LOCUS       NM_001346880            2846 bp    mRNA    linear   PRI 03-FEB-2025
DEFINITION  Homo sapiens MFSD2 lysolipid transporter B, sphingolipid (MFSD2B),
            mRNA.
ACCESSION   NM_001346880 XM_005264301
VERSION     NM_001346880.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Ghaderi,S. and Levkau,B.
  TITLE     An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate
            transporter
  JOURNAL   Pharmacol Ther 249, 108483 (2023)
   PUBMED   37390971
  REMARK    GeneRIF: An erythrocyte-centric view on the MFSD2B
            sphingosine-1-phosphate transporter.
            Review article
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Polzin,A., Dannenberg,L., Benkhoff,M., Barcik,M., Helten,C.,
            Mourikis,P., Ahlbrecht,S., Wildeis,L., Ziese,J., Zikeli,D.,
            Metzen,D., Hu,H., Baensch,L., Schroder,N.H., Keul,P., Weske,S.,
            Wollnitzke,P., Duse,D., Saffak,S., Cramer,M., Bonner,F., Muller,T.,
            Graler,M.H., Zeus,T., Kelm,M. and Levkau,B.
  TITLE     Revealing concealed cardioprotection by platelet Mfsd2b-released
            S1P in human and murine myocardial infarction
  JOURNAL   Nat Commun 14 (1), 2404 (2023)
   PUBMED   37100836
  REMARK    GeneRIF: Revealing concealed cardioprotection by platelet
            Mfsd2b-released S1P in human and murine myocardial infarction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Kobayashi,N., Kawasaki-Nishi,S., Otsuka,M., Hisano,Y., Yamaguchi,A.
            and Nishi,T.
  TITLE     MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells
  JOURNAL   Sci Rep 8 (1), 4969 (2018)
   PUBMED   29563527
  REMARK    GeneRIF: Using microarray analysis of erythroid cell lines
            overexpressing human and mouse MFSD2B study showed sphingosine
            1-phosphate (S1P) transport activity. The properties of S1P release
            by MFSD2B were similar to those in erythrocytes. Moreover, knockout
            of MFSD2B in MEDEP-E14 cells decreased S1P export from the cells.
            These results strongly suggest that MFSD2B is a novel S1P
            transporter in erythroid cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Vu,T.M., Ishizu,A.N., Foo,J.C., Toh,X.R., Zhang,F., Whee,D.M.,
            Torta,F., Cazenave-Gassiot,A., Matsumura,T., Kim,S., Toh,S.E.S.,
            Suda,T., Silver,D.L., Wenk,M.R. and Nguyen,L.N.
  TITLE     Mfsd2b is essential for the sphingosine-1-phosphate export in
            erythrocytes and platelets
  JOURNAL   Nature 550 (7677), 524-528 (2017)
   PUBMED   29045386
REFERENCE   5  (bases 1 to 2846)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
  REMARK    Review article
REFERENCE   6  (bases 1 to 2846)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   7  (bases 1 to 2846)
  AUTHORS   Angers,M., Uldry,M., Kong,D., Gimble,J.M. and Jetten,A.M.
  TITLE     Mfsd2a encodes a novel major facilitator superfamily
            domain-containing protein highly induced in brown adipose tissue
            during fasting and adaptive thermogenesis
  JOURNAL   Biochem J 416 (3), 347-355 (2008)
   PUBMED   18694395
  REMARK    GeneRIF: Results identify Mfsd2a (major facilitator superfamily
            domain-containing protein 2a) and an additional closely related
            protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive
            thermogenesis.
REFERENCE   8  (bases 1 to 2846)
  AUTHORS   Law,C.J., Maloney,P.C. and Wang,D.N.
  TITLE     Ins and outs of major facilitator superfamily antiporters
  JOURNAL   Annu Rev Microbiol 62, 289-305 (2008)
   PUBMED   18537473
  REMARK    Review article
REFERENCE   9  (bases 1 to 2846)
  AUTHORS   Saier,M.H. Jr., Beatty,J.T., Goffeau,A., Harley,K.T., Heijne,W.H.,
            Huang,S.C., Jack,D.L., Jahn,P.S., Lew,K., Liu,J., Pao,S.S.,
            Paulsen,I.T., Tseng,T.T. and Virk,P.S.
  TITLE     The major facilitator superfamily
  JOURNAL   J Mol Microbiol Biotechnol 1 (2), 257-279 (1999)
   PUBMED   10943556
  REMARK    Review article
            Erratum:[J Mol Microbiol Biotechnol 2000 Apr;2(2):255]
REFERENCE   10 (bases 1 to 2846)
  AUTHORS   Pao,S.S., Paulsen,I.T. and Saier,M.H. Jr.
  TITLE     Major facilitator superfamily
  JOURNAL   Microbiol Mol Biol Rev 62 (1), 1-34 (1998)
   PUBMED   9529885
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104665.3, BX357394.2, CX751215.1, BX369190.2, DR007952.1,
            DR731151.1 and BX647146.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001346880.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000338315.6/ ENSP00000342501.4
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC104665.3         3115-3116
            3-14                BX357394.2         6-17
            15-108              CX751215.1         1-94
            109-827             BX357394.2         112-830
            828-1141            BX369190.2         119-432
            1142-1142           AC104665.3         16230-16230
            1143-1276           DR007952.1         97-230              c
            1277-1373           DR731151.1         1-97                c
            1374-1864           BX647146.1         1141-1631
            1865-2266           AC104665.3         18824-19225
            2267-2846           BX647146.1         2034-2613
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2846
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /note="MFSD2 lysolipid transporter B, sphingolipid"
                     /db_xref="GeneID:388931"
                     /db_xref="HGNC:HGNC:37207"
                     /db_xref="MIM:617845"
     exon            1..108
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1527
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /note="major facilitator superfamily domain-containing
                     protein 2b; hMfsd2b; S1P transporter; sphingosine
                     1-phosphate transporter; major facilitator superfamily
                     domain containing 2B"
                     /codon_start=1
                     /product="sphingosine-1-phosphate transporter MFSD2B"
                     /protein_id="NP_001333809.1"
                     /db_xref="CCDS:CCDS86824.1"
                     /db_xref="GeneID:388931"
                     /db_xref="HGNC:HGNC:37207"
                     /db_xref="MIM:617845"
                     /translation="MAAPPAPAAKGSPQPEPHAPEPGPGSAKRGREDSRAGRLSFCTK
                     VCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFI
                     NRSQRTGSGRLMPWVLGCTPFIALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQ
                     VPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHRPHRCEATATP
                     GPVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSL
                     TTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTP
                     LWEWVLQRFGKKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSM
                     LPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYKAGVCKQA
                     EEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTPSRDASSRLSLRRRTSYSLA"
     exon            109..234
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..359
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..483
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..562
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..693
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..784
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..906
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..990
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1071
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1181
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1325
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1502
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..2846
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="MFSD2B"
                     /gene_synonym="SLC59A2"
                     /note="major polyA site"
ORIGIN      
        1 gctgcggtgg caatggcggc gccccctgca ccagccgcca aggggtcccc gcagccggag
       61 ccgcacgccc cagagcccgg cccggggagc gccaagcgag ggcgagagga cagcagagcc
      121 ggtcgcctct cattctgtac aaaggtgtgc tatggcattg gtggggtccc caaccagata
      181 gcctccagcg ccacagcctt ttacctgcag cttttcctgc ttgatatagc acagatccct
      241 gccgcccagg tgtcacttgt tctgtttggg ggaaaagtgt ctggggcggc tgctgaccct
      301 gtggctgggt tcttcatcaa caggagccag aggacagggt ctggacggct catgccttgg
      361 gtgctgggct gcaccccctt catcgccctg gcctacttct tcctgtggtt cctgcccccc
      421 ttcaccagcc tgcgaggcct ctggtacacg actttctact gcctgttcca ggccctggcc
      481 acgttcttcc aggtgcccta cacagcgctc accatgctgc tgactccctg cccaagggag
      541 cgggactcgg ccaccgccta ccggatgact gtggagatgg cgggaacact gatgggggcc
      601 actgtccacg ggctcatcgt gtccggcgcc cacagacccc acaggtgcga ggccactgcg
      661 accccggggc cagtcactgt ctccccgaat gcagcccatc tctactgcat tgcggctgcc
      721 gtggttgtag tgacttaccc cgtgtgcatc agtttactgt gcctaggggt gaaggagcgg
      781 ccagacccct ctgccccagc ctcaggccca ggcttgagtt tcctggctgg gctgagcctc
      841 actacccggc acccacccta cctgaagctg gtgatctcct tcctgttcat ctctgctgct
      901 gttcaggtgg agcagagcta cctggtcctg ttctgtacac atgcctccca gctacacgac
      961 cacgtccagg gcctggtact aactgtcctg gtctcagccg tgctgagcac cccgctgtgg
     1021 gagtgggttc tccagcgctt tgggaagaag acgtcagcct ttgggatctt tgcgatggtg
     1081 ccctttgcga tcttgctggc tgctgtgccc acagcacctg tggcatatgt cgtggccttt
     1141 gtatctggcg tgagcattgc tgtgtccttg ctgctaccct ggtccatgct gccagacgtg
     1201 gtggatgact ttcagctgca gcaccgtcac gggccaggcc tggagaccat cttctactcc
     1261 tcctacgtct tcttcaccaa gctgtctggc gcatgtgccc tgggcatctc caccctcagt
     1321 ctggagttct cggggtataa ggcaggggtc tgcaagcaag cagaggaggt ggtggtcacc
     1381 ctcaaagtcc tcattggcgc cgtgcccacc tgcatgatcc ttgctgggct ctgcatcctc
     1441 atggtcggct ccactccaaa gacacccagt cgggacgcct ccagccggct gagccttcgg
     1501 aggaggacca gctacagcct ggcctaaagc ttaggagggc gactgtgaat ggacacagga
     1561 gccagcaccc tcggggcctg acatcgccct cctcagccct ccagcacctg gtctggcagt
     1621 ttagtatgtg acctttctcc ctgggatgtg gagtcttcgg caacgtgtcc tgaagggact
     1681 ggcccgcact ccaggacccc acttggcatt tcttgtctgt tgccttcaga ctatctcaga
     1741 taggcctgtg cccctgacta gcccagtagc acttgtctct agaaaaagga agctcctgcc
     1801 caacctggct tgtggaccag taatatctgt ggcctaccac ccattcaaga aaacgttaca
     1861 gccggctcac tgcaaaatcc gcctcccggg ttcacgccat tctcctgcct cagcctcccg
     1921 agtagctggg actacaggtg cccgccacca cgcccagcta atttttgtat ttttagtaga
     1981 gacggggttt caccgtgtta gccagaatgg tttcgatctc ctgacctcgt gatccgcccc
     2041 gcctcagcct cccaaaggca tgagccaccg tactcggcct gcccaggctg gtcttaaact
     2101 cctggcctca ggtgatccta ctgcctcagc ctcctgagta gctgggatta cagacacagc
     2161 ccccgttccc agctctagca tttcttaagg acaaaattgg tgtgtaagta acaggaaatt
     2221 cacattatgc tgtactcatt ctctaatatc acagccatgt tagaacaaat ttgggttttc
     2281 aaaacaagcg taactgaaca gagtatatat atgtatgtat ataaatatat agaaatccta
     2341 aatggtccct gtgacataag aaatacacat ttggtctctg ccccaggttc ctggcacaga
     2401 gcttctaaaa tgctagtaac ttcctgagtg gtaggggtga ggggaacatc ttttgttata
     2461 cataagaagc ccttttcaaa cagatctgag tttatgctaa tgatgtgact ggcagaggat
     2521 gggggctggt tgccagagaa accaaccatg tgattagaag gttgaaactt tcagccttat
     2581 cttcctaccg ggaggggaca ggggctgaag actgagctca tcatcaatga tttaatcaat
     2641 tgtgcccatg taatggagcc tccacttcca aacgaagggt ttcagagagc ttctaggttg
     2701 gtgaacacat ccatgtacca ggaggtctac cccactccac ggggacagaa actcttgtgt
     2761 aggggaccct tttagatttc attctatata cctcttcagc tggctgttca ttttataatc
     2821 aaccaataaa tgttaagtaa agtgtt
//
