LOCUS       NM_001277353            2370 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens MGAT4 family member D (MGAT4D), mRNA.
ACCESSION   NM_001277353
VERSION     NM_001277353.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Akintayo,A., Mayoral,J., Asada,M., Tang,J., Sundaram,S. and
            Stanley,P.
  TITLE     Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and
            complex N-glycan synthesis
  JOURNAL   J Biol Chem 295 (41), 14053-14064 (2020)
   PUBMED   32763972
  REMARK    GeneRIF: Point mutations that inactivate MGAT4D-L, an inhibitor of
            MGAT1 and complex N-glycan synthesis.
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Huang,H.H., Hassinen,A., Sundaram,S., Spiess,A.N., Kellokumpu,S.
            and Stanley,P.
  TITLE     GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal
            domain
  JOURNAL   Elife 4, e08916 (2015)
   PUBMED   26371870
  REMARK    GeneRIF: The authors show here that the luminal domain of GnT1IP-L
            contains its MGAT1 inhibitory activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Huang,H.H. and Stanley,P.
  TITLE     A testis-specific regulator of complex and hybrid N-glycan
            synthesis
  JOURNAL   J Cell Biol 190 (5), 893-910 (2010)
   PUBMED   20805325
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Benjamin,E.J., Dupuis,J., Larson,M.G., Lunetta,K.L., Booth,S.L.,
            Govindaraju,D.R., Kathiresan,S., Keaney,J.F. Jr., Keyes,M.J.,
            Lin,J.P., Meigs,J.B., Robins,S.J., Rong,J., Schnabel,R., Vita,J.A.,
            Wang,T.J., Wilson,P.W., Wolf,P.A. and Vasan,R.S.
  TITLE     Genome-wide association with select biomarker traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S11 (2007)
   PUBMED   17903293
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Hodgson,U., Pulkkinen,V., Dixon,M., Peyrard-Janvid,M., Rehn,M.,
            Lahermo,P., Ollikainen,V., Salmenkivi,K., Kinnula,V., Kere,J.,
            Tukiainen,P. and Laitinen,T.
  TITLE     ELMOD2 is a candidate gene for familial idiopathic pulmonary
            fibrosis
  JOURNAL   Am J Hum Genet 79 (1), 149-154 (2006)
   PUBMED   16773575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB462368.1, BI826002.1, AC093671.3, DB444046.1 and BI828214.1.
            
            On May 17, 2019 this sequence version replaced NM_001277353.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA2148093
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000511113.6/ ENSP00000421185.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               DB462368.1         86-206
            122-270             BI826002.1         182-330
            271-271             AC093671.3         111492-111492       c
            272-324             BI826002.1         331-383
            325-462             AC093671.3         108602-108739       c
            463-512             DB444046.1         206-255
            513-513             AC093671.3         104008-104008       c
            514-617             DB444046.1         256-359
            618-618             AC093671.3         100912-100912       c
            619-646             DB444046.1         360-387
            647-651             AC093671.3         94114-94118         c
            652-1051            BI828214.1         248-647
            1052-1257           BI826002.1         487-692
            1258-2370           AC093671.3         71374-72486         c
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..2370
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /note="MGAT4 family member D"
                     /db_xref="GeneID:152586"
                     /db_xref="HGNC:HGNC:43619"
                     /db_xref="MIM:610310"
     exon            1..165
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1196
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /EC_number="2.4.1.-"
                     /note="glycosyltransferase 54 domain-containing protein;
                     glycosyltransferase 54 domain containing 1; mannosyl
                     (alpha-1,3-)-glycoprotein
                     beta-1,4-N-acetylglucosaminyltransferase family, member D;
                     GlcNAcT-I Inhibitory Protein;
                     alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase-like protein
                     MGAT4D; N-acetylglucosaminyltransferase MGAT1 inhibitory
                     protein"
                     /codon_start=1
                     /product="alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
                     precursor"
                     /protein_id="NP_001264282.1"
                     /db_xref="CCDS:CCDS64066.1"
                     /db_xref="GeneID:152586"
                     /db_xref="HGNC:HGNC:43619"
                     /db_xref="MIM:610310"
                     /translation="MRTKQVNLLITLVAVALFSFSCFSIYRITQTNNQLINCRNHILE
                     FKENMLHLRNKTEKNTQEMMKVLNRMKYEITKREILSGNLVAQKADILNKNETVSNTF
                     EDLKFFFPHLRKEGRIYPDVIIGKGKTGVSFALGISTVNRGNYSYLKQTLTSVVSRMT
                     LSQEKDSVVIVLVADSNEDYLHSVVKMITKKFKRQVRSGSLEVISIPAFLYSSMLNAK
                     HLAEASQKLASWRIKQVLDFCILLLYAQPKAKYYLQLEDDIIAKEMYFTKITDFVGNI
                     SSNNWFFIEFSMLGFIGKLFRSEDLTHFVRFFLMFYKEKPIDWLLNDIFQVKVCDAGE
                     DLRNCMKRKKQIRIQYKPSLFQHVGIHSSFPRKEQYEKKI"
     exon            166..324
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            325..462
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            463..596
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            597..643
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            644..757
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            758..833
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            834..948
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1079
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1187
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2370
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2347..2352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /note="hexamer: TATAAA"
     polyA_site      2370
                     /gene="MGAT4D"
                     /gene_synonym="GnT1IP"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgctcaa ccccgtccct ggcattatcc gccgcctcca cccgccggcc tcccgcagcc
       61 tggccagggc catgaggacc aagcaggtga acttgctgat caccctggtc gccgtcgcgt
      121 tgttcagctt ctcttgcttc tccatctaca ggataactca aaccaataat caattaatta
      181 actgtagaaa ccatattttg gagtttaaag aaaatatgct acacttaaga aacaaaactg
      241 aaaaaaatac ccaagagatg atgaaagttt tgaatcgaat gaagtatgaa attacaaaga
      301 gagaaatttt gtcaggaaac ttagttgcac agaaagcaga catattaaat aaaaatgaaa
      361 cagtatctaa tacatttgaa gacttaaagt tcttttttcc tcatctaagg aaagaaggta
      421 gaatttatcc tgatgtaatc attggcaaag ggaaaactgg tgtttctttt gcgctgggta
      481 tttccactgt taacagagga aattatagtt acctgaaaca gacactgacc tctgttgtct
      541 ccaggatgac gctctcccaa gagaaggatt ctgtagtgat tgtcttggtt gcagatagta
      601 atgaagatta tttacattct gttgttaaaa tgattacaaa aaaattcaaa aggcaagtga
      661 ggtctggatc cttagaggtc atttcaatac ctgccttttt atactcaagc atgttaaatg
      721 ccaagcactt agctgaggcc tcacaaaaat tagccagttg gcgaatcaaa caggtattgg
      781 atttttgcat tttgttgctg tatgcccaac ccaaggccaa gtattattta cagctagaag
      841 atgatatcat agctaaagag atgtacttta caaaaataac agattttgta ggtaatatca
      901 gttcaaataa ttggtttttt attgagtttt caatgcttgg attcatagga aagctgttta
      961 gatctgagga cttaactcac tttgtacggt tttttttaat gttctacaaa gagaaaccca
     1021 tagactggct cttgaatgac atttttcagg taaaggtgtg tgacgcagga gaagatctta
     1081 gaaactgtat gaaacgaaag aagcaaatac gtattcagta taaaccttct cttttccagc
     1141 atgtgggtat acattcatca ttccctagaa aagaacaata tgaaaaaaaa atatgaagat
     1201 aaataagaag aaactctgta atacctggaa cctcagataa ccttgatatc taatggcatg
     1261 tttcagaaat tgtagtaatg aaaatacata attatctagc agataagtaa acaatgcata
     1321 aactagtaga cttgaaagta ctaaatgact tcttatgtca agacaaggta gaacatttat
     1381 attgctttta ccctattaca atttaattta aaaatactaa aggcaaggaa gtttttttta
     1441 aattaagaac tgcactttat tgacttcgat agtgagacca tcacataatc tcaataaaca
     1501 gttaaaagtt cgaaagcttg ctattgtcag ggagaagttt ggggtgaatt ggtatatgcc
     1561 gttatccatt ttgttaagac acctaaagaa atagaaagca caaatttaaa caagcctgga
     1621 tctgacagtg ccacaatgtc ttcttgtcta ttaatagatg catttaaaac tataaactta
     1681 tccctatgtg ccatttgaac cgattatcaa acatcttgat atatatgtat tcttatagtc
     1741 atttagttct aaagatttca tagtttctct catcattgcc ttcttaacac acagattatt
     1801 tgggagtttt tttcccaaat atattggttt tctccatctt ttattgttaa tttctaaatt
     1861 acttgcatag tggttataga actttacctg tgtgataaaa ttttgagaat tgttgtgaat
     1921 ccttgtgttc catatgactt tggaaagaat gtatagtttc tgtatactcc cttttaaata
     1981 tgttatattc atttgttttt aaaagtgttg gttttgtgct ttaaaaatat ctcttaaaag
     2041 tattcctatc tattgggtgc aaaattctct tatatcaggc tttctaattt ggttgttgaa
     2101 aacttttcac tccttactaa tttctatatg cttgatccat cagtttctac aggggcccat
     2161 taaaatctat ttttcttctt gatgttattc tgtaaggtat tacttatttt gagcaataat
     2221 aagtgatatt tatttgttat cctttaatca aatattgtga aattcttcat ttcccattgt
     2281 tgccttattc ttgagtgcca agatctcaca cattcgcctc agtatgaact gtatcaaata
     2341 ccaatttata aagataatat gaaagacgaa
//
