LOCUS       NM_001400225           12193 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens MAX dimerization protein MGA (MGA), transcript variant
            3, mRNA.
ACCESSION   NM_001400225 XM_005254248
VERSION     NM_001400225.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12193)
  AUTHORS   Feng,X., Yang,C., Huang,Y., Su,D., Wang,C., Wilson,L.L., Yin,L.,
            Tang,M., Li,S., Chen,Z., Zhu,D., Wang,S., Zhang,S., Zhang,J.,
            Zhang,H., Nie,L., Huang,M., Park,J.I., Hart,T., Jiang,D., Jiang,K.
            and Chen,J.
  TITLE     In vivo CRISPR screens identify Mga as an immunotherapy target in
            triple-negative breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2406325121 (2024)
   PUBMED   39298484
  REMARK    GeneRIF: In vivo CRISPR screens identify Mga as an immunotherapy
            target in triple-negative breast cancer.
REFERENCE   2  (bases 1 to 12193)
  AUTHORS   Thomas,M.E. 3rd, Qi,W., Walsh,M.P., Ma,J., Westover,T.,
            Abdelhamed,S., Ezzell,L.J., Rolle,C., Xiong,E., Rosikiewicz,W.,
            Xu,B., Loughran,A.J., Pruett-Miller,S.M., Janke,L.J. and Klco,J.M.
  TITLE     Functional characterization of cooperating MGA mutations in
            RUNX1::RUNX1T1 acute myeloid leukemia
  JOURNAL   Leukemia 38 (5), 991-1002 (2024)
   PUBMED   38454121
  REMARK    GeneRIF: Functional characterization of cooperating MGA mutations
            in RUNX1::RUNX1T1 acute myeloid leukemia.
REFERENCE   3  (bases 1 to 12193)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 12193)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 12193)
  AUTHORS   Llabata,P., Mitsuishi,Y., Choi,P.S., Cai,D., Francis,J.M.,
            Torres-Diz,M., Udeshi,N.D., Golomb,L., Wu,Z., Zhou,J., Svinkina,T.,
            Aguilera-Jimenez,E., Liu,Y., Carr,S.A., Sanchez-Cespedes,M.,
            Meyerson,M. and Zhang,X.
  TITLE     Multi-Omics Analysis Identifies MGA as a Negative Regulator of the
            MYC Pathway in Lung Adenocarcinoma
  JOURNAL   Mol Cancer Res 18 (4), 574-584 (2020)
   PUBMED   31862696
  REMARK    GeneRIF: Multi-Omics Analysis Identifies MGA as a Negative
            Regulator of the MYC Pathway in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 12193)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 12193)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   8  (bases 1 to 12193)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 12193)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   10 (bases 1 to 12193)
  AUTHORS   Hurlin,P.J., Steingrimsson,E., Copeland,N.G., Jenkins,N.A. and
            Eisenman,R.N.
  TITLE     Mga, a dual-specificity transcription factor that interacts with
            Max and contains a T-domain DNA-binding motif
  JOURNAL   EMBO J 18 (24), 7019-7028 (1999)
   PUBMED   10601024
  REMARK    Erratum:[EMBO J 2000 Jul 17;19(14):3841]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016134.7 and AC073657.5.
            
            On Jan 20, 2022 this sequence version replaced XM_005254248.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.705638.1,
                                           SRR14038196.1330397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000703841.1/ ENSP00000515495.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC016134.7         156183-156303
            122-1252            AC016134.7         164606-165736
            1253-2201           AC073657.5         51013-51961
            2202-2280           AC073657.5         53801-53879
            2281-2376           AC073657.5         54002-54097
            2377-2508           AC073657.5         62666-62797
            2509-2613           AC073657.5         63042-63146
            2614-3272           AC073657.5         65629-66287
            3273-3618           AC073657.5         68089-68434
            3619-3845           AC073657.5         82118-82344
            3846-4031           AC073657.5         84102-84287
            4032-4104           AC073657.5         89460-89532
            4105-4622           AC073657.5         91119-91636
            4623-4920           AC073657.5         94844-95141
            4921-5547           AC073657.5         97484-98110
            5548-5838           AC073657.5         103575-103865
            5839-7343           AC073657.5         104049-105553
            7344-7474           AC073657.5         109375-109505
            7475-7526           AC073657.5         112726-112777
            7527-7733           AC073657.5         115261-115467
            7734-7845           AC073657.5         116677-116788
            7846-8079           AC073657.5         117067-117300
            8080-8256           AC073657.5         119824-120000
            8257-12193          AC073657.5         120942-124878
FEATURES             Location/Qualifiers
     source          1..12193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..12193
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="MAX dimerization protein MGA"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
     exon            1..121
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1252
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..9533
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="isoform 3 is encoded by transcript variant 3; MAX
                     dimerization protein 5; MAX gene-associated protein; MGA,
                     MAX dimerization protein"
                     /codon_start=1
                     /product="MAX gene-associated protein isoform 3"
                     /protein_id="NP_001387154.1"
                     /db_xref="CCDS:CCDS91982.1"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
                     /translation="MEEKQQIILANQDGGTVAGAAPTFFVILKQPGNGKTDQGILVTN
                     QDACALASSVSSPVKSKGKICLPADCTVGGITVTLDNNSMWNEFYHRSTEMILTKQGR
                     RMFPYCRYWITGLDSNLKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHP
                     ESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKAVEVIQL
                     NGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNNKPQRDGKQKNS
                     SDQEGNNISSSSGHRVRLTEGQGSEIQPGDLDPLSRGHETSGKGLEKTSLNIKRDFLG
                     FMDTDSALSEVPQLKQEISECLIASSFEDDSRVASPLDQNGSFNVVIKEEPLDDYDYE
                     LGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNPEADHLSSKWLPSSP
                     SGVAKAKMFKLDTGKMPVVYLEPCAVTRSTVKISELPDNMLSTSRKDKSSMLAELEYL
                     PTYIENSNETAFCLGKESENGLRKHSPDLRVVQKYPLLKEPQWKYPDISDSISTERIL
                     DDSKDSVGDSLSGKEDLGRKRTTMLKIATAAKVVNANQNASPNVPGKRGRPRKLKLCK
                     AGRPPKNTGKSLISTKNTPVSPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGT
                     TEESSSLQASTTNDSGYRARISQLEKELIEDLKTLRHKQVIHPGLQEVGLKLNSVDPT
                     MSIDLKYLGVQLPLAPATSFPFWNLTGTNPASPDAGFPFVSRTGKTNDFTKIKGWRGK
                     FHSASASRNEGGNSESSLKNRSAFCSDKLDEYLENEGKLMETSMGFSSNAPTSPVVYQ
                     LPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPPVSRKAKSQNRQATFSGRTKSS
                     YKSILPYPVSPKQKYSHVILGDKVTKNSSGIISENQANNFVVPTLDENIFPKQISLRQ
                     AQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQAS
                     LKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVV
                     LVKGGSKTKHFQRKAAHRDPVFYDTLGEEAREEEEGIREEEEQLKEKKKRKKLEYTIC
                     ETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSPTVKGKLLT
                     GIKSPRSYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEDQRQPSSSSSPSP
                     SFQQQTSCHSSPENHNNAKEPDSEQQPLKQLTCDLEDDSDKLQEKSWKSSCNEGESSS
                     TSYMHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELAS
                     QRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMEDISPVQTDA
                     LDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVNGKSYPQAKLLLGQM
                     GALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKM
                     ASSSGTATNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQT
                     LAGTQKFSIRPSPVMVVTPVVSSEPVQVCSPVTAAVTTTTPQVFLENTTAVTPMTAIS
                     DVETKETTYSSGATTTGVVEVSETNTSTSVTSTQSTATVNLTKTTGITTPVASVAFPK
                     SLVASPSTITLPVASTASTSLVVVTAAASSSMVTTPTSSLGSVPIILSGINGSPPVSQ
                     RPENAAQIPVATPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVSNTQLQGHRMVLQPVR
                     SPSGMNLFRHPNGQIVQLLPLHQLRGSNTQPNLQPVMFRNPGSVMGIRLPAPSKPSET
                     PPSSTSSSAFSVMNPVIQAVGSSSAVNVITQAPSLLSSGASFVSQAGTLTLRISPPEP
                     QSFASKTGSETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQ
                     MKRESQNPDQKDETNSIKREQETKKVLQSEGEAVDPEANVIKQNSGAATSEETLNDSL
                     EDRGDHLDEECLPEEGCATVKPSEHSCITGSHTDQDYKDVNEEYGARNRKSSKEKVAV
                     LEVRTISEKASNKTVQNLSKVQHQKLGDVKVEQQKGFDNPEENSSEFPVTFKEESKFE
                     LSGSKVMEQQSNLQPEAKEKECGDSLEKDRERWRKHLKGPLTRKCVGASQECKKEADE
                     QLIKETKTCQENSDVFQQEQGISDLLGKSGITEDARVLKTECDSWSRISNPSAFSIVP
                     RRAAKSSRGNGHFQGHLLLPGEQIQPKQEKKGGRSSADFTVLDLEEDDEDDNEKTDDS
                     IDEIVDVVSDYQSEEVDDVEKNNCVEYIEDDEEHVDIETVEELSEEINVAHLKTTAAH
                     TQSFKQPSCTHISADEKAAERSRKAPPIPLKLKPDYWSDKLQKEAEAFAYYRRTHTAN
                     ERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQADKLIGQKNLLT
                     RKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKMGSDEFDISPRISKQ
                     QEGSSASSVDLGQMFINNRRGKPLILSRKKDQATENTSPLNTPHTSANLVMTPQGQLL
                     TLKGPLFSGPVVAVSPDLLESDLKPQVAGSAVALPENDDLFMMPRIVNVTSLATEGGL
                     VDMGGSKYPHEVPDSKPSDHLKDTVRNEDNSLEDKGRISSRGNRDGRVTLGPTQVFLA
                     NKDSGYPQIVDVSNMQKAQEFLPKKISGDMRGIQYKWKESESRGERVKSKDSSFHKLK
                     MKDLKDSSIEMELRKVTSAIEEAALDSSELLTNMEDEDDTDETLTSLLNEIAFLNQQL
                     NDDSVGLAELPSSMDTEFPGDARRAFISKVPPGSRATFQVEHLGTGLKELPDVQGESD
                     SISPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDSLLSNKKAIDGGKNTSG
                     LPAEPESVSSPPTLHMKTGLENSNSTDTLWRPMPKLAPLGLKVANPSSDADGQSLKVM
                     PCLAPIAAKVGSVGHKMNLTGNDQEGRESKVMPTLAPVVAKLGNSGASPSSAGK"
     exon            1253..2201
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2280
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2376
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2508
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2613
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..3272
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3618
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3845
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..4031
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4104
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4622
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4920
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5547
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            5548..5838
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            5839..7343
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            7344..7474
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            7475..7526
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            7527..7733
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            7734..7845
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            7846..8079
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            8080..8256
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     exon            8257..12193
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12004..12009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="hexamer: AATAAA"
     polyA_site      12028
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="major polyA site"
     regulatory      12066..12071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="hexamer: AATATA"
     polyA_site      12099
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="major polyA site"
     regulatory      12156..12161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="hexamer: TATAAA"
     regulatory      12167..12172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="hexamer: AATAAA"
     polyA_site      12182
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
     polyA_site      12193
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /note="major polyA site"
ORIGIN      
        1 gtccggtgcg cgcgcgcagg ctcttcagct ggagcggaca cacggtgtgc gaaccgaaca
       61 gaataacccg cccccagcgg gatgtgaagg actccgggtg aggccggcca cgccccgcac
      121 ggatgggaag gccattgtga ctatgtggtg attacagttg tcttactact gagtttccta
      181 ctgaaatcat ggaggagaaa cagcagatta tattggctaa tcaagatggt ggaacagtgg
      241 caggagcagc acctaccttc tttgtcatct taaagcagcc aggaaatggc aaaactgatc
      301 aaggaatttt ggttactaat caggatgcct gtgctttggc tagtagtgtg tcatcaccag
      361 taaaatctaa agggaagatt tgccttccag ctgattgtac tgtgggtgga atcactgtta
      421 ccctcgataa caatagtatg tggaatgagt tctatcatcg aagcacagag atgattctga
      481 ccaagcaagg aagacgcatg tttccttact gtcgttattg gataacaggt ttagattcaa
      541 atttgaagta tattcttgtc atggatatat ctcctgtgga taaccatcgt tataagtgga
      601 atggtcgttg gtgggaacct agtgggaagg ctgaacctca tgttttgggg agggttttca
      661 ttcatccaga atctccttcc acaggtcatt attggatgca tcaaccagta tctttctata
      721 aactcaaact taccaacaat acactggacc aagaagggca tatcatcttg cactctatgc
      781 atcgttacct gccgaggctt catttggtgc ctgcagaaaa ggctgtggag gtgatacaat
      841 taaatggccc tggtgtccac acttttacct tcccacagac tgaattcttt gcagtaacag
      901 cttatcagaa cattcagatt actcagctga aaatagatta caatccattt gccaaaggct
      961 ttcgggatga tgggctgaat aataagcccc agagagatgg aaaacaaaag aacagctctg
     1021 accaagaagg gaataatatt tccagttctt ctggtcatcg ggtccgtctt acagaaggtc
     1081 aggggtcaga gatacaacca ggtgatttgg atcctttgtc aaggggtcat gaaacatcag
     1141 gcaagggttt ggagaagact tcccttaata taaaacgaga ctttcttggt ttcatggata
     1201 ctgattcagc acttagtgaa gttcctcaat tgaagcaaga gatttctgaa tgtcttattg
     1261 ccagcagttt tgaagatgac tcccgtgtag cctcaccgtt agaccagaac ggaagcttca
     1321 atgttgttat taaagaggaa cctctagatg attatgacta cgaacttggt gagtgcccag
     1381 aaggggtcac tgtgaaacag gaagagacag atgaagagac ggatgtatac tcaaacagtg
     1441 atgatgatcc tatactagag aaacagctaa agaggcacaa taaagttgac aacccagaag
     1501 ctgaccatct atcttctaaa tggcttccaa gcagcccatc aggtgttgct aaagctaaaa
     1561 tgttcaaatt agacactgga aagatgccag tagtctatct ggagccctgt gctgtcacca
     1621 gaagcacagt taagatttct gaactccccg ataacatgct ttccacatct cgaaaggata
     1681 aatcttctat gttggcagaa ttggaatatt tgcctacata cattgaaaat tccaatgaga
     1741 ctgccttctg cttaggcaag gaatcagaaa atggtcttag aaaacattca ccagatctca
     1801 gagtggtaca aaaatatccc ttactgaaag agcctcagtg gaaatatcct gatatatctg
     1861 acagcattag cacagaaaga atactcgacg attcaaagga ttcagttgga gactcacttt
     1921 caggaaaaga ggacttgggc agaaagagaa caactatgct taagattgca acagccgcaa
     1981 aggtagtgaa tgctaatcag aatgcctctc caaatgtccc tggaaaaaga ggaaggccac
     2041 gaaaattgaa actctgtaag gcaggacgac cacctaagaa cacaggaaag tctttaattt
     2101 ctacaaagaa tacacctgta agccctggga gtacctttcc agatgtgaag cctgatctgg
     2161 aagatgtgga tggtgttctc tttgtttcct ttgaatcaaa ggaagctcta gacattcatg
     2221 cagttgatgg gacaacagaa gaatcttcta gtctccaggc atcaaccaca aatgactcag
     2281 gttacagagc aagaatttcc cagttggaaa aggaattgat agaagatttg aagactttgc
     2341 ggcacaagca ggtgatacat cctggtcttc aagaagtggg cttaaaattg aattcagtgg
     2401 atccaacaat gagcattgat cttaaatact tgggagtaca gttacctttg gctccagcta
     2461 ctagctttcc tttttggaac cttacaggaa ccaaccctgc ctctcctgat gcgggatttc
     2521 cctttgtttc taggacaggg aaaaccaatg atttcactaa gatcaaggga tggaggggaa
     2581 aatttcatag tgcttctgca tctaggaatg aaggtggaaa ttcagaaagt tcactgaaaa
     2641 atcgttctgc tttctgtagt gataagctag atgaatactt ggaaaatgaa ggcaagctga
     2701 tggaaacaag catgggtttt tcttctaatg ctcccacatc tcctgtggtg taccagcttc
     2761 ccactaagag taccagttat gtacgaacac ttgatagtgt actaaagaag caatctacta
     2821 tttccccttc tacctcttat tctttgaaac ctcattctgt accccctgtc tctcgaaagg
     2881 caaagtctca aaacagacag gcaactttca gtggccgaac taaatcatct tataaatcca
     2941 ttttaccata ccctgtttca ccaaagcaga aatactctca tgtgattcta ggagataagg
     3001 ttaccaagaa ttcttcaggc atcatctcag aaaatcaggc gaataacttt gttgtgccaa
     3061 ctttggatga aaatatattt ccaaagcaga ttagtttgcg gcaggcacag cagcagcagc
     3121 aacagcaaca gggaagtcgc cctccaggct tgtctaaatc tcaggtgaag ctaatggacc
     3181 tggaagactg tgcactttgg gaaggaaaac caaggacata catcacagaa gagcgagcag
     3241 atgtatcctt aacaactcta cttacagctc aagcatccct caaaactaaa cctatccaca
     3301 caatcataag gaaacgagcc cctccctgca acaatgactt ctgtcgactg ggttgtgtat
     3361 gttccagtct agctttggag aagcgccaac ctgctcactg ccgccgacca gactgcatgt
     3421 ttggttgtac ttgtttgaaa agaaaagttg tacttgttaa aggaggatcc aaaactaagc
     3481 attttcagag gaaggctgct catcgagatc cagtatttta tgatactctg ggagaggagg
     3541 caagggagga ggaagaagga atcagggagg aggaggaaca attgaaagag aaaaagaaga
     3601 gaaagaagct agaatacact atatgtgaga cagagcctga acagcctgtt cgacattacc
     3661 cattatgggt aaaagtagaa ggtgaagtag atccagaacc agtttatatc cccacgcctt
     3721 ctgtcattga gcctatgaaa ccattgttat tgcctcagcc agaagtttta tctcctactg
     3781 tgaagggcaa actgctcact ggaattaaat ctccacggtc atatactccc aaacccaatc
     3841 ctgtgattcg ggaagaggac aaagatccag tctacttgta ctttgaaagt atgatgactt
     3901 gtgctcgagt tcgagtatat gagcgaaaaa aagaggacca gagacaacca tcttcctcct
     3961 cctccccatc tccatcattt cagcagcaaa cttcatgtca ttctagccct gagaaccata
     4021 ataatgcaaa ggaacctgat tctgaacagc agcccttaaa acaactcacc tgtgacttgg
     4081 aggatgattc tgataaatta caagaaaaga gctggaagtc ttcctgcaat gaaggagaat
     4141 cctcttctac ttcttatatg catcagaggt cacctggtgg tcccaccaaa ctgattgaga
     4201 tcatctcaga ctgcaactgg gaggaagatc ggaacaagat tttgagcatc ttatcccagc
     4261 acatcaatag caacatgcca caatcactta aggtgggcag cttcatcatt gagttggctt
     4321 ctcagcgaaa gagccggggt gagaagaacc ctcctgttta ttcttctcgt gtgaaaatct
     4381 ctatgccatc atgtcaagac caagatgata tggctgagaa atctggatca gagactcctg
     4441 atggtccatt gtcccctggg aaaatggagg atatctctcc tgtgcagaca gatgccctgg
     4501 attcagtgag ggagagatta catggaggca aaggtctgcc tttttatgca gggctttctc
     4561 ctgcagggaa gcttgtggcc tataaacgta aacccagttc aagtacatct gggcttatcc
     4621 aggttaatgg taagagttac ccgcaggcta agttgctatt gggacagatg ggggcattgc
     4681 atccagccaa taggctagct gcttatatca caggcaggtt gcgaccctca gtcctggacc
     4741 tctcaaccct cagtactgtc atctccaagg tagcatccaa tgccaaggtg gctgcatcca
     4801 ggaaaccacg taccctgttg ccttcaacat ccaattccaa aatggcatcc tcctctggca
     4861 ctgcaacaaa tcgccctggg aagaatctga aggcgtttgt cccagcaaaa cggccaattg
     4921 cggctcgacc ctctcctggt ggtgtgttca cacagtttgt gatgagtaaa gttggagcct
     4981 tgcagcagaa gatacctgga gttagcacac cccaaaccct ggcagggaca cagaagttca
     5041 gtatcagacc ttctccagta atggtcgtca cacctgtggt ttcttctgag ccagttcagg
     5101 tgtgcagccc tgtgactgct gctgtcacta ctaccacccc tcaagtgttt ttagaaaata
     5161 ctactgctgt gacacctatg actgctattt ctgacgtgga aactaaagaa actacttatt
     5221 cttctggtgc caccactaca ggggttgttg aggtctctga aactaatacc agcacctctg
     5281 taacatctac ccagtctaca gccactgtga accttaccaa aaccactggg ataactaccc
     5341 ctgtggcttc agttgctttt cctaagtctt tggtagcatc tccttcaacc ataactcttc
     5401 ctgttgcttc cactgcttcc acctccttag tcgtggtgac tgcagctgca tcttcctcca
     5461 tggtgaccac accaacttca tctctgggct ctgttcctat tatactctca ggaattaatg
     5521 ggagtccacc agtgagccag agaccagaaa atgctgctca aattccagtg gctactccac
     5581 aggtctctcc taacacagtg aaacgtgctg gacctcgatt gttgttgatt ccagtgcagc
     5641 agggttctcc tactcttaga cctgtctcaa acacacaact tcagggacat cggatggtct
     5701 tgcagcctgt taggagtcca agtggaatga acttattcag gcaccctaat gggcagattg
     5761 tccagcttct acctttgcat cagcttcgag gctctaatac ccagcccaac ttacagcctg
     5821 tcatgtttcg gaacccaggg tctgtgatgg gaatccggtt acctgctcct tccaaaccct
     5881 ctgagactcc gccatcttcc acttcgtcct ctgctttctc tgtcatgaat cctgtaattc
     5941 aagctgttgg gtcttcttca gcagtgaatg ttatcactca ggcaccatca ttgctttcct
     6001 ctggagctag ttttgtgtct caggctggta cattgaccct gaggatttct cctcctgaac
     6061 cacaaagctt tgcaagtaaa acaggctctg aaaccaaaat aacttatagc tcaggaggac
     6121 agcctgttgg tacagccagt cttattcctc tccagtctgg tagttttgcc ttgttacagc
     6181 tcccaggaca aaagcctgtt cctagctcca ttcttcagca tgttgcttcc cttcagatga
     6241 agagagaatc tcagaatcca gaccagaaag atgaaacaaa ctcaataaaa agagagcaag
     6301 aaacgaagaa ggttctacag tcagaaggag aggctgtaga ccctgaggct aatgtaataa
     6361 aacaaaactc aggagctgct acctcagaag aaactctgaa tgattccttg gaagataggg
     6421 gtgatcattt ggatgaagaa tgccttccag aagaaggttg tgcaactgtc aaaccatctg
     6481 agcattcctg tatcactggg tcacatacag atcaagatta taaagatgtt aatgaagaat
     6541 atggggctag gaatcgtaag agttccaaag aaaaagtggc tgttctggaa gttaggacca
     6601 tttctgaaaa agccagtaat aagacagtcc aaaatttaag taaagtacag catcaaaaac
     6661 ttggtgatgt gaaggtggaa cagcagaaag gatttgacaa tccagaagaa aactcaagtg
     6721 aatttccagt cacctttaag gaagaaagta aatttgaatt gtcaggaagc aaagttatgg
     6781 agcagcaatc taatctacag ccagaggcca aagagaagga atgtggagac tctctggaga
     6841 aagacaggga aagatggaga aaacatctga agggcccctt aaccaggaaa tgtgttggag
     6901 cttcacagga atgtaagaaa gaggcagacg agcagttaat taaagaaaca aagacatgtc
     6961 aggaaaattc agatgtgttt cagcaagaac aaggcatctc tgacttactt ggaaaaagtg
     7021 gaattactga agatgccaga gttttgaaaa ctgaatgtga ttcttggagt aggatttcta
     7081 atccttcagc cttctccatt gttcctagga gagctgcaaa aagcagcaga gggaatggac
     7141 attttcaggg tcacttactg ctacctggag aacagataca accaaagcaa gagaagaagg
     7201 gtgggagaag cagtgctgac ttcactgttt tggatttgga agaagatgat gaagatgata
     7261 atgagaaaac tgatgattct attgatgaaa ttgtggatgt tgtttctgac taccagagtg
     7321 aggaggttga tgatgtagaa aagaataact gtgtagaata cattgaggat gatgaggagc
     7381 acgtggacat tgagactgta gaagagctct cagaggaaat taatgttgct cacctgaaga
     7441 ccacagcggc ccacacacag tcattcaaac agccgtcctg tactcacatc tctgcagatg
     7501 aaaaagcagc tgaaaggagt cgaaaggctc caccaattcc tctaaaactg aagcctgatt
     7561 actggagtga caaactacag aaagaagcag aagcgtttgc ttattatcgc cggacacaca
     7621 ctgccaatga gcggcggcgg cgtggtgaaa tgagggatct ctttgagaaa ttaaagatca
     7681 cattgggatt acttcattct tccaaggttt ccaaaagtct cattcttact cgagccttca
     7741 gtgaaattca gggactaaca gatcaggcag acaaattgat aggacagaaa aatctcctga
     7801 ctcgaaaacg gaatattctg atacggaaag tatcgtctct ttcaggtaag acagaagaag
     7861 tggtcctgaa gaagctagag tatatttatg caaaacagca agcactagag gcacaaaaaa
     7921 gaaaaaagaa gatgggatca gatgagtttg acatatctcc cagaattagc aaacagcagg
     7981 aaggatcttc tgcatcatct gtagatcttg gacagatgtt tataaataac aggaggggga
     8041 aacctttgat tctttccaga aaaaaagacc aggccacaga aaatacctca cccttgaaca
     8101 ctccacacac ctctgccaac cttgtgatga ctccgcaagg gcaattgctc accctaaaag
     8161 gtcccctatt ctcaggacca gtggtagctg tttctcctga tctcttagaa tctgatctta
     8221 agcctcaagt tgccggtagt gctgtggctc taccagaaaa tgacgactta tttatgatgc
     8281 cacgaattgt taatgtgaca tcattggcca cagagggagg tttggtagat atgggtggca
     8341 gcaaatatcc tcatgaagtt cctgatagca agccatctga ccatctgaaa gacaccgtca
     8401 ggaatgaaga taattcctta gaggataagg gtagaatctc ttccagagga aacagagatg
     8461 gcagagtgac gttgggtcca acgcaggttt ttctggcaaa caaagattct ggttatccac
     8521 aaatagttga cgtttccaat atgcagaaag cacaagagtt cttacctaaa aagatttctg
     8581 gtgatatgag agggattcag tataaatgga aagagagtga atcaagaggg gagagagtga
     8641 agtcaaagga ttcttcattt cataaattaa agatgaaaga tctcaaggac tcaagcatag
     8701 agatggaact gaggaaagta acatcagcta tagaggaagc agctcttgat tccagtgaac
     8761 tgctgactaa catggaagat gaggatgata ctgatgagac actgacttca ctgctcaatg
     8821 aaattgcctt tcttaatcaa caactaaatg atgactctgt tggcctggct gaactaccca
     8881 gctctatgga tacagagttc ccaggggatg ctcggcgggc ttttattagt aaggttcctc
     8941 ctggaagcag agcaactttc caggttgagc acttgggaac tggtttgaaa gagttgcctg
     9001 atgttcaagg ggagagtgac tctatcagtc ccctcctctt gcacttggaa gacgatgact
     9061 tttctgagaa tgaaaaacaa cttgcagaac cagcctctga gccagatgtc cttaagattg
     9121 ttattgactc tgaaataaag gattccctcc tttccaacaa gaaagctatt gatggaggga
     9181 agaatacttc tggcctccct gcagagcccg aaagtgtgtc ctcacccccc accctacaca
     9241 tgaagactgg cttggagaac agcaacagca cagacacttt gtggaggcct atgccaaagt
     9301 tggcccctct aggtttaaaa gtagctaatc cttccagtga tgcagatggt cagagtctca
     9361 aggtgatgcc ttgtttggca cctatagctg ccaaagttgg gtcagttgga cacaaaatga
     9421 acttaacagg gaatgaccag gaaggccggg aaagcaaggt gatgcctaca ttggcacctg
     9481 ttgtggctaa attgggcaac tcgggggcct caccaagttc tgcagggaaa tgaacttact
     9541 tgtccttaag cagaagccag gctgtgaggg gaaatagatc tcacctcctt tctctgcagg
     9601 catctgtttg tttgtgtctt agaacttgga tccttgactt caatgatgca gtggataatg
     9661 atgggagaaa gggggtaggg tgctgaccct ggtataagaa gtactctgaa attctgatca
     9721 tgttaaaatg tgttacctca cttgtggtgc tgggtcccct catcctctct aagaagatgt
     9781 gatccattac tgaacatgag gtgcccctct tacccaagga atttataaca tgactctggc
     9841 tccacagtgg tttctagttc ttcccccaca agcgaaagag ctgtttgcaa ctttggagtt
     9901 gctgtagact gaactgtagc ttgtagctgt tgaattaagt ccaaaatcta aggaatgcga
     9961 tggacttgtg caaagggatc cagaagagac actttttagt tgatgtttca agaataggga
    10021 gagagaggat gggtaccatg gaataccaaa gtgaaggact ttgtgtcatt cagtaaaatt
    10081 ttcttttttc atatcctaag tagctcccat tccctcacct tttcaatcag aattaacaaa
    10141 ttcaagcctt cagtaaagta gggatgcttt taacttttat tattaattat tttgagatct
    10201 taaaaaaata gtagttctcc cttattattt ttgtgggcat tgaaaagctc atttcacagt
    10261 accagagatt tttactggga gtatatattt tggaggtagg catagaggga gccctacccc
    10321 ttccacaaat tacgttactc aagagacagc taaaataaaa tgcattatct ccccagacca
    10381 gagacagtgg ccaaaataaa aaatcatggg gctggaaatt tcccaaatca aaccagcctc
    10441 ctggtgcttg aaggtttcat tcactattac ctgcacagga tgtaaagaaa agtcacagta
    10501 ggcactcttt accagggaaa taaggcagta tttgaatcac aagatatatt ttttatctgc
    10561 aaccatggat ccaatgatct gtagagcttt ttcactcatt aactgtcagg atatgaagga
    10621 ctgacagtct gtaaagatat ttatattttt gtatagttgt tttcatagat ttctcaaagg
    10681 ctgaagtttt caacctagaa gatgagattt gtattgagta tagaaatgat gtttcctatc
    10741 tagtttgtaa ataatcatgg tgcacttgag gggtctcttg gaaactccta gggggtcaag
    10801 aatcactatt ctgaaactgt atagactggg atttagctgc tgcattttgc ctttcttaaa
    10861 taattatatt ttggaatgta acccctgttc tgtcttcatt gacaggattt gcttgtgttg
    10921 ttaaaacact aacacaagag cttccagtgc ctgggccgtg cctaggtgat gctatttctt
    10981 ctatatctcc tgtcttcttt atcccaaatc ccactcagca tatcttcaga cctaggttgt
    11041 aagaccaact ttggattgga tctagccagt gaattattat ttccatggtt ggttcccttt
    11101 ctgttaactc tggtaatcaa cagattgaaa acggtggaag aacttctgaa aattgcagtg
    11161 ggagcaaatt cttgttggtt ttgtgctgct tgcctttcta gatctgctca tcagcactta
    11221 accttccctc ctctaaaggt tactaaagaa gcctgaagta ggtaaagagt gctcctcagc
    11281 ttcttatcct tccactcttt acccagcaga tttcattcaa tgccttagcc aaggagtcca
    11341 gcacctgtct cccctgctaa taattgtcct tagagatgct agtactttaa tccaggtata
    11401 gcagtttccc gttattttct tgcttgtcgt tcccctacat ttcctcctga tttcccaaga
    11461 ctctctttgt ggcttttgag ggtcagccaa ggagcaggca agtgagtgaa caatcctcag
    11521 gaaaagaagg accattttag cttaacactt cctttttttt tttttttttt ttaagaagaa
    11581 tataggtaaa caggtaatga ttcttgattg gagataccat ttgactcttg atgagagttg
    11641 tacgaagatg gaaatgaggg atgattccag gcgttttagg gggaaggctg cagataccat
    11701 tctaaccccc aagatactgt gttctcaaga cctcttagaa ctaggtgttg tcagggataa
    11761 tttgaggagg gcttagtctt cagaacaatc ctgcagtctt gacagaaatc taaaatctcc
    11821 aaaaactcct accctttaac cttaccctag ggggaactga tctatgaata ttacatgtgt
    11881 gattatgaaa ggtgaagttg agtgagagga gttgaggaac gtggaagaca gtgagctctc
    11941 accctaacac tataagaagc atgatctcaa tagaccaata attcaccttt ttatacatct
    12001 gtaaataaat ggaatgtttt taagaatata attatgtcag atttagcatt ttcttttata
    12061 tattaaatat atatatcttt ccttttctgc tttcgaaaag tgactatttt tttagaaatc
    12121 taagaacaga agtttggtga ttgaaaggta gaatatataa acctgaaata aagcagttaa
    12181 aacaattaaa gca
//
