LOCUS       NM_152599               2256 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 6 like
            (MFSD6L), mRNA.
ACCESSION   NM_152599
VERSION     NM_152599.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2256)
  AUTHORS   Zhou,D., Wu,H., Wang,L., Wang,X., Tang,S., Zhou,Y., Wang,J., Wu,B.,
            Tang,J., Zhou,X., Tian,S., Liu,S., Lv,M., He,X., Jin,L., Shi,H.,
            Zhang,F., Cao,Y. and Liu,C.
  TITLE     Deficiency of MFSD6L, an acrosome membrane protein, causes
            oligoasthenoteratozoospermia in humans and mice
  JOURNAL   J Genet Genomics 51 (10), 1007-1019 (2024)
   PUBMED   38909778
  REMARK    GeneRIF: Deficiency of MFSD6L, an acrosome membrane protein, causes
            oligoasthenoteratozoospermia in humans and mice.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009451.21, AK093092.1 and BM986935.1.
            
            On May 17, 2019 this sequence version replaced NM_152599.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY129026.1, BC040487.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329805.6/ ENSP00000330051.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC009451.21        21876-21942
            68-1074             AK093092.1         5-1011
            1075-1075           AC009451.21        22950-22950
            1076-2203           AK093092.1         1013-2140
            2204-2256           BM986935.1         19-71               c
FEATURES             Location/Qualifiers
     source          1..2256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2256
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /note="major facilitator superfamily domain containing 6
                     like"
                     /db_xref="GeneID:162387"
                     /db_xref="HGNC:HGNC:26656"
     exon            1..2256
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2006
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 6-like"
                     /protein_id="NP_689812.3"
                     /db_xref="CCDS:CCDS11146.1"
                     /db_xref="GeneID:162387"
                     /db_xref="HGNC:HGNC:26656"
                     /translation="MSANPRWDISRALGVAKLFHLVCGVREACVTPFLTLYLRQLGLA
                     APWVGTLMGTKHLIAAFWAPVCAFLAKSYRKRRALLIGSLLGSVGASLLMVLVPPVDK
                     NRVHFPCNGSSGLTSTDALPGVTLPVNITSAQESASSHPAKRTAEVEMPGFRNPPGES
                     DRETFRDLHVYLAPSVEGARTTSQALLHPVTSGLKDHPWEVTFEVVKTALPLLPGGKG
                     PGNPANLSGTKGKAWAFDLSLEALRRTFILSLGSVAFWELLTAPLEQVADDSLYEFLD
                     FVDATDRYRSLWVWRLLGMSAGVCGITALVGQLDCFLMTSGPRGVVHFYGYSVVSTLA
                     LLVSIAFPIPICQQWEPSYKRVKALSIVGGDPHLILLASTTVLVGAIVSTVQNFLFWH
                     MKDHGSGELVMGFSVALSLLGEILLHPFKATLLRKLSRTGLVGLGLSCLAGQLLYYSF
                     LWSWWSVLPIQILSAISNRALWWAVGASVEDLATPRMERALSALFRGHFYGSGCSLGS
                     FVGGFVVMRFSLAVLYQACCVALLLWLALLLSIQRRLPRERKIKYSKLLSMEVSDTSD
                     SEQGTEQDWLVKAMREEHSD"
     regulatory      2182..2187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /note="hexamer: AGTAAA"
     polyA_site      2203
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /note="major polyA site"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
                     /note="hexamer: AATACA"
     polyA_site      2256
                     /gene="MFSD6L"
                     /gene_synonym="SLC73A2"
ORIGIN      
        1 accttcgccc ccgccccgcc tctccctccg ggcggggccc ctttcggtcc aacggcagga
       61 cctgggggct gtggccgggg gcggccgttg acctggtgac cgcggcgccg ccccagaccg
      121 ggggcgcagt cccactcgct ccgagccccg gtcccccaag cctccctccc gggtacctgg
      181 ggccgcgccc gccctgcgcc cagctccgcc ctccgtcggc ccaggcctga cagagcccgg
      241 cagccatgag tgccaacccc cggtgggaca tcagcagggc gctgggggtg gccaagctct
      301 tccacctggt gtgcggggtg cgggaagcct gcgtgacccc gttcctgacc ctttacctga
      361 ggcagctggg cttggccgcg ccctgggtgg gcaccctaat gggaaccaag cacctaatcg
      421 ctgccttctg ggctcccgtc tgtgccttcc tggccaaaag ctaccggaaa aggagagcgc
      481 ttctgatcgg ctccctgctc ggctcggtgg gggccagcct gctgatggtc ctggtcccac
      541 cggtagacaa aaatcgggtg cacttccctt gtaatggaag cagcggcctg accagcacag
      601 acgcactccc gggggtcacg ctacctgtga acatcacctc ggcccaagag tctgcctcca
      661 gccacccagc caagaggact gcagaggtgg aaatgcctgg cttcagaaac ccacctggtg
      721 aaagtgaccg agaaactttc cgtgatctgc acgtctactt agcgccctcc gttgaaggag
      781 ctaggaccac atcccaagct ctcctccatc ctgtcacttc ggggctgaaa gatcatccct
      841 gggaagttac ttttgaggtg gtcaagacag ccctcccctt gcttcctggg gggaaagggc
      901 ccgggaatcc agccaatttg tcagggacca aggggaaagc ctgggctttt gacctgtcct
      961 tggaggcgtt gcggcggact tttatcctct ccttggggtc cgtggcgttc tgggagctgc
     1021 tgacagcgcc tctggagcag gtggcagatg acagccttta tgagttcctg gattttgtgg
     1081 atgccactga ccgatacaga agcctgtggg tctggaggtt gctgggcatg tcggcaggcg
     1141 tgtgtggcat cacagccttg gtggggcagc tggactgctt cctgatgacc agtggccccc
     1201 gaggtgtggt ccacttctat gggtactcgg tggtcagcac cctggcctta ctggtgagca
     1261 ttgcctttcc cattcccatc tgtcagcagt gggagcccag ctacaaaagg gtcaaagcac
     1321 tgtccattgt ggggggtgac ccccacctca ttctcctcgc ctccaccact gttttggtag
     1381 gagccatcgt cagtactgtc cagaactttc tgttctggca catgaaggac catgggagcg
     1441 gcgagctggt catgggtttc tcggtcgccc tcagcttgct gggggaaatt ctgcttcatc
     1501 cgttcaaagc tacattgctt aggaaactgt ccaggacggg cctggtgggg ctggggctga
     1561 gctgcctcgc tgggcagctg ctgtactact ctttcctctg gagctggtgg tccgtcctcc
     1621 ccattcagat cttgagtgcc attagcaaca gagctttgtg gtgggctgtg ggggcctcag
     1681 tagaggacct ggccactccc cgcatggaga gggctctgag tgccttgttc cgaggccact
     1741 tttacgggag tggctgtagc ctgggcagct ttgtcggggg cttcgtggtg atgcgcttca
     1801 gcctggctgt gctctaccag gcctgctgtg tggccctgtt gctctggttg gccttgctcc
     1861 tgtccataca gcggaggctg ccccgagagc ggaaaatcaa gtactcgaag ctgctgtcca
     1921 tggaggtgag tgacaccagt gactctgagc aggggacaga acaggactgg cttgtgaagg
     1981 ccatgaggga ggaacactca gactgaaagg gctgagaaat ccagagtgtg ctgatccagc
     2041 aaggaacgaa tggactgaac aaaactcagc ctgctgagga cagaaacctg ccctggactg
     2101 ctgggagccg gggaagagag gatgggtctg tgctgaaggc ccaacaggat catctcattg
     2161 catgattttc tttacttttg aagtaaaagg agatttaact ttttgccaat cttttttaga
     2221 taatggagga agaatacatt tgctttttaa aaagtt
//
