LOCUS       NM_021647               6301 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens microfibril associated protein 3 like (MFAP3L),
            transcript variant 1, mRNA.
ACCESSION   NM_021647 XM_376355
VERSION     NM_021647.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6301)
  AUTHORS   Otowa,T., Maher,B.S., Aggen,S.H., McClay,J.L., van den Oord,E.J.
            and Hettema,J.M.
  TITLE     Genome-wide and gene-based association studies of anxiety disorders
            in European and African American samples
  JOURNAL   PLoS One 9 (11), e112559 (2014)
   PUBMED   25390645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6301)
  AUTHORS   Lou,X., Kang,B., Zhang,J., Hao,C., Tian,X., Li,W., Xu,N., Lu,Y. and
            Liu,S.
  TITLE     MFAP3L activation promotes colorectal cancer cell invasion and
            metastasis
  JOURNAL   Biochim Biophys Acta 1842 (9), 1423-1432 (2014)
   PUBMED   24735981
  REMARK    GeneRIF: MFAP3L activation promotes colorectal cancer cell invasion
            and metastasis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA324165.1 and AB014526.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021647.7.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014526.1, SRR1660809.198773.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361618.4/ ENSP00000354583.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               DA324165.1         36-152
            118-6301            AB014526.1         1-6184
FEATURES             Location/Qualifiers
     source          1..6301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q33"
     gene            1..6301
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /note="microfibril associated protein 3 like"
                     /db_xref="GeneID:9848"
                     /db_xref="HGNC:HGNC:29083"
                     /db_xref="MIM:616523"
     exon            1..162
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /inference="alignment:Splign:2.1.0"
     exon            163..593
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1525
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; testis development protein NYD-SP9; microfi
                     brillar-associated protein 3-like; microfibrillar
                     associated protein 3 like"
                     /codon_start=1
                     /product="microfibrillar-associated protein 3-like isoform
                     1 precursor"
                     /protein_id="NP_067679.6"
                     /db_xref="CCDS:CCDS34103.1"
                     /db_xref="GeneID:9848"
                     /db_xref="HGNC:HGNC:29083"
                     /db_xref="MIM:616523"
                     /translation="MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLG
                     SVPVIIARTDHIIVKEGNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKW
                     QMHDSGLLNITKVSFSDRGKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVA
                     FTIVMVLNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLE
                     LAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPE
                     GQEAADRDEVYTIPNSLKRSDSPAADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQE
                     GGQFEVKDVEETELSAEHSPETAEPSTDVTSTELTSEEPTPVEVPDKVLPPAYLEATE
                     PAVTHDKNTCIIYESHV"
     exon            594..6301
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6279..6284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /note="hexamer: AATAAA"
     polyA_site      6301
                     /gene="MFAP3L"
                     /gene_synonym="NYD-sp9"
                     /note="major polyA site"
ORIGIN      
        1 agccggcggc gcagctcgca acgctgtgag gcgccggcgg aggcggctcg cccgcagtag
       61 gcgctaccgg gcgtccggcg cagagtgcgg cgcagcggcc gctgtcgggc tggccatggc
      121 gaggggtgca cggcggccac ctgagtggcg cggcggtgtc aggttcttgc tcaagtacca
      181 actctatgga cccaggacag gtttgtccca tgacctgctg tgaacagtgt gttgtctgat
      241 agaagattcg gttggcaaac catctctcta ttgccttaca gagcaagcaa agaagatgga
      301 tcgattgaag agccatctga ctgtgtgctt tctaccttct gtgccctttt taatcctagt
      361 atccactcta gccaccgcta agagtgtgac taacagcact ttaaatggca ctaacgtggt
      421 cttgggctct gtgcccgtaa tcattgccag aactgaccat atcatagtca aggaagggaa
      481 cagtgccttg attaactgta gtgtttatgg catccctgac ccacagttca agtggtataa
      541 ttccattggc aagctgctga aagaagaaga ggatgagaag gagagaggag gaggaaaatg
      601 gcaaatgcac gacagcggcc tcctgaacat caccaaggta tccttctcag accgaggtaa
      661 atacacgtgt gtggcttcta acatctacgg caccgtgaac aacacggtga ccttgcgcgt
      721 catcttcact tctggagaca tgggtgtcta ctacatggtc gtgtgcctgg tggccttcac
      781 catcgtcatg gtcctcaata tcacccgcct gtgcatgatg agcagccatc taaagaagac
      841 tgagaaggcc atcaatgagt tctttaggac cgaaggtgca gagaagctgc agaaggcatt
      901 tgagatcgcc aagcgcatcc ccatcatcac ctccgccaaa actctagagc ttgccaaagt
      961 cacccagttc aaaaccatgg agttcgcccg ctacatcgaa gagcttgcca ggagcgtgcc
     1021 tctgccgcct ctcattatga actgcaggac tatcatggag gagattatgg aggtggttgg
     1081 gctggaggag caggggcaga attttgtgag gcatactcca gagggccagg aggccgcaga
     1141 cagggatgag gtctacacaa tccccaactc tctgaagcgg agcgactccc ctgccgctga
     1201 ctcggacgcc tcatcgctgc acgagcaacc tcagcaaatt gccatcaagg tgtcagttca
     1261 cccgcagtcc aaaaaagagc atgcagatga ccaagagggt ggacagtttg aagtcaaaga
     1321 tgtagaggag acagaactgt cggcggaaca ttcccccgaa actgcagaac cttctaccga
     1381 tgtcacgtcc accgagctaa catctgaaga gccaacacct gttgaggtac cagataaggt
     1441 actgccgcca gcttacctgg aagccacaga gccagcagtg acacatgaca aaaacacctg
     1501 cattatttac gaaagccatg tctaatacca accccgaaaa gctatgcata tcaagaaaat
     1561 caggggctgc tccttgtaat acagatgtag tacgcacttg ccgctaagcc ttaccaggag
     1621 actctcatcc cttaggtagg agtgatgcca ctttaaaagg agaaacacct gcctgcagtg
     1681 aatgggactg gaatttcccc agtagagaag ggtgcgagaa acatcagggt gcagaattga
     1741 taccagacag aaggtgtcta tgtgataatg agtttcagag gctgatctct gccaaatacc
     1801 ttaattggtg atgccttctt ggcaaagagt acaccactgt aagatattct gagttcaaga
     1861 accctgtcca gtgccccctg cattgctttt ccttttaaaa agtataggtc tgctacaata
     1921 gcaaatgcac gtacgtgggt tttttgcagt ttcttctcag ttttaatttt gcttttcctt
     1981 tataatgggg tcattgttat taatactaat tgttctttct ggtttagtcc tcattgccac
     2041 ttttgtcctt atgtttccct agaacacgta cctcagagac tttggtatca gtcaccagta
     2101 ccagggctga tatctacaag tcacattaca tttgtcatgt tccaaagtag ttacgaggct
     2161 tgttattttt ttttcattcc ccaggcctat ttccatagat agcttttttt gtttgtttcc
     2221 aacgaagctg ctgttaaacg aaactgagaa aaactttgcc ccggaatagc actttaatag
     2281 tcaaaaatgt gtttacctgt ctgattgagt gagccttttg gtgagctcag ctgagatgta
     2341 gagggagatt gtaaaaggtt aaatataccc acaccaccca tgaaagtcac tgtttaagtt
     2401 acatcatcct ccaaataaag actgattctt tacctggaaa atatattgct tccaaagaca
     2461 tcagattcag tggattcctg taggttatag aatattggct tccaaacagg cttgcaggga
     2521 ccatatgctg ttggatgaca tataaccagg tccactttta tgaactgcat agctgacttg
     2581 gttgtcctta aagaggaaag cgaaaggtta gggtaatagc aaagggaact gtgccatcag
     2641 attttatgcc aaaactgttg aataattatg cagtcctgca agaaagtggt tatatgtgag
     2701 gtgcgtgatg ttatggaaag aagacaaaat tagtcatcca aaggcttaat acccactgtg
     2761 ccaataacca gctgcctggc tttggacaag tctggacctc aggtccctta tctgtagaag
     2821 gggcagatga catgagctct gagcactgtt gaaatggtat cactgtcaca cagaaccaaa
     2881 ccaatattca catccttgct ccttttcaca atgactttaa agatttttgc tttcatctct
     2941 tggtccacct aacattttca tgcttcatta cttaaataag aatgttggtt ttgagaaata
     3001 gcattttaaa caaattgtgg atcttctcct tccaaaaaaa ccattaggac cacatctgca
     3061 attaagattt aatattggtg agaatgagtg gttttattta attttccctt aaaagcaaag
     3121 gagacagtaa tcttaataaa ttcatagggg ccgtggccac atcaggtaat ggggttatga
     3181 tgtccaagat tgcatggatc acattggtga tgagagcaga cccagatgtt tagtcctcac
     3241 tctgtcacca tctgaggagg tgaccttgga caactccctt cctctctctg ggatttaatc
     3301 tttttcatct gtaaaatatg caggtagtac tcgagggtct acaggatccc ttctagttga
     3361 aacatttata gttcacagaa agtttgcagt cttccaggat aaccaacccc cgttgcatga
     3421 gacaagcaaa aaatgggtcc atgaaattgg atacttttgc catccaaact ttacaacaaa
     3481 cattatctgg ctctgtaatt gagagcagtg ggcttggttt taaacctagc cttgattagt
     3541 ttgtttatag ataactgttg tggaaggtga tagaactagt catggagttt gatgagacat
     3601 ctcttgaaaa ggactgaact gttgacttct ggttagaagt gctttgggca gtcacataaa
     3661 gaaatgagca gtgagaaatc aggagaaatt atgactcctg ttgggctttc tggactagca
     3721 ttgtatgttt ttgggttgca gaaaagtttt aacaccacct cttagaatat aaaaattttc
     3781 cagttgtcat ggaggtccac agattcatta ccatgggttt atatgcccaa agcaacaaca
     3841 gaggacttaa gttcattttg tgatactgta tggatgttac cccatcctat tcagttgtca
     3901 ttccacccaa acccatgtgt aggtttccac atggaaagga gaaggcatcc attccaccta
     3961 gacattgaat agtgataata agctaaaagt gggcagattt tcagtggagc aagagcagaa
     4021 atatgcggcc aaagaatgtt tcctgattgg ttttgctgct ttagactgca gtggggagag
     4081 cttatgtaga ttttcaaaac tttctccctc tttaaggcat cataatgctc tcggttttga
     4141 taacaactga cataaaggga ggttgactta aaatgggaat ttctccttcc aaaaatgcta
     4201 cactcttcct atccatccta cagcttcttt atgaaatgag aggccctcct gctagaatat
     4261 gaaatgcaga agacctcatg actttcagct gatttttcaa agataaagtg aactgttcag
     4321 cttcatagaa attcatgcga gtgtgactga acgtgtgtgc atacacactc gtgcacattg
     4381 gactcatttg ggcagtttta aaagcttcac actaaatcca aagcctcgtc ctttgggtcg
     4441 tatgtagtcg tttgtaaaat caatttctgg cttctgagtc atcctggtca tatctctagc
     4501 aatgtttttc ttgaaattct gaaaatgatt cacatatgtg tgtacattta attcacttag
     4561 atgatctgta aacttggatg gtatttattc taaatgggga aaacaatttt atatggaaaa
     4621 atctatgtaa tttataatgg ttttgtttta tatattatat tttcatatct ctagggcaca
     4681 tctatcctca tctttttgta taccatactt agcaaaaaga aatactaata cttgactaaa
     4741 atctctagga accaaacgtg atacatgtga tatatagctt ctagaaatcg ctctaaaaat
     4801 ctctgaatgt ctcatccatc ccaagcatta ttgtgctgtg tcattatgtc cagaatgatt
     4861 tgtcttggat gcttatgagc atttgttttt cacaactaag gttgaaagac ctgacatctc
     4921 acacaatggg gttctggaat tcccctttcc tcctttatct gtttttattg tttgtttcat
     4981 ttttaattgc accagtctat gttgtcgaaa ctttgttttg aagggcaaat gtgagataac
     5041 aagaaagcaa tgtgatggaa agactggatg aatttaccta tggctatgta aattatttta
     5101 atggactgat aagatgtttc aagtctcatg cttggatctt tatttattgg tgatctagga
     5161 tctgctcagc tctttagcac atgaagaaaa tcaggtacaa aggacatttg catgtttgga
     5221 acagcatgct ctaagccccg tgcagccaac acaaattaac ttgactgtag aaacaccaat
     5281 tccagctgct ggaagaaatg gtttagaaag gcaaaccaga taccttttat tctgccctag
     5341 gaaatacagt gttgatcagt gctaaaactc ttcagtggca gtcactgtgg ttcttttaac
     5401 tggggatttc ctttcagtgt ttcatttggt accaaaacag aacatttacc ttacatttca
     5461 gatactctgt tttctcagca ttgttcagat actttccttt accgctcttc acgtaccctt
     5521 ttggcattga gtaattctat aaatgtttct atccttggtt tttaaaccaa gttattcata
     5581 ctcttaaaat atctaccaaa tctcattgta ttttcacata ttttgagcat caagatactg
     5641 gtcattttaa aaaatccttc agtaaatagc acagtttatt ttcctaatga catttttagg
     5701 gtttcttcat tgatcaacca ggtttgggtt acacaaatca attgtggggg aaaaatcaaa
     5761 taaaacaatt gcttattata ttttccaaag gactgagcat ttatctttta ttcacgaaga
     5821 tatcatatga ggatgataat gatctttaac agatttttta gagatagaat ttataaagag
     5881 gctgatacta agaatactac aatcaaaatt gaagctagag aatgtaaaaa tagaaagtaa
     5941 atagttctaa gaatattctg gcataaatta tttttattta gccaataaaa tagcctccaa
     6001 atgtatatct cagacaccat agagctgcta acaatgagaa tcaaggaaga tgcttgcact
     6061 tagatttcgt ttgttgtatt tcagtagttc tggatgtcct ttgttaaaat tggaaaatgg
     6121 aaaaatgtct cgacagaaat gtcaatctgg tgattctgtg aactgtaaaa tgttcacttt
     6181 taaaaataaa gttgtaaaca agttactcat ataagttggt attacagtag caaaaacaga
     6241 aaaccatgtg atccatcctg tattttgatt gatgctttaa taaagggttt gcacagctgt
     6301 g
//
