LOCUS       NM_004528               1158 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens microsomal glutathione S-transferase 3 (MGST3), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_004528
VERSION     NM_004528.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1158)
  AUTHORS   Steinmetz-Spah,J., Liu,J., Singh,R., Ekoff,M., Boddul,S., Tang,X.,
            Bergqvist,F., Idborg,H., Heitel,P., Ronnberg,E., Merk,D.,
            Wermeling,F., Haeggstrom,J.Z., Nilsson,G., Steinhilber,D.,
            Larsson,K., Korotkova,M. and Jakobsson,P.J.
  TITLE     Biosynthesis of prostaglandin 15dPGJ2 -glutathione and
            15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3
  JOURNAL   J Lipid Res 63 (12), 100310 (2022)
   PUBMED   36370807
REFERENCE   2  (bases 1 to 1158)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1158)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1158)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1158)
  AUTHORS   Lee,S.Y., Kang,M.G., Park,J.S., Lee,G., Ting,A.Y. and Rhee,H.W.
  TITLE     APEX Fingerprinting Reveals the Subcellular Localization of
            Proteins of Interest
  JOURNAL   Cell Rep 15 (8), 1837-1847 (2016)
   PUBMED   27184847
REFERENCE   6  (bases 1 to 1158)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1158)
  AUTHORS   Kobayashi,K., Xin,Y., Ymer,S.I., Werther,G.A. and Russo,V.C.
  TITLE     Subtractive hybridisation screen identifies genes regulated by
            glucose deprivation in human neuroblastoma cells
  JOURNAL   Brain Res 1170, 129-139 (2007)
   PUBMED   17719568
REFERENCE   8  (bases 1 to 1158)
  AUTHORS   Thameem,F., Yang,X., Permana,P.A., Wolford,J.K., Bogardus,C. and
            Prochazka,M.
  TITLE     Evaluation of the microsomal glutathione S-transferase 3 (MGST3)
            locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima
            Indians
  JOURNAL   Hum Genet 113 (4), 353-358 (2003)
   PUBMED   12898215
REFERENCE   9  (bases 1 to 1158)
  AUTHORS   Jakobsson,P.J., Morgenstern,R., Mancini,J., Ford-Hutchinson,A. and
            Persson,B.
  TITLE     Membrane-associated proteins in eicosanoid and glutathione
            metabolism (MAPEG). A widespread protein superfamily
  JOURNAL   Am J Respir Crit Care Med 161 (2 Pt 2), S20-S24 (2000)
   PUBMED   10673221
  REMARK    Review article
REFERENCE   10 (bases 1 to 1158)
  AUTHORS   Jakobsson,P.J., Mancini,J.A., Riendeau,D. and Ford-Hutchinson,A.W.
  TITLE     Identification and characterization of a novel microsomal enzyme
            with glutathione-dependent transferase and peroxidase activities
  JOURNAL   J Biol Chem 272 (36), 22934-22939 (1997)
   PUBMED   9278457
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356441.16, BC000505.2,
            AL451074.13 and AI591182.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004528.3.
            
            Summary: This gene encodes a member of the MAPEG (Membrane
            Associated Proteins in Eicosanoid and Glutathione metabolism)
            protein family. Members of this family are involved in the
            production of leukotrienes and prostaglandin E, important mediators
            of inflammation. This gene encodes an enzyme which catalyzes the
            conjugation of leukotriene A4 and reduced glutathione to produce
            leukotriene C4. This enzyme also demonstrates glutathione-dependent
            peroxidase activity towards lipid hydroperoxides.[provided by
            RefSeq, May 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN284845.1, SRR14038194.10639.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367889.8/ ENSP00000356864.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL356441.16        58075-58114
            41-642              BC000505.2         1-602
            643-746             AL451074.13        8548-8651
            747-1158            AI591182.1         10-421              c
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..1158
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /note="microsomal glutathione S-transferase 3"
                     /db_xref="GeneID:4259"
                     /db_xref="HGNC:HGNC:7064"
                     /db_xref="MIM:604564"
     exon            1..60
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            61..184
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..526
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /EC_number="4.4.1.20"
                     /note="microsomal glutathione S-transferase III;
                     microsomal GST-3; microsomal GST-III; LTC4 synthase MGST3;
                     glutathione peroxidase MGST3"
                     /codon_start=1
                     /product="glutathione S-transferase 3, mitochondrial"
                     /protein_id="NP_004519.1"
                     /db_xref="CCDS:CCDS1249.1"
                     /db_xref="GeneID:4259"
                     /db_xref="HGNC:HGNC:7064"
                     /db_xref="MIM:604564"
                     /translation="MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMY
                     STDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAY
                     GYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH"
     exon            185..258
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            259..316
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            317..389
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1158
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      606..611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /note="hexamer: AATAAA"
     polyA_site      642
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /note="major polyA site"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /note="hexamer: ATTAAA"
     polyA_site      860
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="MGST3"
                     /gene_synonym="GST-3; GST-III"
ORIGIN      
        1 gccgcaccca caccgcgctg cgcagttttg ttctgctcca gctgttcgaa ggtgatccag
       61 acgcaagatg gctgtcctct ctaaggaata tggttttgtg cttctaactg gtgctgccag
      121 ctttataatg gtggcccacc tagccatcaa tgtttccaag gcccgcaaga agtacaaagt
      181 ggagtatcct atcatgtaca gcacggaccc tgaaaatggg cacatcttca actgcattca
      241 gcgagcccac cagaacacgt tggaagtgta tcctcccttc ttattttttc tagctgttgg
      301 aggtgtttac cacccgcgta tagcttctgg cctgggcttg gcctggattg ttggacgagt
      361 tctttatgct tatggctatt acacgggaga acccagcaag cgtagtcgag gagccctggg
      421 gtccatcgcc ctcctgggct tggtgggcac aactgtgtgc tctgctttcc agcatcttgg
      481 ttgggttaaa agtggcttgg gcagtggacc caaatgctgc cattaaagaa ttataggggt
      541 ttaaaaactc tcattcattt taaatgactt acctttattt ccagttacat tttttttcta
      601 aatataataa aaacttacct ggcatcagcc tcatacctaa aactcctgac tcttaccact
      661 catttccgtt tgagtctgta tctgaaatca gtagcctagt cctactagat gagaaaggag
      721 ccacaagtat tgtgccctct cctcaccctt ccagcagatg cttctgtagt atgtgaggtt
      781 gagaaaaagt ctgattgtgg tgatgtaggt atagtcatgc cacagtgatg aaaaattaaa
      841 gaaaaatctt ctagctctca ggatatgcat tatcacttgc tacagatact ccaaggccaa
      901 aggaatgctt gagcctaaaa gttcaagacc agcctgggca acatagcaaa accccatctc
      961 tacaaaaaaa tatacaacag ttagccaggc atgatggcac atgtctgcag tcccagctac
     1021 ttgggaggct aaggtgggag gatcacttga gcccagggtg tcaaggctgc agtgagttat
     1081 gatcacactg ctgcactcca gcgtgggtga cagagcaaga ccctgtctca aataaataaa
     1141 aattaagttt ctattaaa
//
