LOCUS       NM_001365693            9172 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens maltase-glucoamylase (MGAM), transcript variant 1,
            mRNA.
ACCESSION   NM_001365693 XM_006716168
VERSION     NM_001365693.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9172)
  AUTHORS   Tannous,S., Stellbrinck,T., Hoter,A. and Naim,H.Y.
  TITLE     Interaction between the alpha-glucosidases, sucrase-isomaltase and
            maltase-glucoamylase, in human intestinal brush border membranes
            and its potential impact on disaccharide digestion
  JOURNAL   Front Mol Biosci 10, 1160860 (2023)
   PUBMED   36968271
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9172)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9172)
  AUTHORS   Bras,N.F., Santos-Martins,D., Fernandes,P.A. and Ramos,M.J.
  TITLE     Mechanistic Pathway on Human alpha-Glucosidase Maltase-Glucoamylase
            Unveiled by QM/MM Calculations
  JOURNAL   J Phys Chem B 122 (14), 3889-3899 (2018)
   PUBMED   29548257
  REMARK    GeneRIF: Mechanistic Pathway on Human alpha-Glucosidase
            Maltase-Glucoamylase Unveiled by QM/MM Calculations
REFERENCE   4  (bases 1 to 9172)
  AUTHORS   Lee,B.H., Rose,D.R., Lin,A.H., Quezada-Calvillo,R., Nichols,B.L.
            and Hamaker,B.R.
  TITLE     Contribution of the Individual Small Intestinal alpha-Glucosidases
            to Digestion of Unusual alpha-Linked Glycemic Disaccharides
  JOURNAL   J Agric Food Chem 64 (33), 6487-6494 (2016)
   PUBMED   27480812
REFERENCE   5  (bases 1 to 9172)
  AUTHORS   Younkin,S.G., Scharpf,R.B., Schwender,H., Parker,M.M., Scott,A.F.,
            Marazita,M.L., Beaty,T.H. and Ruczinski,I.
  TITLE     A genome-wide study of inherited deletions identified two regions
            associated with nonsyndromic isolated oral clefts
  JOURNAL   Birth Defects Res A Clin Mol Teratol 103 (4), 276-283 (2015)
   PUBMED   25776870
  REMARK    GeneRIF: MGAM, or nearby regulatory elements, may be involved in
            the etiology of oral clefts.
REFERENCE   6  (bases 1 to 9172)
  AUTHORS   Ao,Z., Quezada-Calvillo,R., Sim,L., Nichols,B.L., Rose,D.R.,
            Sterchi,E.E. and Hamaker,B.R.
  TITLE     Evidence of native starch degradation with human small intestinal
            maltase-glucoamylase (recombinant)
  JOURNAL   FEBS Lett 581 (13), 2381-2388 (2007)
   PUBMED   17485087
  REMARK    GeneRIF: Raw starch granule degradation with recombinanat human
            MGAM indicates that pancreatic alpha-amylase hydrolysis is not a
            requirement for native starch digestion in the human small
            intestine.
REFERENCE   7  (bases 1 to 9172)
  AUTHORS   Nichols,B.L., Avery,S., Sen,P., Swallow,D.M., Hahn,D. and
            Sterchi,E.
  TITLE     The maltase-glucoamylase gene: common ancestry to
            sucrase-isomaltase with complementary starch digestion activities
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 1432-1437 (2003)
   PUBMED   12547908
  REMARK    GeneRIF: genetic analysis of MGAM, exon boundaries, and chromosome
            mapping
REFERENCE   8  (bases 1 to 9172)
  AUTHORS   Nichols,B.L., Eldering,J., Avery,S., Hahn,D., Quaroni,A. and
            Sterchi,E.
  TITLE     Human small intestinal maltase-glucoamylase cDNA cloning. Homology
            to sucrase-isomaltase
  JOURNAL   J Biol Chem 273 (5), 3076-3081 (1998)
   PUBMED   9446624
REFERENCE   9  (bases 1 to 9172)
  AUTHORS   Naim,H.Y., Sterchi,E.E. and Lentze,M.J.
  TITLE     Structure, biosynthesis, and glycosylation of human small
            intestinal maltase-glucoamylase
  JOURNAL   J Biol Chem 263 (36), 19709-19717 (1988)
   PUBMED   3143729
REFERENCE   10 (bases 1 to 9172)
  AUTHORS   Danielsen,E.M.
  TITLE     Tyrosine sulfation, a post-translational modification of
            microvillar enzymes in the small intestinal enterocyte
  JOURNAL   EMBO J 6 (10), 2891-2896 (1987)
   PUBMED   3121301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073647.9, AC091684.4 and
            AC091742.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 12, 2018 this sequence version replaced XM_006716168.2.
            
            Summary: This gene encodes maltase-glucoamylase, which is a brush
            border membrane enzyme that plays a role in the final steps of
            digestion of starch. The protein has two catalytic sites identical
            to those of sucrase-isomaltase, but the proteins are only 59%
            homologous. Both are members of glycosyl hydrolase family 31, which
            has a variety of substrate specificities. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1970526,
                              SAMEA2142586 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000475668.6/ ENSP00000417515.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC073647.9         32898-32949         c
            53-181              AC073647.9         23171-23299         c
            182-381             AC073647.9         20123-20322         c
            382-502             AC073647.9         9509-9629           c
            503-612             AC073647.9         7745-7854           c
            613-764             AC073647.9         7091-7242           c
            765-936             AC073647.9         6389-6560           c
            937-1036            AC073647.9         3679-3778           c
            1037-1149           AC073647.9         1601-1713           c
            1150-1275           AC073647.9         1093-1218           c
            1276-1407           AC091684.4         3535-3666
            1408-1524           AC091684.4         3814-3930
            1525-1638           AC091684.4         4853-4966
            1639-1723           AC091684.4         5998-6082
            1724-1841           AC091684.4         7435-7552
            1842-2013           AC091684.4         7843-8014
            2014-2130           AC091684.4         9342-9458
            2131-2285           AC091684.4         9996-10150
            2286-2370           AC091742.5         411-495
            2371-2427           AC091742.5         1995-2051
            2428-2552           AC091742.5         2602-2726
            2553-2641           AC091742.5         9665-9753
            2642-2691           AC091742.5         12115-12164
            2692-2859           AC091742.5         12577-12744
            2860-3012           AC091742.5         14174-14326
            3013-3213           AC091742.5         14664-14864
            3214-3368           AC091742.5         16634-16788
            3369-3537           AC091742.5         17438-17606
            3538-3634           AC091742.5         17880-17976
            3635-3747           AC091742.5         18710-18822
            3748-3873           AC091742.5         20083-20208
            3874-4002           AC091742.5         21352-21480
            4003-4113           AC091742.5         21736-21846
            4114-4176           AC091742.5         22191-22253
            4177-4311           AC091742.5         24448-24582
            4312-4399           AC091742.5         25379-25466
            4400-4538           AC091742.5         26264-26402
            4539-4672           AC091742.5         27215-27348
            4673-4707           AC091742.5         27468-27502
            4708-4824           AC091742.5         27595-27711
            4825-4973           AC091742.5         28453-28601
            4974-5058           AC091742.5         29221-29305
            5059-5115           AC091742.5         30527-30583
            5116-5240           AC091742.5         32874-32998
            5241-5329           AC091742.5         35965-36053
            5330-5379           AC091742.5         38083-38132
            5380-5547           AC091742.5         38539-38706
            5548-5700           AC091742.5         40198-40350
            5701-5901           AC091742.5         40688-40888
            5902-6056           AC091742.5         42671-42825
            6057-6225           AC091742.5         43922-44090
            6226-6322           AC091742.5         44355-44451
            6323-6435           AC091742.5         45181-45293
            6436-6561           AC091742.5         46399-46524
            6562-6690           AC091742.5         47713-47841
            6691-6801           AC091742.5         48098-48208
            6802-6864           AC091742.5         48535-48597
            6865-6999           AC091742.5         53793-53927
            7000-7087           AC091742.5         54401-54488
            7088-7226           AC091742.5         55292-55430
            7227-7360           AC091742.5         56244-56377
            7361-7395           AC091742.5         56500-56534
            7396-7512           AC091742.5         56627-56743
            7513-7661           AC091742.5         57445-57593
            7662-7746           AC091742.5         58211-58295
            7747-7803           AC091742.5         59473-59529
            7804-7928           AC091742.5         61493-61617
            7929-8017           AC091742.5         62682-62770
            8018-8067           AC091742.5         64510-64559
            8068-8238           AC091742.5         65149-65319
            8239-9172           AC091742.5         67694-68627
FEATURES             Location/Qualifiers
     source          1..9172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..9172
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /note="maltase-glucoamylase"
                     /db_xref="GeneID:8972"
                     /db_xref="HGNC:HGNC:7043"
                     /db_xref="MIM:154360"
     exon            1..52
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            53..181
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..8316
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /EC_number="3.2.1.20"
                     /note="isoform 1 is encoded by transcript variant 1; brush
                     border hydrolase; maltase-glucoamylase, intestinal;
                     maltase-glucoamylase (alpha-glucosidase);
                     alpha-1,4-glucosidase"
                     /codon_start=1
                     /product="maltase-glucoamylase isoform 1"
                     /protein_id="NP_001352622.1"
                     /db_xref="CCDS:CCDS94221.1"
                     /db_xref="GeneID:8972"
                     /db_xref="HGNC:HGNC:7043"
                     /db_xref="MIM:154360"
                     /translation="MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAP
                     DPGTTGTPDPGTTGTPDPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCI
                     PDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPS
                     SPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVE
                     ISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRH
                     DMNWKTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPA
                     PAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDN
                     MREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFKGFPEFVNELHNNGQKLVII
                     VDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVWPGQTVFPDYTNPNCAV
                     WWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILDGYLFCK
                     TLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAH
                     WLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPF
                     SRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARP
                     LLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETGSQVRWR
                     KQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGLIIALDENKEAKGELFW
                     DNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEPSNVT
                     VKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENG
                     ASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAF
                     PSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIK
                     KNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHRSYRRDL
                     EWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPLPALT
                     YRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIASL
                     YDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAI
                     SGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRA
                     YVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGC
                     RDASLNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTY
                     EAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYT
                     GADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDAAFVNISRNVLQ
                     TRYTLLPYLYTLMQKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLER
                     NARNVTAYFPRARWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNT
                     HLSRKNPLGLIIALDENKEAKGELFWDDGQTKDTVAKKVYLLCEFSVTQNHLEVTISQ
                     STYKDPNNLAFNEIKILGMEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDINLFL
                     GEAYTVEWSIKIRDEEKIDCYPDENGDSAENCTARGCIWEASNSSGVPFCYFVNDLYS
                     VSDVQYNSHGATADISLKSSVHANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNNNRY
                     EVPVPLNIPSVPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFNDMFI
                     RISTRLPSKYLYGFGETEHTSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEE
                     DGSAHGVLLLNSNAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRP
                     VMVPYWSLGFQLCRYGYQNDSEISSLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPK
                     FAGFPALINRMKADGMRVILILDPAISGNETQPYPAFTRGVEDDVFIKYPNDGDIVWG
                     KVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEELYNNPQNPER
                     SLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPYLESRDRGLSSKTLCMESQQ
                     ILPDGSPVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGD
                     NTAAWDQLKKSIIGMMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNH
                     NTIGTRRQDPVSWDVAFVNISRTVLQTRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFV
                     SDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRARWYDYYTGVDINARGEWKTL
                     PAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWLFWDDGQSI
                     DTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISV
                     SGMVITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL"
     exon            182..381
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            382..502
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            503..612
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            613..764
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            765..936
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1036
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1149
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1275
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1407
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1524
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1638
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1723
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1841
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2013
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2130
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2285
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2370
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2427
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2552
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2641
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2691
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2859
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3012
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3213
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3368
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3537
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3634
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3747
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3873
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..4002
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4113
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4176
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4311
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4399
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4538
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..4672
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4673..4707
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4824
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4973
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5058
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5115
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5240
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5329
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5330..5379
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5380..5547
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5548..5700
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5701..5901
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            5902..6056
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6057..6225
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6226..6322
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6323..6435
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6436..6561
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6562..6690
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6691..6801
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6802..6864
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            6865..6999
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7000..7087
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7088..7226
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7227..7360
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7361..7395
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7396..7512
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7513..7661
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7662..7746
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7747..7803
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7804..7928
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            7929..8017
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            8018..8067
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            8068..8238
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     exon            8239..9172
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9152..9157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /note="hexamer: AACAAG"
     polyA_site      9172
                     /gene="MGAM"
                     /gene_synonym="MG; MGA"
                     /note="major polyA site"
ORIGIN      
        1 attgctaagc catccttcag acagagaggg agcggctgca agaggtaatg agagatggca
       61 agaaagaagc tgaaaaaatt tactactttg gagattgtgc tcagtgttct tctgcttgtg
      121 ttgtttatca tcagtattgt tctaattgtg cttttagcca aagagtcact gaaatcaaca
      181 gccccagatc ctgggacaac tggtacccca gatcctggga caactggtac cccagatcct
      241 ggaacaactg gtaccacaca tgctaggaca acgggtcccc cagatcctgg aacaactggt
      301 accactcctg tttctgctga atgtccagtg gtaaatgaat tggaacgaat taattgcatc
      361 cctgaccagc cgccaacaaa ggccacatgt gaccaacgtg gctgttgctg gaatccccag
      421 ggagctgtaa gtgttccctg gtgctactat tccaagaatc atagctacca tgtagagggc
      481 aaccttgtca acacaaatgc aggattcaca gcccggttga aaaatctgcc ttcttcacca
      541 gtgtttggaa gcaatgttga caatgttctt ctcacagcag aatatcagac atctaatcgt
      601 ttccacttta agttgactga ccaaaccaat aacaggtttg aagtgcccca cgaacacgtg
      661 cagtccttca gtggaaatgc tgctgcttct ttgacctacc aagttgaaat ctccagacag
      721 ccatttagca tcaaagtgac cagaagaagc aacaatcgtg ttttgtttga ctcgagcatt
      781 gggcccctac tgtttgctga ccagttcttg cagctctcca ctcgactgcc tagcactaac
      841 gtgtatggcc tgggagagca tgtgcaccag cagtatcggc atgatatgaa ttggaagacc
      901 tggcccatat ttaacagaga cacaactccc aatggaaacg gaactaattt gtatggtgcg
      961 cagacattct tcttgtgcct tgaagatgct agtggattgt cctttggggt gtttctgatg
     1021 aacagcaatg ccatggaggt tgtccttcag cctgcgccag ccatcactta ccgcaccatt
     1081 gggggcattc tcgacttcta tgtgttcttg ggaaacactc cagagcaagt tgttcaagaa
     1141 tatctagagc tcattgggcg gccagccctt ccctcctact gggcgcttgg atttcacctc
     1201 agtcgttacg aatatggaac cttagacaac atgagggaag tcgtggagag aaatcgcgca
     1261 gcacagctcc cttatgatgt tcagcatgct gatattgatt atatggatga gagaagggac
     1321 ttcacttatg attcagtgga ttttaaaggc ttccctgaat ttgtcaacga gttacacaat
     1381 aatggacaga agcttgtcat cattgtggat ccagccatct ccaacaactc ttcctcaagt
     1441 aaaccctatg gcccatatga caggggttca gatatgaaga tatgggtgaa tagttcagat
     1501 ggagtgactc cactcattgg ggaggtctgg cctggacaaa ctgtgtttcc tgattatacc
     1561 aatcccaact gtgctgtttg gtggacaaag gaatttgagc tttttcacaa tcaagtagag
     1621 tttgatggaa tctggattga tatgaatgaa gtctccaact ttgttgatgg ttcggtctca
     1681 ggatgttcca caaacaacct aaataatccc ccattcactc ccagaatcct ggatgggtac
     1741 ctgttctgca agactctctg tatggatgca gtgcagcact ggggcaagca gtatgacatt
     1801 cacaatctgt atggctactc catggcggtc gccacagcag aagctgccaa gactgtgttc
     1861 cctaataaga gaagcttcat tctgacccgt tctacctttg cgggctctgg caagtttgca
     1921 gcacattggt taggagacaa cactgccacc tgggatgacc tgagatggtc catccctggc
     1981 gtgcttgagt tcaacctttt tggcatccca atggtgggtc ctgacatatg tggctttgct
     2041 ttggacaccc ctgaggagct ctgtaggcgg tggatgcagt tgggtgcatt ttatccgttt
     2101 tctagaaatc acaatggcca aggctacaag gaccaggatc ctgcctcctt tggagctgac
     2161 tccctgctgt tgaattcctc caggcactac cttaacatcc gctatactct attgccctac
     2221 ctatacaccc tcttcttccg tgctcacagc cgaggggaca cggtggccag gccccttttg
     2281 catgagttct acgaggacaa cagcacttgg gatgtgcacc aacagttctt atgggggccc
     2341 ggcctcctca tcactccagt tctggatgaa ggtgcagaga aagtgatggc atatgtgcct
     2401 gatgctgtct ggtatgacta cgagactggg agccaagtga gatggaggaa gcaaaaagtc
     2461 gagatggaac ttcctggaga caaaattgga cttcaccttc gaggaggcta catcttcccc
     2521 acacagcagc caaatacaac cactctggcc agtcgaaaga accctcttgg tcttatcatt
     2581 gccctagatg agaacaaaga agcaaaagga gaacttttct gggataatgg ggaaacgaag
     2641 gatactgtgg ccaataaagt gtatctttta tgtgagtttt ctgtcactca aaaccgcttg
     2701 gaggtgaata tttcacaatc aacctacaag gaccccaata atttagcatt taatgagatt
     2761 aaaattcttg ggacggagga acctagcaat gttacagtga aacacaatgg tgtcccaagt
     2821 cagacttctc ctacagtcac ttatgattct aacctgaagg ttgccattat cacagatatt
     2881 gatcttctcc tgggagaagc atacacagtg gaatggagca taaagataag ggatgaagaa
     2941 aaaatagact gttaccctga tgagaatggt gcttctgccg aaaactgcac tgcccgtggc
     3001 tgtatctggg aggcatccaa ttcttctgga gtcccttttt gctattttgt caacgaccta
     3061 tactctgtca gtgatgttca gtataattcc catggggcca cagctgacat ctccttaaag
     3121 tcttccgttt atgccaatgc cttcccctcc acacccgtga acccccttcg cctggatgtc
     3181 acttaccata agaatgaaat gctgcagttc aagatttatg atcccaacaa gaatcggtat
     3241 gaagttccag tccctctgaa catacccagc atgccatcca gcacccctga gggtcaactc
     3301 tatgatgtgc tcattaagaa gaatccattt gggattgaaa ttcgccggaa gagtacaggc
     3361 actataattt gggactctca gctccttggc tttaccttca gtgacatgtt tatccgcatc
     3421 tccacccgcc ttccctccaa gtacctctat ggctttgggg aaactgagca caggtcctat
     3481 aggagagact tggagtggca cacttggggg atgttctccc gagaccagcc cccagggtac
     3541 aagaagaatt cctatggtgt ccacccctac tacatggggc tggaggagga cggcagtgcc
     3601 catggagtgc tcctgctgaa cagcaatgcc atggatgtga cgttccagcc cctgcctgcc
     3661 ttgacatacc gcaccacagg gggagttctg gacttttatg tgttcttggg gccgactcca
     3721 gagcttgtca cccagcagta cactgagttg attggccggc ctgtgatggt accttactgg
     3781 tctttggggt tccagctgtg tcgctatggc taccagaatg actctgagat cgccagcttg
     3841 tatgatgaga tggtggctgc ccagatccct tatgatgtgc agtactcaga catcgactac
     3901 atggagcggc agctggactt caccctcagc cccaagtttg ctgggtttcc agctctgatc
     3961 aatcgcatga aggctgatgg gatgcgggtc atcctcattc tggatccagc catttctggc
     4021 aatgagacac agccttatcc tgccttcact cggggcgtgg aggatgacgt cttcatcaaa
     4081 tacccaaatg atggagacat tgtctgggga aaggtctggc ctgattttcc tgatgttgtt
     4141 gtgaatgggt ctctagactg ggacagccaa gtggagctat atcgagctta tgtggccttc
     4201 ccagactttt tccgtaattc aactgccaag tggtggaaga gggaaataga agaactatac
     4261 aacaatccac agaatccaga gaggagcttg aagtttgatg gcatgtggat tgatatgaat
     4321 gaaccatcaa gcttcgtgaa tggggcagtt tctccaggct gcagggacgc ctctctgaac
     4381 caccctccct acatgccaca tttggagtcc agggacaggg gcctgagcag caagaccctt
     4441 tgtatggaga gtcagcagat cctcccagac ggctccctgg tgcagcacta caacgtgcac
     4501 aacctgtatg ggtggtccca gaccagaccc acatacgaag ccgtgcagga ggtgacggga
     4561 cagcgagggg tcgtcatcac ccgctccaca tttccctctt ctggccgctg ggcaggacat
     4621 tggctgggag acaacacggc cgcatgggat cagctgaaga agtctatcat tggcatgatg
     4681 gagttcagcc tctttggcat atcctatacg ggagcagata tctgtgggtt ctttcaagac
     4741 gctgagtacg agatgtgtgt tcgctggatg cagctggggg ccttttaccc cttctcaaga
     4801 aaccacaata ccattgggac caggagacaa gaccctgtgt cctgggatgc tgcttttgtg
     4861 aatatttcca gaaatgtcct gcagaccaga tacaccctgt tgccatatct gtataccttg
     4921 atgcaaaagg cccacacgga gggcgtcact gttgtgcggc ctctgctcca tgagtttgtg
     4981 tcagaccagg tgacatggga catagacagt cagttcctgc tgggcccagc cttcctggtc
     5041 agccctgtcc tggagcgcaa tgccagaaat gtcactgcat atttccctag agcccgttgg
     5101 tacgattact acacgggtgt ggatattaat gcaagaggag agtggaagac cttgccagcc
     5161 cctcttgacc acattaatct tcatgtccgt gggggctaca tcctgccctg gcaagagcct
     5221 gcactgaaca cccacttaag tcgaaagaac cctcttggtc ttattattgc cctagatgaa
     5281 aacaaagaag caaaaggaga acttttctgg gatgatgggc aaacaaagga tactgtggcc
     5341 aagaaagtat atcttttatg tgagttttct gtcactcaaa accacttgga ggtgactatt
     5401 tcacaatcaa cctacaagga ccccaataat ttagcattca atgagattaa aattcttggg
     5461 atggaggaac ctagcaatgt tacggtgaaa cacaatggtg tcccaagtca gacttctcct
     5521 acagtcactt atgattctaa cctgaaggtc gccattatca cagacatcaa tcttttcctg
     5581 ggagaagcat acacagtgga gtggagcata aagataaggg atgaagaaaa aatagactgt
     5641 taccctgatg agaatggtga ttctgcagaa aactgcactg cccgtggctg tatctgggag
     5701 gcatccaatt cttctggagt ccctttttgc tattttgtca acgacctata ctctgtcagt
     5761 gatgttcagt ataactccca tggggccaca gctgacatct ccttaaagtc ttctgttcat
     5821 gccaatgcct tcccttccac acccgtgaac ccccttcgcc tggatgtcac ttaccataag
     5881 aatgaaatgc tacagttcaa gatttatgat cccaacaaca atcggtatga agttccagtc
     5941 cctctgaaca tacccagcgt gccatccagc acccctgagg gtcaactcta tgatgtcctc
     6001 attaagaaga atccatttgg gattgaaatt cgccggaaga gtacaggcac tataatttgg
     6061 gactctcagc tccttggctt caccttcaat gacatgttta tccgcatctc cacccgcctt
     6121 ccctccaagt acctctatgg ctttggggag actgagcaca cgtcctacag gagagacttg
     6181 gagtggcaca cttgggggat gttctcccga gaccagcccc cagggtacaa gaagaattcc
     6241 tatggtgtcc acccctacta catggggcta gaggaggatg gcagtgccca tggagtgctc
     6301 ctgctgaaca gcaatgccat ggatgtgacg ttccagcccc tgcctgcctt gacataccgt
     6361 accacagggg gagttctgga cttttatgtg ttcttggggc caactccaga gcttgtcacc
     6421 cagcagtaca ctgagttgat tggccggcct gtgatggtac cttactggtc tttggggttc
     6481 cagctgtgtc gctatggcta ccagaacgac tctgagatct ccagcttgta tgatgagatg
     6541 gtggctgccc agatccctta tgacgtgcag tactcagaca tcgactacat ggagcggcag
     6601 ctggacttca ccctcagccc caagtttgcc gggtttccag ctctgatcaa tcgcatgaag
     6661 gctgatggga tgcgggtcat cctcattctg gatccagcca tttctggcaa tgagacacag
     6721 ccctatcctg ccttcactcg gggcgtggag gatgacgtct tcatcaagta cccaaatgat
     6781 ggagacattg tctggggaaa ggtctggcct gattttcctg atgttgttgt gaatgggtct
     6841 ctagactggg acagtcaagt ggagctatat cgagcttatg tggccttccc agactttttc
     6901 cgtaattcaa ctgccaagtg gtggaagagg gaaatagaag aactatacaa caatccacag
     6961 aatccagaga ggagcttgaa gtttgatggc atgtggattg atatgaatga accatcaagc
     7021 ttcgtgaatg gggcagtttc tccaggctgc agggatgcct ctctgaacca ccctccctac
     7081 atgccgtatt tggagtccag ggacaggggc ctgagcagca agaccctgtg catggagagt
     7141 cagcagatcc tcccagacgg ctccccggtg cagcactaca atgtgcacaa cctgtacggg
     7201 tggtcccaga ccagacccac atacgaagcc gtgcaggagg tgacaggaca gcgaggggtc
     7261 gtcatcaccc gctccacatt tccctcttct ggccgctggg caggacattg gctgggagac
     7321 aacacagccg cgtgggatca gctgaagaag tctatcattg gcatgatgga gttcagcctc
     7381 ttcggcatat cctatacggg agcagatatc tgtgggttct ttcaagatgc tgaatatgag
     7441 atgtgtgttc gctggatgca gctgggggcc ttttacccct tctcaagaaa ccacaacacc
     7501 attgggacca ggagacaaga ccctgtgtcc tgggatgttg cttttgtgaa tatttccaga
     7561 actgtcctgc agaccagata caccctgttg ccatatctgt ataccttgat gcataaggcc
     7621 cacacggagg gcgtcactgt tgtgcggcct ctgctccatg agtttgtgtc agaccaggtg
     7681 acatgggaca tagacagtca gttcctgctg ggcccagcct tcctggtcag ccctgtcctg
     7741 gagcgtaatg ccagaaatgt cactgcatat ttccctagag cccgctggta tgattactac
     7801 acgggtgtgg atattaatgc aagaggagag tggaagacct tgccagcccc tcttgaccac
     7861 attaatcttc atgtccgtgg gggctacatc ctgccctggc aagagcctgc actgaacacc
     7921 cacttaagcc gccagaaatt catgggcttc aaaattgcct tggatgatga aggaactgct
     7981 gggggctggc tcttctggga tgatgggcaa agcattgata cctatgggaa aggactctat
     8041 tacttggcca gcttttctgc cagccagaat acgatgcaaa gccatataat tttcaacaat
     8101 tacatcactg gtacaaatcc tttgaaactg ggctacattg aaatctgggg agtgggcagt
     8161 gtccccgtta ccagtgtcag catctctgtg agtggcatgg tcataacacc ctccttcaac
     8221 aatgacccca cgacacaggt attaagcatc gatgtgactg acagaaacat cagcctacat
     8281 aattttactt cattgacgtg gataagcact ctgtgaattt ttacagcaag attctaacta
     8341 actatgaatg actttgaaac tacttatact tcatactcat aaaaattatt gtgtgttgct
     8401 aatttgttca tacccactat tggtgaaata tttctgttaa ttttgttata tgttttttgt
     8461 gtgaacccta aaggttaaac cttagccctg tgggataggc agttagggag gtgtggaaaa
     8521 tctatgcatt accttaatgt ctctgtgtgg ttagtatggt agtgactgtt catcatatga
     8581 catttactga agatgaactg ggtccatgat gaagtgtgtg tatgtccacg tttgtaatca
     8641 tagaatggac cccattcttt tgttaaatac acaagagaaa gctttctgtg acagttccag
     8701 gtcttgaagc taatcagcat ctcaagaaag tatccagaaa gaacatctgc tagttggtta
     8761 taggcggtgg gaggaataat atacctaatt ggttataggt ggggggagca tgataagcaa
     8821 agaaaaggca aacacaagga aagatcagat gaaacagaag atgatagtaa aagtgatcct
     8881 aagtaagaac ataatgtaaa attgtcagca gcctcatggg gaggaaaaag gaagagtcaa
     8941 ctcacttgaa gaagagggtc ttgagaaatc cttagcataa agggctactg gtgagattga
     9001 gatctgagca ggcaaagctc aaaagagagt ttggaggtta aaaataattt atttttgcag
     9061 tagtgtgctt tgaaatgtgt aaatcttatt tctaatgtat acaaccacat ttcacataaa
     9121 aatatgcaat ttatatgcca gataaaaata aaacaagtga atttgcaagt ga
//
