LOCUS       NM_001120               1903 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens major facilitator superfamily domain containing 10
            (MFSD10), transcript variant 1, mRNA.
ACCESSION   NM_001120
VERSION     NM_001120.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Ushijima,H., Hiasa,M., Namba,T., Hwang,H.J., Hoshino,T., Mima,S.,
            Tsuchiya,T., Moriyama,Y. and Mizushima,T.
  TITLE     Expression and function of TETRAN, a new type of membrane
            transporter
  JOURNAL   Biochem Biophys Res Commun 374 (2), 325-330 (2008)
   PUBMED   18638446
  REMARK    GeneRIF: TETRAN is a novel human organic anion transporter, and
            that it serves as a transporter for some NSAIDs and various other
            organic anions at the final excretion step.
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Mima,S., Ushijima,H., Hwang,H.J., Tsutsumi,S., Makise,M.,
            Yamaguchi,Y., Tsuchiya,T., Mizushima,H. and Mizushima,T.
  TITLE     Identification of the TPO1 gene in yeast, and its human orthologue
            TETRAN, which cause resistance to NSAIDs
  JOURNAL   FEBS Lett 581 (7), 1457-1463 (2007)
   PUBMED   17362938
  REMARK    GeneRIF: A BLAST search identified the possible human orthologue of
            Tpo1p, tetracycline transporter-like protein (TETRAN), whose
            overexpression in cultured human cells caused resistance to some
            NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Duyao,M.P., Taylor,S.A., Buckler,A.J., Ambrose,C.M., Lin,C.,
            Groot,N., Church,D., Barnes,G., Wasmuth,J.J., Housman,D.E. et al.
  TITLE     A gene from chromosome 4p16.3 with similarity to a superfamily of
            transporter proteins
  JOURNAL   Hum Mol Genet 2 (6), 673-676 (1993)
   PUBMED   8353488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390065.20, BI769550.1,
            L11669.1, BC001502.2 and BC023537.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001120.4.
            
            Summary: This gene encodes a member of the major facilitator
            superfamily of transporter proteins. The encoded protein likely
            functions in efflux of organic anions, including the non-steroidal
            anti-inflammatory drugs indomethacin and diclofenac. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11669.1, SRR14038197.1546112.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL390065.20        139055-139119
            66-145              BI769550.1         114-193
            146-296             L11669.1           2-152
            297-341             BC001502.2         71-115
            342-1902            L11669.1           198-1758
            1903-1903           BC023537.2         1540-1540
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1903
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="major facilitator superfamily domain containing 10"
                     /db_xref="GeneID:10227"
                     /db_xref="HGNC:HGNC:16894"
                     /db_xref="MIM:610977"
     exon            1..435
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1632
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="isoform a is encoded by transcript variant 1;
                     tetracycline transporter-like protein; major facilitator
                     superfamily domain-containing protein 10"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 10 isoform a"
                     /protein_id="NP_001111.3"
                     /db_xref="CCDS:CCDS3365.1"
                     /db_xref="GeneID:10227"
                     /db_xref="HGNC:HGNC:16894"
                     /db_xref="MIM:610977"
                     /translation="MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLP
                     LLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFL
                     CAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLS
                     TAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFI
                     FCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLG
                     LVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGG
                     EVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQ
                     KGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQ
                     TLKAE"
     exon            436..532
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            533..636
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            637..795
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            796..957
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1066
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1178
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1287
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1378
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1426
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1516
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1903
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="MFSD10"
                     /gene_synonym="SLC75A1; TETRAN; TETTRAN"
                     /note="major polyA site"
ORIGIN      
        1 accctggtct ctcaggaccg ttgcctttgc ggctattttt tgtgcaatcc ccgaagcctg
       61 cgtttcctgc tgcctgggtt cggggcgggg gcatcgcgca ggccagaacg gcccctgcgt
      121 ccgtaggcca gagcccctgc catcagcccc tttagggtgc tcgccggctg tcgggtgtgg
      181 gggtatgcca ggccccggag gactcggctt ccccgctaac ccgacccgcc gcaccccacc
      241 caggccaggt cagagcagcc caccatggga tggggagggg gtggaggctg caccccgcgc
      301 ccacccatcc accagcagcc gccggagcgc cgcgtggtca ccgttgtctt tctcggcctc
      361 ctgctggacc tcctggcctt cacgctgctg ctgcccctgc tgcccgggct gttggagagc
      421 cacggccgtg cccacgaccc cctctatggc tcctggcagg gcggggtgga ctggtttgcc
      481 accgccatcg ggatgccagt ggagaagagg tacaacagtg tcctgttcgg aggtctcatt
      541 ggctcggcat tctctgtcct gcagtttctg tgtgcgccac tcactggggc cacctctgac
      601 tgcttgggga ggcgcccggt gatgctgctg tgcctgatgg gtgtggccac ctcatatgca
      661 gtctgggcca cctctcggag ctttgcggcc ttcctggcct ccaggctgat tgggggcatc
      721 agcaaaggga acgtcagcct ctccacggcc atcgttgctg acctgggctc gcctctggcc
      781 cgcagtcaag gcatggcggt cattggggtg gccttctcac tgggcttcac cctgggccct
      841 atgctcggag cctccctgcc cctggaaatg gcaccctggt ttgccctgct cttcgcagcc
      901 tccgacctgc tgttcatctt ctgcttcctg ccagagacgc tgcccctgga gaaacgggcg
      961 ccctctatcg ccctggggtt ccgtgatgcg gctgatctgc tcagccccct ggccctgctg
     1021 cgcttctcgg ctgtcgctcg tggccaggac ccaccctctg gagacaggct cagcagcctg
     1081 cgccgcctgg gcctagtcta cttcctctac ctcttcctgt tctcgggcct ggagtacacg
     1141 ctgagcttcc tcacacacca gcgcttccag ttcagtagcc tacagcaggg gaagatgttt
     1201 ttcctcatcg gcctcaccat ggccaccatc cagggtgcct atgcccggcg gatccaccct
     1261 ggcggggaag ttgctgccgt gaagcgggcc ctcctgctgc tggtgcccgc cttcctcctc
     1321 atcggctggg gacgttctct gcccgtgctg ggcctggggc tgctgctcta ctcctttgcc
     1381 gccgccgttg tggtgccctg cctgtcctcc gtggtcgctg gctatggctc accagggcag
     1441 aagggcacgg tcatgggtac actgcgcagc ctaggtgctc tggccagggc cgcggggccc
     1501 ctggtggccg cttcagtgta ctggctggcc ggggcccagg cctgcttcac cacgtggtcc
     1561 gggctctttt tgctcccctt cttcctcctg cagaagctga gttacccggc acagacgctc
     1621 aaggctgagt agctgagcca ctgtgcccag gctgtgggca ccaggcagag tgggagccta
     1681 ggtcaggccc ctgcccactg cctgaccccc accccccgcc agtccaggga gaccctgtgg
     1741 gtgggggccg gcccctaagc aggaagctca ggcagctcct ccagacttac ttactccttc
     1801 agtgactccg agctgcagca ctccaaggct gtcagggctt ctgtttgttt tttaaactat
     1861 gcaccaggtt tctgatgatg aaataaagca cctgtttgtt tta
//
