LOCUS       NM_024789               2852 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 13A
            (MFSD13A), mRNA.
ACCESSION   NM_024789 XM_370576
VERSION     NM_024789.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2852)
  AUTHORS   Wang,J.Y., Li,X.Y., Li,H.J., Liu,J.W., Yao,Y.G., Li,M., Xiao,X. and
            Luo,X.J.
  TITLE     Integrative Analyses Followed by Functional Characterization Reveal
            TMEM180 as a Schizophrenia Risk Gene
  JOURNAL   Schizophr Bull 47 (5), 1364-1374 (2021)
   PUBMED   33768244
  REMARK    GeneRIF: Integrative Analyses Followed by Functional
            Characterization Reveal TMEM180 as a Schizophrenia Risk Gene.
REFERENCE   2  (bases 1 to 2852)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2852)
  AUTHORS   Anzai,T. and Matsumura,Y.
  TITLE     Topological analysis of TMEM180, a newly identified membrane
            protein that is highly expressed in colorectal cancer cells
  JOURNAL   Biochem Biophys Res Commun 520 (3), 566-572 (2019)
   PUBMED   31615651
  REMARK    GeneRIF: Using a homology model of TMEM180, we experimentally
            determined that the protein has 12 transmembrane domains, and that
            its N-terminal and C-termini are exposed extracellularly. Moreover,
            we found that the putative cation-binding site of TMEM180 is
            conserved among orthologs, and that its position is similar to that
            of melibiose transporter MelB.
REFERENCE   4  (bases 1 to 2852)
  AUTHORS   Mei,S., Ke,J., Tian,J., Ying,P., Yang,N., Wang,X., Zou,D., Peng,X.,
            Yang,Y., Zhu,Y., Gong,Y., Zhong,R., Chang,J. and Miao,X.
  TITLE     A functional variant in the boundary of a topological association
            domain is associated with pancreatic cancer risk
  JOURNAL   Mol Carcinog 58 (10), 1855-1862 (2019)
   PUBMED   31237042
  REMARK    GeneRIF: The allele G of rs2001389 weakened the binding activity
            with CTCF, and it was related to the lower expression of a putative
            antioncogene MFSD13A whose knockdown promoted proliferation of PC
            cells. By integrating analysis on multiomics data, association
            studies and functional assays, we proposed that the common variant
            rs2001389 and the gene MFSD13A might be genetic modifiers of PC
            tumorigenesis.
REFERENCE   5  (bases 1 to 2852)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   6  (bases 1 to 2852)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 2852)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 2852)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121928.13, BG830198.1 and BC057787.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024789.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.161077.1,
                                           SRR3476690.1124193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238936.8/ ENSP00000238936.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL121928.13        106761-106778
            19-440              BG830198.1         2-423
            441-446             AL121928.13        115394-115399
            447-645             BG830198.1         430-628
            646-965             BC057787.1         2-321
            966-970             AL121928.13        116663-116667
            971-1702            BC057787.1         327-1058
            1703-2852           AL121928.13        121262-122411
FEATURES             Location/Qualifiers
     source          1..2852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2852
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /note="major facilitator superfamily domain containing
                     13A"
                     /db_xref="GeneID:79847"
                     /db_xref="HGNC:HGNC:26196"
                     /db_xref="MIM:620255"
     exon            1..56
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            57..162
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            163..405
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1791
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /codon_start=1
                     /product="transmembrane protein 180"
                     /protein_id="NP_079065.2"
                     /db_xref="CCDS:CCDS7535.1"
                     /db_xref="GeneID:79847"
                     /db_xref="HGNC:HGNC:26196"
                     /db_xref="MIM:620255"
                     /translation="MGLGQPQAWLLGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSV
                     YKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPRSGAGLSSRAVVLARVQAL
                     GWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRT
                     HLNFYCSLFSAAGSLSVFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRV
                     EAARKDPGCSGLVVDSGLCGEELLVGSEEADSITLGRYLRQLARHRNFLWFVSMDLVQ
                     VFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAV
                     VRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVL
                     NHRKQAASALLFGMVALVTKPGQTFAPLLGTWLLCFYTGHDLFQQSLITPVGSAHPWP
                     EPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRLHMVKAQRQNLSQ
                     AQTLDVKMV"
     exon            406..488
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            489..941
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1065
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1162
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1334
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1528
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..2852
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /note="hexamer: ATTAAA"
     polyA_site      2852
                     /gene="MFSD13A"
                     /gene_synonym="bA18I14.8; C10orf77; SLC68A1; TMEM180"
                     /note="major polyA site"
ORIGIN      
        1 ggctcgcacc tggctcccgc cagccgtggg attaggcttc gccggctacg attgcggccc
       61 ccatcttctg acttttcctc gtgtgaccca tcttttcaaa ttcccttacc tgaggaagga
      121 gcccgattac aaggatattt acctgctcct accctgatct agggacgagg atgggaagac
      181 cgcctgtggc catgagccct ccccggtgct cctggggcta aggctggggc tgcagccatg
      241 gggctgggtc agccccaggc ctggttgctg ggtctgccca cagctgtggt ctatggctcc
      301 ctggctctct tcaccaccat cctgcacaat gtcttcctgc tctactatgt ggacaccttt
      361 gtctcagtgt acaagatcaa caaaatggcc ttctgggtcg gagagacagt gtttctcctc
      421 tggaacagcc tcaatgaccc cctcttcggt tggctcagtg accggcagtt cctcagctcc
      481 cagccccggt caggcgccgg gctctcctca agggctgtgg tgctggcccg ggtgcaggcc
      541 ctgggctggc atgggccgct gctggcgctg tcgttcctgg cgttctgggt gccctgggcc
      601 ccagctggcc tgcagttctt gctgtgcctg tgcctctatg atggcttcct gacgctcgtg
      661 gacctgcacc accatgcctt gctggccgac ctggccctct cagcccacga ccgcacccac
      721 ctcaacttct actgctccct cttcagcgcg gccggctccc tctctgtctt tgcatcctat
      781 gccttttgga acaaggagga tttctcctcc ttccgcgctt tctgcgtgac actggctgtc
      841 agctctgggc tgggctttct gggggccaca cagctgctga ggcggcgggt tgaggcggcc
      901 cgaaaggacc cagggtgctc aggcctggtt gtggatagcg gcctgtgtgg agaggagctg
      961 cttgtaggca gtgaggaggc ggacagcatc accttgggcc ggtatctccg gcagctggca
     1021 cgccatcgga acttcctgtg gttcgtgagc atggacctgg tgcaggtctt ccactgccac
     1081 ttcaacagca acttcttccc tctcttcctg gagcatctgt tgtccgacca tatctccctt
     1141 tccacgggct ccatcctgtt gggcctctcc tatgtcgctc cccatctcaa caacctctac
     1201 ttcctgtccc tgtgccggcg ctggggcgtc tacgcggtgg tgcgggggct cttcctgctc
     1261 aagctgggac ttagcctgct catgttgttg gccggcccgg accacctcag cctgctgtgc
     1321 ctcttcattg ccagcaaccg cgtcttcact gagggcacct gtaagctgct gaccttggtg
     1381 gtcactgacc tggtagacga ggacctggtg ctgaaccacc gcaagcaggc agcctcggca
     1441 ctcctctttg gcatggttgc cttggtgacc aagccaggcc agacctttgc cccgctgctg
     1501 ggcacctggc tgctctgttt ctacacaggt catgacctct tccagcagtc cctcataacc
     1561 cctgtgggga gtgcccatcc ctggccagag cccccagctc cagcccctgc acaggccccg
     1621 acgctccgcc agggctgctt ctacctgctg gtgctggtgc ccatcacctg tgctctgctg
     1681 cagctcttca cctggtccca gttcacgctg catgggagac gcctgcacat ggtcaaggcc
     1741 cagcgccaga acctgtcaca ggcccaaacc ctggatgtta agatggtgtg agagctgtgg
     1801 caaggtcacc ccactgagga tgctgctggc agcctgggga aggagccagt tttttttggt
     1861 ttttttttta aggatttcat agtttttttt tttttttttt ggagctgttg cccaaaaaaa
     1921 tggatctgtt gcagtggtgc aatctgggct cactgaaacc accacccagg ttcaagcaat
     1981 tatcctgcct cagcctcccg agtaggtggg attataggag cgtgccacca tgcccggcta
     2041 ctttttgtat ttttagtaga gacagggttt catcatgttg gccaggctag tctcaaaccc
     2101 ctgaccttag gtgatcagcc cgcctcggcc tcccagagtg ctgggattac aggcgtgagc
     2161 cactgtggcc aacctaattt ttgtattatt tagtagagac agggtttcac cacattggcc
     2221 aggctggtct cgaactcctg acctcaagtg atctgcctgc cttggtctcc caaagtgctg
     2281 ggaatacagg catgagccac cgcactcggc caggagctag ttttaccagc accctgctcc
     2341 actgccttcc tctagtgcag cctggaagac atggcagcgg gtagctcctg gggctgagcc
     2401 agaagcatca ctgcagtgaa agtctctgct tacctgtctg gctcagcttg ggcaagggct
     2461 gggccatatg tgctcaggga cgtgcttctc ttgtaaggca ggaggacaga agaggaccaa
     2521 gaagggaggg ggctgccctg tggtgcacac aggcctgcca tggggcgtgg gagcccatcc
     2581 cgctgcctga ctggagctgg ccgctgtggt ggactcagga accactttta atactgcaac
     2641 tgctcccttt tgcccagtca gggaaagctg actgtaagtc ccacctccca ctccgtccac
     2701 ccttctagtg gtttctctga gaggtttctc tgcttcagct gtgcttgaag tggcatgcct
     2761 cctctgctgc agggctcccc cacccccaca cggcctctaa agatgtttat ttccttatag
     2821 actgattaaa gtcagccatt ctttttcctc aa
//
