LOCUS       NP_001139541             455 aa            linear   PRI 09-FEB-2025
DEFINITION  major facilitator superfamily domain-containing protein 10 isoform
            a [Homo sapiens].
ACCESSION   NP_001139541
VERSION     NP_001139541.1
DBSOURCE    REFSEQ: accession NM_001146069.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 455)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (residues 1 to 455)
  AUTHORS   Ushijima,H., Hiasa,M., Namba,T., Hwang,H.J., Hoshino,T., Mima,S.,
            Tsuchiya,T., Moriyama,Y. and Mizushima,T.
  TITLE     Expression and function of TETRAN, a new type of membrane
            transporter
  JOURNAL   Biochem Biophys Res Commun 374 (2), 325-330 (2008)
   PUBMED   18638446
  REMARK    GeneRIF: TETRAN is a novel human organic anion transporter, and
            that it serves as a transporter for some NSAIDs and various other
            organic anions at the final excretion step.
REFERENCE   3  (residues 1 to 455)
  AUTHORS   Mima,S., Ushijima,H., Hwang,H.J., Tsutsumi,S., Makise,M.,
            Yamaguchi,Y., Tsuchiya,T., Mizushima,H. and Mizushima,T.
  TITLE     Identification of the TPO1 gene in yeast, and its human orthologue
            TETRAN, which cause resistance to NSAIDs
  JOURNAL   FEBS Lett 581 (7), 1457-1463 (2007)
   PUBMED   17362938
  REMARK    GeneRIF: A BLAST search identified the possible human orthologue of
            Tpo1p, tetracycline transporter-like protein (TETRAN), whose
            overexpression in cultured human cells caused resistance to some
            NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
REFERENCE   4  (residues 1 to 455)
  AUTHORS   Duyao,M.P., Taylor,S.A., Buckler,A.J., Ambrose,C.M., Lin,C.,
            Groot,N., Church,D., Barnes,G., Wasmuth,J.J., Housman,D.E. et al.
  TITLE     A gene from chromosome 4p16.3 with similarity to a superfamily of
            transporter proteins
  JOURNAL   Hum Mol Genet 2 (6), 673-676 (1993)
   PUBMED   8353488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN422014.1 and BC001502.2.
            
            Summary: This gene encodes a member of the major facilitator
            superfamily of transporter proteins. The encoded protein likely
            functions in efflux of organic anions, including the non-steroidal
            anti-inflammatory drugs indomethacin and diclofenac. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.622709.1,
                                           SRR3476690.998362.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355443.9/ ENSP00000347619.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     Protein         1..455
                     /product="major facilitator superfamily domain-containing
                     protein 10 isoform a"
                     /note="tetracycline transporter-like protein; major
                     facilitator superfamily domain-containing protein 10"
                     /calculated_mol_wt=48208
     Site            27..47
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Region          51..432
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     Site            86..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            order(104,154..155,157..159,162,181,184..185,188,279,
                     282..283,286..288,291,319,323,372..373,377,381,397,
                     400..401,404..405,408)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
     Site            113..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            148..168
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            176..196
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            275..295
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            310..327
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            336..356
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            359..379
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     Site            421..441
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14728.1)"
     CDS             1..455
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /coded_by="NM_001146069.2:79..1446"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS3365.1"
                     /db_xref="GeneID:10227"
                     /db_xref="HGNC:HGNC:16894"
                     /db_xref="MIM:610977"
ORIGIN      
        1 mgwgggggct prppihqqpp errvvtvvfl gllldllaft lllpllpgll eshgrahdpl
       61 ygswqggvdw fataigmpve krynsvlfgg ligsafsvlq flcapltgat sdclgrrpvm
      121 llclmgvats yavwatsrsf aaflasrlig giskgnvsls taivadlgsp larsqgmavi
      181 gvafslgftl gpmlgaslpl emapwfallf aasdllfifc flpetlplek rapsialgfr
      241 daadllspla llrfsavarg qdppsgdrls slrrlglvyf lylflfsgle ytlsflthqr
      301 fqfsslqqgk mffligltma tiqgayarri hpggevaavk rallllvpaf lligwgrslp
      361 vlglglllys faaavvvpcl ssvvagygsp gqkgtvmgtl rslgalaraa gplvaasvyw
      421 lagaqacftt wsglfllpff llqklsypaq tlkae
//
