LOCUS       NM_005926               2043 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens microfibril associated protein 1 (MFAP1), mRNA.
ACCESSION   NM_005926
VERSION     NM_005926.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Salas-Armenteros,I., Barroso,S.I., Rondon,A.G., Perez,M.,
            Andujar,E., Luna,R. and Aguilera,A.
  TITLE     Depletion of the MFAP1/SPP381 Splicing Factor Causes
            R-Loop-Independent Genome Instability
  JOURNAL   Cell Rep 28 (6), 1551-1563 (2019)
   PUBMED   31390568
  REMARK    GeneRIF: Depletion of the MFAP1/SPP381 Splicing Factor Causes
            R-Loop-Independent Genome Instability.
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Yeh,H., Chow,M., Abrams,W.R., Fan,J., Foster,J., Mitchell,H.,
            Muenke,M. and Rosenbloom,J.
  TITLE     Structure of the human gene encoding the associated microfibrillar
            protein (MFAP1) and localization to chromosome 15q15-q21
  JOURNAL   Genomics 23 (2), 443-449 (1994)
   PUBMED   7835894
REFERENCE   10 (bases 1 to 2043)
  AUTHORS   Horrigan,S.K., Rich,C.B., Streeten,B.W., Li,Z.Y. and Foster,J.A.
  TITLE     Characterization of an associated microfibril protein through
            recombinant DNA techniques
  JOURNAL   J Biol Chem 267 (14), 10087-10095 (1992)
   PUBMED   1374398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF981568.1, BC050742.1 and AC018512.6.
            
            On Nov 23, 2018 this sequence version replaced NM_005926.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.904167.1,
                                           SRR1660805.97660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267812.4/ ENSP00000267812.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BF981568.1         64-139
            77-2000             BC050742.1         86-2009
            2001-2043           AC018512.6         119690-119732       c
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..2043
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="microfibril associated protein 1"
                     /db_xref="GeneID:4236"
                     /db_xref="HGNC:HGNC:7032"
                     /db_xref="MIM:600215"
     exon            1..200
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1441
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="microfibrillar associated protein 1; spliceosome B
                     complex protein MFAP1"
                     /codon_start=1
                     /product="microfibrillar-associated protein 1"
                     /protein_id="NP_005917.2"
                     /db_xref="CCDS:CCDS10105.1"
                     /db_xref="GeneID:4236"
                     /db_xref="HGNC:HGNC:7032"
                     /db_xref="MIM:600215"
                     /translation="MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKR
                     PDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLA
                     RHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERK
                     NEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAE
                     ALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEY
                     EAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK
                     YKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYT
                     HLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT"
     exon            201..420
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            421..550
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            551..738
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            739..847
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1008
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1168
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1258
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..2043
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="hexamer: AATAAA"
     polyA_site      1957
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="major polyA site"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="hexamer: AATAAA"
     polyA_site      2003
                     /gene="MFAP1"
                     /gene_synonym="AMP"
     regulatory      2014..2019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MFAP1"
                     /gene_synonym="AMP"
                     /note="hexamer: ATTAAA"
     polyA_site      2043
                     /gene="MFAP1"
                     /gene_synonym="AMP"
ORIGIN      
        1 atcagtcgcg cagctgtgtt cgcggactca ggtggaagga atttcttctc ttcgttgacg
       61 ttgctggtgt tcactgtttg gaattagtca agtttcggga atcaccgtcg ctgccatcaa
      121 catgtcggtc ccaagcgctc tcatgaagca accgcccatt cagtctacgg ctggggccgt
      181 cccagttcgc aatgagaaag gtgagatttc aatggaaaaa gtgaaggtaa agcgttatgt
      241 gtccggaaaa aggccagact atgcccctat ggagtcctca gatgaggagg atgaagaatt
      301 tcagttcatt aagaaagcca aagaacaaga agcagagcct gaggaacagg aggaggattc
      361 atccagtgac ccccggctac ggcgtttaca gaaccgtatt agtgaagatg tggaagagag
      421 attggctcga catcgaaaaa tagtggaacc tgaagtggta ggagagagtg actcagaagt
      481 agaaggagat gcttggcgca tggaacgaga agacagcagt gaagaagagg aggaggaaat
      541 tgatgatgag gaaatagagc ggcggcgtgg catgatgcgt cagcgagcac aggagagaaa
      601 aaatgaagag atggaagtca tggaagtgga agatgagggt cgttctggag aggagtcaga
      661 atcagagtct gagtatgaag agtacacaga cagtgaagat gagatggagc ctcgccttaa
      721 gccagtcttc attcgaaaga aggaccgagt gacagttcaa gaacgtgaag ccgaagcatt
      781 gaaacagaag gagctggagc aggaagcaaa acgcatggct gaggaaaggc gcaagtacac
      841 actcaagatt gtcgaagagg aaaccaaaaa agagctggaa gagaacaagc gatccctggc
      901 tgcattggat gcactcaata ctgatgatga aaatgatgag gaggaatatg aggcatggaa
      961 agttcgagag ctaaaaagaa tcaagaggga cagagaagat cgagaagcgc ttgagaagga
     1021 gaaagcagaa attgaacgca tgcgaaacct gactgaggaa gagaggagag ctgaacttcg
     1081 ggcaaacggc aaagtcatta ccaacaaagc tgttaagggc aaatacaagt tcttacagaa
     1141 gtattatcac cggggtgcct tcttcatgga tgaggatgaa gaagtataca agagagattt
     1201 cagcgctcct accctggagg atcatttcaa taaaaccatt cttcctaaag tcatgcaggt
     1261 caagaacttt ggacgctcag gtcgcaccaa atacactcac cttgtggatc aagataccac
     1321 ctcctttgac tcagcttggg gccaagagag tgcccagaac acaaagttct tcaaacaaaa
     1381 ggcagctggg gtacgagatg tatttgagcg gccatctgcc aagaagcgga aaactaccta
     1441 gggtccaact gcttattctt ccaactgtgg aacacaaggg gagtctcagc atctggtcct
     1501 tgatttggtt ttttcattgt ttccttggcc cctgtatcca gatattggac ttactgctat
     1561 acttgtgata ctgggtagcc cagactttga aggtgctttg tgaggtttgg actcatgctg
     1621 agaaacccac aggaaagcac tgtccaggta ggattagagg cttcccactt aaaactattt
     1681 ctgagaaatc ttaggtttta tcactgctat ggtttcccat atttacttgg gactgttctg
     1741 actttctttt tccagccctt agcttgggtt agaaaagtgg acatgtaagt gaacaatgca
     1801 ttacttctac cttaggttta ggagtaatat acccggaaat ctaagctcat ggaaacatgt
     1861 tttccatttt tgcttggagt ccgtttttct agttgtacat actttttgat ccatatatgt
     1921 gtgcatgtca agaaataaaa gaatcacaca acaaggagat ttttagcatg atactggaaa
     1981 taaaatgtcc aagctgacaa gtattaattg cctattaaag taaaagataa caattgtcag
     2041 gca
//
