcc tctccaccct cggggatttt
     5521 tacctggaca cgcaccattt agacctttag gttcacttgg cccaagagag tactttattc
     5581 ctggtacccg attaccaccc ccaacccatg gtccccagga atacccacca ccacctgctg
     5641 taagagactt actgccgtca ggctctagag atgagcctcc acctgcctct cagagcacta
     5701 gccaggactg ttcacaggct ttaaaacaga gcccataaaa ctatgacctc tgaggtttca
     5761 ttggaaagaa agtgtactgt gcattatcca ttacagtaaa ggatttcatt ggcttcaaaa
     5821 tccaaaagtt tattttaaaa ggtttgttgt tagaactaag ctgccttggc agtgtgcatt
     5881 tttgagccaa acaattcaaa aatgtcattt cttccctaaa taaaaatcac cttttaagct
     5941 agagcgtcct tacaactttg aaatgtgcaa taaagaatac ctgtgtttta gctaatgtag
     6001 catatgtaat tgcaaaatga tttagaatgt catgaaaaat atgaacattt cctgtggaaa
     6061 tgctttaaga acatgtattt ccattatcct atttttagtg tacaccagct gaatacggag
     6121 caatggtgtt tataagcgtt tttttaaact atctggtcac aaagactgtt acgctaaaaa
     6181 tgtttactaa aagatcacta aactatctcc cctcttgctg aagttctttg tagtaatagc
     6241 tcataaaaat ttgtttatta atatttccca agtgtctgtt gactcattgg actgttatga
     6301 ggcttgtgcc atttggggaa catgtaaact caggctccca gaactgaaga tggtggctgg
     6361 tggcacactt ccggctgctc ctccgtcacc tgtgaactct acaagtgacg tctttttatt
     6421 tcaaagaagt ttatttccca cttgtatagc attcacatgc tttctttacg atcctcattg
     6481 tctatttgag aatggttttc tgagagtgag tttacattag tagcaagagt tgtttgacct
     6541 gatgttccat tgtttttacc attcctgtag aaaaagggtg cacaacagaa aaatgaaaat
     6601 gatgtgtcat ggccataaaa gtatagaaat ctttaaaaat tttaaaatgt acagtccctt
     6661 atctatcttt cccattcctt gccactgatt tttgaggaat ataataaaaa gattggaaga
     6721 gtataatgcc atgagaaaga atgatttagg actgtgaggg ttataacatg ccctaggtca
     6781 gcaaccaagg gttgaaatca gttctgtttt agggggaaat gggggcgaca gatattattc
     6841 caaaattaat attaattaat atttaaacgt tggtgttttt atttaaaaat cagtaactaa
     6901 ccatctggaa ttgcaccata cttaaagtct tatccattac tacactgtct ttaaaacaat
     6961 gtttctttaa atactctaca acgtttctaa gaacgaactt cagacatttt aattacagta
     7021 ataatagcac tccttttaag gagtttcaga tccacactaa aactaaaatc ataaaaggct
     7081 gatacttttg tttgctgcta ggctatattc ttccattctt tgaagtccta tgatgtaata
     7141 tttttgaaac ctagtgtatg tcttgtcact gttgtgatat ttaatcgatt aagaatacct
     7201 tgtaaaaagg agcaaaagct tcaatgtgaa acaattttct ctctttatac taaacaactg
     7261 aagatagata gtttagaaag ataaggacct ttgaaagaag acaactctgt caaagttcat
     7321 aaggaatata aaaattcttc aggaaaagag aattcaatct atatgtcctc ccgtttaata
     7381 tcaagaatag aagaaattaa gaggaaaact ccacagaaga gcataggcca cttttagcca
     7441 tgtaaaaata agattaagtc acaaatacaa cttttgaatt tacctgtcaa tatctcttta
     7501 ggacacaaaa caatgctgaa gttaatataa tttctaattt taaatgtcat ttaagtgtag
     7561 attatgccat ctaggaaggt aagtaggaaa ggtaaattaa atctattttt aaaattcaaa
     7621 atattagagt atttttcccc tctaaagcct tttttggtga ttattctgta tctgacataa
     7681 ttgagaaact ggtaagctgt aaagattcca gtgtagcttc tctgagaagt tgtgagccag
     7741 tccataactg cttcctcaca tccatctgat tgcaccattt ctgcagcaaa ccccaaagca
     7801 gggtgccaat atgcagatgg catagggagt atcatccctc agccaaatca cttttccatc
     7861 tctaaagttt catctatttt ggaagtcatc tccaactaat tgtgtctgga tttagttgct
     7921 aaaattgtct tatttatgaa gcagcaatat tcagcctgaa agcatttctg ccatagttgt
     7981 tgtagttata tcgccaatgg ctgatttttt tcattggaaa gtaaatttaa gtaattcgtg
     8041 ggatgtggta tattctgtgt caacttcaag ataatcactc attttctcgt tatattcagg
     8101 tctgaattaa agttaagtta atcaca
//
