LOCUS       NM_006533                488 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens MIA SH3 domain containing (MIA), transcript variant 1,
            mRNA.
ACCESSION   NM_006533
VERSION     NM_006533.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Li,C., Liu,J., Jiang,L., Xu,J., Ren,A., Lin,Y. and Yao,G.
  TITLE     The value of melanoma inhibitory activity and LDH with melanoma
            patients in a Chinese population
  JOURNAL   Medicine (Baltimore) 100 (8), e24840 (2021)
   PUBMED   33663104
  REMARK    GeneRIF: The value of melanoma inhibitory activity and LDH with
            melanoma patients in a Chinese population.
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Gu,Q.H., Li,D., Xie,Z.H. and Shen,Q.B.
  TITLE     The clinical significance of MIA gene in tumorigenesis of lung
            cancer
  JOURNAL   Neoplasma 67 (3), 660-667 (2020)
   PUBMED   31986890
  REMARK    GeneRIF: The clinical significance of MIA gene in tumorigenesis of
            lung cancer.
REFERENCE   3  (bases 1 to 488)
  AUTHORS   Feuerer,L., Lamm,S., Henz,I., Kappelmann-Fenzl,M., Haferkamp,S.,
            Meierjohann,S., Hellerbrand,C., Kuphal,S. and Bosserhoff,A.K.
  TITLE     Role of melanoma inhibitory activity in melanocyte senescence
  JOURNAL   Pigment Cell Melanoma Res 32 (6), 777-791 (2019)
   PUBMED   31172672
  REMARK    GeneRIF: MIA is a regulator of cellular senescence in human and
            murine melanocytes.
REFERENCE   4  (bases 1 to 488)
  AUTHORS   Uslu,U., Schliep,S., Schliep,K., Erdmann,M., Koch,H.U., Parsch,H.,
            Rosenheinrich,S., Anzengruber,D., Bosserhoff,A.K., Schuler,G. and
            Schuler-Thurner,B.
  TITLE     Comparison of the Serum Tumor Markers S100 and Melanoma-inhibitory
            Activity (MIA) in the Monitoring of Patients with Metastatic
            Melanoma Receiving Vaccination Immunotherapy with Dendritic Cells
  JOURNAL   Anticancer Res 37 (9), 5033-5037 (2017)
   PUBMED   28870930
  REMARK    GeneRIF: MIA had a slightly superior sensitivity to detect
            progressive disease compared to S100 and seems to be more useful in
            monitoring of patients with metastatic melanoma receiving
            immunotherapy
REFERENCE   5  (bases 1 to 488)
  AUTHORS   Yip,K.T., Zhong,X., Seibel,N., Arnolds,O., Schopel,M. and Stoll,R.
  TITLE     Human melanoma inhibitory protein binds to the FN12-14 Hep II
            domain of fibronectin
  JOURNAL   Biointerphases 12 (2), 02D415 (2017)
   PUBMED   28565914
  REMARK    GeneRIF: the molecular basis of the interaction of MIA with the Hep
            II domain of fibronectin based on nuclear magnetic resonance
            spectroscopic binding assays.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 488)
  AUTHORS   Lougheed,J.C., Holton,J.M., Alber,T., Bazan,J.F. and Handel,T.M.
  TITLE     Structure of melanoma inhibitory activity protein, a member of a
            recently identified family of secreted proteins
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5515-5520 (2001)
   PUBMED   11331761
REFERENCE   7  (bases 1 to 488)
  AUTHORS   Stoll,R., Renner,C., Zweckstetter,M., Bruggert,M., Ambrosius,D.,
            Palme,S., Engh,R.A., Golob,M., Breibach,I., Buettner,R.,
            Voelter,W., Holak,T.A. and Bosserhoff,A.K.
  TITLE     The extracellular human melanoma inhibitory activity (MIA) protein
            adopts an SH3 domain-like fold
  JOURNAL   EMBO J 20 (3), 340-349 (2001)
   PUBMED   11157741
REFERENCE   8  (bases 1 to 488)
  AUTHORS   Koehler,M.R., Bosserhoff,A., von Beust,G., Bauer,A., Blesch,A.,
            Buettner,R., Schlegel,J., Bogdahn,U. and Schmid,M.
  TITLE     Assignment of the human melanoma inhibitory activity gene (MIA) to
            19q13.32-q13.33 by fluorescence in situ hybridization (FISH)
  JOURNAL   Genomics 35 (1), 265-267 (1996)
   PUBMED   8661134
REFERENCE   9  (bases 1 to 488)
  AUTHORS   Bosserhoff,A.K., Hein,R., Bogdahn,U. and Buettner,R.
  TITLE     Structure and promoter analysis of the gene encoding the human
            melanoma-inhibiting protein MIA
  JOURNAL   J Biol Chem 271 (1), 490-495 (1996)
   PUBMED   8550608
REFERENCE   10 (bases 1 to 488)
  AUTHORS   Blesch,A., Bosserhoff,A.K., Apfel,R., Behl,C., Hessdoerfer,B.,
            Schmitt,A., Jachimczak,P., Lottspeich,F., Buettner,R. and
            Bogdahn,U.
  TITLE     Cloning of a novel malignant melanoma-derived growth-regulatory
            protein, MIA
  JOURNAL   Cancer Res 54 (21), 5695-5701 (1994)
   PUBMED   7923218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005910.1 and BM856478.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006533.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005910.1, BM856478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263369.4/ ENSP00000263369.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               BC005910.1         4-460
            458-488             BM856478.1         459-489
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..488
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /note="MIA SH3 domain containing"
                     /db_xref="GeneID:8190"
                     /db_xref="HGNC:HGNC:7076"
                     /db_xref="MIM:601340"
     exon            1..149
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..418
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /note="melanoma-derived growth regulatory protein;
                     melanoma inhibitory activity"
                     /codon_start=1
                     /product="melanoma-derived growth regulatory protein
                     precursor"
                     /protein_id="NP_006524.1"
                     /db_xref="CCDS:CCDS12566.1"
                     /db_xref="GeneID:8190"
                     /db_xref="HGNC:HGNC:7076"
                     /db_xref="MIM:601340"
                     /translation="MARSLVCLGVIILLSAFSGPGVRGGPMPKLADRKLCADQECSHP
                     ISMAVALQDYMAPDCRFLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGY
                     FPSSIVREDQTLKPGKVDVKTDKWDFYCQ"
     exon            150..283
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..394
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..488
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      467..472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /note="hexamer: AATACA"
     polyA_site      488
                     /gene="MIA"
                     /gene_synonym="CD-RAP; MIA1"
                     /note="major polyA site"
ORIGIN      
        1 actctcttgc tcacagtcca cgatggcccg gtccctggtg tgccttggtg tcatcatctt
       61 gctgtctgcc ttctccggac ctggtgtcag gggtggtcct atgcccaagc tggctgaccg
      121 gaagctgtgt gcggaccagg agtgcagcca ccctatctcc atggctgtgg cccttcagga
      181 ctacatggcc cccgactgcc gattcctgac cattcaccgg ggccaagtgg tgtatgtctt
      241 ctccaagctg aagggccgtg ggcggctctt ctggggaggc agcgttcagg gagattacta
      301 tggagatctg gctgctcgcc tgggctattt ccccagtagc attgtccgag aggaccagac
      361 cctgaaacct ggcaaagtcg atgtgaagac agacaaatgg gatttctact gccagtgagc
      421 tcagcctacc gctggccctg ccgtttcccc tccttggctt tatgcaaata caatcagccc
      481 agtgcaaa
//
