LOCUS       NM_032558               3402 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 14B
            (MFSD14B), mRNA.
ACCESSION   NM_032558 XM_001130181
VERSION     NM_032558.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Gong,J., Hutter,C.M., Newcomb,P.A., Ulrich,C.M., Bien,S.A.,
            Campbell,P.T., Baron,J.A., Berndt,S.I., Bezieau,S., Brenner,H.,
            Casey,G., Chan,A.T., Chang-Claude,J., Du,M., Duggan,D.,
            Figueiredo,J.C., Gallinger,S., Giovannucci,E.L., Haile,R.W.,
            Harrison,T.A., Hayes,R.B., Hoffmeister,M., Hopper,J.L.,
            Hudson,T.J., Jeon,J., Jenkins,M.A., Kocarnik,J., Kury,S., Le
            Marchand,L., Lin,Y., Lindor,N.M., Nishihara,R., Ogino,S.,
            Potter,J.D., Rudolph,A., Schoen,R.E., Schrotz-King,P., Seminara,D.,
            Slattery,M.L., Thibodeau,S.N., Thornquist,M., Toth,R., Wallace,R.,
            White,E., Jiao,S., Lemire,M., Hsu,L. and Peters,U.
  CONSRTM   CCFR and GECCO
  TITLE     Genome-Wide Interaction Analyses between Genetic Variants and
            Alcohol Consumption and Smoking for Risk of Colorectal Cancer
  JOURNAL   PLoS Genet 12 (10), e1006296 (2016)
   PUBMED   27723779
  REMARK    GeneRIF: We identified interaction between CRC risk and alcohol
            consumption and variants in the 9q22.32/HIATL1 region. Compared to
            non-/occasional drinking light to moderate alcohol consumption was
            associated with a lower risk of colorectal cancer among individuals
            with rs9409565 CT genotype and TT genotypes
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3402)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   4  (bases 1 to 3402)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX359483.2, BU507687.1, BC106062.1 and AL358232.19.
            
            On May 17, 2019 this sequence version replaced NM_032558.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.145726.1, BC106062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375344.8/ ENSP00000364493.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BX359483.2         26-41
            17-245              BU507687.1         12-240
            246-3280            BC106062.1         1-3035
            3281-3402           AL358232.19        61791-61912         c
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..3402
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /note="major facilitator superfamily domain containing
                     14B"
                     /db_xref="GeneID:84641"
                     /db_xref="HGNC:HGNC:23376"
                     /db_xref="MIM:620348"
     exon            1..359
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1772
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /note="hippocampus abundant transcript-like 1"
                     /codon_start=1
                     /product="hippocampus abundant transcript-like protein 1"
                     /protein_id="NP_115947.2"
                     /db_xref="CCDS:CCDS6710.2"
                     /db_xref="GeneID:84641"
                     /db_xref="HGNC:HGNC:23376"
                     /db_xref="MIM:620348"
                     /translation="MSVEPPPELEEKAASEPEAGAMPEKRAGAQAAGSTWLQGFGRPS
                     VYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGA
                     LSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIFAYVADVTQ
                     EHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVP
                     ESLPEKMRPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFF
                     LYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLA
                     WYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGL
                     GPALYGFIFYMFHVELTELGPKLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP
                     EYSKASGVQKHSNSSSGSLTNTPERGSDEDIEPLLQDSSIWELSSFEEPGNQCTEL"
     exon            360..455
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..518
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..646
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..761
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..980
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1094
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1166
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1279
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1377
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1520
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..3402
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3256..3261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /note="hexamer: AATAAA"
     polyA_site      3280
                     /gene="MFSD14B"
                     /gene_synonym="HIATL1; SLC71A2"
                     /note="major polyA site"
ORIGIN      
        1 ggtaactgcg agagtcgggg tcggtgcggt ttgataagtg gtcggttcct ggagctgcgg
       61 tcttctgcta gcctgatccg cagcttcagc ctccgccgcc tcctcagccc tcggcgccgc
      121 cgctggcgcc gccgcctgac ccgcaggccg ccgcgggccg cagagcccat gagggcgcgg
      181 gcaccgccgc cgcctccgcg gcgtcgccgt cgtcccggag cgccccgggc tggcgcgggc
      241 atggccgcgg catgagcgtg gagccgccgc cggagctgga ggagaaggcg gcgtcggagc
      301 ccgaggcggg agccatgccg gagaagcgcg cgggcgcgca ggccgcgggg agcacctggc
      361 tacaaggctt tggccgacca agtgtgtacc atgctgctat tgtcatcttc cttgaattct
      421 ttgcgtgggg cctgttgaca actccaatgt tgactgttct acatgaaaca ttttctcaac
      481 acacattcct catgaatggt ctcattcaag gtgtaaaggg cctgctctct tttttgagtg
      541 ccccactcat tggtgccctg tctgatgtgt gggggaggaa gccctttctc ctcggcactg
      601 tattctttac ctgcttccca atcccactga tgaggatcag cccatggtgg tattttgcga
      661 tgatttctgt gtctggagtc ttctcggtca cgttttctgt tatatttgcc tatgtagctg
      721 atgtcactca ggagcacgag cgaagtacag cttatggatg ggtctcagcc acctttgcgg
      781 ctagtcttgt cagcagcccg gccattggag catatctttc tgccagttac ggagacagcc
      841 tcgttgtgct ggtggccaca gtggtggctc ttctggacat ctgcttcatc ttagtggctg
      901 ttccagaatc tctgcctgag aaaatgagac cggtttcctg gggagctcag atttcttgga
      961 aacaagcaga cccttttgcg tcgttgaaga aagttggaaa agattctact gtcttactaa
     1021 tctgcatcac cgtgtttctt tcataccttc ctgaagctgg acagtattca agtttttttc
     1081 tctatctcag gcaggtcata ggttttggat ctgttaaaat tgcagcattc atagctatgg
     1141 taggaattct gtctattgtg gctcagacgg cctttcttag catcttgatg agatcattag
     1201 gaaataagaa tactgtcctc cttggcttgg gcttccagat gctccagtta gcctggtacg
     1261 gttttggatc acaggcctgg atgatgtggg cagcagggac cgtggctgcc atgtccagca
     1321 tcacgtttcc ggcaatcagt gccctcgtct ctcggaatgc agagtcagat cagcaaggag
     1381 ttgcccaggg gatcataact ggaataagag gactatgcaa tggcctgggg ccagcactgt
     1441 atggcttcat attctacatg ttccatgtgg aactgactga gttgggcccg aaattgaatt
     1501 ctaacaacgt tcccctgcag ggagctgtca tcccaggccc gccgttttta tttggggcat
     1561 gtatagtcct tatgtctttt ctggttgcct tattcattcc tgaatacagt aaagccagtg
     1621 gagttcaaaa acacagtaac agcagcagcg gcagcctgac caacacccca gaacggggca
     1681 gtgatgagga cattgagcca ctactgcaag acagcagcat ctgggagctc tcttcatttg
     1741 aggagcctgg gaatcagtgc actgagctgt aaactcggca gaaagtggga ttctgcatac
     1801 gccatctctg agagccatgg agggagccac acccctggtg acttcatggt gctggatggg
     1861 agacgctagc ggcatccttc agggccaagt ttgataaata ccaccgccat cattctgctc
     1921 atcctcctcc tgtttttttt ttttctctta cattcttttt ttttttcctg tttatacatt
     1981 agaacaagat aagatttgaa atacttcctt gcaaataatg tgcaactccc aaggtgaaac
     2041 tcaaatagaa aaagtcatct ctctggtaga aaggatggct ttcctgtaat gactatagag
     2101 taagagtggc agcaatcttt ccatgccctt ttcagcagaa ggcacagaac agtagcggga
     2161 ctgccatctc tggcaagatt tcaggtaaag aatctcttct taatttctac cttcctgttt
     2221 ctctgaatca gcccataggt gttgatgagt ggccactctt aaagagtcac tcagtatcag
     2281 ggatctactg tctttgttca aaggtcaaat aaaaacctag tctcctttta ttctactttc
     2341 tattcttagc tagaatgaaa ctcagcatat atacacttct ggacataata atattgaata
     2401 gtaattacct ttactagatg aaagaaattt tcattacaaa cttaaatcat gtaaaactca
     2461 acaactcaga ttcctggacc tggtgtcctg gttgggtcca aggtgatttt acagaagaaa
     2521 aaaacaactc aagcattctg gtggcaacat agagattgta ggctgcttct aagaaagtta
     2581 ttaacaattt ggaaattcct aagtaggatg agagttagta actggatacg agtgaagttt
     2641 atatccaagt tcagactcaa aggcattatt atgatttgct tcttcccatg tcttccatgt
     2701 cctgcttctc aaagtttttc tcatccatca cactcctgcc ttaactgctc tgagtatgca
     2761 tttgttttca attcatcttt atttcaatct gtttaacttt tgaatcgcat gggaatacgc
     2821 acattaagtt cctttctaaa ataaggtttt atgaagctga gtttcacgat aagtgtcttg
     2881 ctattttttg agatgtttta tggacaaaga aaactttaca gatttatatg tattttgctg
     2941 caccagtaaa tggaccatta actagggccc acctttaaca gagcacccct ttgaaagttt
     3001 tataggtatg aaatatatgt agatatttgt aaagggtttt aatttttttt ttttgatggg
     3061 gtgctgtgta aatcttgtat ttataaatgt aatgaaggta ttgacagaaa aaaatatata
     3121 caacttttat aaaggattgt gtactgactg aatacattta aaagaaaata tattttgaaa
     3181 cctgttctgc tatgaacaga gataacatat ctttttacta tgctattggt ttttaggtta
     3241 agcttcctaa tgcataataa atttacagtg gttactttta tgtcttgtgt ctttttttta
     3301 aagcaaatag tattgctctt ttgggttctc tgttgggtgg ctttcaatta aactgagttg
     3361 taatctttca gctgatgcaa aaggtatgta ttttcaaaaa aa
//
