LOCUS       NM_002409               5394 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens beta-1,4-mannosyl-glycoprotein
            4-beta-N-acetylglucosaminyltransferase (MGAT3), transcript variant
            1, mRNA.
ACCESSION   NM_002409
VERSION     NM_002409.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Niu,H., Qu,A. and Guan,C.
  TITLE     Suppression of MGAT3 expression and the epithelial-mesenchymal
            transition of lung cancer cells by miR-188-5p
  JOURNAL   Biomed J 44 (6), 678-685 (2021)
   PUBMED   35166206
  REMARK    GeneRIF: Suppression of MGAT3 expression and the
            epithelial-mesenchymal transition of lung cancer cells by
            miR-188-5p.
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Zhao,L., Liu,H., Luo,S., Moorman,P.G., Walsh,K.M., Li,W. and Wei,Q.
  TITLE     Associations between genetic variants of KIF5B, FMN1, and MGAT3 in
            the cadherin pathway and pancreatic cancer risk
  JOURNAL   Cancer Med 9 (24), 9620-9631 (2020)
   PUBMED   33200553
  REMARK    GeneRIF: Associations between genetic variants of KIF5B, FMN1, and
            MGAT3 in the cadherin pathway and pancreatic cancer risk.
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5394)
  AUTHORS   Deng,Q., Liu,X., Yang,Z. and Xie,L.
  TITLE     Expression of N-Acetylglucosaminyltransferase III Promotes
            Trophoblast Invasion and Migration in Early Human Placenta
  JOURNAL   Reprod Sci 26 (10), 1373-1381 (2019)
   PUBMED   29642803
  REMARK    GeneRIF: Study found that N-Acetylglucosaminyltransferase III
            (GnT-III) is expressed in trophoblasts during normal human
            pregnancy and is involved in regulating trophoblast function.
REFERENCE   5  (bases 1 to 5394)
  AUTHORS   Klasic,M., Markulin,D., Vojta,A., Samarzija,I., Birus,I.,
            Dobrinic,P., Ventham,N.T., Trbojevic-Akmacic,I., Simurina,M.,
            Stambuk,J., Razdorov,G., Kennedy,N.A., Satsangi,J., Dias,A.M.,
            Pinho,S., Annese,V., Latiano,A., D'Inca,R., Lauc,G. and Zoldos,V.
  CONSRTM   IBD consortium
  TITLE     Promoter methylation of the MGAT3 and BACH2 genes correlates with
            the composition of the immunoglobulin G glycome in inflammatory
            bowel disease
  JOURNAL   Clin Epigenetics 10, 75 (2018)
   PUBMED   29991969
  REMARK    GeneRIF: Results strongly indicate that the MGAT3 and BACH2 genes
            play an important role in IBD pathogenesis and suggest a possible
            disease pathway mediated by the pro-inflammatory properties of IgG
            antibodies acquired by alterations in Fc glycosylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5394)
  AUTHORS   Song,E.Y., Kang,S.K., Lee,Y.C., Park,Y.G., Chung,T.H., Kwon,D.H.,
            Byun,S.M. and Kim,C.H.
  TITLE     Expression of bisecting N-acetylglucosaminyltransferase-III in
            human hepatocarcinoma tissues, fetal liver tissues, and hepatoma
            cell lines of Hep3B and HepG2
  JOURNAL   Cancer Invest 19 (8), 799-807 (2001)
   PUBMED   11768033
REFERENCE   7  (bases 1 to 5394)
  AUTHORS   Ikeda,Y., Koyota,S., Ihara,H., Yamaguchi,Y., Korekane,H., Tsuda,T.,
            Sasai,K. and Taniguchi,N.
  TITLE     Kinetic basis for the donor nucleotide-sugar specificity of beta1,
            4-N-acetylglucosaminyltransferase III
  JOURNAL   J Biochem 128 (4), 609-619 (2000)
   PUBMED   11011143
REFERENCE   8  (bases 1 to 5394)
  AUTHORS   Koyama,N., Miyoshi,E., Ihara,Y., Kang,R., Nishikawa,A. and
            Taniguchi,N.
  TITLE     Human N-acetylglucosaminyltransferase III gene is transcribed from
            multiple promoters
  JOURNAL   Eur J Biochem 238 (3), 853-861 (1996)
   PUBMED   8706690
REFERENCE   9  (bases 1 to 5394)
  AUTHORS   Kim,Y.J., Park,J.H., Kim,K.S., Chang,J.E., Ko,J.H., Kim,M.H.,
            Chung,D.H., Chung,T.W., Choe,I.S., Lee,Y.C. and Kim,C.H.
  TITLE     Sequence analysis of the 5'-flanking region of the gene encoding
            human N-acetylglucosaminyltransferase III
  JOURNAL   Gene 170 (2), 281-283 (1996)
   PUBMED   8666260
REFERENCE   10 (bases 1 to 5394)
  AUTHORS   Ihara,Y., Nishikawa,A., Tohma,T., Soejima,H., Niikawa,N. and
            Taniguchi,N.
  TITLE     cDNA cloning, expression, and chromosomal localization of human
            N-acetylglucosaminyltransferase III (GnT-III)
  JOURNAL   J Biochem 113 (6), 692-698 (1993)
   PUBMED   8370666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z83845.14, BC113383.1,
            DA519457.1, DA370485.1, DA261678.1, BG683192.1, AK125361.1 and
            BM675328.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002409.4.
            
            Summary: There are believed to be over 100 different
            glycosyltransferases involved in the synthesis of protein-bound and
            lipid-bound oligosaccharides. The enzyme encoded by this gene
            transfers a GlcNAc residue to the beta-linked mannose of the
            trimannosyl core of N-linked oligosaccharides and produces a
            bisecting GlcNAc. Multiple alternatively spliced variants, encoding
            the same protein, have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and is transcribed from the H20 promoter. Both variants
            1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR3476690.147719.1, SRR3476690.988813.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341184.7/ ENSP00000345270.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               Z83845.14          67261-67568
            309-521             Z83845.14          67569-67781
            522-2408            BC113383.1         1-1887
            2409-2944           DA519457.1         26-561
            2945-3447           DA370485.1         32-534
            3448-4003           DA261678.1         2-557
            4004-4175           BG683192.1         309-480
            4176-5392           AK125361.1         1177-2393
            5393-5394           BM675328.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..5394
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /note="beta-1,4-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:4248"
                     /db_xref="HGNC:HGNC:7046"
                     /db_xref="MIM:604621"
     exon            1..546
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..5394
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..2149
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /EC_number="2.4.1.144"
                     /note="N-acetylglucosaminyltransferase III;
                     N-glycosyl-oligosaccharide-glycoprotein
                     N-acetylglucosaminyltransferase III; GlcNAc-T III;
                     mannosyl (beta-1,4-)-glycoprotein
                     beta-1,4-N-acetylglucosaminyltransferase"
                     /codon_start=1
                     /product="beta-1,4-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase"
                     /protein_id="NP_002400.3"
                     /db_xref="CCDS:CCDS13994.2"
                     /db_xref="GeneID:4248"
                     /db_xref="HGNC:HGNC:7046"
                     /db_xref="MIM:604621"
                     /translation="MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPN
                     LVSSFFWNNAPVTPQASPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPE
                     DTTEYFVRTKAGGVCFKPGTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTG
                     GRGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEF
                     DLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDH
                     FPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYD
                     GWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNF
                     RQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKR
                     DLNYIRGLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDRFHYLLDNPYQEPRST
                     AAGGWRHRGPEGRPPARGKLDEAEV"
     regulatory      5370..5375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /note="hexamer: AATAAA"
     polyA_site      5394
                     /gene="MGAT3"
                     /gene_synonym="GNT-III; GNT3"
                     /note="major polyA site"
ORIGIN      
        1 actcacacac actcgctcgc acacgcacac actcgatcca gcacgcgcgg gcggcgcggg
       61 gcggcggcgg ccggagtctg cggtgcgagg cgcccccggc ccggcgcggc ggcggagccc
      121 ggctggcggg ggaggggagg gggttgcgga gggggcgggg tgggggccgg agccgcttga
      181 gccggcggga gcgggcaccc ctgcgcgccg cgctcggcct cgcctccgcg ccccccgcgc
      241 gcccgccgcg gtccctcccc cgcgcccgtc cgctcgccgg gcccccgccg ccgccccggg
      301 gtgcagccga gcggccgcgc cgggtccccg ggacggggtg gaagtggggg tggggggagg
      361 ggatcggggc cgggccgggg ccgcgctgcc tgcgatgccg ggcgcccgcc gcagccgctg
      421 ccgccggagc ccgggatggg gcgagaggct gcggcggacg ccagcatctc cccgccgggg
      481 accccggggg ccgcggagcc gccgccgccg ctgctgccgc cgttgctgag acccagcggg
      541 cgatgggatg aagatgagac gctacaagct ctttctcatg ttctgtatgg ccggcctgtg
      601 cctcatctcc ttcctgcact tcttcaagac cctgtcctat gtcaccttcc cccgagaact
      661 ggcctccctc agccctaacc tggtgtccag ctttttctgg aacaatgccc cggtcacgcc
      721 ccaggccagc cccgagccag gaggccctga cctgctgcgt accccactct actcccactc
      781 gcccctgctg cagccgctgc cgcccagcaa ggcggccgag gagctccacc gggtggactt
      841 ggtgctgccc gaggacacca ccgagtattt cgtgcgcacc aaggccggcg gcgtctgctt
      901 caaacccggc accaagatgc tggagaggcc gcccccggga cggccggagg agaagcctga
      961 gggggccaac ggctcctcgg cccggcggcc accccggtac ctcctgagcg cccgggagcg
     1021 cacggggggc cgaggcgccc ggcgcaagtg ggtggagtgc gtgtgcctgc ccggctggca
     1081 cggacccagc tgcggcgtgc ccactgtggt gcagtactcc aacctgccca ccaaggagcg
     1141 gctggtgccc agggaggtgc cgcgccgcgt catcaacgcc atcaacgtca accacgagtt
     1201 cgacctgctg gacgtgcgct tccacgagct gggcgacgtg gtggacgcct ttgtggtgtg
     1261 cgagtccaac ttcacggctt atggggagcc gcggccgctc aagttccggg agatgctgac
     1321 caatggcacc ttcgagtaca tccgccacaa ggtgctctat gtcttcctgg accacttccc
     1381 gcccggcggc cggcaggacg gctggatcgc cgacgactac ctgcgcacct tcctcaccca
     1441 ggacggcgtc tcgcggctgc gcaacctgcg gcccgacgac gtcttcatca ttgacgatgc
     1501 ggacgagatc ccggcccgtg acggcgtcct tttcctcaag ctctacgatg gctggaccga
     1561 gcccttcgcc ttccacatgc gcaagtcgct ctacggcttc ttctggaagc agccgggcac
     1621 cctggaggtg gtgtcaggct gcacggtgga catgctgcag gcagtgtatg ggctggacgg
     1681 catccgcctg cgccgccgcc agtactacac catgcccaac ttcagacagt atgagaaccg
     1741 caccggccac atcctggtgc agtggtcgct gggcagcccc ctgcacttcg ccggctggca
     1801 ctgctcctgg tgcttcacgc ccgagggcat ctacttcaag ctcgtgtccg cccagaatgg
     1861 cgacttccca cgctggggtg actacgagga caagcgggac ctgaactaca tccgcggcct
     1921 gatccgcacc gggggctggt tcgacggcac gcagcaggag tacccgcctg cagaccccag
     1981 cgagcacatg tatgcgccca agtacctgct gaagaactac gaccggttcc actacctgct
     2041 ggacaacccc taccaggagc ccaggagcac ggcggcgggc gggtggcgcc acaggggtcc
     2101 cgagggaagg ccgcccgccc ggggcaaact ggacgaggcg gaagtctaga gctgcatgat
     2161 ctgatagggt ttgtgacagg gcgggggtgg cggcggcccc tagcgctatc tccctgcctc
     2221 ctgccggctc cttggttctt gaggggacca ggagtgggtg gggagtgggg gtgggggtag
     2281 ggtttcccta ctgaagccct tgtgaatcaa gggtcaggcc tttgagctca gaaaatatcc
     2341 ctcctgttgg gagagggcgc aggccgtgac gtctgggtgg cccttatgac tgccaagact
     2401 gctgtggcca ggaggtgcca ctggagtgtg cgtggtggtc cctgggtagc gggggagggt
     2461 aggcaggatt ggggaagaga gcctgcagga tctcaccagg cagcctctgg ggggtggcca
     2521 ggccgggaaa aagcccacca tttggcatcc ctgggccttg ggctccgtgt gggagaccgg
     2581 cctgccagga ggacccaggg ctctgtaagt agatgcattt gggtccagga ggaagcgtgg
     2641 acacctcgta gggaagagat gaaaaagcca catcctacca agaggaggtg ctgagggatg
     2701 ctttgcagtg tagtcagaag tgctgggcca gatggagaca gaactccacc ccctgccgca
     2761 aaggacagga cctggctgcc ctgggatgct ggtgcctgag tctgtctctg tgcacccctc
     2821 aggctgtcgt gagccaacac aggggcctgg agaaccctga ggagctttcc ttttggttct
     2881 aaacccggcg ttgacgttcc ttctcccttt cacattgctg tcttgtggac tgtgcactca
     2941 gtccttgcaa ggccaagagt ccagttgtag gtgtggcctt gagggggaag tggggaggag
     3001 aagactgaca tgagtcctct gcacggatcc gtctctccct ccccatcacc ccttccttct
     3061 gacacccagt cccagctgtc cactgtccca ggtgcagtca ctgttgtgcc cttccttggg
     3121 gcaggctggc tgggggccag aaaggggcca tgaggctgtc ttgggcccaa aaagggacaa
     3181 taaggccagt tgtatgcttc ctgttcctca tagcttgcct tggtggggat gtctttgttg
     3241 gagttgattc tgagctgctg tgattaggag accctgaaat acagtggttt aagcaagatg
     3301 gaagcttgtt tctaattagt ctagattgag atggcccaga gctggtaggg cagctctgcg
     3361 tttcttcata cgcaccttcc aattctgggt acacagcggc tgctccagcg cccaccctcc
     3421 tgtgtgcatc caagcctggg ggaagcagaa atagacaaga gggcacaccc actttttgct
     3481 aaaggcatga gccagaattg gcaggctcac ctctgctggc ctctcattgg ctgggactca
     3541 gtcacatggc cacaagcagc tgctagggaa cctgggaagt gtagtcttca gcggggccgc
     3601 catgtgcctg gcctcacctt gggagttatc ttattgatgg aggagaagag aatggatatg
     3661 ggggaccagt agcatctctg ggagaggggg agggagcagc aataactcag tcgtcggatc
     3721 cagctctcat tgtcagagtt tccggaacag cttgctcctg tttccctcac tgtgcagccc
     3781 agggctgggg gcagtgagga gcttgcagct ctgtgggaag gggaaacacc ccctcccctc
     3841 ggcccctcag acgctaccca atgatgccgg tttgcagagt tggcctgtgg aatggctcat
     3901 gtttgtgcgt gtgtgtgtgt atatttatgg gcatgggtgc atgcttggtg tgtatttgta
     3961 catgtctgta ttgctgtgtc cctgtaaata catgcttgtg tatggatgga agaggccagg
     4021 cccaggcctg gcctcttcct cgggcctgtg gccacacctc ctgcagctcc ccaaaatgac
     4081 tgaggcagaa agcccttggg gagcctagaa agcaaagcta aaggggatgc agggtctgtc
     4141 tgtctgtctg tctttcagtc tgaggaatga gaatcctgac ctgagggctg tgcagctgag
     4201 agcccactac ctccccagcc cctctcggcc ccagccgcat catcccacct gtcccctccc
     4261 ccccacctcc agtggggctt tctccagatg tcttatggtt gggggtttcc tgatgggcca
     4321 ggagaggagg gcatcttctt gcgacagcac tgtctgggtt aagtgcccag tgagggcatg
     4381 gtgtggggag ctggcctcag aggagccgct ggtgggcaag cgtgaagtgg gctgaggggc
     4441 tctgagccac tttgctccca tctaggggac tgccccccat ggaactcctt tgaagtcaca
     4501 gcagccttcc tttctgtttg ctcttggggc tgagaggtgg ctcaaacact cggggtccct
     4561 atggctctgg gtcaatctag gccaggctgc accccatgga cagggagtct cagggctcct
     4621 gatcatgccc aggccctggc ctggggcctc cctccttggc agctttccca cccccacgcc
     4681 cctggcatcc tcagttgcta tgggatgccc ctccagggca ccagctcagg gctaagcgaa
     4741 ggaagatagg agcagctcag agctgccagg ctctgccttc ctcacagacc tggtggggca
     4801 ggtcctgttc acagcagcag gagtgaaggc ctggccatcg gtggagaggg cagctgtcag
     4861 agggctgggg gccagggcac aggattgaag agtttcacat atcatcacag catacactgg
     4921 gaatttggtg ggggcagaag aacccagggc cactccctca atatgaaggg aaaccaagct
     4981 gaatgtgacc accggcacac tgctgccatg tcccatgtcc acctttctcc ccgggaataa
     5041 ctggccctga gacccctaga cccaaggagg cctgtccatg ccaagcatcc gggaagcatg
     5101 gctggcctta tccacccatg ggtcacgtcg gttcccaggg gcagcatggg agatctttgg
     5161 gggcaacagg gagagtctgg gtggggagac gggacttgtc caagcagaag gcaggaccct
     5221 gggaaatgca taatgtaagg acatcaataa tagtattatt ttttttgtaa gggaaaatca
     5281 atatgtacat tctgaaatca ttttctctgt aaatggttgg atttcatttc acccttaaag
     5341 ggatgcttaa aggagaagat aatattaata ataaaaacag ctacaaagtc tgaa
//
