LOCUS       NM_001329214            4869 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens MIA SH3 domain ER export factor 2 (MIA2), transcript
            variant 8, mRNA.
ACCESSION   NM_001329214
VERSION     NM_001329214.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4869)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4869)
  AUTHORS   Raote,I., Ortega-Bellido,M., Santos,A.J., Foresti,O., Zhang,C.,
            Garcia-Parajo,M.F., Campelo,F. and Malhotra,V.
  TITLE     TANGO1 builds a machine for collagen export by recruiting and
            spatially organizing COPII, tethers and membranes
  JOURNAL   Elife 7, e32723 (2018)
   PUBMED   29513218
  REMARK    GeneRIF: These data showed that the NRZ tether is required for
            TANGO1 to assemble into a ring and indicated that stable complexes
            of TANGO1, cTAGE5 and TANGO1-short, recruit the tether.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4869)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   4  (bases 1 to 4869)
  AUTHORS   Ma,W. and Goldberg,J.
  TITLE     TANGO1/cTAGE5 receptor as a polyvalent template for assembly of
            large COPII coats
  JOURNAL   Proc Natl Acad Sci U S A 113 (36), 10061-10066 (2016)
   PUBMED   27551091
  REMARK    GeneRIF: TANGO1/CTAGE5 receptor serves as a polyvalent template for
            assembly of large COPII coats.
REFERENCE   5  (bases 1 to 4869)
  AUTHORS   Tanabe,T., Maeda,M., Saito,K. and Katada,T.
  TITLE     Dual function of cTAGE5 in collagen export from the endoplasmic
            reticulum
  JOURNAL   Mol Biol Cell 27 (13), 2008-2013 (2016)
   PUBMED   27170179
  REMARK    GeneRIF: In this study, we identified specific and critical
            residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A,
            and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at
            ER exit sites is required for collagen VII secretion.
REFERENCE   6  (bases 1 to 4869)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   7  (bases 1 to 4869)
  AUTHORS   Comtesse,N., Niedermayer,I., Glass,B., Heckel,D., Maldener,E.,
            Nastainczyk,W., Feiden,W. and Meese,E.
  TITLE     MGEA6 is tumor-specific overexpressed and frequently recognized by
            patient-serum antibodies
  JOURNAL   Oncogene 21 (2), 239-247 (2002)
   PUBMED   11803467
REFERENCE   8  (bases 1 to 4869)
  AUTHORS   Comtesse,N., Reus,K. and Meese,E.
  TITLE     The MGEA6 multigene family has an active locus on 14q and at least
            nine pseudogenes on different chromosomes
  JOURNAL   Genomics 75 (1-3), 43-48 (2001)
   PUBMED   11472066
REFERENCE   9  (bases 1 to 4869)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   10 (bases 1 to 4869)
  AUTHORS   Heckel,D., Brass,N., Fischer,U., Blin,N., Steudel,I., Tureci,O.,
            Fackler,O., Zang,K.D. and Meese,E.
  TITLE     cDNA cloning and chromosomal mapping of a predicted coiled-coil
            proline-rich protein immunogenic in meningioma patients
  JOURNAL   Hum Mol Genet 6 (12), 2031-2041 (1997)
   PUBMED   9356211
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132639.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 5, 2021 this sequence version replaced NM_001329214.3.
            
            Summary: This gene encodes s receptor in the endoplasmic reticulum,
            which plays a role in the export of large pre-chylomicrons and
            pre-very low density lipoproteins (pre-VLDLs). Three major classes
            of transcripts are generated from this gene- melanoma inhibitory
            activity 2-specific transcripts, cTAGE family member 5-specific
            transcripts and transcripts that include exons from both these
            transcript species (TANGO1-like or TALI). Additionally, alternative
            splicing in these transcripts results in multiple transcript
            variants encoding multiple isoforms. [provided by RefSeq, Sep
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KX388743.1, SRR14038194.807851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640607.2/ ENSP00000491014.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AL132639.4         76745-77059
            316-449             AL132639.4         79752-79885
            450-536             AL132639.4         83391-83477
            537-1767            AL132639.4         89741-90971
            1768-1986           AL132639.4         95578-95796
            1987-2087           AL132639.4         95901-96001
            2088-2219           AL132639.4         119764-119895
            2220-2241           AL132639.4         122167-122188
            2242-2330           AL132639.4         122279-122367
            2331-2408           AL132639.4         133849-133926
            2409-2519           AL132639.4         136101-136211
            2520-2591           AL132639.4         136830-136901
            2592-2696           AL132639.4         137755-137859
            2697-2819           AL132639.4         142694-142816
            2820-2940           AL132639.4         144959-145079
            2941-2987           AL132639.4         146308-146354
            2988-3078           AL132639.4         147121-147211
            3079-3217           AL132639.4         151279-151417
            3218-3319           AL132639.4         156170-156271
            3320-3380           AL132639.4         157569-157629
            3381-3416           AL132639.4         158513-158548
            3417-3484           AL132639.4         160774-160841
            3485-3567           AL132639.4         162039-162121
            3568-3696           AL132639.4         163758-163886
            3697-3855           AL132639.4         169694-169852
            3856-3978           AL132639.4         188734-188856
            3979-4037           AL132639.4         190543-190601
            4038-4272           AL132639.4         191573-191807
            4273-4869           AL132639.4         192928-193524
FEATURES             Location/Qualifiers
     source          1..4869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..4869
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="MIA SH3 domain ER export factor 2"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
     exon            1..315
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..4439
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="isoform 8 precursor is encoded by transcript
                     variant 8; meningioma expressed antigen 6 (coiled-coil
                     proline-rich); cutaneous T-cell lymphoma-associated
                     antigen 5; protein cTAGE-5; meningioma-expressed antigen
                     6/11; melanoma inhibitory activity 2; TANGO1-like; CTAGE
                     family, member 5; CTAGE family member 5, ER export factor;
                     melanoma inhibitory activity protein 2; MIA protein 2"
                     /codon_start=1
                     /product="melanoma inhibitory activity protein 2 isoform 8
                     precursor"
                     /protein_id="NP_001316143.1"
                     /db_xref="CCDS:CCDS86384.1"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
                     /translation="MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECEALINRV
                     SAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVF
                     ISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQ
                     IEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESMEQDRIPEVHVPPSS
                     AVSGVKEWFGLGGEQAEEKAFESVIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEH
                     QQESESEIDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYLGFGDEDTGLELIAEES
                     NPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKE
                     DKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIETIKIIETEDQIDKKPVSEKTDE
                     SDTIPYLKKFLYNFDNPWNFQNIPKETELPFPKQILDQNNVIENEETGEFSIDNYPTD
                     NTKVMIFKSSYSLSDMVSNIELPTRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEI
                     DRSVENTLLNSQMVSTDNSLSSQNYISQKEDASEFQILKYLFQIDVYDFMNSAFSPIV
                     ILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGR
                     EKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCE
                     KLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA
                     KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFED
                     SKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLD
                     NPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASL
                     QSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKIS
                     HATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKE
                     NAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPP
                     TLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLS
                     PPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGS
                     MPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPF
                     LRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFF
                     PPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET"
     exon            316..449
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            450..536
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1767
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1986
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2087
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2219
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2241
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2330
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2408
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2519
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2591
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2696
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2819
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2940
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..2987
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3078
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3217
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3319
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3380
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3416
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3484
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3567
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3696
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3855
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..3978
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4037
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..4272
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4869
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="hexamer: ATTATA"
     polyA_site      4823
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="major polyA site"
     regulatory      4845..4850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="hexamer: AATAAA"
     polyA_site      4869
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /note="major polyA site"
ORIGIN      
        1 gaaaacagac agtgtttgtc tctcaagtta aaccaacaag ccgatagaaa aaggtagtta
       61 tcaagagatt tttaaaactt caaccctttt tctcttatag ttagtgaaga gagtagaata
      121 tctccagttt tggctgacat ctctacaacc tgaacaattg gcttaaactt cacttgggat
      181 tcccggttgc ttgttttagc atggcaaaat ttggcgttca cagaatcctt cttctggcta
      241 tttctctgac aaagtgtctg gagagtacaa aactgctggc agaccttaaa aaatgtggtg
      301 acttggaatg tgaagcttta ataaacagag tctcagccat gagagattat agaggacctg
      361 actgccgata cctgaacttc actaagggag aagagatatc tgtttatgtt aaacttgcag
      421 gagaaaggga agatttgtgg gcaggaagta aaggaaagga gtttggatat tttcccagag
      481 atgcagtcca gattgaagag gtgttcatat ctgaggaaat tcagatgtca acgaaagaat
      541 ctgactttct ttgtcttctt ggagtaagtt acacatttga caatgaagat agtgaattaa
      601 acggtgatta tggtgaaaat atatatcctt atgaagaaga taaagatgaa aaatctagta
      661 tatatgaaag tgattttcag atagaacctg gattttatgc aacttatgaa agtactttgt
      721 ttgaagacca agttccagca ttagaggctc ctgaagatat cggaagtacc agtgaatcaa
      781 aagactggga agaagtagtt gttgaaagta tggaacagga tcgtattcca gaagtgcatg
      841 tcccaccatc ttcagctgtg tctggagtca aagaatggtt tggattggga ggagaacaag
      901 ctgaagagaa ggcttttgaa tcagttattg aacctgtaca agaaagctca tttcggagta
      961 gaaaaatagc agtggaagat gagaatgacc tagaggaatt aaataatggt gagcctcaaa
     1021 cagaacatca gcaagaatct gaatcagaaa ttgattcagt gccaaagaca cagtctgaac
     1081 tagcatctga gtcagagcac attcccaaac ctcaatccac tggttggttt ggtggaggat
     1141 ttacaagtta tttaggtttt ggagatgagg atacagggct tgaattaata gctgaagaaa
     1201 gcaatccacc actacaagat tttcccaatt ccatatcatc tgataaagaa gccacagttc
     1261 catgtacaga aatattaaca gaaaaaaaag acacaatcac taatgatagc ttgagtctca
     1321 agccaagttg gtttgatttt ggttttgcta tactaggctt tgcatatgcc aaggaagata
     1381 aaattatgtt agatgacagg aaaaatgaag aagatggtgg ggcagatgaa catgaacatc
     1441 ctctaacaag tgaattagac cctgaaaaag aacaagaaat agaaacgata aaaattatag
     1501 aaacagaaga tcaaatagac aagaaaccag tctcagaaaa aacagacgaa tctgatacta
     1561 taccatattt gaaaaagttc ttgtataatt ttgacaaccc ttggaacttc cagaacattc
     1621 caaaggaaac agaattgcca tttcccaaac agatactgga tcaaaataat gtaattgaaa
     1681 atgaagaaac tggagaattt tccattgata attatcccac agataataca aaagttatga
     1741 tattcaaaag ttcatacagt ctgtcagata tggtctctaa catagagtta cctacgagaa
     1801 ttcacgaaga agtatatttt gaaccctcat cttctaaaga tagtgatgaa aattcgaaac
     1861 catcagtaga caccgaaggg cctgctctgg tggagataga cagatctgtg gaaaataccc
     1921 tgctaaatag tcagatggtt tcaactgata actctttgtc ttctcaaaat tatatttctc
     1981 agaaagaaga tgcttctgag tttcagattc tgaaatactt attccaaatt gatgtttatg
     2041 atttcatgaa ttctgcattt tcaccaattg taattcttac agaaagggtt gtggcagcac
     2101 tgcctgaagg tatgagacca gattctaatc tttatggttt tccatgggaa ttggtgatat
     2161 gtgcagctgt tgttggattt tttgctgttc tctttttttt gtggagaagt tttagatcgg
     2221 ttaggagtcg gctttatgtg ggacgagaga aaaagcttgc tctaatgctt tctggactaa
     2281 ttgaagaaaa aagtaaacta cttgaaaaat ttagccttgt tcaaaaagag tatgaaggct
     2341 atgaagtaga gtcatcttta aaggatgcca gctttgagaa ggaggcaaca gaagcacaaa
     2401 gtttggaggc aacctgtgaa aagctgaaca ggtccaattc tgaacttgag gatgaaatac
     2461 tctgtctaga aaaagagtta aaagaagaga aatccaaaca ttctgaacaa gatgaattga
     2521 tggcggatat ttcaaaaagg atacagtctc tagaagatga gtcaaaatcc ctcaaatcac
     2581 aagtagctga agccaaaatg accttcaaga tatttcaaat gaatgaagaa cgactgaaga
     2641 tagcaataaa agatgctttg aatgaaaatt ctcaacttca ggaaagccag aaacagcttt
     2701 tgcaagaagc tgaagtatgg aaagaacaag tgagtgaact taataaacag aaagtaacat
     2761 ttgaagactc caaagtacat gcagaacaag ttctaaatga taaagaaagt cacatcaaga
     2821 ctctgactga acgcttgtta aagatgaaag attgggctgc tatgcttgga gaagacataa
     2881 cggatgatga taacttggaa ttagaaatga acagtgaatc ggaaaatggt gcttacttag
     2941 ataatcctcc aaaaggagct ttgaagaaac tgattcatgc tgctaagtta aatgcttctt
     3001 taaaaacctt agaaggagaa agaaaccaaa tttatattca gttgtctgaa gttgataaaa
     3061 caaaggaaga gcttacagag catattaaaa atcttcagac tgaacaagca tctttgcagt
     3121 cagaaaacac acattttgaa aatgagaatc agaagcttca acagaaactt aaagtaatga
     3181 ctgaattata tcaagaaaat gaaatgaaac tccacaggaa attaacagta gaggaaaatt
     3241 atcggttaga gaaagaagag aaactttcta aagtagatga aaagatcagc catgccactg
     3301 aagagctgga gacctataga aagcgagcca aagatcttga agaagaattg gagagaacta
     3361 ttcattctta tcaagggcag attatttccc atgagaaaaa agcacatgat aattggttgg
     3421 cagctcggaa tgctgaaaga aacctcaatg atttaaggaa agaaaatgct cacaacagac
     3481 aaaaattaac tgaaacagag cttaaatttg aacttttaga aaaagatcct tatgcactcg
     3541 atgttccaaa tacagcattt ggcagagagc attccccata tggtccctca ccattgggtt
     3601 ggccttcatc tgaaacaaga gcttttctct ctcctccaac tttgttggag ggtccactca
     3661 gactctcacc tttgcttcca gggggaggag gaagaggctc acgaggccca gggaatcctc
     3721 tggaccatca gattaccaat gaaagaggag aatcaagctg tgataggtta accgatcctc
     3781 atagggctcc ctctgacact gggtctctgt cacctccatg ggaccaggac cgtaggatga
     3841 tgtttcctcc gccaggacaa tcatatcctg attcagccct tcctccacaa aggcaagaca
     3901 gattttgttc taattctggt agactgtctg gaccagcaga actcagaagt tttaatatgc
     3961 cttctttgga taaaatggat gggtcaatgc cttcagaaat ggaatccagt agaaatgata
     4021 ccaaagatga tcttggtaat ttaaatgtgc ctgattcatc tctccctgct gaaaatgaag
     4081 ccactggccc tggctttgtt cctccacctc ttgctccaat cagaggtcca ttgtttccag
     4141 tggatgcaag aggcccattc ttgagaagag gacctccttt ccccccacct cctccaggag
     4201 ccatgtttgg agcttctcga gattattttc caccagggga tttcccaggt ccaccacctg
     4261 ctccatttgc aatgagaaat gtctatccac cgaggggttt tcctccttac cttcccccaa
     4321 gacctggatt tttcccccca cccccacatt ctgaaggtag aagtgagttc ccctcaggtt
     4381 tgattccacc ttcaaatgag cctgctactg aacatccaga accacagcaa gaaacctgac
     4441 aatatttttg ctctcttcaa aagtaatttt gactgatctc attttcagtt taagtaactg
     4501 ctgttactta agtgattaca cttttgctca aattgaagct taatggaatt ataattctca
     4561 ggatagtatt ttgtaaataa agatgattta aatatgaatc ttatgagtaa attatttcaa
     4621 ttttatttta gacggtataa ctatttcaat ttgattaatc cactattata taaacaatag
     4681 tgggagtttt atatatgtaa tctttcaggt ggggaggctt taaattctga agtctgtgtc
     4741 tttatgccaa gaactgtatt tactgtggtt gtggacaaat gtgaaagtaa ctttatgctt
     4801 aaataaatta tagttgattt aaagatttgt ttggcattga taataataaa atcagtagtt
     4861 tttctataa
//
