LOCUS       NM_001242532            2573 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens major facilitator superfamily domain containing 11
            (MFSD11), transcript variant 1, mRNA.
ACCESSION   NM_001242532
VERSION     NM_001242532.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Ceder,M.M., Lindberg,F.A., Perland,E., Williams,M.J. and
            Fredriksson,R.
  TITLE     The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient
            Homeostasis and Has a Potential Role in Locomotion: A First
            Characterization of the Atypical Solute Carrier CG18549 in
            Drosophila Melanogaster
  JOURNAL   Insects 12 (11), 1024 (2021)
   PUBMED   34821824
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2573)
  AUTHORS   Perland,E., Lekholm,E., Eriksson,M.M., Bagchi,S., Arapi,V. and
            Fredriksson,R.
  TITLE     The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly
            Expressed in the Mouse Brain and Have a Potential Role in Energy
            Homeostasis
  JOURNAL   PLoS One 11 (6), e0156912 (2016)
   PUBMED   27272503
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2573)
  AUTHORS   Hasegawa,Y., Taylor,D., Ovchinnikov,D.A., Wolvetang,E.J., de
            Torrente,L. and Mar,J.C.
  TITLE     Variability of Gene Expression Identifies Transcriptional
            Regulators of Early Human Embryonic Development
  JOURNAL   PLoS Genet 11 (8), e1005428 (2015)
   PUBMED   26288249
  REMARK    GeneRIF: Results from a study on gene expression variability
            markers in early-stage human embryos shows that MFSD11 is a
            putative marker for the 3-day, 8-cell embryo stage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2573)
  AUTHORS   Sim,X., Jensen,R.A., Ikram,M.K., Cotch,M.F., Li,X., MacGregor,S.,
            Xie,J., Smith,A.V., Boerwinkle,E., Mitchell,P., Klein,R.,
            Klein,B.E., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M., de
            Jong,P.T., Hofman,A., Rivadeneira,F., Uitterlinden,A.G., van
            Duijn,C.M., Aspelund,T., Eiriksdottir,G., Harris,T.B., Jonasson,F.,
            Launer,L.J., Attia,J., Baird,P.N., Harrap,S., Holliday,E.G.,
            Inouye,M., Rochtchina,E., Scott,R.J., Viswanathan,A., Li,G.,
            Smith,N.L., Wiggins,K.L., Kuo,J.Z., Taylor,K.D., Hewitt,A.W.,
            Martin,N.G., Montgomery,G.W., Sun,C., Young,T.L., Mackey,D.A., van
            Zuydam,N.R., Doney,A.S., Palmer,C.N., Morris,A.D., Rotter,J.I.,
            Tai,E.S., Gudnason,V., Vingerling,J.R., Siscovick,D.S., Wang,J.J.
            and Wong,T.Y.
  CONSRTM   Wellcome Trust Case Control Consortium 2; Global BPGen Consortium
  TITLE     Genetic loci for retinal arteriolar microcirculation
  JOURNAL   PLoS One 8 (6), e65804 (2013)
   PUBMED   23776548
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2573)
  AUTHORS   Sureau,A., Soret,J., Guyon,C., Gaillard,C., Dumon,S., Keller,M.,
            Crisanti,P. and Perbal,B.
  TITLE     Characterization of multiple alternative RNAs resulting from
            antisense transcription of the PR264/SC35 splicing factor gene
  JOURNAL   Nucleic Acids Res 25 (22), 4513-4522 (1997)
   PUBMED   9358160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005837.1 and AC027694.8.
            
            On Aug 13, 2020 this sequence version replaced NM_001242532.4.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants
            1-5 and 8-10 encode the same protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000233.1, AK025849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685175.1/ ENSP00000508960.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC005837.1         25042-25371         c
            331-386             AC005837.1         24497-24552         c
            387-494             AC005837.1         22426-22533         c
            495-574             AC005837.1         21442-21521         c
            575-671             AC005837.1         21217-21313         c
            672-730             AC005837.1         20034-20092         c
            731-875             AC005837.1         19024-19168         c
            876-916             AC005837.1         9403-9443           c
            917-982             AC027694.8         67514-67579         c
            983-1108            AC027694.8         65094-65219         c
            1109-1283           AC027694.8         59794-59968         c
            1284-1419           AC027694.8         58424-58559         c
            1420-2573           AC027694.8         55624-56777         c
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1-q25.2"
     gene            1..2573
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /note="major facilitator superfamily domain containing 11"
                     /db_xref="GeneID:79157"
                     /db_xref="HGNC:HGNC:25458"
                     /db_xref="MIM:620346"
     exon            1..330
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1584
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UNC93-like protein MFSD11; protein ET; major facilitator
                     superfamily domain-containing protein 11"
                     /codon_start=1
                     /product="UNC93-like protein MFSD11 isoform 1"
                     /protein_id="NP_001229461.1"
                     /db_xref="CCDS:CCDS11750.1"
                     /db_xref="GeneID:79157"
                     /db_xref="HGNC:HGNC:25458"
                     /db_xref="MIM:620346"
                     /translation="MSPESKKLFNIIILGVAFMFMFTAFQTCGNVAQTVIRSLNRTDF
                     HGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSMYIAVFIQPFPWSFY
                     TASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQG
                     KTQISESDRRTVFIALTVISLVGTVLFFLIRKPDSENVLGEDESSDDQDMEVNESAQN
                     NLTKAVDAFKKSFKLCVTKEMLLLSITTAYTGLELTFFSGVYGTCIGATNKFGAEEKS
                     LIGLSGIFIGIGEILGGSLFGLLSKNNRFGRNPVVLLGILVHFIAFYLIFLNMPGDAP
                     IAPVKGTDSSAYIKSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFK
                     FVQSICAAVAFFYSNYLLLHWQLLVMVIFGFFGTISFFTVEWEAAAFVARGSDYRSI"
     exon            331..386
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            387..494
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            495..574
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            575..671
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            672..730
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            731..875
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            876..916
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            917..982
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1108
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1283
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1419
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..2573
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1939..1944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /note="hexamer: TATAAA"
     polyA_site      1957
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /note="major polyA site"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD11"
                     /gene_synonym="ET"
                     /note="hexamer: AACAAG"
     polyA_site      2573
                     /gene="MFSD11"
                     /gene_synonym="ET"
ORIGIN      
        1 gtgctcttcc gtactcggat cgcttcttag gagtatccta actgccggtg gggagaactt
       61 cgccctaaac ctggggttcc gatccaggaa ctggaagttg acagcttggc tgcctggctc
      121 ctgcatctgc cttctccact caccatctca tttctttctc caggattgtc agtggcttcg
      181 ccccgaggag agctgactgc cctgggctgc tgcctccggc agagctgagc caaaatgtcc
      241 ccggaatcta aaaagctttt caacatcatt attttaggag ttgcctttat gtttatgttc
      301 actgcctttc aaacttgtgg aaatgtggcg caaactgtca tcaggagctt aaataggaca
      361 gattttcacg gcagtggata taccagcatg gctattatct atggagtgtt ctctgcttca
      421 aatttgatta caccgtcagt ggttgccatt gtaggacctc aactctctat gtttgccagt
      481 ggtttatttt acagcatgta cattgccgtt ttcatccagc ctttcccgtg gtccttctac
      541 acagcctctg ttttcattgg aattgctgct gctgtgcttt ggacagcaca aggaaactgc
      601 ctgacaatca attcggatga gcacagcatt gggagaaaca gtgggatttt ctgggcactt
      661 ctgcagtcta gcttgttctt tggaaatctc tacatatatt ttgcctggca agggaaaact
      721 cagatatcag agagtgaccg aagaacagtg tttattgccc taacggtgat tagccttgtg
      781 gggacagttc tattctttct cattcggaaa ccagattctg aaaatgtcct aggagaagat
      841 gagtcttctg atgaccagga catggaagtc aacgagtctg cccagaacaa tctgacaaag
      901 gcagtagatg cttttaaaaa gtcttttaag ttatgtgtca ccaaggagat gctccttctt
      961 agtattacaa ctgcttatac aggtctggaa ttaactttct tctctggtgt atatggaacc
     1021 tgtattggtg ctacaaataa atttggagca gaagagaaaa gccttattgg actttctggc
     1081 attttcatcg gcattggaga aattttaggt ggaagcctct tcggcctgct gagcaagaac
     1141 aatcgttttg gtagaaatcc agttgtgctg ttgggcatcc tggtgcactt catagctttt
     1201 tatctaatat ttctcaacat gcctggagat gccccgattg ctcctgttaa aggaactgac
     1261 agcagtgctt acatcaaatc cagcaaagaa gttgccattc tctgcagttt tctgttgggc
     1321 cttggagaca gctgctttaa tacccagctg cttagtatct tgggctttct gtattctgaa
     1381 gacagcgccc cagcatttgc catcttcaag tttgttcagt ctatttgcgc agccgtggca
     1441 tttttctaca gcaactacct tctccttcac tggcaactcc tggtcatggt gatatttggg
     1501 ttttttggaa caatttcttt cttcactgtg gaatgggaag ctgccgcctt tgtagcccgc
     1561 ggctctgact accgaagtat ctgatctggt gtccgtgagg ggacacgtat gacctcagaa
     1621 acacagctgg acacagagct tggtggaaga agtcgccttt gatcttcact atatattggg
     1681 tgatgttcag tatggaaaat caagggatta agactgttaa atcagccaga gttggtgttc
     1741 aagtttacag atatgagtta tttaaagcaa gtagaataag ggaaagctgt tctgtcaact
     1801 gtaattgttc aaagatgttg tttttcattt catctatctc aattcttata atcatgttat
     1861 agaatgtaaa tgttttcttc tctctcctgc tcttgttgga agatcctgcc ttgatttaga
     1921 atactaggcc atatgtcata taaatatttt ttctggatat ggagtatgtt ttgccatgta
     1981 ataatgggaa gcatatgtca ttccccatat gtgttggaga atgacattta aataaatagc
     2041 aaagctgggt gtggtgttgc accgctatac tcccagctgt tggggaggct gagacagaag
     2101 gatcacttca gcccaggaga ttgaggctgc ggtgagctat gatcacacca ctgcactcca
     2161 ggctgggcaa cagagtgaga ccctgtcttg aaaataataa taggctggtc acagtggctc
     2221 atgcctgtaa tcccaacact ttgggaggct gaggtgggtg gatcacctga ggtcaggagt
     2281 ttgagaccag cctggccaac atggtgaaac ctcatctcta ctaaaaatac aaaaatgtgt
     2341 tgggtttggt ggtgcatgcc tgtaatccta gctactaggg aggctgaggt aagagaattc
     2401 gcttgaacct gggaggcgga ggttgcagtg agccgagatc gtgccattgc actccagcct
     2461 ggatgacaag agtgaaactc catctcaaaa aaaaaaaaaa aaaaaagaaa agaaaataat
     2521 aatgataatt ttttaaaata atgaaaaata aataacaaga tgctgaaatg aaa
//
