LOCUS       NM_032718               5293 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 9
            (MFSD9), transcript variant 1, mRNA.
ACCESSION   NM_032718
VERSION     NM_032718.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5293)
  AUTHORS   Perland,E., Hellsten,S.V., Schweizer,N., Arapi,V., Rezayee,F.,
            Bushra,M. and Fredriksson,R.
  TITLE     Structural prediction of two novel human atypical SLC transporters,
            MFSD4A and MFSD9, and their neuroanatomical distribution in mice
  JOURNAL   PLoS One 12 (10), e0186325 (2017)
   PUBMED   29049335
  REMARK    GeneRIF: propose MFSD4A and MFSD9 to be novel transporters,
            belonging to disparate SLC families. Both proteins were located to
            neurons in mouse brain, and their mRNA expression levels were
            affected by the diet
            Erratum:[PLoS One. 2018 May 10;13(5):e0197417. doi:
            10.1371/journal.pone.0197417.. PMID: 29746586]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5293)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   3  (bases 1 to 5293)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK296768.1, BC006242.2, BC009310.2, AC007239.3 and U79290.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032718.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.104650.1,
                                           SRR1803616.150763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258436.10/ ENSP00000258436.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK296768.1         1-31
            32-1412             BC006242.2         1-1381
            1413-2232           BC009310.2         829-1648
            2233-3478           AC007239.3         125561-126806       c
            3479-5293           U79290.1           1-1815
FEATURES             Location/Qualifiers
     source          1..5293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..5293
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /note="major facilitator superfamily domain containing 9"
                     /db_xref="GeneID:84804"
                     /db_xref="HGNC:HGNC:28158"
                     /db_xref="MIM:620301"
     exon            1..243
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1503
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /note="isoform 1 is encoded by transcript variant 1; major
                     facilitator superfamily domain-containing protein 9"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 9 isoform 1"
                     /protein_id="NP_116107.3"
                     /db_xref="CCDS:CCDS2063.1"
                     /db_xref="GeneID:84804"
                     /db_xref="HGNC:HGNC:28158"
                     /db_xref="MIM:620301"
                     /translation="MELGGHWDMNSAPRLVSETAERKQEQKTGTEAEAADSGAVGARR
                     FLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCW
                     SDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVV
                     PEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFF
                     PWREAKPGSTEKGLPLRKTHVLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRN
                     MKNLLFSEMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAV
                     AGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGR
                     TCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLAL
                     VAIFIMSLNKRHSSGDGNSKLKSE"
     exon            244..331
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..375
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..505
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..715
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..5293
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4063..4068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /note="hexamer: ATTAAA"
     polyA_site      4083
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /note="major polyA site"
     regulatory      5273..5278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
                     /note="hexamer: AATAAA"
     polyA_site      5293
                     /gene="MFSD9"
                     /gene_synonym="SLC67A2"
ORIGIN      
        1 gcttccgctc ggggcggggc tgggctcccg gggtaggtcc gcggctgctg ctgcgtccga
       61 cccccggccg gcgcgggtat ggagcttggg ggtcactggg acatgaactc ggccccgagg
      121 ctggtctcgg agaccgcaga gcggaaacag gagcagaaga caggaaccga ggcggaggct
      181 gccgactccg gtgccgtcgg agcccgccgc ttcctgctct gtctctactt ggtgggcttc
      241 ttggatttgt ttggtgtcag catggttgtg cctttattga gccttcatgt caagtccctt
      301 ggagcaagtc caacagttgc tggaatagta ggctcctcct atggcatttt gcaactcttt
      361 tctagcacat tggtgggctg ctggagcgat gtagtgggaa gacggtcttc cttgctggca
      421 tgcattctac tcagtgctct gggctatctc cttctcggag cagccaccaa tgtgtttctg
      481 tttgtcctgg ctagagtccc ggcaggtatt tttaaacaca ctctctccat ctcaagggct
      541 ctactttctg atgtggttcc agagaaggaa cggccgcttg taatcggaca cttcaacaca
      601 gcctccggtg tgggcttcat cttgggcccc gtggtcggtg gctatctcac tgaattagag
      661 gatgggtttt atctcacagc cttcatctgc tttttggtct tcattctcaa tgctggtctc
      721 gtttggttct ttccatggag ggaagcaaaa ccgggcagta cagagaaggg cctgccattg
      781 cgaaagaccc atgtgctgtt gggaaggagc catgacacag tgcaggaggc agccaccagc
      841 cgcagagcca gggccagcaa gaagactgcc cagccctggg tcgaagtagt gttggccttg
      901 cggaacatga agaacctgct gttttccgaa atgtgggaca tatttctggt gcgcttgctg
      961 atggccatgg cagtcatgct gtactacagt aactttgtcc tggccctgga ggagcgcttt
     1021 ggggtgcggc ccaaggtgac aggctacctc atcagttaca gcagcatgct gggggccgtg
     1081 gccggccttg ccctggggcc aatcctacgg ctgtacaagc acaactcgca ggcactgctg
     1141 ctgcattcca gcatactcac ctgcacactg ctgctgctct actccttggc ccccaccatg
     1201 ggtgcagttg tcctctcctc cactctcctg tccttctcca ctgccattgg caggacgtgc
     1261 atcacggacc tccagctgac tgtgggcggg gcccaggcca gcggcaccct tattggcgtg
     1321 gggcagtctg tgactgcagt gggccgcatc atcgcccctc tcctctcggg ggttgcccag
     1381 gaggtcagcc cttgcggccc ccccagcctg ggcgctgtgt tagccttagt ggccattttc
     1441 ataatgtctc taaacaagcg acactctagt ggtgatggga atagtaaatt aaaaagtgag
     1501 tagatggatt tggacaacat aaagcaacaa aatttgagat ggttgaatga gggccggagg
     1561 ccatgatgaa aagggcactt tggaaagggt tggggtggaa gggaaatatt tccgggtggg
     1621 tgtgagctgt tgggcttcca ggtcagctct tggccatgca gccatgcctg caggatgatc
     1681 agaagtcacg gcacctcatg ggaaggttaa gactggagca aagcttttcc aaggtgagca
     1741 tattcagcgt ttacctggaa gtctcttctt cccacctggg ctaatcaggt tacaattttc
     1801 aagggtaaac aaactaccag ctacaggata gggaagtggt ggtggaataa gagaacatga
     1861 tacctggagg aagggaagaa accacaagca ttttcctact gaaaaatagg gtgacatgtc
     1921 agtcaaattc tgatcaactg gaacttgagt ttccagttaa attccataca ctaggaggga
     1981 gttttctatc aaaatcctgc agattgaaga agctggttta ttagaaccag cctgtcgctt
     2041 ttcaaagctg cttaaaaata agatactgac ctcaccccta gagatgattc agtgggcctg
     2101 ggtggggcca agaaatccgt ggtgttttgt aagcactgct ggcgatttct catggcagta
     2161 aagaccacac tgagactgca ctgattttga ttaaagtaca taggcttggc tgtttttaca
     2221 cagctaacta aatttggact cttaaaattg tgtttgtaat cacagtgtgt tacacctttc
     2281 ccagctctca gcagttgtac tgcatgatgg agcagcgggc ccctgggacc tgttccctgt
     2341 gctccctgcc tctgagagcc cagcttgctc tgaagttgga ctaaaccact tagatgctgg
     2401 ggttgccaca gcctgctcct ggaagcctgc attccagtca ggttgcatcc ttctggtgct
     2461 gacagaaccc agtggtgaag ccaaagcaca ggaatgcttt aaaaatgaac agtttatgca
     2521 gaataagggt caggagtcat gccagaccag aacttgatgc tactgtgtct tgtgttaaga
     2581 atcatttcct ggccaggctc ggtggctcag gcctgtaatc ccagcacttt gggaggctga
     2641 ggcaggtgaa tcacttggtc aggagatgga gaccattctg gctaacatgg tgaaaccccg
     2701 tctctactaa aaatacaaaa aaaaaattag ccgggcgtga tggcgggcgc ctgcagtccc
     2761 agctattcgg gaggctgagg tagaatggcg tgaacctggg aggcggagct tgcggtgagc
     2821 caagattgtg ccactgctct ccagcctggg cgacagagtg agactccgtc tcaaaaaaaa
     2881 aagaatcatt tcctttattt ttagtttcac gcctgcaaac acaagcattc tgttgatcaa
     2941 cggaaatatt ttgatgtgcc atttcttgtc taaacaagtt tcatatacag caccgagggg
     3001 gccacgagag gcagaggccc agacagaagg tgaacatagc cttgcaggga gacatatgcc
     3061 aggcaggatg accattggga ttgcatcaag tattaatcag ttacttaagg gcttcctgtc
     3121 agacagttga agttcacatt ccttttactt ttcttaatta gtccactagg atggtatgcc
     3181 tgttttcaac ttaacacatg catacttgta aatattttag tatgctacag taatttgtca
     3241 tatctttaat atttattgtt tgtaaagcag taaacatttc tgtattttag aagtcatgga
     3301 gtaaaatcaa atatttatga taaataattg gaagtatgtt ttagtttgaa gattgtcctt
     3361 tttcctatct tgctgcaagg aaaaatggac ttctgattag gttttacaat tgtgaacttt
     3421 tatgtaaatg ttaagtgctt tcgaggagac caaactatta ttaatatata aaatggcctt
     3481 gcccttaagg agcaaattaa atctcatgga gattagactc aaaaggcaat aaataatcga
     3541 gggtttatgc aatgaaatag aatttcagaa gagtttggat ctcaaagatt gtccttcact
     3601 ctcagaaaca ggcaagtttc ttaaaagccc ttatagtcgt gtttttattt taaaaatcgt
     3661 agcactttat ttttgaagtt taaaaagccc ataaacttaa tgagtcttta taatcagaca
     3721 catggaaata tagaaaacca aagactgatc ttagaatata gagtagagag acatgtttgt
     3781 tattctccac tagtgacttt agtattttgt tatgtgatgt tttttaggtg caccttttct
     3841 catgactcct tttactttat ctaatgtctt cctctttaaa gtgtgaccca gagaccagta
     3901 gcatcagcat cacctgagac ctgtgaacac tgaagctcca gctcagacat gttggggacc
     3961 attttaataa gatacctagc tgattttttg cacagcaaac tttgaaaacc cctggtctaa
     4021 ggggtagtat ttgtatcact tatggaatat aatctcaggg aaattaaatc tgctcaattg
     4081 acatttgtgg tgtttcattt tttaaattct cttgagtaac ttctgtagcc ctttccagtg
     4141 tgtcaggttg agccacatga agttgctatt tttgtaagtc aaaaatatct tcatagggtg
     4201 caactcacta ttctatggaa tcttatttta ggagtattga accttcctga aatgtctttg
     4261 aaggaagtgt caccctttcc aacactctgc cagccataac tgcttgggaa caggtctcca
     4321 ggatttgggt tccatagagc agaaggtagg cctctgccct catgtctaga gggatgaata
     4381 acattctgaa aaggtacagg gtgtgtctag tcacaggagt cacctgcaag gctccaaact
     4441 caggctggat ggccccttgg ggagtgaatt ctgcaagagt tgcacctggg gccaacagaa
     4501 ggagctggaa tcactgattc tgtatcctgg ctacatgcct tagaccacag gaaccagact
     4561 ctgaagcacc acagatgttt ctgtgaacat ctggagttgg gaatcactga gttagatcaa
     4621 gaatggattc ggctgccatg ctcgggttga gattgtattg acggatgaag gggaatgacg
     4681 gaagaattcc tgcggtaaag tgctgtgaag acactcctgt tttagaaaga gctctctagc
     4741 cgcagcaagg aggattaact ggaggcccaa ggagtagtct ggactttggg gcagtaactt
     4801 taggggggcc ctgagggaga gctggtcgcg aggacaggga cagcaggcag aggttgtggc
     4861 ccacagggca atcgcaggag aggttgtgaa taattcccag gtgatgagtg tgcagctttg
     4921 aggaatttca aagggttgct tggcgtcttt tcctgaagac acttctataa ggtatttaga
     4981 aatctatcag gagtgagaat cagtccagtc agaaaatttt aggcatttgg gcaactgcat
     5041 tcagaaaaca gctatttatt tggaatgcat aataaaagcc atgagactga atctccatgc
     5101 ctctttgccc cctagtagcc ttcaagaagt ctctaaaaca gggttaccac agatttagcc
     5161 aggatgatgt gtagcagctt ttcttggaac aggttgatgg attaaaataa ctttttttca
     5221 gctctaatgt ttttttcttg aatttgccag tcacatgata attttcttca aaaataaaac
     5281 tttataattg taa
//
