LOCUS       NM_001146069            1717 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 10
            (MFSD10), transcript variant 2, mRNA.
ACCESSION   NM_001146069
VERSION     NM_001146069.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1717)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1717)
  AUTHORS   Ushijima,H., Hiasa,M., Namba,T., Hwang,H.J., Hoshino,T., Mima,S.,
            Tsuchiya,T., Moriyama,Y. and Mizushima,T.
  TITLE     Expression and function of TETRAN, a new type of membrane
            transporter
  JOURNAL   Biochem Biophys Res Commun 374 (2), 325-330 (2008)
   PUBMED   18638446
  REMARK    GeneRIF: TETRAN is a novel human organic anion transporter, and
            that it serves as a transporter for some NSAIDs and various other
            organic anions at the final excretion step.
REFERENCE   3  (bases 1 to 1717)
  AUTHORS   Mima,S., Ushijima,H., Hwang,H.J., Tsutsumi,S., Makise,M.,
            Yamaguchi,Y., Tsuchiya,T., Mizushima,H. and Mizushima,T.
  TITLE     Identification of the TPO1 gene in yeast, and its human orthologue
            TETRAN, which cause resistance to NSAIDs
  JOURNAL   FEBS Lett 581 (7), 1457-1463 (2007)
   PUBMED   17362938
  REMARK    GeneRIF: A BLAST search identified the possible human orthologue of
            Tpo1p, tetracycline transporter-like protein (TETRAN), whose
            overexpression in cultured human cells caused resistance to some
            NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
REFERENCE   4  (bases 1 to 1717)
  AUTHORS   Duyao,M.P., Taylor,S.A., Buckler,A.J., Ambrose,C.M., Lin,C.,
            Groot,N., Church,D., Barnes,G., Wasmuth,J.J., Housman,D.E. et al.
  TITLE     A gene from chromosome 4p16.3 with similarity to a superfamily of
            transporter proteins
  JOURNAL   Hum Mol Genet 2 (6), 673-676 (1993)
   PUBMED   8353488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN422014.1 and BC001502.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001146069.1.
            
            Summary: This gene encodes a member of the major facilitator
            superfamily of transporter proteins. The encoded protein likely
            functions in efflux of organic anions, including the non-steroidal
            anti-inflammatory drugs indomethacin and diclofenac. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.622709.1,
                                           SRR3476690.998362.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355443.9/ ENSP00000347619.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                CN422014.1         23-62
            41-1717             BC001502.2         1-1677
FEATURES             Location/Qualifiers
     source          1..1717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1717
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="major facilitator superfamily domain containing 10"
                     /db_xref="GeneID:10227"
                     /db_xref="HGNC:HGNC:16894"
                     /db_xref="MIM:610977"
     exon            1..57
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            58..249
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1446
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="isoform a is encoded by transcript variant 2;
                     tetracycline transporter-like protein; major facilitator
                     superfamily domain-containing protein 10"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 10 isoform a"
                     /protein_id="NP_001139541.1"
                     /db_xref="CCDS:CCDS3365.1"
                     /db_xref="GeneID:10227"
                     /db_xref="HGNC:HGNC:16894"
                     /db_xref="MIM:610977"
                     /translation="MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLP
                     LLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFL
                     CAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLS
                     TAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFI
                     FCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLG
                     LVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGG
                     EVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQ
                     KGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQ
                     TLKAE"
     exon            250..346
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            347..450
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            451..609
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            610..771
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            772..880
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            881..992
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1101
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1192
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1240
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1330
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1717
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="hexamer: AATAAA"
     polyA_site      1717
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="major polyA site"
ORIGIN      
        1 ctggtgccct gttccgcgtc tgtgcgaccg tccgtcccga gcgcgcagcc gcggcaggcc
       61 aggtcagagc agcccaccat gggatgggga gggggtggag gctgcacccc gcgcccaccc
      121 atccaccagc agccgccgga gcgccgcgtg gtcaccgttg tctttctcgg cctcctgctg
      181 gacctcctgg ccttcacgct gctgctgccc ctgctgcccg ggctgttgga gagccacggc
      241 cgtgcccacg accccctcta tggctcctgg cagggcgggg tggactggtt tgccaccgcc
      301 atcgggatgc cagtggagaa gaggtacaac agtgtcctgt tcggaggtct cattggctcg
      361 gcattctctg tcctgcagtt tctgtgtgcg ccactcactg gggccacctc tgactgcttg
      421 gggaggcgcc cggtgatgct gctgtgcctg atgggtgtgg ccacctcata tgcagtctgg
      481 gccacctctc ggagctttgc ggccttcctg gcctccaggc tgattggggg catcagcaaa
      541 gggaacgtca gcctctccac ggccatcgtt gctgacctgg gctcgcctct ggcccgcagt
      601 caaggcatgg cggtcattgg ggtggccttc tcactgggct tcaccctggg ccctatgctc
      661 ggagcctccc tgcccctgga aatggcaccc tggtttgccc tgctcttcgc agcctccgac
      721 ctgctgttca tcttctgctt cctgccagag acgctgcccc tggagaaacg ggcgccctct
      781 atcgccctgg ggttccgtga tgcggctgat ctgctcagcc ccctggccct gctgcgcttc
      841 tcggctgtcg ctcgtggcca ggacccaccc tctggagaca ggctcagcag cctgcgccgc
      901 ctgggcctag tctacttcct ctacctcttc ctgttctcgg gcctggagta cacgctgagc
      961 ttcctcacac accagcgctt ccagttcagt agcctacagc aggggaagat gtttttcctc
     1021 atcggcctca ccatggccac catccagggt gcctatgccc ggcggatcca ccctggcggg
     1081 gaagttgctg ccgtgaagcg ggccctcctg ctgctggtgc ccgccttcct cctcatcggc
     1141 tggggacgtt ctctgcccgt gctgggcctg gggctgctgc tctactcctt tgccgccgcc
     1201 gttgtggtgc cctgcctgtc ctccgtggtc gctggctatg gctcaccagg gcagaagggc
     1261 acggtcatgg gtacactgcg cagcctaggt gctctggcca gggccgcggg gcccctggtg
     1321 gccgcttcag tgtactggct ggccggggcc caggcctgct tcaccacgtg gtccgggctc
     1381 tttttgctcc ccttcttcct cctgcagaag ctgagttacc cggcacagac gctcaaggct
     1441 gagtagctga gccactgtgc ccaggctgtg ggcaccaggc agagtgggag cctaggtcag
     1501 gcccctgccc actgcctgac ccccaccccc cgccagtcca gggagaccct gtgggtgggg
     1561 gccggcccct aagcaggaag ctcaggcagc tcctccagac ttacttactc cttcagtgac
     1621 tccgagctgc agcactccaa ggctgtcagg gcttctgttt gttttttaaa ctatgcacca
     1681 ggtttctgat gatgaaataa agcacctgtt tgtttta
//
