LOCUS       NM_032623               1224 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondria localized glutamic acid rich protein
            (MGARP), mRNA.
ACCESSION   NM_032623
VERSION     NM_032623.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Zhang,S.
  TITLE     MGARP is ultrastructurally located in the inner faces of
            mitochondrial membranes
  JOURNAL   Biochem Biophys Res Commun 516 (1), 138-143 (2019)
   PUBMED   31202457
  REMARK    GeneRIF: MGARP overexpression caused both mitochondrial remodeling
            and cristae shaping, leading to the collapse of the mitochondrial
            network. The mitochondrial morphologies in MGARP-overexpressing
            cells were diverse; the cells became round or short, and their
            cristae were deformed and became discontinuous or circular.
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Jin,D., Li,R., Mao,D., Luo,N., Wang,Y., Chen,S. and Zhang,S.
  TITLE     Mitochondria-localized glutamic acid-rich protein (MGARP) gene
            transcription is regulated by Sp1
  JOURNAL   PLoS One 7 (11), e50053 (2012)
   PUBMED   23209644
  REMARK    GeneRIF: The present study identified a proximal core sequence in
            the MGARP promoter that is composed of two enriched Sp1 binding
            motifs and established Sp1 as one major MGARP transactivator.
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Zhou,M., Wang,Y., Qi,S., Wang,J. and Zhang,S.
  TITLE     The expression of a mitochondria-localized glutamic acid-rich
            protein (MGARP/OSAP) is under the regulation of the HPG axis
  JOURNAL   Endocrinology 152 (6), 2311-2320 (2011)
   PUBMED   21447634
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Li,Y. and Rempe,D.A.
  TITLE     During hypoxia, HUMMR joins the mitochondrial dance
  JOURNAL   Cell Cycle 9 (1), 50-57 (2010)
   PUBMED   20016276
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Matsumoto,T., Minegishi,K., Ishimoto,H., Tanaka,M., Hennebold,J.D.,
            Teranishi,T., Hattori,Y., Furuya,M., Higuchi,T., Asai,S., Kim,S.H.,
            Miyakoshi,K. and Yoshimura,Y.
  TITLE     Expression of ovary-specific acidic protein in steroidogenic
            tissues: a possible role in steroidogenesis
  JOURNAL   Endocrinology 150 (7), 3353-3359 (2009)
   PUBMED   19325000
  REMARK    GeneRIF: OSAP is prominently expressed in steroidogenic tissues;
            results suggest that OSAP is involved in steroidogenesis,
            potentially through its ability to maintain mitochondrial abundance
            and morphology
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Li,Y., Lim,S., Hoffman,D., Aspenstrom,P., Federoff,H.J. and
            Rempe,D.A.
  TITLE     HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters
            mitochondrial distribution and transport
  JOURNAL   J Cell Biol 185 (6), 1065-1081 (2009)
   PUBMED   19528298
  REMARK    GeneRIF: Results identify a novel mitochondria protein, hypoxia
            up-regulated mitochondrial movement regulator (HUMMR), which is
            expressed in neurons and is markedly induced by hypoxia-inducible
            factor 1 alpha (HIF-1alpha).
REFERENCE   9  (bases 1 to 1224)
  AUTHORS   Kinouchi,R., Kinouchi,T., Hamamoto,T., Saito,T., Tavares,A.,
            Tsuru,T. and Yamagami,S.
  TITLE     Distribution of CESP-1 protein in the corneal endothelium and other
            tissues
  JOURNAL   Invest Ophthalmol Vis Sci 47 (4), 1397-1403 (2006)
   PUBMED   16565373
REFERENCE   10 (bases 1 to 1224)
  AUTHORS   Sakai,R., Kinouchi,T., Kawamoto,S., Dana,M.R., Hamamoto,T.,
            Tsuru,T., Okubo,K. and Yamagami,S.
  TITLE     Construction of human corneal endothelial cDNA library and
            identification of novel active genes
  JOURNAL   Invest Ophthalmol Vis Sci 43 (6), 1749-1756 (2002)
   PUBMED   12036975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF484960.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032623.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329088.1, AF484960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267761 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000398955.2/
                                                  ENSP00000381928.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1224              AF484960.1         114-1337
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..1224
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="mitochondria localized glutamic acid rich protein"
                     /db_xref="GeneID:84709"
                     /db_xref="HGNC:HGNC:29969"
                     /db_xref="MIM:619684"
     exon            1..149
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..790
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="ovary-specific acidic protein; corneal
                     endothelium-specific protein 1; hypoxia up-regulated
                     mitochondrial movement regulator protein"
                     /codon_start=1
                     /product="protein MGARP"
                     /protein_id="NP_116012.2"
                     /db_xref="CCDS:CCDS43269.1"
                     /db_xref="GeneID:84709"
                     /db_xref="HGNC:HGNC:29969"
                     /db_xref="MIM:619684"
                     /translation="MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGS
                     NMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAET
                     EKASSEAPEELIVEAEVVDAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEV
                     TDAAARETTEVNPETTPEVTNAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESE
                     SSAGDDLQEEASVGSEAASAQG"
     exon            150..253
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            254..347
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            348..1224
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1101..1106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="hexamer: ATTAAA"
     polyA_site      1124
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="major polyA site"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="hexamer: AATAAA"
     polyA_site      1224
                     /gene="MGARP"
                     /gene_synonym="C4orf49; CESP-1; HUMMR; OSAP"
                     /note="major polyA site"
ORIGIN      
        1 agcctctctg tggaagggca gcctgcgcct gggtaccgag gctgctgcgc ggcggacagc
       61 gggcgcgatg tatctccgca gggcggtctc caagactctg gcgctgccgc tgagggcgcc
      121 ccccaacccc gcgccgctcg gaaaggacgc atctctgcgc cggatgtcat ctaacagatt
      181 ccctggatca tctggatcaa atatgattta ttatctggtt gtaggcgtca cagtcagtgc
      241 tggtggatat tatgcttaca agacagtcac atcagaccaa gccaaacaca cagaacataa
      301 aacaaatttg aaagaaaaaa caaaagcaga gatacatcca tttcaaggtg aaaaggagaa
      361 tgttgcggaa actgagaaag caagttcaga agccccagaa gaacttatag tggaagctga
      421 ggtggtagat gctgaagaaa gtcccagtgc tacagttgtg gtcataaaag aggcatctgc
      481 ctgtccaggt cacgtggagg ctgctccgga gaccacagca gtcagtgctg aaaccgggcc
      541 agaggtcaca gatgcagcgg cgagggaaac cacggaagta aaccctgaaa caaccccaga
      601 ggttacaaat gctgccctgg atgaagctgt caccatcgat aatgataaag atacaacaaa
      661 gaacgaaacc tctgatgaat atgctgaact agaagaagaa aattctccag ctgagtcaga
      721 gtcctctgct ggagatgatt tacaggagga agccagtgtt ggctctgagg ctgcttcggc
      781 tcaaggctaa tctccagccg gtagacattt cagcaacaaa tgccataggg tgtctgataa
      841 gtgcttttgt gtttttagta cacttagttt aaaaaaaaaa agacttattt tctagaaaac
      901 gttaatgggt cttgaagatt tttggcatcc actgatagat tttaggactg agagacttga
      961 gattgtacat ttcttactac tcttctactg tctgagatca gaatatgaca ttgcagtaaa
     1021 gagcttaaat agtttcatct ttggtttttt tttctagaca cttttctttt atcccagtca
     1081 tctctgaatt tacattttat attaaagaaa ttgagctatc catacaacct gtatttactt
     1141 taatttcact atgctttcag cttactttat tgtatgatat gtaggtctaa aatatagttt
     1201 gagtcaaata aaattagaaa agct
//
