LOCUS       NM_007283               4271 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens monoglyceride lipase (MGLL), transcript variant 1,
            mRNA.
ACCESSION   NM_007283
VERSION     NM_007283.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4271)
  AUTHORS   Fan,C., Du,J., Yu,Z., Wang,J., Yao,L., Ji,Z., He,W., Deng,Y.,
            Geng,D., Wu,X. and Mao,H.
  TITLE     Inhibition of MAGL attenuates Intervertebral Disc Degeneration by
            Delaying nucleus pulposus senescence through STING
  JOURNAL   Int Immunopharmacol 131, 111904 (2024)
   PUBMED   38518595
  REMARK    GeneRIF: Inhibition of MAGL attenuates Intervertebral Disc
            Degeneration by Delaying nucleus pulposus senescence through STING.
REFERENCE   2  (bases 1 to 4271)
  AUTHORS   Zhou,S., Ling,X., Zhu,J., Liang,Y., Feng,Q., Xie,C., Li,J.,
            Chen,Q., Chen,S., Miao,J., Zhang,M., Li,Z., Shen,W., Li,X., Wu,Q.,
            Wang,X., Liu,R., Wang,C., Hou,F.F., Kong,Y., Liu,Y. and Zhou,L.
  TITLE     MAGL protects against renal fibrosis through inhibiting tubular
            cell lipotoxicity
  JOURNAL   Theranostics 14 (4), 1583-1601 (2024)
   PUBMED   38389852
  REMARK    GeneRIF: MAGL protects against renal fibrosis through inhibiting
            tubular cell lipotoxicity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4271)
  AUTHORS   Liu,C.Z., Liu,X.B., Sun,J., Yu,C.Q., Yao,J.C., Liu,Z. and Hao,J.C.
  TITLE     IL-8-induced CXCR2 down-regulation in circulating monocytes in
            hepatocellular carcinoma is partially dependent on MAGL
  JOURNAL   BMC Cancer 23 (1), 626 (2023)
   PUBMED   37403022
  REMARK    GeneRIF: IL-8-induced CXCR2 down-regulation in circulating
            monocytes in hepatocellular carcinoma is partially dependent on
            MAGL.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4271)
  AUTHORS   Karaosmanoglu Yoneten,K., Kasap,M., Arga,K.Y., Akpinar,G. and
            Utkan,N.Z.
  TITLE     Decreased serum levels of glycerol-3- phosphate dehydrogenase 1 and
            monoacylglycerol lipase act as diagnostic biomarkers for breast
            cancer
  JOURNAL   Cancer Biomark 34 (1), 67-76 (2022)
   PUBMED   34657876
  REMARK    GeneRIF: Decreased serum levels of glycerol-3- phosphate
            dehydrogenase 1 and monoacylglycerol lipase act as diagnostic
            biomarkers for breast cancer.
REFERENCE   5  (bases 1 to 4271)
  AUTHORS   Labar,G., Bauvois,C., Borel,F., Ferrer,J.L., Wouters,J. and
            Lambert,D.M.
  TITLE     Crystal structure of the human monoacylglycerol lipase, a key actor
            in endocannabinoid signaling
  JOURNAL   Chembiochem 11 (2), 218-227 (2010)
   PUBMED   19957260
  REMARK    GeneRIF: An apolar helix covering the active site also gives
            structural insight into the amphitropic character of MAGL, and
            likely explains how MAGL interacts with membranes to recruit its
            substrate.
REFERENCE   6  (bases 1 to 4271)
  AUTHORS   Zvonok,N., Williams,J., Johnston,M., Pandarinathan,L., Janero,D.R.,
            Li,J., Krishnan,S.C. and Makriyannis,A.
  TITLE     Full mass spectrometric characterization of human monoacylglycerol
            lipase generated by large-scale expression and single-step
            purification
  JOURNAL   J Proteome Res 7 (5), 2158-2164 (2008)
   PUBMED   18452279
  REMARK    GeneRIF: full proteomic characterization of hMGL was carried out,
            which showed (1) an absence of intramolecular disulfide bridges in
            the functional, recombinant enzyme and (2) the post-translational
            removal of the enzyme's N-terminal methionine
REFERENCE   7  (bases 1 to 4271)
  AUTHORS   Iwasaki,S., Ishiguro,H., Higuchi,S., Onaivi,E.S. and Arinami,T.
  TITLE     Association study between alcoholism and endocannabinoid metabolic
            enzyme genes encoding fatty acid amide hydrolase and monoglyceride
            lipase in a Japanese population
  JOURNAL   Psychiatr Genet 17 (4), 215-220 (2007)
   PUBMED   17621164
  REMARK    GeneRIF: not associated with susceptibility to alcoholism in a
            Japanese population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4271)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   9  (bases 1 to 4271)
  AUTHORS   Karlsson,M., Reue,K., Xia,Y.R., Lusis,A.J., Langin,D., Tornqvist,H.
            and Holm,C.
  TITLE     Exon-intron organization and chromosomal localization of the mouse
            monoglyceride lipase gene
  JOURNAL   Gene 272 (1-2), 11-18 (2001)
   PUBMED   11470505
REFERENCE   10 (bases 1 to 4271)
  AUTHORS   Wall,E.M., Cao,J., Chen,N., Buller,R.M. and Upton,C.
  TITLE     A novel poxvirus gene and its human homolog are similar to an E.
            coli lysophospholipase
  JOURNAL   Virus Res 52 (2), 157-167 (1997)
   PUBMED   9495531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC006230.2, AC023593.14 and
            AL833254.1.
            
            On Aug 14, 2020 this sequence version replaced NM_007283.6.
            
            Summary: This gene encodes a serine hydrolase of the AB hydrolase
            superfamily that catalyzes the conversion of monoacylglycerides to
            free fatty acids and glycerol. The encoded protein plays a critical
            role in several physiological processes including pain and
            nociperception through hydrolysis of the endocannabinoid
            2-arachidonoylglycerol. Expression of this gene may play a role in
            cancer tumorigenesis and metastasis. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3808542.1,
                                           SRR14038194.4494130.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265052.10/ ENSP00000265052.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1220              BC006230.2         323-1542
            1221-1257           AC023593.14        89406-89442
            1258-4271           AL833254.1         1-3014
FEATURES             Location/Qualifiers
     source          1..4271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..4271
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /note="monoglyceride lipase"
                     /db_xref="GeneID:11343"
                     /db_xref="HGNC:HGNC:17038"
                     /db_xref="MIM:609699"
     exon            1..207
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1139
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /EC_number="3.1.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monoacylglycerol lipase; lysophospholipase homolog"
                     /codon_start=1
                     /product="monoglyceride lipase isoform 1"
                     /protein_id="NP_009214.1"
                     /db_xref="CCDS:CCDS46902.1"
                     /db_xref="GeneID:11343"
                     /db_xref="HGNC:HGNC:17038"
                     /db_xref="MIM:609699"
                     /translation="METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRY
                     WKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSD
                     FHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVL
                     ANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVC
                     FGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEG
                     AYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP"
     exon            208..352
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            353..459
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            460..596
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            597..707
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            708..797
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1013
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..4271
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4250..4255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /note="hexamer: AATAAA"
     polyA_site      4271
                     /gene="MGLL"
                     /gene_synonym="HU-K5; HUK5; MAGL; MGL"
                     /note="major polyA site"
ORIGIN      
        1 ggagagcctg ccggtgggag ctggaagcag gctcccggct gagcgcccca gcccgaaagg
       61 cagggtctgg gtgcgggaag agggctcgga gctgccttcc tgctgccttg gggccgccca
      121 gatgagggaa cagcccgatt tgcctggttc tgattctcca ggctgtcgtg gttgtggaat
      181 gcaaacgcca gcacataatg gaaacaggac ctgaagaccc ttccagcatg ccagaggaaa
      241 gttcccccag gcggaccccg cagagcattc cctaccagga cctccctcac ctggtcaatg
      301 cagacggaca gtacctcttc tgcaggtact ggaaacccac aggcacaccc aaggccctca
      361 tctttgtgtc ccatggagcc ggagagcaca gtggccgcta tgaagagctg gctcggatgc
      421 tgatggggct ggacctgctg gtgttcgccc acgaccatgt tggccacgga cagagcgaag
      481 gggagaggat ggtagtgtct gacttccacg ttttcgtcag ggatgtgttg cagcatgtgg
      541 attccatgca gaaagactac cctgggcttc ctgtcttcct tctgggccac tccatgggag
      601 gcgccatcgc catcctcacg gccgcagaga ggccgggcca cttcgccggc atggtactca
      661 tttcgcctct ggttcttgcc aatcctgaat ctgcaacaac tttcaaggtc cttgctgcga
      721 aagtgctcaa ccttgtgctg ccaaacttgt ccctcgggcc catcgactcc agcgtgctct
      781 ctcggaataa gacagaggtc gacatttata actcagaccc cctgatctgc cgggcagggc
      841 tgaaggtgtg cttcggcatc caactgctga atgccgtctc acgggtggag cgcgccctcc
      901 ccaagctgac tgtgcccttc ctgctgctcc agggctctgc cgatcgccta tgtgacagca
      961 aaggggccta cctgctcatg gagttagcca agagccagga caagactctc aagatttatg
     1021 aaggtgccta ccatgttctc cacaaggagc ttcctgaagt caccaactcc gtcttccatg
     1081 aaataaacat gtgggtctct caaaggacag ccacggcagg aactgcgtcc ccaccctgaa
     1141 tgcattggcc ggtgcccggc tcatggtctg ggggatgcag gcaggggaag ggcagagatg
     1201 gcttctcaga tatggcttgc caaaaaaaaa aaaaaaaaaa aatcagaaat tggagaaatc
     1261 cttagcacaa ttttctaaaa aataacagac atttttgtta tacattagac tatcagacac
     1321 tggacctacc ttaatggtta gacactttat gcaaaaaaag agaaaggtcc caggtgattt
     1381 tccacaaaga atgtgctaaa atgtccactg aaaacaaagc caagcctctg ccctgcctct
     1441 cccagctccc acaagggttc caggaattcc tggtgttccc aggacaccag actgcaataa
     1501 ctggaggcgc ctccttcctg cccacccttc gctcacgccc cagcgccctc tctgaccagc
     1561 ctccgcttgg tggccttcct ctggccgtgt gatgaggtgg ttgctgtctc cataggggcc
     1621 agctccccag ggcagactca cgtgcccctc tgaggctcag aaaatgccca gcccttcctc
     1681 aaaatgagca gccacccatg actttgtggg ctccttgtta gcctgagacc aggctttgca
     1741 gaggggcggg gggtgaggct tagcccagaa ggagaactga gcaggaaacc aaggctcttc
     1801 tctgtcccct gcccttcccc tcctgccagg gggaggctca ggttggtccc cgagtgccgc
     1861 ctgtactcac aaaggctgcc tttcctctag agtcactaat tttacctgat gctatgagag
     1921 aatcatattg aagatgaaat gtctaatata taatgtatat tttaaagcag agactatttt
     1981 ggtggatagg tgggagggag caaggggagt ttgagggaat cagagcttga tgctactgta
     2041 cagaactgga caggttgggc cggcagtggt ggggccagag ggctctgtgc tctaggagct
     2101 aagccagcag cccccgagag gggacttggc tgggcctttc ctatgggcaa ggcccagtgc
     2161 tcttcctgcc caccagggac catggagcag tggcacccta tggggctatg atccctaggc
     2221 ctgggcctgg gcctgcctat ggcccagagc taccctggga gtgtcagtgc tagcagcaca
     2281 gctacctctg gtggcaggag aagagaggcc cagcacagca gcaggccagg ccttcctgtc
     2341 caggtctgca tggagcactc ggtgacccag agcagggact ggaggcaccc ccagccctgc
     2401 cccaggccac agcaggacag gccgggacag gcctcaccca aggccaaggc tggcatcagc
     2461 caatcattca gagctgaggc cctgggccta gcctgccctt ctcaggtgcc aataccaccc
     2521 cagccctgcc cttggcctca ctttttccca gcaataagtg gggttcacca cccgcctcgg
     2581 gaatactttc cccttctaaa tgggacttgc tgttacctca ggaggctcct tagtgcaaat
     2641 atgaccctgg tcagggcttt gccaccgttg aagccctgca gaaggtgcaa tgtaggggtt
     2701 ctggggccac agaggagagg ccacttccca ccaggacccc caacatgaag tctaggcctc
     2761 aggggctccc gcccttcttc ctccagcagc gggaactgcc actgctctcc caggccctgt
     2821 tctggaggct aaccttggtt cctggagagt gtgcccctcc accctccctc cagcagccct
     2881 gatcacacca tgagagccag gaacgggtca ccctgctgaa gatcactctg tgccctgggg
     2941 gaggagccaa gccctcaccc cacaaggggc aggtgggggc ttggttgctg acccggccca
     3001 agtccccaca gagcaccttc tgtagctcca gcttgtctcc ctggcttctc tttgaaggag
     3061 aaaaatgtaa aatatgcact gagaaagcca gccccgcctg cttagtcagc cccggcagca
     3121 gggcagccat gggaactcag gaaaagcagg aaccctttcc aaaagcccag agatgccctg
     3181 ggctcagatc tgtaattctc ccaggagctg tgatagagca ggccacacaa agtccctacg
     3241 cctccctgct gcctccccca gatgcatgtg gtggcatcac cattccccaa attgaatatc
     3301 agcatgcggc ctgaccaggg actctttaga tgcatgaatt tatttatatg aaggctctca
     3361 cagagacaca cacagcactt cagtagcatt tgcattcctg gttaaagaat caccaatatt
     3421 taaaataaaa actttcctga aattgggact gtcatgttat ccagaagggc tggtacatcc
     3481 gcccaccatg tccccctgct gggtcaggag ccaacacagg accctgcgtg tgagcgtgcc
     3541 tgacatctca cgcacggcca ctccagagcc ggtccctgtc cttggaaagc tgtgaagcct
     3601 tgcgttgagt tccttctcga tactgacggc tccgtgctga cattctgagc tctggagtca
     3661 caccagcgca ggggcgtgga ggaactgagg tttggaagga atgccaggtc tcgcacagct
     3721 tggcctcgag aaggtgagag gaaggcaaag gccagggagg ggacccagag aggcctggca
     3781 cacaaggccc aagcaccacc gtcaacacag cccagtccat acagaaatgg gtttcatgcc
     3841 tgaaaagctt tttacagaaa gatgccgcct gtagccagtg acagccgcaa ccctacaggc
     3901 ctcagttcct tgcagaggtg aggggtagag agtcagcctc cctcccttcc agcagcgacc
     3961 cagcttccct ccacttccag gtggtgctgg gctcaccgag ggagcactgg tgggtgctct
     4021 gaaaacccac aggatcccac ctccaggccc acctgggtcc catctcactc tcttcttctt
     4081 tcaccaattg ctaacataga ccttgttggg atcacgatgg cttcacaagc cagctgttgg
     4141 gtttgctatg tcactgtggc tcagtcacat ccctgcgtgt atactgtctg cggggcacat
     4201 atgtatccat ttagagctaa aggaatcagt gtacactaca gctaatccta ataaatccga
     4261 tgttttcgga a
//
