LOCUS       NM_015246               3930 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mahogunin ring finger 1 (MGRN1), transcript variant 1,
            mRNA.
ACCESSION   NM_015246 XM_048119
VERSION     NM_015246.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3930)
  AUTHORS   Cerdido,S., Abrisqueta,M., Sanchez-Beltran,J., Lambertos,A.,
            Castejon-Grinan,M., Munoz,C., Olivares,C., Garcia-Borron,J.C.,
            Jimenez-Cervantes,C. and Herraiz,C.
  TITLE     MGRN1 depletion promotes intercellular adhesion in melanoma by
            upregulation of E-cadherin and inhibition of CDC42
  JOURNAL   Cancer Lett 581, 216484 (2024)
   PUBMED   38008393
  REMARK    GeneRIF: MGRN1 depletion promotes intercellular adhesion in
            melanoma by upregulation of E-cadherin and inhibition of CDC42.
REFERENCE   2  (bases 1 to 3930)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 3930)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 3930)
  AUTHORS   Sires-Campos,J., Lambertos,A., Delevoye,C., Raposo,G.,
            Bennett,D.C., Sviderskaya,E., Jimenez-Cervantes,C., Olivares,C. and
            Garcia-Borron,J.C.
  TITLE     Mahogunin Ring Finger 1 regulates pigmentation by controlling the
            pH of melanosomes in melanocytes and melanoma cells
  JOURNAL   Cell Mol Life Sci 79 (1), 47 (2021)
   PUBMED   34921635
  REMARK    GeneRIF: Mahogunin Ring Finger 1 regulates pigmentation by
            controlling the pH of melanosomes in melanocytes and melanoma
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3930)
  AUTHORS   Abrisqueta,M., Olivares,C., Herraiz,C., Castejon-Grinan,M.,
            Sires-Campos,J., Garcia-Borron,J.C. and Jimenez-Cervantes,C.
  TITLE     Human melanocortin 1 receptor-mediated ubiquitination of nonvisual
            arrestins. Role of Mahogunin Ring Finger 1 E3 ligase
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (1), 76-94 (2018)
   PUBMED   28947386
  REMARK    GeneRIF: In a heterologous expression system, MC1R-dependent
            Arrestins B ubiquitination was enhanced by overexpression of MGRN1
            and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to
            MGRN1 as the responsible E3-ligase.
REFERENCE   6  (bases 1 to 3930)
  AUTHORS   Perez-Oliva,A.B., Olivares,C., Jimenez-Cervantes,C. and
            Garcia-Borron,J.C.
  TITLE     Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits
            signaling from melanocortin receptor by competition with Galphas
  JOURNAL   J Biol Chem 284 (46), 31714-31725 (2009)
   PUBMED   19737927
REFERENCE   7  (bases 1 to 3930)
  AUTHORS   Fernandez,L.P., Milne,R.L., Pita,G., Floristan,U., Sendagorta,E.,
            Feito,M., Aviles,J.A., Martin-Gonzalez,M., Lazaro,P., Benitez,J.
            and Ribas,G.
  TITLE     Pigmentation-related genes and their implication in malignant
            melanoma susceptibility
  JOURNAL   Exp Dermatol 18 (7), 634-642 (2009)
   PUBMED   19320733
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3930)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3930)
  AUTHORS   Kim,B.Y., Olzmann,J.A., Barsh,G.S., Chin,L.S. and Li,L.
  TITLE     Spongiform neurodegeneration-associated E3 ligase Mahogunin
            ubiquitylates TSG101 and regulates endosomal trafficking
  JOURNAL   Mol Biol Cell 18 (4), 1129-1142 (2007)
   PUBMED   17229889
  REMARK    GeneRIF: a role for Mahogunin in a proteasome-independent
            ubiquitylation pathway: TSG101 is a specific Mahogunin substrate
REFERENCE   10 (bases 1 to 3930)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA590130.1, BC050389.1 and AC023830.9.
            
            On Nov 23, 2018 this sequence version replaced NM_015246.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050389.1, SRR7346977.1840605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262370.12/ ENSP00000262370.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA590130.1         3-28
            27-127              BC050389.1         1-101
            128-128             AC023830.9         94661-94661
            129-2390            BC050389.1         103-2364
            2391-3930           AC023830.9         159141-160680
FEATURES             Location/Qualifiers
     source          1..3930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3930
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /note="mahogunin ring finger 1"
                     /db_xref="GeneID:23295"
                     /db_xref="HGNC:HGNC:20254"
                     /db_xref="MIM:607559"
     exon            1..223
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1866
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable E3 ubiquitin-protein ligase MGRN1; RING finger
                     protein 156; mahogunin RING finger protein 1; mahogunin
                     ring finger 1, E3 ubiquitin protein ligase; RING-type E3
                     ubiquitin transferase MGRN1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MGRN1 isoform 1"
                     /protein_id="NP_056061.1"
                     /db_xref="CCDS:CCDS42115.1"
                     /db_xref="GeneID:23295"
                     /db_xref="HGNC:HGNC:20254"
                     /db_xref="MIM:607559"
                     /translation="MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKF
                     DTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKD
                     DADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSET
                     VHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAH
                     VLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSN
                     ECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPG
                     ALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLL
                     EALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKA
                     PDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQ
                     QGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMETAHGLATTSPTWPPLGGPSP
                     DPSAAELTPL"
     exon            224..342
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            343..431
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            432..578
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            579..696
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            697..763
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            764..813
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            814..861
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            862..930
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1090
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1200
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1266
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1493
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1617
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1663
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1753
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..3930
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3913..3918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /note="hexamer: AATAAA"
     polyA_site      3930
                     /gene="MGRN1"
                     /gene_synonym="RNF156"
                     /note="major polyA site"
ORIGIN      
        1 gggggctcga ggcgcctccg cggccgtgga cgagcgtccg tgcggcctgg tccgggccat
       61 gtccgcgtga ggaccccgcc gctgtcgccg ctcccgttcc ggccctggcc cctctgcccg
      121 gcagcgccgc gcaccatggg ctccattctc agccgccgca tcgcgggggt ggaggacatc
      181 gacatccagg cgaactcggc ctatcgctac cctccgaagt ccggaaacta ctttgcttcg
      241 cactttttca tgggaggaga gaaattcgac accccccacc ctgaaggtta cctctttgga
      301 gagaacatgg atctgaactt cctgggcagc cgcccggtcc agtttcccta cgtcactcct
      361 gccccccacg agcccgtgaa gacgctgcgg agcctggtga acatccgcaa agactccctg
      421 cggctggtga ggtacaaaga cgatgccgac agccccaccg aggacggcga caagccccgg
      481 gtgctctaca gcctggagtt caccttcgac gccgatgccc gcgtggccat caccatctac
      541 tgccaggcat cggaggagtt cctgaacggc agggcagtat acagccccaa gagcccctcg
      601 ctacagtccg agaccgtcca ctacaagaga ggggtgagcc agcagttctc cctgccctcc
      661 ttcaagattg acttctcgga atggaaggat gacgagctga actttgacct ggaccggggc
      721 gtgtttccag tagtcatcca ggctgtggtg gacgaaggag atgtggtgga agtgactggc
      781 cacgcccacg tgctcttggc tgcctttgaa aagcacatgg acggcagctt ctctgtgaag
      841 cctttaaagc agaagcaaat tgtggaccgg gtcagctacc tcctgcagga gatctatggc
      901 attgagaaca agaacaacca ggagaccaag ccctcggacg acgagaacag cgacaacagc
      961 aacgagtgtg tggtgtgcct gtccgacctg cgggacacgc tgatcctgcc ctgccgccac
     1021 ctgtgcctct gtacctcctg cgccgacacg ctgcgctacc aggccaacaa ctgccccatc
     1081 tgccggctgc ctttccgggc cctcctgcag atccgggcgg tgcggaagaa gccaggagcc
     1141 ctgtcccccg tgtccttcag ccccgtcctg gcccagagcc tggagcatga tgagcactct
     1201 tgtcccttta aaaaatcaaa gccgcacccc gcctccctgg ccagcaagaa acctaaaagg
     1261 gaaacaaact ctgacagcgt cccacctggc tacgagccca tctcgctgct cgaggcgctc
     1321 aacggcctcc gggctgtctc cccggccatc ccctcggccc ctctttatga agaaatcacc
     1381 tattcaggca tctcggacgg cctgtcccag gccagctgtc ccctcgcggc tatcgaccac
     1441 atcctggaca gcagccgcca gaagggcagg ccgcagagca aggcccccga cagcacccta
     1501 cggtccccgt cttcccccat ccacgaagag gatgaggaga agctctccga ggacgtggac
     1561 gcccctcccc cactgggtgg cgcagagctg gccctgcggg aaagcagctc ccctgagagt
     1621 ttcataacag aagaggttga tgagtcgtcg tcaccacagc aagggacccg agcagcttcc
     1681 attgagaatg tcctgcagga cagcagcccc gagcactgtg gccgaggccc acctgctgac
     1741 atctacctgc caggacggcc cacctccatg gagacggccc acggcctcgc caccaccagc
     1801 cccacctggc ctccacttgg tggccccagc cccgatccca gcgccgccga gctgacccca
     1861 ctctgagagc ctggccgagc tggcagcatg gagccctcgg ctccccagac tttgccgagg
     1921 ggctgctccg gaccccgttg tgagccggcc tcctgtctgc atgccccctg tggccaccag
     1981 gctccgaggg gccgtggtga ctcttgatca aagagcacag tgaactgtcc cttctgagtc
     2041 tcccttttct acagttgata tatttgtaac tggtacaaga tgaaggacag cagctttcca
     2101 tccctagttc agagcccccg ttccccaggg tcctgtgggc tgagcggctg gggctggggc
     2161 tgcccacgtg tggcctccgc tggctctgcc tgctcctgca acagtgcggt ccctgcccgg
     2221 agaactcagg aggcctgcag aagagaactg attggtggtc gaagcaccat cttcacagat
     2281 gttcaggggc agtggggggc tccaggcacg gtcaatgaag gaaacagtgc ctgtccaccc
     2341 accctgcgtg tcactgtggc ggcctggctg tcgctgcttt ttgtcctctg ccgtgtttgc
     2401 gcggcctcag tgccctccct ggtgcgtctg cgctggggcc ctcagtgctc ggggccttgg
     2461 ggtgcatggg tgccgccctg ggcagctaga gtgtctcagc ccggtgctgg gcctggccga
     2521 ggggcggagg cacagctgct tccagcagcc agcattcagt ggccttgtca ccaagctcca
     2581 cacctcctcc tggtgctggc tttggtgaca tcacaaggcc cctccaggtg caggggcttc
     2641 tgtttggcag gcccctgcca gggaggacct ggtggcctcc tcattctctt ttgccattgg
     2701 aatgtcccct tgcagttctc ttctcttttt tttttttttt gagatggagt ttcactcttg
     2761 ctgcccaggc tggagtgcag tggctcaatc tcgggtcact gcaacctccg cctcccgggt
     2821 tcaagtgatc gtcctgcctt aggctcctga gtagctgggg attacaggtg cctaccagca
     2881 tgctcggcta atttttttgt atttttagta gagaagggat ttcaccatgt tggccgggct
     2941 ggtctcaaac tcctaaggtc atccacctgc ctcggcctcc cagagtgctg agattacagg
     3001 cgtgagcctc cgcgcccggc ccccttgcag ttctctctga tttggtttgt tctgtctcag
     3061 gcttctgtgg caggactggc ccagggagga ggaagccagc agcacacctg gggaatgggg
     3121 tcccggccgg gaggcttggc ctctgggcga cctcgtcctg ttttttttgt ttgtttgttt
     3181 gtttttttaa aggtaaacct cctgggccgc agatggcaaa gggagtgcct gggcctggtg
     3241 acccagggct ggatccaccc ctgcggagcc ctgggccagg caggtgtctg ctgctcacct
     3301 ggctctggag ggctgccctg cagctgggcc tggggacagg tcggctgtgg ggcagctcag
     3361 taccctccct gaggctcacg gtggctccga gcatgaggtc cgcctcctgg gcgagaccca
     3421 gcagtggaca gcatggtcct cacacccagc tccctgcaca cccaggccag ccacccctcc
     3481 cgctcgtgca caggcacgca gatgcgctca cacgtacaca cacacaaatg cacgcccact
     3541 tgcacatgct cacgcacatg ttcacacatg cacactcacg ctcacacatg ctgtcacgca
     3601 tacacacacg cacatactcc tgcacatgtt cccatgcatg tgtgtgcact cggaccgagc
     3661 atctcccacg cacctctacc ccaccccaag cacctctctc cccccatgca cctctcccca
     3721 acaacacaca cagccccctg caccgcccgc cccccgcccc caccaaggcc ccagcctctg
     3781 gccatcagtc ctggtgccag agctttgcgt gaagttcggg ccgcagagtg gcccgctggg
     3841 actcccatgt gctgccgtct gatgtgctca gatgggctca tcgttggttc gtttttactg
     3901 tatatttata gtaataaaat catgcagcaa
//
