LOCUS       NM_002403               1045 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens microfibril associated protein 2 (MFAP2), transcript
            variant 2, mRNA.
ACCESSION   NM_002403
VERSION     NM_002403.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1045)
  AUTHORS   Lv,F., Li,X., Wang,Y. and Hao,L.
  TITLE     MAGP1 maintains tumorigenicity and angiogenesis of laryngeal cancer
            by activating Wnt/beta-catenin/MMP7 pathway
  JOURNAL   Carcinogenesis 45 (4), 220-234 (2024)
   PUBMED   36645203
  REMARK    GeneRIF: MAGP1 maintains tumorigenicity and angiogenesis of
            laryngeal cancer by activating Wnt/beta-catenin/MMP7 pathway.
REFERENCE   2  (bases 1 to 1045)
  AUTHORS   Zhang,H., Shen,S., Feng,C., Chen,G. and Wang,X.
  TITLE     MFAP2 promotes the progression of oral squamous cell carcinoma by
            activating the Wnt/beta-catenin signaling pathway through autophagy
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1445-1455 (2023)
   PUBMED   37592847
  REMARK    GeneRIF: MFAP2 promotes the progression of oral squamous cell
            carcinoma by activating the Wnt/beta-catenin signaling pathway
            through autophagy.
REFERENCE   3  (bases 1 to 1045)
  AUTHORS   Zhao,L.Q., Sun,W., Zhang,P., Gao,W., Fang,C.Y. and Zheng,A.W.
  TITLE     MFAP2 aggravates tumor progression through activating
            FOXM1/beta-catenin-mediated glycolysis in ovarian cancer
  JOURNAL   Kaohsiung J Med Sci 38 (8), 772-780 (2022)
   PUBMED   35546486
  REMARK    GeneRIF: MFAP2 aggravates tumor progression through activating
            FOXM1/beta-catenin-mediated glycolysis in ovarian cancer.
REFERENCE   4  (bases 1 to 1045)
  AUTHORS   Gomez de Segura,I., Ahechu,P., Gomez-Ambrosi,J., Rodriguez,A.,
            Ramirez,B., Becerril,S., Unamuno,X., Mentxaka,A., Baixauli,J.,
            Valenti,V., Moncada,R., Silva,C., Fruhbeck,G. and Catalan,V.
  TITLE     Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in
            Patients with Colon Cancer and Obesity Are Associated with Changes
            in Extracellular Matrix Remodelling
  JOURNAL   Int J Mol Sci 22 (16), 8485 (2021)
   PUBMED   34445187
  REMARK    GeneRIF: Decreased Levels of Microfibril-Associated Glycoprotein
            (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated
            with Changes in Extracellular Matrix Remodelling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1045)
  AUTHORS   Shan,Z., Wang,W., Tong,Y. and Zhang,J.
  TITLE     Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as
            Prognosis Markers of Overall Survival in Gastric Cancer
  JOURNAL   Med Sci Monit 27, e929558 (2021)
   PUBMED   33758160
  REMARK    GeneRIF: Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as
            Prognosis Markers of Overall Survival in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1045)
  AUTHORS   Fujimoto,N., Tajima,S. and Ishibashi,A.
  TITLE     Expression of microfibril-associated glycoprotein-1 (MAGP-1) in
            human epidermal keratinocytes
  JOURNAL   Arch Dermatol Res 292 (1), 21-26 (2000)
   PUBMED   10664011
REFERENCE   7  (bases 1 to 1045)
  AUTHORS   Finnis,M.L. and Gibson,M.A.
  TITLE     Microfibril-associated glycoprotein-1 (MAGP-1) binds to the
            pepsin-resistant domain of the alpha3(VI) chain of type VI collagen
  JOURNAL   J Biol Chem 272 (36), 22817-22823 (1997)
   PUBMED   9278443
REFERENCE   8  (bases 1 to 1045)
  AUTHORS   Brown-Augsburger,P., Broekelmann,T., Rosenbloom,J. and Mecham,R.P.
  TITLE     Functional domains on elastin and microfibril-associated
            glycoprotein involved in elastic fibre assembly
  JOURNAL   Biochem J 318 (Pt 1) (Pt 1), 149-155 (1996)
   PUBMED   8761465
  REMARK    Erratum:[Biochem J 1997 May 1;323(Pt 3):863]
REFERENCE   9  (bases 1 to 1045)
  AUTHORS   Faraco,J., Bashir,M., Rosenbloom,J. and Francke,U.
  TITLE     Characterization of the human gene for microfibril-associated
            glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and
            linkage to D1S170
  JOURNAL   Genomics 25 (3), 630-637 (1995)
   PUBMED   7759096
REFERENCE   10 (bases 1 to 1045)
  AUTHORS   Gibson,M.A., Hughes,J.L., Fanning,J.C. and Cleary,E.G.
  TITLE     The major antigen of elastin-associated microfibrils is a 31-kDa
            glycoprotein
  JOURNAL   J Biol Chem 261 (24), 11429-11436 (1986)
   PUBMED   3015971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN996554.1 and BC028033.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002403.3.
            
            Summary: Microfibrillar-associated protein 2 is a major antigen of
            elastin-associated microfibrils and a candidate for involvement in
            the etiology of inherited connective tissue diseases. Four
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.588010.1,
                                           SRR7346977.206278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375535.4/ ENSP00000364685.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               DN996554.1         9-601
            594-1045            BC028033.1         1920-2371
FEATURES             Location/Qualifiers
     source          1..1045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1045
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /note="microfibril associated protein 2"
                     /db_xref="GeneID:4237"
                     /db_xref="HGNC:HGNC:7033"
                     /db_xref="MIM:156790"
     exon            1..34
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..112
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..627
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; microfibril-associated glycoprotein 1;
                     microfibrillar associated protein 2"
                     /codon_start=1
                     /product="microfibrillar-associated protein 2 isoform a
                     precursor"
                     /protein_id="NP_002394.1"
                     /db_xref="CCDS:CCDS174.1"
                     /db_xref="GeneID:4237"
                     /db_xref="HGNC:HGNC:7033"
                     /db_xref="MIM:156790"
                     /translation="MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDN
                     PDYYDYQEVTPRPSEEQFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQY
                     PCTRLYSIHRPCKQCLNEVCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKC
                     GVMASSGLCQSVAASCARSCGSC"
     exon            113..202
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..229
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..316
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..361
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..449
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..523
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1045
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /note="hexamer: AACAAG"
     polyA_site      1045
                     /gene="MFAP2"
                     /gene_synonym="MAGP; MAGP-1; MAGP1"
                     /note="major polyA site"
ORIGIN      
        1 ggactcggag cgggcggcgg agtgacccgg acagctgtcc tctctgacac caccccggcc
       61 tgcctctttg ttgccatgag agctgcctac ctcttcctgc tattcctgcc tgcaggcttg
      121 ctggctcagg gccagtatga cctggacccg ctgccgccgt tccctgacca cgtccagtac
      181 acccactata gcgaccagat cgacaaccca gactactatg attatcaaga ggtgactcct
      241 cggccctccg aggaacagtt ccagttccag tcccagcagc aagtccaaca ggaagtcatc
      301 ccagccccaa ccccagaacc aggaaatgca gagctggagc ccacagagcc tgggcctctt
      361 gactgccgtg aggaacagta cccgtgcacc cgcctctact ccatacacag gccttgcaaa
      421 cagtgtctca acgaggtctg cttctacagc ctccgccgtg tgtacgtcat taacaaggag
      481 atctgtgttc gtacagtgtg tgcccatgag gagctcctcc gagctgacct ctgtcgggac
      541 aagttctcca aatgtggcgt gatggccagc agcggcctgt gccaatccgt ggcggcctcc
      601 tgtgccagga gctgtgggag ctgctagggt ggtgctggca tcctgagtcc tggccctcct
      661 gggatctggg gccctcgggc cctgcctgac ctggtgcttt tttccccatc cccatgttcc
      721 ttttattctg taaaaagtta gtggactgca gccctggggg ttgcaggctg cggtgcctca
      781 ggcccctcct tcagcctgtg gccacctctg gggcacaatg ggggctcccc actgcccagt
      841 ctgcccctcg ggttggggga gtatcccagg cctctctgtg ggacctgggc ccctgacggg
      901 ccttctcagc ccgttttgag gacagacagt cccccgaggt aggctacatc cccccacccc
      961 agctggtctg cttggatttc ctacagcccc cgtgggcatg gaccaccttt attttataca
     1021 aaattaaaaa caagttttta caaaa
//
