LOCUS       NM_005927               5037 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens microfibril associated protein 3 (MFAP3), transcript
            variant 1, mRNA.
ACCESSION   NM_005927
VERSION     NM_005927.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5037)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5037)
  AUTHORS   Ng,M.C., Hester,J.M., Wing,M.R., Li,J., Xu,J., Hicks,P.J.,
            Roh,B.H., Lu,L., Divers,J., Langefeld,C.D., Freedman,B.I.,
            Palmer,N.D. and Bowden,D.W.
  TITLE     Genome-wide association of BMI in African Americans
  JOURNAL   Obesity (Silver Spring) 20 (3), 622-627 (2012)
   PUBMED   21701570
REFERENCE   3  (bases 1 to 5037)
  AUTHORS   Abrams,W.R., Ma,R.I., Kucich,U., Bashir,M.M., Decker,S.,
            Tsipouras,P., McPherson,J.D., Wasmuth,J.J. and Rosenbloom,J.
  TITLE     Molecular cloning of the microfibrillar protein MFAP3 and
            assignment of the gene to human chromosome 5q32-q33.2
  JOURNAL   Genomics 26 (1), 47-54 (1995)
   PUBMED   7782085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK296468.1, CB994356.1 and AC022088.5.
            
            On Jun 2, 2019 this sequence version replaced NM_005927.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.112556.1,
                                           SRR1803615.87214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522782.6/ ENSP00000430852.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK296468.1         9-53
            46-719              CB994356.1         55-728
            720-5037            AC022088.5         12100-16417
FEATURES             Location/Qualifiers
     source          1..5037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..5037
                     /gene="MFAP3"
                     /note="microfibril associated protein 3"
                     /db_xref="GeneID:4238"
                     /db_xref="HGNC:HGNC:7034"
                     /db_xref="MIM:600491"
     exon            1..45
                     /gene="MFAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            46..506
                     /gene="MFAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1300
                     /gene="MFAP3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; microfibril-associated glycoprotein 3;
                     microfibrillar associated protein 3"
                     /codon_start=1
                     /product="microfibril-associated glycoprotein 3 isoform 1
                     precursor"
                     /protein_id="NP_005918.1"
                     /db_xref="CCDS:CCDS4324.1"
                     /db_xref="GeneID:4238"
                     /db_xref="HGNC:HGNC:7034"
                     /db_xref="MIM:600491"
                     /translation="MKLHCCLFTLVASIIVPAAFVLEDVDFDQMVSLEANRSSYNASF
                     PSSFELSASSHSDDDVIIAKEGTSVSIECLLTASHYEDVHWHNSKGQQLDGRSRGGKW
                     LVSDNFLNITNVAFDDRGLYTCFVTSPIRASYSVTLRVIFTSGDMSVYYMIVCLIAFT
                     ITLILNVTRLCMMSSHLRKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELA
                     KVTQFKTMEFARYIEELARSVPLPPLILNCRAFVEEMFEAVRVDDPDDLGERIKERPA
                     LNAQGGIYVINPEMGRSNSPGGDSDDGSLNEQGQEIAVQVSVHLQSETKSIDTESQGS
                     SHFSPPDDIGSAESNCNYKDGAYENCQL"
     exon            507..5037
                     /gene="MFAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4940..4945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP3"
                     /note="hexamer: AATAAA"
     polyA_site      4959
                     /gene="MFAP3"
                     /note="major polyA site"
     regulatory      5002..5007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP3"
                     /note="hexamer: ATTAAA"
     polyA_site      5037
                     /gene="MFAP3"
ORIGIN      
        1 gagttaagcc gccgctgagg ccggaaggag ctagacggcg gtcgggttct ctactcacat
       61 cttttaatct tgaagactag aaaatataac tggatctacc acttgtttgg aaaatttctc
      121 taccaagcaa taaattaccc gctgtgcttt tgttgtagtg tagaagtttt tgagttctcc
      181 aaatctaaac aagattttgt cccattttcc catgaagcta cattgttgct tattcacttt
      241 agtggcaagt attattgtgc cagctgcttt tgttttggaa gatgtggact tcgaccaaat
      301 ggtttcactg gaagcaaatc gtagttctta caatgcatcc tttccctcaa gctttgaact
      361 ctcagcaagt tcccactcgg atgatgatgt catcatagcc aaagagggaa ctagcgtttc
      421 aattgagtgt cttctcacag ccagtcacta tgaagatgtc cattggcaca attcaaaagg
      481 acagcaactg gatggcagaa gcagaggtgg aaagtggttg gtttctgata acttcctaaa
      541 catcaccaat gtagcttttg atgaccgtgg gctctatacc tgtttcgtca cctctccaat
      601 tcgtgcctcc tactctgtca ccctacgtgt tatcttcacc tcgggagaca tgagtgtcta
      661 ttacatgatt gtttgcctga ttgcctttac aatcacactc atcttgaatg tcacacggct
      721 gtgcatgatg agcagccatc ttcgcaagac tgagaaggct atcaatgagt tctttagaac
      781 tgaaggggct gagaaacttc agaaggcctt tgagattgca aaacgtatcc ccatcattac
      841 ctcagccaaa actctggagc tcgccaaagt cacacaattt aagaccatgg agtttgctcg
      901 ttatattgaa gaactggcaa gaagtgtccc tcttccacct cttattctaa actgtcgagc
      961 ctttgttgag gagatgtttg aggctgtgcg agtggacgac cctgatgacc tgggtgaaag
     1021 aattaaagag agacctgcct tgaatgctca aggtggcatc tatgtcatta acccagagat
     1081 gggacggagt aattcaccag gaggagattc agatgatggc tctctgaatg aacaaggcca
     1141 ggaaatagca gttcaggttt ctgtccacct tcagtcagaa accaaaagta ttgatacaga
     1201 gtctcaaggc agcagtcatt tcagtccacc tgatgatata ggatctgcag aatctaactg
     1261 taactacaaa gatggggcat atgaaaactg tcagctgtaa cctacaatgc tgtaacccag
     1321 tacctacaaa atcagctcgc tctcagaaaa ggaacctgtt tcttagaaga agtaacattt
     1381 ttgccaaaag atgactgggg ttttccgttt gttaatatta agcacatcag aacgtgaatt
     1441 gccaaagtct tcattagaag gcagcatttt tcctctctga tacttttcag tcattttcct
     1501 tagagcttta ttaaattatg catgctaaga tttaaaggag ccccagataa acatgatggg
     1561 gaaaagcact gaactaagag tcccatggtt tctcttctgg tcacagttct tccattggtt
     1621 ggatctgata cttatcttgg gacttcagtt tttccgtcaa taagatgagg gattaggtga
     1681 gatctgaagt tgtttctagc tctatagctt cttaacccat cacctttaaa ttaccagaat
     1741 cttcactcat ctctaagtaa acctttcccg ggacttttac tcgcttcttt tggaaaggat
     1801 taagctgaga tctaaatttc cacaccaatg tcataatgca cagaggtttt tgaaaaacat
     1861 ctgagtgttt ttcagatgtt ttgccatgtg gagcatataa tgatatgtgc aagattgaat
     1921 cttttcaatg tagcacatgt ctgtagggtt atacagatgt cagagagcta actgctctgt
     1981 aaactacttt ccatgagtaa attggtcctt ggtgggggtg tatcatattt ttaacttact
     2041 gagatatcat tttagttcat tgaggttggc agggattgcc taactgatct tccaaagtga
     2101 gcagtttatt tctaaggtat aacgtctttg atgcttttag aataagaaca gtgtcaaatc
     2161 atctgtcttc tggaaaatca tggattttca tatttctgtt aacagaattt ctcaggcttt
     2221 ccctttttaa aagtattgga ctctacaaat aggttctata tttgggatct catcctagga
     2281 gaaaacccaa aactggattc ctcttaagac ctctgtcaac cctcctgccc tttgtggtct
     2341 taggtatggt gctataggtt gcatgcgtct ttatcttgtt tgtttggtta atattttgtt
     2401 gttgaggttt ttatttttgt ttacttcaga tacataattc tgagctatgg ctgcttttgt
     2461 agcctttcca agaagcacta acctgaaata agattagata attgtgaggg tgtgttacta
     2521 tattaaaata cacacacaac tgatctagac atcaagagga agaaaaatga tggatgatgc
     2581 cacctgcttc aactgtatat aataaacact tatgatgaca tttcttgcct ggctgagatc
     2641 tgatataatg gaattgtaaa tactcttcag aacaatttct tcagctacag gaagcgtggt
     2701 gccatataat tttaagaact tggcagtgga gctccatttg gggcttcacg tttcttcata
     2761 tgacttctga ttattgaagc attacttcag ctagaggctc ctgagggaaa tgttcagagg
     2821 aggttttatc aggattttaa tttaaggttt caaacagggg aagacaggaa attcaaagcg
     2881 tgacgggata aaactcatgc ctccctttgt ccaggcttat cagaagtaat acatctgctc
     2941 tgaatagcat gaatgaatca atgtgcagtt ttatcagatg gcatcatgga taaagatgat
     3001 aatgctgcct tttctgtctc tcaggctgtt tccatggaaa cctctagagc caaataaaag
     3061 ctaaccaatc atttagccaa agcttgcctt ggctcataga ctggtatttc tttaaggaaa
     3121 attgttttta tatatttgac tataagagca aaggctcttg aacatatcct agattatgga
     3181 acactttttc ccttcccttt tctctggaaa aattaaattt tttttctgtc cactgagact
     3241 ggagtgcagt ggcaagatca tagctcactg cagcctccaa ctcctggggt caagcgatcg
     3301 tcctgcttca gcctcccaag cagctaggac tacaggtgtg caccaccttt cctggctaat
     3361 ttttttttat tttttgtaga gatgggggtc tcactttgtt gcccaggctg accttgtact
     3421 tgtggcttca aatgatcctc ctgccttacc tcccaaagtg ttgagattac aggcatgagc
     3481 cactgtgcct ggccaaaaaa cattttaaat cccttgtctg ggggtcagtc ctctaaacat
     3541 ccctcagatt tcagatagta ctttcaaccc tgtcctaaca tagcaggttt gcagtaatct
     3601 tttagaatat agcttgtcaa attagagaat ggttttaccc cacatgttct cataggagac
     3661 attattattt agaaccctaa ggtagacatg tttaaaatca aagtcctaag aaacagaact
     3721 ttggaaaaat ggaggaaatg tttttaaagt ctgtaagttt gcacgatact gtatagtaac
     3781 taaatgcatg ctactccgtt gtatcctagt tattttagaa acagaggtgg cctaatttgg
     3841 tggccaaagt aactggttta ctttgagtgt accagcttat ggtgccattg atgaggaatt
     3901 aaagtaggtc aaaatttaat tggagttggt attacttcgt aaagctagtt ttcaagagga
     3961 agaaaaccac acttactaat gttttctgta tctaatcaaa tactcttcat atataattaa
     4021 gcctcatgtt atcttttttt taaatcaacc ttttgaactt caactacagt ctaaaagtct
     4081 tgatggtaac tatagtgtaa ttatcttttt gtctcactgg attttatagt tagtggaaaa
     4141 tgcctttaca aaatgtattt aaaatagctg tcatctcatt tgtaaatttt gtcgtgtatt
     4201 gtgatatagt gaaccttatt gtccttatga aatggtagct ttgtgaaata cattcaccaa
     4261 aaatcaaaat ttgaacatct ttatgattcc ttaccagctg aagccagata gacaggtatt
     4321 aattgagctg atgccccact tgagtttata gactgtttga taactgcctg tcctccaaat
     4381 tgtgtatgta tatgttacga tggtttaatt cttgagtcag ggccagcacg catttatatt
     4441 ttctaccaat taccttgata gaaatatctt agaaattgct gacctggaac ggttgtgaga
     4501 agactcctgg cttctttctt gcctcactta acaaatattt taaggtcaaa gcaatatctg
     4561 tgcacggctt tccttttgct cctccagaca agtgaggctg ttggtatagt cctcttcacc
     4621 ctctgcatgt agcttcaccc tagatcagac ttttgtctct tgggtcccag atggcacagg
     4681 agcactgcat gcttgttttc tagagcccag ccagtcatgg gtgctagcct agtctccaca
     4741 caccagcaag tagaacccaa gtgtattgta taaatatttc ctgagtacca gtaagagaat
     4801 gcattctttt ctcatctagg ccaggaatgt tgaaaatgct cagccttaca tagaaactcc
     4861 tagattttca ctaacgcatt tcacaaaagt aaataagtat ttcatataat tcagaggatg
     4921 tttaaattgt cagcatttta ataaatactt gcattataat tttgtctctt ttttaaagaa
     4981 agtcatactt gaatataatt tattaaacgt tcaatggagt atatagtcta tttgaaa
//
